Greater specificity for cerebrospinal fluid P-tau231 over P-tau181 in the differentiation of healthy controls from Alzheimer's disease
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Cerebrospinal fluid (CSF) measures of phosphorylated-tau (P-tau) 231 and P-tau181 are two biomarkers for the identification of tau pathology as related to Alzheimer’s disease (AD). While both are pathologically validated, their relative diagnostic performances are not well known. This cross-sectional diagnostic study of 87 normal (NL) subjects and 28 AD subjects compared CSF P-tau231 with CSF P-tau181. Logistic regression modeling demonstrated that the P-tau231 was superior to the P-tau181 in the diagnostic classifications. At a fixed 85% sensitivity cutoff, the ROC analysis shows that P-tau231 has greater overall specificity than P-tau181. While both P-tau analytes demonstrated equivalent negative predictive accuracies, P-tau231 yielded significantly fewer false positives. Moreover, P-tau231, but not P-tau181, demonstrated sensitivity to the E4 genotype. A postmortem validation with 9 AD subjects confirmed the superiority of the CSF P-tau231 specificity. This study suggests that P-tau231 has the potential to improve the CSF tau biomarker diagnosis of AD.
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CSF p-tau231 has been widely reported as a biomarker to detect AD at both the MCI and dementia stages, but often it has been concluded that these changes are not different from CSF p-tau181 when directly compared.
“CSF p-tau231 has been widely reported as a biomarker to detect AD at both the MCI and dementia stages of disease11,49, 50, 51, 52, 53 but often it has been concluded these changes are not different from CSF p-tau181 when directly compared.54”
From Cerebrospinal fluid p-tau231 as an early indicator of emerging pathology in Alzheimer's disease (2022) · cites this paper as [50]
The Introduction reports that one meta-analysis found P-tau181 and P-tau231 comparably good for AD diagnosis, supporting the claim that a direct comparison has found them similar. But it does not establish that this was often concluded, and the paper’s Discussion concludes that P-tau231 was superior at separating AD patients from normal controls. Page numbers are unavailable in our copy. (LLM, conf=0.85)
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Cites
Folstein, M. F., Folstein, S. E., & McHugh, P. R. (1975) · Journal of Psychiatric Research · doi:10.1016/0022-3956(75)90026-6 · Cited by 88,282 · see citing works
McKhann, G., Drachman, D., Folstein, M., Katzman, R., Price, D., & Stadlan, E. M. (1984) · Neurology · doi:10.1212/wnl.34.7.939 · Cited by 27,915 · see citing works
Hirono, N., Mori, E., Ikejiri, Y., Imamura, T., Shimomura, T., Hashimoto, M., Yamashita, H., & Ikeda, M. (1997) · PubMed · Cited by 21,010 · see citing works
Kok, J. S., Berg, I. J., & Scherder, E. J. A. (2013) · Dementia and Geriatric Cognitive Disorders Extra · doi:10.1159/000353441 · Cited by 20,589 · see citing works
Older Adults' Reasons for Using Technology while Aging in Place
Peek, S. T. M., Luijkx, K. G., Rijnaard, M. D., Nieboer, M. E., van der Voort, C. S., Aarts, S., van Hoof, J., Vrijhoef, H. J., & Wouters, E. (2015) · Gerontology · doi:10.1159/000430949 · Cited by 19,803 · see citing works
