Enzyme Inhibition in Relation to Chemotherapy.

Ackermann, W. W.; Potter, V. R.

doi:10.3181/00379727-72-17313

Cited by 266Cancer and biochemical researchBioactive Compounds and Antitumor AgentsBiochemical and Molecular Research

Enzyme Inhibition in Relation to Chemotherapy.

Ackermann, W. W., Potter, V. R.·1949·Experimental Biology and Medicine

DOI 10.3181/00379727-72-17313

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Abstract

1. The effect of enzyme concentration on the inhibition produced by certain inhibitors of the succinic dehydrogenase system has been experimentally determined. The inhibitors studied were malonate, itaconate, oxalacetate, quinone and cupric ion.

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Itaconate acts as a competitive SDH inhibitor in immune cells.
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From Immunoresponsive Gene 1 and Itaconate Inhibit Succinate Dehydrogenase to Modulate Intracellular Succinate Levels (2016) · cites this paper as [27]
Itaconate inhibits SDH ex vivo.
“Although itaconate has been shown previously to inhibit SDH ex vivo (26 -28)”
From Immunoresponsive Gene 1 and Itaconate Inhibit Succinate Dehydrogenase to Modulate Intracellular Succinate Levels (2016) · cites this paper as [27]

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Authors: Ackermann, W. W., & Potter, V. R.
Venue: Experimental Biology and Medicine
Publisher: Frontiers Media SA
Published: 1949-10-01
Volume: 72
Issue: 1
Pages: 1-9
ISSN: 0071-3384 (ISSN-L)
1535-3702
1535-3699
DOI: 10.3181/00379727-72-17313
OpenAlex: W2315543398
Cited by: 262
References: 0
Citations by year: 2026: 2 · 2025: 6 · 2024: 7 · 2023: 9 · 2022: 4 · 2021: 4 · 2020: 7 · 2019: 4 · 2018: 2 · 2017: 2 · 2016: 3 · 2015: 3 · 2013: 1
FWCI: 4.58
Type: journal article
Language: en
Open access: closed
Locations: Experimental Biology and Medicine (publishedVersion)
PubMed (publishedVersion)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Cancer and biochemical research
Life Sciences › Pharmacology, Toxicology and Pharmaceutics › Toxicology › Bioactive Compounds and Antitumor Agents
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Biochemical and Molecular Research
Keywords: enzyme inhibition, succinate dehydrogenase, succinate dehydrogenase inhibitors, malonate, itaconate, oxaloacetate, quinones, copper(II) ions, enzyme concentration, chemotherapy
MeSH terms: Biochemical Phenomena, Drug Therapy, Enzymes, Humans

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Enzyme Inhibition in Relation to Chemotherapy.

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