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Coccidioidomycosis as a Common Cause of Community-acquired Pneumonia
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The early manifestations of coccidioidomycosis (valley fever) are similar to those of other causes of community-acquired pneumonia (CAP). Without specific etiologic testing, the true frequency of valley fever may be underestimated by public health statistics. Therefore, we conducted a prospective observational study of adults with recent onset of a lower respiratory tract syndrome. Valley fever was serologically confirmed in 16 (29%) of 55 persons (95% confidence interval 16%-44%). Antimicrobial medications were used in 81% of persons with valley fever. Symptomatic differences at the time of enrollment had insufficient predictive value for valley fever to guide clinicians without specific laboratory tests. Thus, valley fever is a common cause of CAP after exposure in a disease-endemic region. If CAP develops in persons who travel or reside in Coccidioides-endemic regions, diagnostic evaluation should routinely include laboratory evaluation for this organism.
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“However, it is thought that around 25% of all community-acquired pneumonia in endemic regions is secondary to coccidioidomycosis [135].”
From Race and ethnicity: Risk factors for fungal infections? (2023) · cites this paper as [135]
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Metadata
- Authors
- Valdivia, L., Nix, D., Wright, M., Lindberg, E., Fagan, T., Lieberman, D., Stoffer, T., Ampel, N. M., & Galgiani, J. N.
- Affiliations
- University of Arizona (US)
- Arizona Community Physicians, Tucson, Arizona, USA
- Corresponding author
- Galgiani, John N.
- Venue
- Emerging Infectious Diseases
- Published
- 2006-06
- Volume
- 12
- Issue
- 6
- Pages
- 958-962
- ISSN
- 1080-6040 (ISSN-L)
- 1080-6059
- PMC
- PMC3373055
- OpenAlex
- W2131843801
- Cited by
- 285
- References
- 19
- Citations by year
- 2026: 11 · 2025: 17 · 2024: 17 · 2023: 17 · 2022: 21 · 2021: 15 · 2020: 16 · 2019: 20 · 2018: 12 · 2017: 16 · 2016: 10 · 2015: 12 · 2014: 12 · 2013: 8 · 2012: 11
- FWCI
- 10.78
- Type
- journal article
- Language
- en
- Open access
- diamond
- doi.org
- Licence
- cc-by
- Locations
- Emerging infectious diseases (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion)
- Funders
- U.S. Department of Health and Human Services
- U.S. Department of Veterans Affairs
- National Institutes of Health
- National Institute of Allergy and Infectious Diseases (P01AI061310, 1 PO 1AI061310-01)
- Topics
- Health Sciences › Medicine › Infectious Diseases › Fungal Infections and Studies
- Health Sciences › Medicine › Epidemiology › Pneumonia and Respiratory Infections
- Health Sciences › Medicine › Microbiology (medical) › Actinomycetales infections and treatment
- Keywords
- coccidioidomycosis, community-acquired pneumonia, Coccidioides, serological diagnosis, endemic areas, antimicrobial therapy, travel-associated infection
- MeSH terms
- Adult, Antibodies, Fungal, Arizona, Coccidioides, Coccidioidomycosis, Enzyme-Linked Immunosorbent Assay, Female, Immunodiffusion, Humans, Male, Middle Aged, Pneumonia, Prospective Studies, Community-Acquired Infections
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