Validation of microRNAs in Cerebrospinal Fluid as Biomarkers for Different Forms of Dementia in a Multicenter Study
Abstract
MicroRNAs (miRNAs) regulate translational inhibition of proteins, but are also detected in body fluids, including cerebrospinal fluid (CSF), where they may serve as disease-specific biomarkers. Previously, we showed differential expression of miR-146a, miR-29a, and miR-125b in the CSF of Alzheimer's disease (AD) patients versus controls. In this study, we aim to confirm these findings by using larger, independent sample cohorts of AD patients and controls from three different centers. Furthermore, we aim to identify confounding factors that possibly arise using such a multicenter approach. The study was extended by including patients diagnosed with mild cognitive impairment due to AD, frontotemporal dementia and dementia with Lewy bodies. Previous results of decreased miR-146a levels in AD patients compared to controls were confirmed in one center. When samples from all three centers were combined, several confounding factors were identified. After controlling for these factors, we did not identify differences in miRNA levels between the different groups. However, we provide suggestions to circumvent various pitfalls when measuring miRNAs in CSF to improve future studies.
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The level of miR-125b was reported to be significantly increased, decreased, or not altered in the CSF of AD patients.
“The level of miR-125b was reported to be significantly increased11, decreased13,14, or not altered16 in the CSF of AD patients.”
From Intra- and Inter-individual Variability of microRNA Levels in Human Cerebrospinal Fluid: Critical Implications for Biomarker Discovery (2017) · cites this paper as [16]
There has been a lack of consistent findings and even conflicting data among miRNA biomarker studies.
“Although the expression profiles of circulating miRNAs have been extensively studied under various disease conditions, it is noteworthy that there has been a lack of consistent finding and even conflicting data among miRNA biomarker studies16,20–22.”
From Intra- and Inter-individual Variability of microRNA Levels in Human Cerebrospinal Fluid: Critical Implications for Biomarker Discovery (2017) · cites this paper as [16]
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- Authors
- Müller, M., Kuiperij, H. B., Versleijen, A. A. M., Chiasserini, D., Farotti, L., Baschieri, F., Parnetti, L., Struyfs, H., De Roeck, N., Luyckx, J., Engelborghs, S., Claassen, J. A., & Verbeek, M. M.
- Affiliations
- Radboud University Nijmegen (NL)
- Radboud University Medical Center (NL)
- University of Perugia (IT)
- University of Antwerp (BE)
- Reference Center for Biological Markers of Dementia (BIODEM), Institute Born-Bunge, University of Antwerp, Antwerp, Belgium
- Corresponding author
- Verbeek, Marcel M.
- ORCID
- Venue
- Journal of Alzheimer’s Disease
- Publisher
- SAGE Publications
- Published
- 2016-04-16
- Volume
- 52
- Issue
- 4
- Pages
- 1321-1333
- ISSN
- 1387-2877 (ISSN-L)
- 1875-8908
- OpenAlex
- W2407839457
- Cited by
- 41
- References
- 46
- Citations by year
- 2023: 6 · 2022: 3 · 2021: 5 · 2020: 6 · 2019: 9 · 2018: 5 · 2017: 3 · 2016: 4
- FWCI
- 2.92
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Journal of Alzheimer s Disease (publishedVersion)
- PubMed (publishedVersion)
- Radboud Repository (Radboud University) (submittedVersion)
- VUBIR (Vrije Universiteit Brussel) (submittedVersion)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › MicroRNA in disease regulation
- Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
- Health Sciences › Medicine › Physiology › Alzheimer's disease research and treatments
- Keywords
- microRNA, cerebrospinal fluid
- MeSH terms
- Aged, Alzheimer Disease, Dementia, Female, Humans, Male, Middle Aged, Biomarkers, Case-Control Studies, Disease Progression, Lewy Body Disease, MicroRNAs, Frontotemporal Dementia, Cognitive Dysfunction
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
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