The DOI matches its Crossref record; 9 of the 9 references it cites were found in a registry or an index.
The use of neurophysiological endophenotypes to understand the genetic basis of schizophrenia
Open accessAbstract
Specifying the complex genetic architecture of the "fuzzy" clinical phenotype of schizophrenia is an imposing problem. Utilizing metabolic, neurocognitive, and neurophysiological "intermediate" endophenotypic measures offers significant advantages from a statistical genetics standpoint. Endophenotypic measures are amenable to quantitative genetic analyses, conferring upon them a major methodological advantage compared with largely qualitative diagnoses using the Diagnostic and Statistical Manual of Mental Health, 4th Edition (DSM-IV). Endophenotypic deficits occur across the schizophrenia spectrum in schizophrenia patients, schizotypal patients, and clinically unaffected relatives of schizophrenia patients. Neurophysiological measures, such as P50 event-related suppression and the prepulse inhibition (PPI) of the startle response, are endophenotypes that can be conceptualized as being impaired because of a single genetic abnormality in the functional cascade of DNA to RNA to protein. The "endophenotype approach" is also being used to understand other medical disorders, such as colon cancer, hemochromatosis, and hypertension, where there is interplay between genetically conferred vulnerability and nongenetic stressors. The power and utility of utilizing endophenotypes to understand the genetics of schizophrenia is discussed in detail in this article.
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Cites
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Self-citationLinkage of a neurophysiological deficit in schizophrenia to a chromosome 15 locus
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“plexities into understanding the genetic architecture and nongenetic contributions into quantitative measures that are amenable to analysis via advanced statistical quantitative trait analytic genetic methods.(11-14) Thus, for a complex psychiatric illness like schizophrenia, the relationship between genes, gene produ…”
BackgroundMeasuring P50 suppression and prepulse inhibition in a single recording session
Light, G. A., & Braff, D. L. (2001) · American Journal of Psychiatry · doi:10.1176/appi.ajp.158.12.2066 · Cited by 59 · cited 1×
“While PPI and P50 suppression measures of “gating” are often conceptually linked, there is evidence that they actually diverge in nonpsychiatric and clinical populations.(65-68) Thus, these two different, but seemingly closely related gating abnormalities, may be characteristic of different subgroups of patients.”
BackgroundSelf-citation21 Genome partitioning and whole-genome analysis
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Cited by
Neurophysiological Endophenotypes of Schizophrenia: The Viability of Selected Candidate Measures
Turetsky, B. I., Calkins, M. E., Light, G. A., Olincy, A., Radant, A. D., & Swerdlow, N. R. (2006) · Schizophrenia Bulletin · doi:10.1093/schbul/sbl060 · Cited by 567
Self-citationCognitive Control Deficits in Schizophrenia: Mechanisms and Meaning
Lesh, T. A., Niendam, T. A., Minzenberg, M. J., & Carter, C. S. (2011) · Neuropsychopharmacology · doi:10.1038/npp.2010.156 · Cited by 506
Light, G. A., Hsu, J. L., Hsieh, M. H., Meyer-Gomes, K., Sprock, J., Swerdlow, N. R., & Braff, D. L. (2006) · Biological Psychiatry · doi:10.1016/j.biopsych.2006.03.055 · Cited by 422
Self-citationGreenwood, T. A., Braff, D. L., Light, G. A., Cadenhead, K. S., Calkins, M. E., Dobie, D. J., Freedman, R., Green, M. F., Gur, R. E., Gur, R. C., et al. (2007) · Archives of General Psychiatry · doi:10.1001/archpsyc.64.11.1242 · Cited by 381
Self-citationSchizophrenia, “just the facts”: What we know in 2008Part 3: Neurobiology
KESHAVAN, M., TANDON, R., BOUTROS, N., & NASRALLAH, H. (2008) · Schizophrenia Research · doi:10.1016/j.schres.2008.07.020 · Cited by 347
Metadata
- Authors
- Braff, D. L., & Light, G. A.
- Venue
- Dialogues in Clinical Neuroscience
- Publisher
- Informa UK Limited
- Published
- 2005-06-30
- Volume
- 7
- Issue
- 2
- Pages
- 125-135
- ISSN
- 1294-8322 (ISSN-L)
- 1958-5969
- OpenAlex
- W1662387941
- Cited by
- 160
- References
- 9
- FWCI
- 6.42
- Type
- journal article
- Language
- en
- Open access
- diamond
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