Sensitivity and False Alarm Rate of a Fall Sensor in Long-Term Fall Detection in the Elderly
Kangas, M., Korpelainen, R., Vikman, I., Nyberg, L., & Jämsä, T. J. (2014) · Gerontology · doi:10.1159/000362720 · Cited by 19,003 · see citing works
The Amyloid Hypothesis of Alzheimer’s Disease: Progress and Problems on the Road to Therapeutics
Hardy, J., & Selkoe, D. J. (2002) · Science · doi:10.1126/science.1072994 · Cited by 13,864 · see citing works
Amyloid oligomers exacerbate tau pathology in a mouse model of tauopathy
Selenica, M.-L. B., Brownlow, M., Jimenez, J. P., Lee, D. C., Pena, G., Dickey, C. A., Gordon, M. N., & Morgan, D. (2013) · Neurodegenerative Diseases · doi:10.1159/000337230 · Cited by 10,359 · see citing works
Diagnostic and Statistical Manual of Mental Disorders (DSM-IV)
Hu, R. J. (2003) · Elsevier eBooks · doi:10.1016/b0-12-226870-9/01070-4 · Cited by 9,167 · see citing works
The Global Deterioration Scale for assessment of primary degenerative dementia
Reisberg, ., Ferris, S. H., de Leon, M. J., & Crook, T. H. (1982) · American Journal of Psychiatry · doi:10.1176/ajp.139.9.1136 · Cited by 4,982 · see citing works
Note on the Sampling Error of the Difference Between Correlated Proportions or Percentages
McNemar, Q. (1947) · Psychometrika · doi:10.1007/bf02295996 · Cited by 4,754 · see citing works
Jack, C. R., Knopman, D. S., Jagust, W. J., Petersen, R. C., Weiner, M. W., Aisen, P. S., Shaw, L. M., Vemuri, P., Wiste, H. J., Weigand, S. D., et al. (2013) · The Lancet Neurology · doi:10.1016/s1474-4422(12)70291-0 · Cited by 4,396 · see citing works
Hyman, B. T., Phelps, C. H., Beach, T. G., Bigio, E. H., Cairns, N. J., Carrillo, M. C., Dickson, D. W., Duyckaerts, C., Frosch, M. P., Masliah, E., et al. (2012) · Alzheimer's & Dementia · doi:10.1016/j.jalz.2011.10.007 · Cited by 3,092 · see citing works
HYMAN, B. T., & TROJANOWSKI, J. Q. (1997) · Journal of Neuropathology and Experimental Neurology · doi:10.1097/00005072-199710000-00002 · Cited by 1,542 · see citing works
Tau pathology in Alzheimer disease and other tauopathies
Iqbal, K., del C. Alonso, A., Chen, S., Chohan, M. O., El-Akkad, E., Gong, C.-X., Khatoon, S., Li, B., Liu, F., Rahman, A., et al. (2005) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/j.bbadis.2004.09.008 · Cited by 1,037 · see citing works
Augustinack, J. C., Schneider, A., Mandelkow, E.-M., & Hyman, B. T. (2002) · Acta Neuropathologica · doi:10.1007/s004010100423 · Cited by 998 · see citing works
Consensus Report of the Working Group on: “Molecular and Biochemical Markers of Alzheimer’s Disease”
The Ronald and Nancy Reagan Research Institute of the Alzheimer’s Association and, & National Institute on Aging Working Group (1998) · Neurobiology of Aging · doi:10.1016/s0197-4580(98)00022-0 · Cited by 702 · see citing works
Perforant pathway changes and the memory impairment of Alzheimer's disease
Hyman, B. T., Van Hoesen, G. W., Kromer, L. J., & Damasio, A. R. (1986) · Annals of Neurology · doi:10.1002/ana.410200406 · Cited by 672 · see citing works
