Translation of Pre-Clinical Studies into Successful Clinical Trials for Alzheimer’s Disease: What are the Roadblocks and How Can They Be Overcome?

Cites (267)

Items 201–267 of 267

1. Effects of housing density on weight gain, immune function, behavior, and plasma corticosterone concentrations in BALB/c and C57BL/6 mice.
   Kathy Laber, Lynn M. Veatch, Marcelo F. Lopez, Jennifer Konopa Mulligan, Deanne M. Ridley Lathers · 2008 · PubMed Central
2. Beyond amyloid: Getting real about nonamyloid targets in Alzheimer's disease
   Karl Herrup, María C. Carrillo, Dale Schenk, Angela M. Cacace, Susan DeSanti, Robert T. Fremeau, Ratan V. Bhat, Marcie A. Glicksman, Patrick C. May, Russell Howard Swerdlow et al. · 2013 · Alzheimer s & Dementia
3. Applying Epigenetics to Alzheimer’s Disease via the Latent Early–life Associated Regulation (LEARn) Model
   Bryan Maloney, Kumar Sambamurti, Nasser Zawia, Debomoy K. Lahiri · 2012 · Current Alzheimer Research
4. Putting the Alzheimer's cognitive test to the test II: Rasch Measurement Theory
   Jeremy Charles Hobart, Stefan Cano, Holly B. Posner, Ola A. Selnes, Yaakov Stern, Ronald G. Thomas, John Zajicek, Alzheimer’s Disease Neuroimaging Initiative · 2012 · Alzheimer s & Dementia
5. Are Certain Lifestyle Habits Associated with Lower Alzheimer's Disease Risk?
   L. Rami Arab, Marwan Noel Sabbagh · 2010 · Journal of Alzheimer s Disease
6. BEYOND AMYLOID: The Next Generation of Alzheimer's Disease Therapeutics
   Guy R. Seabrook, William J. Ray, M. S. Shearman, Melanie L. Hutton · 2007 · Molecular Interventions
7. Scopolamine induced amnesia is reversed by bacopa monniera through participation of kinase-CREB pathway
   Saraf, Manish Kumar, Anand, Akshay, Prabhakar, Sudesh · 2010 · Neurochemical Research
8. Plasma Biomarkers for Alzheimer’s Disease: Much Needed But Tough to Find
   Chantal E. Bazenet, Simon Lovestone · 2012 · Biomarkers in Medicine
9. Systematic Review on the Efficacy and Safety of Herbal Medicines for Alzheimer's Disease
   Sui Cheung Man, Siva Sundara Kumar Durairajan, Wan Fung Kum, Jiahong Lu, Jian Dong Huang, Ching Fung Cheng, Vincent CH Chung, Min Xu, Min Li · 2008 · Journal of Alzheimer s Disease
10. The value and limitations of transgenic mouse models used in drug discovery for Alzheimer's disease: an update
    Kelly R. Bales · 2012 · Expert Opinion on Drug Discovery
11. Loss of synaptophysin and synaptosomal‐associated protein 25‐kDa (SNAP‐25) in elderly Down syndrome individuals
    Eric C Downes, Jordan Robson, E. Grailly, Zeinab Abdel‐All, John H. Xuereb, Carol Brayne, Anthony John Holland, William G. Honer, Elizabeta B. Mukaetova‐Ladinska · 2007 · Neuropathology and Applied Neurobiology
12. Bacopa monniera ameliorates amnesic effects of diazepam qualifying behavioral–molecular partitioning
    M.K. Saraf, Sudesh K. Prabhakar, P Pandhi, Akshay Anand · 2008 · Neuroscience
13. The Animal Models of Dementia and Alzheimer’s Disease for Pre-Clinical Testing and Clinical Translation
    Akshay Anand, Avijit Banik, Keshav Thakur · 2012 · Current Alzheimer Research
