The DOI matches its Crossref record; 17 of the 17 references it cites were found in a registry or an index.
The Phoenix from the Ashes: Cardiovascular Autonomic Dysfunction in Behavioral Variant of Frontotemporal Dementia
Abstract
BACKGROUND: Patients with autonomic failure may experience postural dizziness, syncope, and falls. Identifying symptomatic dysautonomia in dementia is of importance to ensure appropriate management and reduce risk of falls. OBJECTIVE: The aim of this prospective study is to identify cardiovascular autonomic dysfunction in patients suffering from behavioral variant of frontotemporal dementia (bvFTD), compared to Alzheimer's disease (AD). METHODS: Patients were prospectively recruited from 2009 until 2013. Clinical autonomic function tests were carried out in an Autonomic Unit according to Ewing's cardiovascular battery. Parasympathetic tests included resting heart rate variability, deep breathing, and Valsalva. Sympathetic function tests compromised blood pressure regulation on valsalva, cutaneous cold stimulation, and 70° head up tilt including of plasma noradrenaline. RESULTS: 26 patients (17 female) with bvFTD and 18 patients (10 female) with AD were examined. Mean age of bvFTD was 69 ± 11 years, AD 74 ± 9 years. History taking was often not conclusive and did not correlate with autonomic signs. In 42% bvFTD patients and 44% AD patients, autonomic dysfunction was demonstrated. Manifest orthostatic hypotension (OH) was present in 19% of bvFTD and 33% AD patients. Frequency of autonomic dysfunction and orthostatic hypotension did not differ between bvFTD and AD, but were significantly higher than in healthy controls. Autonomic dysfunction was associated with an increased risk of falling (assessed with Tinetti Score). CONCLUSION: This is the first prospective study to elucidate autonomic dysfunction in bvFTD patients. There is a considerable higher frequency of cardiovascular dysfunction and OH in bvFTD. History taking may be not conclusive thus cannot exclude cardiovascular dysautonomia.
Overview
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
In the citing paper
“There is strong consensus that blunted or abolished variation is suggestive of parasympathetic dysfunction. 142,143,146,147”
From 2018 ESC Guidelines for the diagnosis and management of syncope (2018) · cites this paper as [147]
In the citing paper
“There is weak evidence that these tests may be useful. 13,142,143,147”
From 2018 ESC Guidelines for the diagnosis and management of syncope (2018) · cites this paper as [147]
Citations
Cites
McKhann, G., Drachman, D., Folstein, M., Katzman, R., Price, D., & Stadlan, E. M. (1984) · Neurology · doi:10.1212/wnl.34.7.939 · Cited by 27,915
Sensitivity of revised diagnostic criteria for the behavioural variant of frontotemporal dementia
Rascovsky, K., Hodges, J. R., Knopman, D., Mendez, M. F., Kramer, J. H., Neuhaus, J., van Swieten, J. C., Seelaar, H., Dopper, E. G. P., Onyike, C. U., et al. (2011) · Brain · doi:10.1093/brain/awr179 · Cited by 5,221
Frontotemporal lobar degeneration: A consensus on clinical diagnostic criteria
Neary, D., Snowden, J. S., Gustafson, L., Passant, U., Stuss, D., Black, S., Freedman, M., Kertesz, A., Robert, P. H., Albert, M., et al. (1998) · Neurology · doi:10.1212/wnl.51.6.1546 · Cited by 5,047
Developed in collaboration with, European Heart Rhythm Association (EHRA), Heart Failure Association (HFA), and Heart Rhythm Society (HRS), societies, E. B. T. F., European Society of Emergency Medicine (EuSEM), European Federation of Internal Medicine (EFIM), European Union Geriatric Medicine Society (EUGMS), American Geriatrics Society (AGS), European Neurological Society (ENS), et al. (2009) · European Heart Journal · doi:10.1093/eurheartj/ehp298 · Cited by 2,040
Fall risk index for elderly patients based on number of chronic disabilities
Tinetti, M. E., Franklin Williams, T., & Mayewski, R. (1986) · The American Journal of Medicine · doi:10.1016/0002-9343(86)90717-5 · Cited by 1,587
The Value of Cardiovascular Autonomic Function Tests: 10 Years Experience in Diabetes
Ewing, D. J., Martyn, C., Young, R. J., & Clarke, B. F. (1985) · Diabetes Care · doi:10.2337/diacare.8.5.491 · Cited by 1,436
Cardiovascular effects of human insular cortex stimulation
Oppenheimer, S. M., Gelb, A., Girvin, J. P., & Hachinski, V. C. (1992) · Neurology · doi:10.1212/wnl.42.9.1727 · Cited by 1,272
EFNS guidelines on the diagnosis and management of orthostatic hypotension
Lahrmann, H., Cortelli, P., Hilz, M., Mathias, C. J., Struhal, W., & Tassinari, M. (2006) · European Journal of Neurology · doi:10.1111/j.1468-1331.2006.01512.x · Cited by 334 · cited 1×
“Adaptation of antihypertensive medication often improves OH in those patients [15, 23]. dysfunction is not autonomic testing but history taking [ History taking might be obstructed due to amnesia syncopal episodes in elderly patients [24].”
