Mechanism of miR-132-3p Promoting Neuroinflammation and Dopaminergic Neurodegeneration in Parkinson’s Disease
Open accessAbstract
The major pathology in Parkinson’s disease (PD) is neuron injury induced by degeneration of dopaminergic neurons and the activation of microglial cells. The objective of this study is to determine the effect and mechanism of miR-132-3p in regulating neuroinflammation and the degeneration of dopaminergic neuron in PD. The expressions of miR-132-3p in brain tissues of PD patients, lipopolysaccharide (LPS)-induced BV-2 cells and 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)-induced PD mouse models were detected. The effect of miR-132-3p and GLRX in cell viability, apoptosis and inflammation was verified in BV-2 cells. The activation of Iba1 in substantia nigra pars compacta (SNc) and the loss of tyrosine hydroxylase were detected in PD mouse models and the mobility of mouse models was assessed as well. The targeting relationship between miR-132-3p and GLRX was confirmed by RNA immunoprecipitation (RIP) and dual luciferase reporter gene assay. Elevated expression of miR-132-3p and decreased expression of GLRX were found in PD patients and cells models. Overexpression of miR-132-3p can induce activation of microglial cells, which can be reversed by GLRX overexpression. Collected evidence in both cell model and mouse models showed the effect of miR-132-3p in enhancing the activation of microglial cells and the loss of microglia cells, which was achieved by mediating GLRX.
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Cites a retracted work: 10.1002/jcb.26720
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Cited work 10.1002/jcb.26720 · retracted 2021-06-09 · notice 10.1002/jcb.29978 · this paper published 2022-01
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- Authors
- Gong, X., Huang, M., & Chen, L.
- Affiliations
- Hunan Provincial People's Hospital (CN)
- Corresponding author
- Chen, Lei
- Venue
- eneuro
- Publisher
- Society for Neuroscience
- Published
- 2022-01
- Volume
- 9
- Issue
- 1
- Pages
- ENEURO.0393-21.2021
- ISSN
- 2373-2822 (ISSN-L)
- PMC
- PMC8805200
- OpenAlex
- W4205199896
- Cited by
- 55
- References
- 36
- Citations by year
- 2026: 4 · 2025: 10 · 2024: 17 · 2023: 14 · 2022: 10
- FWCI
- 7.27
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Locations
- eNeuro (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- Funders
- Natural Science Foundation of Hunan Province (2019JJ50322)
- the Science Research Planning Program of Health and Family Planning Comission of Hunan Province (C2019054)
- Topics
- Health Sciences › Medicine › Neurology › Parkinson's Disease Mechanisms and Treatments
- Life Sciences › Neuroscience › Neurology › Neuroinflammation and Neurodegeneration Mechanisms
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Nuclear Receptors and Signaling
- Keywords
- miR-132-3p, Parkinson's disease, neuroinflammation, dopaminergic neuron loss, microglial activation, microglial depletion, substantia nigra pars compacta, apoptosis, MPTP mouse model, tyrosine hydroxylase, microRNA target regulation
- MeSH terms
- Neuroinflammatory Diseases, Animals, Disease Models, Animal, Humans, Mice, Inbred C57BL, Parkinson Disease, Microglia, MicroRNAs, Mice, Glutaredoxins, Dopaminergic Neurons
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
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