14. Meeting report: The future of preclinical mouse models in melanoma treatment is now
    Glenn T Merlino, Keith T. Flaherty, Nicolas Acquavella · 2013 · Pigment Cell & Melanoma Research
15. Intranasal administration of TAT-haFGF14–154 attenuates disease progression in a mouse model of Alzheimer’s disease
    Guofeng Lou, QI-HAO ZHANG, Fei Xiao, Qi Xiang, Zishan Su, L. Zhang, Penghui Yang, Yan Fang Yang, Qiusheng Zheng, Yishan Huang · 2012 · Neuroscience
16. Neuroinflammatory Cytokines - The Common Thread in Alzheimer Pathogenesis
    W. Sue T. Griffin, Steven W. Barger, Dillard Professor and Vice Chairman · 2011 · European Neurological Review
17. The plasma membrane redox system is impaired by amyloid β-peptide and in the hippocampus and cerebral cortex of 3xTgAD mice
    Dong Hoon Hyun, Mohamed R. Mughal, Hyunwon Yang, Ji Hyun Lee, Eun Joo Ko, Nicole D. Hunt, Rafael de Cabo, Mark P. Mattson · 2010 · Experimental Neurology
18. Genetics and epigenetics of Alzheimer's disease
    Kannayiram Alagiakrishnan, Sudeep S. Gill, Andrei D. Fagarasanu · 2012 · Postgraduate Medical Journal
19. Cerebral amyloid β(42) deposits and microvascular pathology in ageing baboons
    M. Ndung’u, W. Härtig, F. Wegner, J. Mwenda, R. Low, R. Akinyemi, R. Kalaria · 2012 · Neuropathology and Applied Neurobiology
20. Impact of Aging: Sporadic, and Genetic Risk Factors on Vulnerability to Apoptosis in Alzheimer's Disease
    Katharina Schindowski, Tilman Kratzsch, Jürgen Peters, Barbara Steiner, Silke Leutner, Natalie Touchet, Konrad Maurer, Christian Czech, Laurent Pradier, Lutz Frölich et al. · 2003 · NeuroMolecular Medicine
21. Fire in the ashes: Can failed Alzheimer's disease drugs succeed with second chances?
    Robert E. Becker, Nigel H. Greig · 2012 · Alzheimer s & Dementia
22. Imaging epigenetics in Alzheimer's disease.
    S. Lista, F. Garaci, N. Toschi, H. Hampel · 2013 · Current pharmaceutical design
23. Statistical Design Considerations in Animal Studies Published Recently in <i>Cancer Research</i>
    Hess, Kenneth R. · 2011 · Cancer Research
24. Statistical analysis, trial design and duration in Alzheimer's disease clinical trials: a review
    Paul Andrew Thompson, David E. Wright, Carl E Counsell · 2011 · International Psychogeriatrics
25. Neuroinflammatory Cytokines-The Common Thread in Alzheimer's Pathogenesis.
    W Sue T Griffin, Steven W Barger · 2010 · PubMed
26. Antiamnesic Effect of B. monniera on L-NNA Induced Amnesia Involves Calmodulin
    Akshay Anand, Manish Kumar Saraf, Sudesh K. Prabhakar · 2010 · Neurochemical Research
27. Alzheimer's disease genetics: lessons to improve disease modelling
    Rita João Guerreiro, John Hardy · 2011 · Biochemical Society Transactions
28. Neuroinflammatory Cytokines—The Common Thread in Alzheimer Pathogenesis
    W. Sue T. Griffin, Steven W. Barger, Dillard Professor and Vice Chairman · 2010 · touchREVIEWS in Neurology
29. Sexual Dimorphism in Healthy Aging and Mild Cognitive Impairment: A DTI Study
    Laurence O’Dwyer, Franck Lamberton, Arun L.W. Bokde, Michael Ewers, Yetunde O. Faluyi, Colby J. Tanner, Bernard M. Mazoyer, Desmond J O’Neill, Mairead M. Bartley, Rónán Collins et al. · 2012 · PLoS ONE