Buerger, K., Ewers, M., Pirttila, T., Zinkowski, R., Alafuzoff, I., Teipel, S. J., DeBernardis, J., Kerkman, D., McCulloch, C., Soininen, H., et al. (2006) · Brain · doi:10.1093/brain/awl269 · Cited by 586 · see citing works
Self-citationVanmechelen, E., Vanderstichele, H., Davidsson, P., Kerschaver, E. V., Perre, B. V. D., Sjögren, M. J. C., Andreasen, N. C., & Blennow, K. (2000) · Neuroscience Letters · doi:10.1016/s0304-3940(00)01036-3 · Cited by 487 · see citing works
Self-citationHampel, H., Buerger, K., Zinkowski, R., Teipel, S. J., Goernitz, A., Andreasen, N., Sjoegren, M., DeBernardis, J., Kerkman, D., Ishiguro, K., et al. (2004) · Archives of General Psychiatry · doi:10.1001/archpsyc.61.1.95 · Cited by 434 · see citing works
Self-citationTotal and phosphorylated tau protein as biological markers of Alzheimer’s disease
Hampel, H., Blennow, K., Shaw, L. M., Hoessler, Y. C., Zetterberg, H., & Trojanowski, J. Q. (2010) · Experimental Gerontology · doi:10.1016/j.exger.2009.10.010 · Cited by 389 · see citing works
Self-citationVanderstichele, H., Bibl, M., Engelborghs, S., Le Bastard, N., Lewczuk, P., Molinuevo, J. L., Parnetti, L., Perret‐Liaudet, A., Shaw, L. M., Teunissen, C., et al. (2012) · Alzheimer's & Dementia · doi:10.1016/j.jalz.2011.07.004 · Cited by 358 · see citing works
Self-citationMulder, C., Verwey, N. A., van der Flier, W. M., Bouwman, F. H., Kok, A., van Elk, E. J., Scheltens, P., & Blankenstein, M. A. (2009) · Clinical Chemistry · doi:10.1373/clinchem.2009.130518 · Cited by 332 · see citing works
Braak, H., & Braak, E. (1985) · Acta Neuropathologica · doi:10.1007/bf00690836 · Cited by 287 · see citing works
Kohnken, R. E., Büerger, K., Zinkowski, R. P., Miller, C., Kerkman, D. J., DeBernardis, J. F., Shen, J., Möller, H., Davies, P., & Hampel, H. J. (2000) · Neuroscience Letters · doi:10.1016/s0304-3940(00)01178-2 · Cited by 173 · see citing works
Self-citationAge and diagnostic performance of Alzheimer disease CSF biomarkers
Mattsson, N., Rosén, E., Hansson, O., Andreasen, N. C., Parnetti, L., Jonsson, M. A. G., Herukka, S., van der Flier, W. M., Blankenstein, M. A., Ewers, M., et al. (2012) · Neurology · doi:10.1212/wnl.0b013e3182477eed · Cited by 166 · see citing works
Self-citationFortea, J., Vilaplana, E., Alcolea, D. A., Carmona‐Iragui, M., Sánchez‐Saudinós, M., Sala, I., Antón‐Aguirre, S., González‐Ortiz, S., Medrano, S., Pegueroles, J., et al. (2014) · Annals of Neurology · doi:10.1002/ana.24186 · Cited by 143 · see citing works
Self-citationMitchell, A. J. (2009) · Journal of Neurology Neurosurgery & Psychiatry · doi:10.1136/jnnp.2008.167791 · Cited by 123 · see citing works
Engelborghs, S., Sleegers, K., Cras, P. P., Brouwers, N., Serneels, S., Leenheir, E. D., Martin, J. J., Vanmechelen, E., Broeckhoven, C. V., & Deyn, P. P. D. (2007) · Brain · doi:10.1093/brain/awm136 · Cited by 113 · see citing works
Lautner, R., Palmqvist, S., Mattsson, N., Andréasson, U., Wallin, A., Pålsson, E., Jakobsson, J., Herukka, S., Owenius, R., Olsson, B., et al. (2014) · JAMA Psychiatry · doi:10.1001/jamapsychiatry.2014.1060 · Cited by 107 · see citing works
Self-citationBüerger, K., Alafuzoff, I. I., Ewers, M., Pirttilä, T., Zinkowski, R. P., & Hampel, H. J. (2007) · Brain · doi:10.1093/brain/awm140 · Cited by 56 · see citing works
