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Nitric Oxide and Cyclic GMP Signaling
Abstract
NO and cGMP constitute an autocrine, paracrine, and possible endocrine signal transduction system. Cytosolic NO-responsive guanylyl cyclase can be stimulated by NO derived from its own cell, from similar or distinct neighboring cell types within a tissue, from a circulating pool of NO (as NO+ equivalents coupled to plasma protein thiol groups), or from pharmacologic agents, the nitrovasodilators. NO and cGMP together comprise an especially wide-ranging signal transduction system when one considers (i) the many roles of cGMP in physiological regulation, including smooth muscle relaxation, visual transduction, intestinal ion transport, and platelet function; (ii) the many sources, biochemical interactions, and functions of NO; and (iii) the interactions of cGMP and its affected pathways with other signaling systems such as phosphoinositides, eicosanoids, cAMP and Ca2+.
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Citations
Cited by
Pall, M. L. (2013) · Journal of Cellular and Molecular Medicine · doi:10.1111/jcmm.12088 · Cited by 440
Nitric oxide function in the skin
Cals-Grierson, M.-M., & Ormerod, A. D. (2004) · Nitric Oxide · doi:10.1016/j.niox.2004.04.005 · Cited by 329
McCANN, S. M., KIMURA, M., KARANTH, S., YU, W. H., MASTRONARDI, C. A., & RETTORI, V. (2000) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.2000.tb05368.x · Cited by 164
Nitric oxide deficiency in pulmonary hypertension: pathobiology and implications for therapy
Tonelli, A. R., Haserodt, S., Aytekin, M., & Dweik, R. A. (2013) · Pulmonary Circulation · doi:10.4103/2045-8932.109911 · Cited by 86
McLellan, A. G., Ahmad, N. S. B., Acton, J. P., Punni, H. K., O'Donnell, E., Shepherd, A. I., Perissiou, M., James, L. J., Clifford, T., & Bailey, S. J. (2026) · Food & Function · doi:10.1039/d6fo02338j
Metadata
- Authors
- McDonald, L. J., & Murad, F.
- Venue
- Experimental Biology and Medicine
- Publisher
- Frontiers Media SA
- Published
- 1996-01-01
- Volume
- 211
- Issue
- 1
- Pages
- 1-6
- ISSN
- 0071-3384 (ISSN-L)
- 1535-3702
- 1535-3699
- OpenAlex
- W2080618408
- Cited by
- 225
- References
- 0
- FWCI
- 10.25
- Type
- journal article
- Language
- en
- Open access
- closed
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- McDonald, L. J., & Murad, F. (1996). Nitric Oxide and Cyclic GMP Signaling. Experimental Biology and Medicine. https://doi.org/10.3181/00379727-211-43950a
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