30. Drosophila as a model to study age-related neurodegenerative disorders: Alzheimer's disease
    Julia Maeve Bonner, Gabrielle L. Boulianne · 2010 · Experimental Gerontology
31. Alzheimer's disease biomarker discovery using in silico literature mining and clinical validation
    Ines Greco, Nicola C. Day, Joanna Riddoch‐Contreras, J. Z. Reed, Hilkka S. Soininen, Iwona Kłoszewska, Magda Tsolaki, Bruno J. Vellas, Christian Spenger, Patrizia Mecocci et al. · 2012 · Journal of Translational Medicine
32. The Role of Monitoring Interpretive Rates, Concordance Between Cytotechnologist and Pathologist Interpretations Before Sign-Out, and Turnaround Time in Gynecologic Cytology Quality Assurance: Findings From the College of American Pathologists Gynecologic Cytopathology Quality Consensus Conference Working Group 1
    Karen M. Clary, Diane Davis Davey, Sonya Naryshkin · 2013 · Archives of Pathology & Laboratory Medicine
33. Life style interventions to reduce the risk of dementia
    Leon A Flicker · 2009 · Maturitas
34. Translational Medicine: An Engine of Change for Bringing New Technology to Community Health
    Christopher‐Paul Milne, Kenneth I. Kaitin · 2009 · Science Translational Medicine
35. Neuron-Enriched Gene Expression Patterns are Regionally Anti-Correlated with Oligodendrocyte-Enriched Patterns in the Adult Mouse and Human Brain
    Powell Patrick Cheng Tan, Leon French, Paul Pavlidis · 2013 · Frontiers in Neuroscience
36. Brain aging and late-onset Alzheimer's disease: many open questions
    Christian Behl · 2012 · International Psychogeriatrics
37. A strategy for developing new treatment paradigms for neuropsychiatric and neurocognitive symptoms in Alzheimer’s disease
    Hugo Geerts, Patrick Roberts, Äthan Spiros, Robert A. Carr · 2013 · Frontiers in Pharmacology
38. Cognitive correlates of cerebrospinal fluid biomarkers in frontotemporal dementia
    Esther Koedam, Annelies E. van der Vlies, Wiesje M. van der Flier, Nicolaas A. Verwey, Teddy Koene, Philip Scheltens, Marinus A. Blankenstein, Yolande A.L. Pijnenburg · 2012 · Alzheimer s & Dementia
39. Prions: A Piece of the Puzzle?
    Debomoy K. Lahiri · 2012 · Science
40. Pharmacogenomics in Alzheimer's disease.
    R. Cacabelos · 2008 · Methods in molecular biology
41. The Benefits of Using Genetic Information to Design Prevention Trials
    Youna Hu, Li Li, Margaret G. Ehm, Nan Bing, Kijoung S Song, Matthew R. Nelson, Philippa J. Talmud, Aroon Dinesh Hingorani, Meena Kumari B, Mika Kivimaki B et al. · 2013 · The American Journal of Human Genetics
42. The Impact of Cerebrospinal Fluid Biomarkers on the Diagnosis of Alzheimer’s Disease
    Sebastiaan Engelborghs, Nathalie Le Bastard · 2012 · Molecular Diagnosis & Therapy
43. Impact of18F-florbetapir PET imaging of β-amyloid neuritic plaque density on clinical decision-making
    Anthony S. Zannas, Pudugramam Murali Doraiswamy, Katie S. Shpanskaya, Kelly Ryan Murphy, Jeffrey R. Petrella, James R. Burke, Terence Z. Wong · 2013 · Neurocase
