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Cited by 97

The DOI matches its Crossref record; 9 of the 9 references it cites were found in a registry or an index.

Serum miR-206 and miR-132 as Potential Circulating Biomarkers for Mild Cognitive Impairment

Xie, Bing, Zhou, Huimin, Zhang, Rui, Song, Mei, Yu, Lulu, Wang, Lan, Liu, Zanchao, Zhang, Qingfu, Cui, Dongsheng, Wang, Xueyi, Xu, Shunjiang·2015·Journal of Alzheimer's Disease
DOI 10.3233/jad-142847
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Abstract

MicroRNAs (miRNAs), a class of small, non-coding RNA molecules with gene regulatory functions, have emerged to play a critical role in the pathogenesis of a variety of diseases. Recently, circulating miRNAs have been reported as potential biomarkers for various pathologic conditions. The present study was performed to investigate the potential role of circulating miRNAs as diagnostic biomarkers for mild cognitive impairment (MCI). We collected 66 patients with MCI and 76 normal controls from our previous cross-sectional cohort study. Seven miRNAs (miR-206, miR-132, miR-193b, miR-130b, miR-20a, miR-296, and miR-329) related to Alzheimer's disease (AD) were detected in serum using a quantitative real-time PCR (qRT-PCR) method. Each miRNA's diagnostic performance was evaluated by receiver operating characteristic curves and the areas under curves (AUC) analysis. The levels of miR-206 and miR-132 in MCI patients' serum were significantly elevated compared to normal controls. Combining detection of miR-206 and miR-132 achieved the highest AUC of 0.981, followed by test of miR-206 (AUC = 0.880) and miR-132 (AUC = 0.912) separately. Importantly, miR-206 and miR-132 were respectively correlated with the Montreal Cognitive Assessment score in MCI patients. These results preliminarily indicated that circulating miR-206 and miR-132 as novel miRNAs upregulated in MCI patient were potential biomarkers for diagnosis of MCI.

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Crossref · 10.3233/jad-142847

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Metadata

Authors
Xie, B., Zhou, H., Zhang, R., Song, M., Yu, L., Wang, L., Liu, Z., Zhang, Q., Cui, D., Wang, X., & Xu, S.
Affiliations
  • Central Laboratory, The First Hospital of Hebei Medical University, Shijiazhuang, P.R. China
  • Department of Mental Health, The First Hospital of Hebei Medical University, Shijiazhuang, P.R. China
  • Department of Endocrinology, The Second Hospital of Shijiazhuang City, Shijiazhuang, P.R. China
  • Department of Burns and Plastic Surgery, The First Hospital of Hebei Medical University, Shijiazhuang, P.R. China
Venue
Journal of Alzheimer's Disease
Publisher
SAGE Publications
Published
2015-03-24
Volume
45
Issue
3
Pages
721-731
ISSN
  • 1875-8908
  • 1387-2877
DOI
10.3233/jad-142847
Cited by
97
References
9

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