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Cited by 22Immunotoxicology and immune responsesAnimal testing and alternativesAntibiotics Pharmacokinetics and Efficacy

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Toxicity of Penicillin for the Syrian Hamster

Schneierson, S. S., Perlman, E.·1956·Experimental Biology and Medicine
DOI 10.3181/00379727-91-22221
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Abstract

A single injection of crystalline penicillin G potassium administered subcutaneously or intraperitoneally is toxic for hamsters in proportion to amount administered. Toxicity is of the delayed type, the vast majority of deaths occurring on 3rd, 4th and 5th days following injection. This parallels the reported experience with guinea pigs and is in contrast to Swiss mice who easily tolerate very large doses of this antibiotic. In the light of these findings, reevaluation of experimental data concerned with Syrian hamsters either treated with or injected with material sterilized with penicillin would seem to be indicated.

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Metadata

Authors
Schneierson, S. S., & Perlman, E.
Affiliations
Mount Sinai Hospital (US)
Venue
Experimental Biology and Medicine
Publisher
Frontiers Media SA
Published
1956-02-01
Volume
91
Issue
2
Pages
229-230
ISSN
  • 0071-3384 (ISSN-L)
  • 1535-3702
  • 1535-3699
DOI
10.3181/00379727-91-22221
OpenAlex
W2028224961
Cited by
22
References
0
Citations by year
2025: 1 · 2024: 1 · 2019: 1 · 2015: 1
FWCI
0.58
Type
journal article
Language
en
Open access
closed
Locations
  • Experimental Biology and Medicine (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Life Sciences › Immunology and Microbiology › Immunology › Immunotoxicology and immune responses
  • Health Sciences › Veterinary › Small Animals › Animal testing and alternatives
  • Health Sciences › Medicine › Pharmacology (medical) › Antibiotics Pharmacokinetics and Efficacy
Keywords
penicillin G potassium, drug toxicity, golden hamster, delayed toxicity, subcutaneous injection, intraperitoneal injection
MeSH terms
Animals, Cricetinae, Mesocricetus, Penicillins

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CoChat. (2026). Citation check: Toxicity of Penicillin for the Syrian Hamster. https://app.cochat.ai/papers/10.3181/00379727-91-22221
The paper
Schneierson, S. S., & Perlman, E. (1956). Toxicity of Penicillin for the Syrian Hamster. Experimental Biology and Medicine. https://doi.org/10.3181/00379727-91-22221