44. Prevention in Psychiatry: Effects of Healthy Lifestyle on Cognition
    David A. Merrill, Gary W. Small · 2010 · Psychiatric Clinics of North America
45. Amyloid deposition and advanced age fails to induce Alzheimer's type progression in a double knock-in mouse model.
    Gauri H. Malthankar‐Phatak, Yin‐Guo Lin, Nicholas Giovannone, Robert G. Siman · 2012 · Europe PMC (PubMed Central)
46. Pharmacological Study on Alzheimer’s Drugs Targeting Calcium/Calmodulin-Dependent Protein Kinase II
    Shigeki Moriguchi · 2011 · Journal of Pharmacological Sciences
47. Validation of experimental medicine methods in psychiatry: The P1vital approach and experience
    Gerard R. Dawson, Kevin J. Craig, Colin Trevor Dourish · 2011 · Biochemical Pharmacology
48. Biomarkers for the clinical evaluation of the cognitively impaired elderly: amyloid is not enough
    Linda K. McEvoy, James B. Brewer · 2012 · Imaging in Medicine
49. Pathological Synergism Between Amyloid-β and Apolipoprotein E4 – The Most Prevalent Yet Understudied Genetic Risk Factor for Alzheimer's Disease
    Haim Belinson, Daniel M. Michaelson · 2009 · Journal of Alzheimer s Disease
50. A Modest Proposal for a Longitudinal Study of Dementia Prevention (with apologies to Jonathan Swift, 1729)
    Robert Paul Friedland, Shivani Nandi · 2012 · Journal of Alzheimer s Disease
51. Animal models of neurological disease: are there any babies in the bathwater?
    Malcolm Robert Macleod, H. Bart van der Worp · 2010 · Practical Neurology
52. Raising standards
    2013 · Nature Neuroscience
53. Alzheimer's disease public‐private partnerships: A landscape of the global nonprofit community
    Heather M. Snyder, Lisa J. Bain, Robert Egge · 2013 · Alzheimer s & Dementia
54. A novel approach for long-term oral drug administration in animal research
    Cassia Overk, Jeffrey Allen Borgia, Elliott Jay Mufson · 2010 · Journal of Neuroscience Methods
55. A cross-species analysis method to analyze animal models' similarity to human's disease state
    Shuhao Yu, Lulu Zheng, Yun Li, Chunyan Li, Chenchen Ma, Yixue Li, Xuan Li, Pei Hao · 2012 · BMC Systems Biology
56. Aging. Alzheimer's disease.
    Juan A. Samper Noa, Juan J. Llibre Rodríguez, Saily Sosa Pérez, Joel Solórzano Romero · 1999 · PubMed
57. Loss of learning in mice when exposed to rat odor: A water maze study
    Avijit Banik, Akshay Anand · 2010 · Behavioural Brain Research
58. Evaluación de la conveniencia del cambio de vía de administración de rivastigmina en pacientes con enfermedad de Alzheimer
    Rafael Blesa, Merçé Boada, C. Martínez Parra, Domènec Gil i Saladié, Carmen Antúnez Almagro, A.L. Gobartt Vázquez · 2011 · Neurología
59. Evaluation of the convenience of changing the rivastigmine administration route in patients with Alzheimer disease
    Rafael Blesa, Merçé Boada, C. Martínez Parra, Domènec Gil i Saladié, Carmen Antúnez Almagro, A.L. Gobartt Vázquez · 2011 · Neurología (English Edition)
60. Introduction to the Good Laboratory Practice Regulations
    Joe Cwiertniewicz · 2005 · Lab Animal
61. The influence of strain, sex and age on selected biochemical parameters in blood serum of Buffalo and Wistar rats.
    Ireneusz Całkosiński, Maciej Dobrzyński, Joanna Kobierska-Brzoza et al. · 2010 · PubMed
62. Improving animal models for nervous system disorders
    Richard E. Brown · 2012 · Genes Brain & Behavior
63. [Nutritional factors in prevention of Alzheimer's disease].
    Joanna Wyka · 2012 · PubMed
64. Mary S. Easton Center of Alzheimer's Disease Research at UCLA: Advancing the Therapeutic Imperative
    Jeffrey L. Cummings, John Matthew Ringman, Karen Metz · 2010 · Journal of Alzheimer s Disease
65. Future issues including broadening the scope of the GLP principles.
    Francisca E. Liem, Mark J. Lehr · 2008 · PubMed
66. What Does the Pediatrician Need to Know About Alzheimer Disease?
    Robert Paul Friedland, Carol Brayne · 2009 · Journal of Developmental & Behavioral Pediatrics
67. Untitled work
    2000 · 10.1002/(sici)1097-0258(20000615/30)19:11/12