The DOI matches its Crossref record.
Enzyme Inhibition in Relation to Chemotherapy.
Abstract
1. The effect of enzyme concentration on the inhibition produced by certain inhibitors of the succinic dehydrogenase system has been experimentally determined. The inhibitors studied were malonate, itaconate, oxalacetate, quinone and cupric ion.
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“it also appears to play a major role in embryo implantation in the womb, a process thought to require immunosuppression70–72.”
From Coupling Krebs cycle metabolites to signalling in immunity and cancer (2018) · cites this paper as [70]
In the citing paper
“our data suggest that itaconate acts as a competitive SDH inhibitor in immune cells”
From Immunoresponsive Gene 1 and Itaconate Inhibit Succinate Dehydrogenase to Modulate Intracellular Succinate Levels (2016) · cites this paper as [27]
In the citing paper
“Although itaconate has been shown previously to inhibit SDH ex vivo (26 -28)”
From Immunoresponsive Gene 1 and Itaconate Inhibit Succinate Dehydrogenase to Modulate Intracellular Succinate Levels (2016) · cites this paper as [27]
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Drougard, A., Ma, E. H., Wegert, V., Sheldon, R. D., Panzeri, I., Vatsa, N., Apostle, S., Fagnocchi, L., Schaf, J., Gossens, K., et al. (2023) · eLife · doi:10.7554/elife.87120.1.sa4
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eLife assessment: A rapid microglial metabolic response controls metabolism and improves memory
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An acute microglial metabolic response controls metabolism and improves memoryPreprint
Drougard, A., Ma, E. H., Wegert, V., Sheldon, R. D., Panzeri, I., Vatsa, N., Apostle, S., Fagnocchi, L., Schaf, J., Gossens, K., et al. (2024) · eLife · doi:10.7554/elife.87120.2
Punekar, N. S. (2025) · Springer eBooks · doi:10.1007/978-981-97-8179-9_19
Metadata
- Authors
- Ackermann, W. W., & Potter, V. R.
- Venue
- Experimental Biology and Medicine
- Publisher
- Frontiers Media SA
- Published
- 1949-10-01
- Volume
- 72
- Issue
- 1
- Pages
- 1-9
- ISSN
- 0071-3384 (ISSN-L)
- 1535-3702
- 1535-3699
- OpenAlex
- W2315543398
- Cited by
- 262
- References
- 0
- Citations by year
- 2026: 2 · 2025: 6 · 2024: 7 · 2023: 9 · 2022: 4 · 2021: 4 · 2020: 7 · 2019: 4 · 2018: 2 · 2017: 2 · 2016: 3 · 2015: 3 · 2013: 1
- FWCI
- 4.58
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Experimental Biology and Medicine (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Cancer and biochemical research
- Life Sciences › Pharmacology, Toxicology and Pharmaceutics › Toxicology › Bioactive Compounds and Antitumor Agents
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Biochemical and Molecular Research
- Keywords
- enzyme inhibition, succinate dehydrogenase, succinate dehydrogenase inhibitors, malonate, itaconate, oxaloacetate, quinones, copper(II) ions, enzyme concentration, chemotherapy
- MeSH terms
- Biochemical Phenomena, Drug Therapy, Enzymes, Humans
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