The DOI matches its Crossref record; 17 of the 17 references it cites were found in a registry or an index.
The Phoenix from the Ashes: Cardiovascular Autonomic Dysfunction in Behavioral Variant of Frontotemporal Dementia
Abstract
BACKGROUND: Patients with autonomic failure may experience postural dizziness, syncope, and falls. Identifying symptomatic dysautonomia in dementia is of importance to ensure appropriate management and reduce risk of falls. OBJECTIVE: The aim of this prospective study is to identify cardiovascular autonomic dysfunction in patients suffering from behavioral variant of frontotemporal dementia (bvFTD), compared to Alzheimer's disease (AD). METHODS: Patients were prospectively recruited from 2009 until 2013. Clinical autonomic function tests were carried out in an Autonomic Unit according to Ewing's cardiovascular battery. Parasympathetic tests included resting heart rate variability, deep breathing, and Valsalva. Sympathetic function tests compromised blood pressure regulation on valsalva, cutaneous cold stimulation, and 70° head up tilt including of plasma noradrenaline. RESULTS: 26 patients (17 female) with bvFTD and 18 patients (10 female) with AD were examined. Mean age of bvFTD was 69 ± 11 years, AD 74 ± 9 years. History taking was often not conclusive and did not correlate with autonomic signs. In 42% bvFTD patients and 44% AD patients, autonomic dysfunction was demonstrated. Manifest orthostatic hypotension (OH) was present in 19% of bvFTD and 33% AD patients. Frequency of autonomic dysfunction and orthostatic hypotension did not differ between bvFTD and AD, but were significantly higher than in healthy controls. Autonomic dysfunction was associated with an increased risk of falling (assessed with Tinetti Score). CONCLUSION: This is the first prospective study to elucidate autonomic dysfunction in bvFTD patients. There is a considerable higher frequency of cardiovascular dysfunction and OH in bvFTD. History taking may be not conclusive thus cannot exclude cardiovascular dysautonomia.
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“There is strong consensus that blunted or abolished variation is suggestive of parasympathetic dysfunction. 142,143,146,147”
From 2018 ESC Guidelines for the diagnosis and management of syncope (2018) · cites this paper as [147]
In the citing paper
“There is weak evidence that these tests may be useful. 13,142,143,147”
From 2018 ESC Guidelines for the diagnosis and management of syncope (2018) · cites this paper as [147]
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Self-citationAutonomic dysfunction in dementia
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Metadata
- Authors
- Struhal, W., Javor, A., Brunner, C., Benesch, T., Schmidt, V., Vosko, M. R., & Ransmayr, G.
- Affiliations
- Autonomic Unit, Department of Neurology and Psychiatry, General Hospital of the City of Linz, Linz, Austria
- Medical University of Vienna (AT)
- Corresponding author
- Struhal, Walter
- Venue
- Journal of Alzheimer s Disease
- Publisher
- SAGE Publications
- Published
- 2014-09-16
- Volume
- 42
- Issue
- 3
- Pages
- 1041-1046
- ISSN
- 1387-2877 (ISSN-L)
- 1875-8908
- OpenAlex
- W1722108979
- Cited by
- 22
- References
- 17
- Citations by year
- 2026: 1 · 2025: 2 · 2024: 1 · 2023: 1 · 2022: 1 · 2021: 2 · 2020: 2 · 2019: 1 · 2018: 3 · 2017: 2 · 2016: 2 · 2015: 4
- FWCI
- 2.64
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Journal of Alzheimer s Disease (publishedVersion)
- PubMed (publishedVersion)
- Funders
- RefleXion Medical
- Oesterreichische Nationalbank
- Topics
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiovascular Syncope and Autonomic Disorders
- Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Heart Rate Variability and Autonomic Control
- Keywords
- behavioral variant frontotemporal dementia, cardiac autonomic dysfunction
- MeSH terms
- Aged, Aged, 80 and over, Alzheimer Disease, Autonomic Nervous System Diseases, Mental Disorders, Blood Pressure, Cardiovascular Diseases, Cold Temperature, Heart Rate, Humans, Hypotension, Orthostatic, Middle Aged, Norepinephrine, Retrospective Studies, Skin, Valsalva Maneuver, Frontotemporal Dementia
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