Self-citationMain, B. F., Jones, P. J. H., MacGillivray, R., & Banfield, D. K. (1991) · Journal of Lipid Research · doi:10.1016/s0022-2275(20)42257-6 · Cited by 48 · see citing works
Braak, H., & Tredici, K. D. (2013) · Acta Neuropathologica · doi:10.1007/s00401-013-1153-2 · Cited by 43 · see citing works
Büerger, K., Teipel, S. J., Zinkowski, R. P., Sunderland, T., Andreasen, N., Blennow, K., Ewers, M., DeBernardis, J. F., Shen, Y., Kerkman, D. J., et al. (2005) · Neuroscience Letters · doi:10.1016/j.neulet.2005.08.030 · Cited by 29 · see citing works
Self-citationRegeniter, A., Kühle, J., Baumann, T., Sollberger, M. A., Herdener, M., Kunze, U., Camuso, M. C., & Monsch, A. U. (2012) · Methods · doi:10.1016/j.ymeth.2012.03.019 · Cited by 12 · see citing works
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- [31]Fortea J Vilaplana E Alcolea D Carmona-Iragui M Sanchez-Saudinos M Sala I Anton-Aguirre S Gonzalez S Medrano S Pegueroles J CSF β-amyloid and phosphotau biomarker interactions on brain structure in preclinical AD Ann Neurol 2014 76 223 230 24852682
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Suárez‐Calvet, M., Karikari, T. K., Ashton, N. J., Lantero Rodríguez, J., Milà‐Alomà, M., Gispert, J. D., Salvadó, G., Minguillon, C., Fauria, K., Shekari, M., et al. (2020) · EMBO Molecular Medicine · doi:10.15252/emmm.202012921 · Cited by 401 · see citing works
Self-citationTraumatic Brain Injury and Alzheimer's Disease: The Cerebrovascular Link
Ramos‐Cejudo, J., Wısnıewskı, T., Marmar, C. R., Zetterberg, H., Blennow, K., de Leon, M. J., & Fossati, S. (2018) · EBioMedicine · doi:10.1016/j.ebiom.2018.01.021 · Cited by 390 · see citing works
Self-citationSharma, R. A., Varga, A. W., Bubu, O. M., Pirraglia, E., Kam, K., Parekh, A., Wohlleber, M. E., Miller, M. D., Andrade, A. G., Lewis, C., et al. (2017) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/rccm.201704-0704oc · Cited by 246 · see citing works
Self-citationXia, Y., Prokop, S., & Giasson, B. I. (2021) · Molecular Neurodegeneration · doi:10.1186/s13024-021-00460-5 · Cited by 218 · see citing works
Cerebrospinal fluid p-tau231 as an early indicator of emerging pathology in Alzheimer's disease
Ashton, N. J., Benedet, A. L., Pascoal, T. A., Karikari, T. K., Lantero-Rodriguez, J., Brum, W. S., Mathotaarachchi, S., Therriault, J., Savard, M., Chamoun, M., et al. (2022) · eBioMedicine · doi:10.1016/j.ebiom.2022.103836 · Cited by 184 · see citing works
Self-citationMuraoka, S., Jedrychowski, M. P., Yanamandra, K., Ikezu, S., Gygi, S. P., & Ikezu, T. (2020) · Cells · doi:10.3390/cells9091959 · Cited by 157 · see citing works
Plasma tau complements CSF tau and P‐tau in the diagnosis of Alzheimer's disease
Fossati, S., Ramos‐Cejudo, J., Debure, L., Pirraglia, E., Sone, J. Y., Li, Y., Chen, J., Butler, T., Zetterberg, H., Blennow, K., et al. (2019) · Alzheimer s & Dementia Diagnosis Assessment & Disease Monitoring · doi:10.1016/j.dadm.2019.05.001 · Cited by 130 · see citing works
Self-citationAlosco, M. L., Tripodis, Y., Fritts, N. G., Heslegrave, A., Baugh, C. M., Conneely, S. E., Mariani, M. L., Martin, B. M., Frank, S., Mez, J., et al. (2018) · Alzheimer s & Dementia · doi:10.1016/j.jalz.2018.05.004 · Cited by 121 · see citing works
