Fatal Sickle Cell Disease and Zika Virus Infection in Girl from Colombia
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further tested with Zika virus-specific real-time quantitative RT-PCR (2) by using the QuantiTect Probe RT-PCR Kit (QIAGEN, Valencia, CA, USA) with amplification in the iCycler iQ5 (Bio-Rad, Hercules, CA, USA), following the manufacturer's instructions.Viral titers of JMB-185, as determined by real-time quantitative RT-PCR, were 4.25 × 10 3 PFU, 5.07 × 10 7 PFU, and 7.33 × 10 6 PFU for the clinical sample, first passage, and second passage, respectively.The isolation and characterization of Zika virus from a resident with no travel history confirm that the virus is circulating in Indonesia and that, by mimicking mild dengue infection, this infection is likely contributing to the large number of undiagnosed cases of acute febrile illness.Although reported human cases of Zika virus infection have been rare in Southeast Asia (1), confusion with dengue and difficulty in obtaining a laboratory diagnosis are likely causing its incidence to be underestimated.Surveillance must be implemented to evaluate and monitor the distribution of Zika virus and the potential public health problems it may cause in Indonesia.
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ZIKV infection is associated with severe neurological syndromes, including Guillain-Barré syndrome in adults and microcephaly in infants.
“Cumulative evidence suggests an association between ZIKV infection and microcephaly in newborn infants.”
From ICR suckling mouse model of Zika virus infection for disease modeling and drug validation (2018) · cites this paper as [15]
The paper’s case report concerns a 15-year-old girl with sickle cell disease and fatal Zika virus infection; it does not discuss microcephaly in newborns or Guillain-Barré syndrome in adults. A reference title mentions congenital malformations, but the paper’s text does not state the claimed association (searched: microcephaly, congenital malformations, Guillain-Barré syndrome). (LLM, conf=0.76)
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Cites
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Characterization of a Novel Murine Model to Study Zika Virus
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ICR suckling mouse model of Zika virus infection for disease modeling and drug validation
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- Authors
- Arzuza-Ortega, L., Polo, A., Pérez-Tatis, G., López-García, H., Parra, E., Pardo-Herrera, L. C., Rico-Turca, A. M., Villamil-Gómez, W., & Rodríguez-Morales, A. J.
- ORCID
- Parra, Edgar
- Venue
- Emerging infectious diseases
- Published
- 2016-05
- Volume
- 22
- Issue
- 5
- Pages
- 925-927
- ISSN
- 1080-6040 (ISSN-L)
- 1080-6059
- PMC
- PMC4861530
- OpenAlex
- W2337074877
- Cited by
- 113
- References
- 9
- Citations by year
- 2025: 3 · 2024: 5 · 2023: 3 · 2022: 4 · 2021: 8 · 2020: 7 · 2019: 7 · 2018: 10 · 2017: 26 · 2016: 40
- FWCI
- 27.43
- Type
- journal article
- Language
- en
- Open access
- diamond
- doi.org
- Licence
- cc-by
- Locations
- Emerging infectious diseases (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Funders
- United States Agency for International Development
- Kementerian Riset, Teknologi dan Pendidikan Tinggi
- Centers for Disease Control and Prevention
- Topics
- Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Mosquito-borne diseases and control
- Health Sciences › Medicine › Infectious Diseases › Viral Infections and Vectors
- Health Sciences › Medicine › Infectious Diseases › Viral Infections and Outbreaks Research
- Keywords
- Zika virus, sickle cell disease, fatal outcome, acute febrile illness, virus isolation, viral titer, Indonesia
- MeSH terms
- Zika Virus Infection, Zika Virus, Adolescent, Anemia, Sickle Cell, Colombia, Female, Humans, Fatal Outcome
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