Self-citationAutonomic dysfunction in dementia
Allan, L. M., Ballard, C. G., Allen, J., Murray, A., Davidson, A. W., McKeith, I. G., & Kenny, R. A. (2006) · Journal of Neurology Neurosurgery & Psychiatry · doi:10.1136/jnnp.2006.102343 · Cited by 238
Selective functional, regional, and neuronal vulnerability in frontotemporal dementia
Seeley, W. W. (2008) · Current Opinion in Neurology · doi:10.1097/wco.0b013e3283168e2d · Cited by 235
Assessing autonomic dysfunction in early diabetic neuropathy
Zilliox, L. A., Peltier, A., Wren, P. A., Anderson, A. L., Smith, A. G., Singleton, J. R., Feldman, E. L., Alexander, N. B., & Russell, J. W. (2011) · Neurology · doi:10.1212/wnl.0b013e3182120147 · Cited by 164
Neurogenic orthostatic hypotension: pathophysiology, evaluation, and management
Metzler, M., Duerr, S., Granata, R., Krismer, F., Robertson, D., & Wenning, G. K. (2012) · Journal of Neurology · doi:10.1007/s00415-012-6736-7 · Cited by 139
Depressed baroreflex sensitivity in patients with Alzheimer’s and Parkinson’s disease
Szili‐Törok, T., Kálmán, J., Paprika, D., Dibó, G., Rózsa, Z., & Rudas, L. (2001) · Neurobiology of Aging · doi:10.1016/s0197-4580(01)00210-x · Cited by 76
Orthostatic hypotension and cognitive impairment: a dangerous association?
Sambati, L., Buonaura, G. C., Poda, R., Guaraldi, P., & Cortelli, P. (2014) · Neurological Sciences · doi:10.1007/s10072-014-1686-8 · Cited by 46
Management of Neurogenic Orthostatic Hypotension in Patients with Autonomic Failure
Schroeder, C., Jordan, J., & Kaufmann, H. (2013) · Drugs · doi:10.1007/s40265-013-0097-0 · Cited by 30
Insular Alzheimer disease pathology and the psychometric correlates of mortality.
Royall, D. R. (2008) · Cleveland Clinic Journal of Medicine · doi:10.3949/ccjm.75.suppl_2.s97 · Cited by 29
Christensen (1997) · doi:10.1002/(sici)1099-1166(199703)12:3
Cited by
Sorted by citations
2018 ESC Guidelines for the diagnosis and management of syncope
Brignole, M., Moya, A., de Lange, F. J., Deharo, J.-C., Elliott, P. M., Fanciulli, A., Fedorowski, A., Furlan, R., Kenny, R. A., Martín, A., et al. (2018) · European Heart Journal · doi:10.1093/eurheartj/ehy037 · Cited by 1,951
2018 ESC Guidelines for the diagnosis and management of syncope
Brignole, M., Moya‐Mitjans, À., de Lange, F. J., Deharo, J., Elliot, P. M., Fanciulli, A., Fedorowski, A., Furlan, R., Kenny, R. A., Martiın, A., et al. (2018) · Kardiologia Polska · doi:10.5603/kp.2018.0161 · Cited by 475
Guo, C. C., Sturm, V. E., Zhou, J. H., Gennatas, E. D., Trujillo, A. J., Hua, A. Y., Crawford, R. K., Stables, L. A., Kramer, J. H., Rankin, K. P., et al. (2016) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1509184113 · Cited by 130
Eating behavior in frontotemporal dementia
Ahmed, R. M., Latheef, S., Bartley, L., Irish, M., Halliday, G. M., Kiernan, M. C., Hodges, J. R., & Piguet, O. (2015) · Neurology · doi:10.1212/wnl.0000000000002018 · Cited by 85
Autonomic Dysfunction in Patients with Mild to Moderate Alzheimer’s Disease
Jensen‐Dahm, C., Waldemar, G., Jensen, T. S., Malmqvist, L., Moeller, M. M., Andersen, B. B., Høgh, P., & Ballegaard, M. (2015) · Journal of Alzheimer s Disease · doi:10.3233/jad-150169 · Cited by 40
Metadata
- Authors
- Struhal, W., Javor, A., Brunner, C., Benesch, T., Schmidt, V., Vosko, M. R., & Ransmayr, G.
- Affiliations
- Autonomic Unit, Department of Neurology and Psychiatry, General Hospital of the City of Linz, Linz, Austria
- Medical University of Vienna (AT)
- Corresponding author
- Struhal, Walter
- Venue
- Journal of Alzheimer s Disease
- Publisher
- SAGE Publications
- Published
- 2014-09-16
- Volume
- 42
- Issue
- 3
- Pages
- 1041-1046
- ISSN
- 1387-2877 (ISSN-L)
- 1875-8908
- OpenAlex
- W1722108979
- Cited by
- 22
- References
- 17
- Citations by year
- 2026: 1 · 2025: 2 · 2024: 1 · 2023: 1 · 2022: 1 · 2021: 2 · 2020: 2 · 2019: 1 · 2018: 3 · 2017: 2 · 2016: 2 · 2015: 4
- FWCI
- 2.64
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Journal of Alzheimer s Disease (publishedVersion)
- PubMed (publishedVersion)
- Funders
- RefleXion Medical
- Oesterreichische Nationalbank
- Topics
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiovascular Syncope and Autonomic Disorders
- Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Heart Rate Variability and Autonomic Control
- Keywords
- behavioral variant frontotemporal dementia, cardiac autonomic dysfunction
- MeSH terms
- Aged, Aged, 80 and over, Alzheimer Disease, Autonomic Nervous System Diseases, Mental Disorders, Blood Pressure, Cardiovascular Diseases, Cold Temperature, Heart Rate, Humans, Hypotension, Orthostatic, Middle Aged, Norepinephrine, Retrospective Studies, Skin, Valsalva Maneuver, Frontotemporal Dementia
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
