Statistical Design Considerations in Animal Studies Published Recently in Cancer Research
Abstract
Good statistical design is one hallmark of meritorious research. Elements such as replication, randomization, and blinding are widely recognized as being fundamental to producing valid research results ([1][1]). Although widely used in clinical research, these practices seem to be less often
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Randomization and blinding of investigators who analyse the results of animal experiments are used in less than 20% of studies.
“Some pivotal aspects of study design, such as randomization and the blinding of investigators who analyse the results of animal experiments, are used in less than 20% of studies16–18”
From How to design preclinical studies in nanomedicine and cell therapy to maximize the prospects of clinical translation (2018) · cites this paper as [16]
Cites
Improving Bioscience Research Reporting: The ARRIVE Guidelines for Reporting Animal Research
Kilkenny, C., Browne, W. J., Cuthill, I. C., Emerson, M., & Altman, D. G. (2010) · PLoS Biology · doi:10.1371/journal.pbio.1000412 · Cited by 7,300 · see citing works
Improving bioscience research reporting: The ARRIVE guidelines for reporting animal research
Kilkenny, C., Browne, W. J., Cuthill, I. C., Emerson, M., & Altman, D. G. (2010) · Journal of Pharmacology and Pharmacotherapeutics · doi:10.4103/0976-500x.72351 · Cited by 6,277 · see citing works
Guidelines for the Design and Statistical Analysis of Experiments Using Laboratory Animals
Festing, M. F. W., & Altman, D. G. (2002) · ILAR Journal · doi:10.1093/ilar.43.4.244 · Cited by 1,110 · see citing works
Kilkenny, C., Parsons, N., Kadyszewski, E., Festing, M. F. W., Cuthill, I. C., Fry, D., Hutton, J., & Altman, D. G. (2009) · PLoS ONE · doi:10.1371/journal.pone.0007824 · Cited by 860 · see citing works
Betulin Is a Potent Anti-Tumor Agent that Is Enhanced by Cholesterol
Mullauer, F. B., Kessler, J. H., & Medema, J. P. (2009) · PLoS ONE · doi:10.1371/journal.pone.0005361 · Cited by 688 · see citing works
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A call for transparent reporting to optimize the predictive value of preclinical research
Landis, S. C., Amara, S. G., Asadullah, K., Austin, C. P., Blumenstein, R., Bradley, E. W., Crystal, R. G., Darnell, R. B., Ferrante, R. J., Fillit, H., et al. (2012) · Nature · doi:10.1038/nature11556 · Cited by 1,196 · see citing works
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Whole animal experiments should be more like human randomized controlled trials
Muhlhausler, B. S., Bloomfield, F. H., & Gillman, M. W. (2013) · PLoS Biology · doi:10.1371/journal.pbio.1001481 · Cited by 105 · see citing works
Banik, A., Brown, R. E., Bamburg, J., Lahiri, D. K., Khurana, D., Friedland, R. P., Chen, W., Ding, Y., Mudher, A., Padjen, A. L., et al. (2015) · Journal of Alzheimer’s Disease · doi:10.3233/jad-150136 · Cited by 102 · see citing works
- Authors
- Hess, K. R.
- Affiliations
- The University of Texas MD Anderson Cancer Center (US)
- Corresponding author
- Hess, Kenneth R.
- ORCID
- Hess, Kenneth R.
- Venue
- Cancer Research
- Published
- 2011-01-13
- Volume
- 71
- Issue
- 2
- Pages
- 625-625
- ISSN
- 0008-5472 (ISSN-L)
- 1538-7445
- OpenAlex
- W2065594595
- Cited by
- 36
- References
- 6
- Citations by year
- 2024: 2 · 2023: 2 · 2020: 5 · 2019: 2 · 2018: 3 · 2017: 9 · 2016: 2 · 2015: 4 · 2014: 4 · 2013: 1 · 2012: 2
- FWCI
- 3.07
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Cancer Research (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Veterinary › Small Animals › Animal testing and alternatives
- Physical Sciences › Mathematics › Statistics and Probability › Statistical Methods in Clinical Trials
- Social Sciences › Decision Sciences › Management Science and Operations Research › Optimal Experimental Design Methods
- Keywords
- statistical design, animal studies, replication, randomization, blinding, research validity
- MeSH terms
- Animals, Neoplasms, Periodicals as Topic, Research, Statistics as Topic
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