Self-citationKam, K., Parekh, A., Sharma, R. A., Andrade, A. G., Lewin, M. P., Castillo, B., Bubu, O. M., Chua, N. J., Miller, M. D., Mullins, A. E., et al. (2019) · Molecular Neurodegeneration · doi:10.1186/s13024-019-0309-5 · Cited by 105 · see citing works
Self-citationVos, S. J. B., Gordon, B. A., Su, Y., Visser, P. J., Holtzman, D. M., Morris, J. C., Fagan, A. M., & Benzinger, T. L. S. (2016) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2016.03.025 · Cited by 98 · see citing works
Eren, E., Hunt, J. F. V., Shardell, M. D., Chawla, S., Tran, J., Gu, J., Vogt, N. M., Johnson, S. C., Bendlin, B. B., & Kapogiannis, D. (2020) · Alzheimer s & Dementia · doi:10.1002/alz.12130 · Cited by 80 · see citing works
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Krishnamurthy, H. K., Jayaraman, V., Krishna, K., Wang, T., Bei, K., Changalath, C., & Rajasekaran, J. J. (2024) · Ageing Research Reviews · doi:10.1016/j.arr.2024.102599 · Cited by 85 · see citing works
Khalafi, M., Dartora, W. J., McIntire, L. B., Butler, T., Wartchow, K. M., Hojjati, S. H., Razlighi, Q. R., Shirbandi, K., Zhou, L., Chen, K., et al. (2024) · Alzheimer s & Dementia · doi:10.1002/alz.14458 · Cited by 79 · see citing works
Self-citationd’Abramo, C., D'adamio, L., & Giliberto, L. (2020) · Journal of Personalized Medicine · doi:10.3390/jpm10030116 · Cited by 68 · see citing works
Hong, H., Li, Y., & Su, B. (2017) · Journal of Alzheimer s Disease · doi:10.3233/jad-170156 · Cited by 64 · see citing works
Self-citationPanitch, R., Hu, J., Chung, J., Zhu, C., Meng, G., Xia, W., Bennett, D. A., Lunetta, K. L., Ikezu, T., Au, R., et al. (2021) · Molecular Psychiatry · doi:10.1038/s41380-021-01266-z · Cited by 58 · see citing works
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Wang, L., Zhou, Y., Chen, D., & Lee, T. H. (2020) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2020.00355 · Cited by 61 · see citing works
de Leon, M. J., Pirraglia, E., Osorio, R. S., Glodzik, L., Saint-Louis, L. A., Kim, H.-J., Fortea, J., Fossati, S., LASKA, E. M., Siegel, C., et al. (2018) · PLoS ONE · doi:10.1371/journal.pone.0191240 · Cited by 58 · see citing works
Self-citationÖhrfelt, A., Johansson, P., Wallin, A., Andréasson, U., Zetterberg, H., Blennow, K., & Svensson, J. (2016) · Dementia and Geriatric Cognitive Disorders Extra · doi:10.1159/000447239 · Cited by 57 · see citing works
Self-citationArendash, G. W., Cao, C., Abulaban, H., Baranowski, R., Wisniewski, G., Becerra, L. R., Andel, R., Lin, X., Zhang, X., Wittwer, D., et al. (2019) · Journal of Alzheimer s Disease · doi:10.3233/jad-190367 · Cited by 49 · see citing works
Jun, G., You, Y., Zhu, C., Meng, G., Chung, J., Panitch, R., Hu, J., Xia, W., Bennett, D. A., Foroud, T., et al. (2022) · Alzheimer s & Dementia · doi:10.1002/alz.12607 · Cited by 35 · see citing works
Edlow, B. L., Bodien, Y. G., Baxter, T., Belanger, H. G., Cali, R. J., Deary, K. B., Fischl, B. R., Foulkes, A. S., Gilmore, N. M., Greve, D. N., et al. (2022) · Journal of Neurotrauma · doi:10.1089/neu.2022.0030 · Cited by 29 · see citing works
BMP4 overexpression induces the upregulation of APP/Tau and memory deficits in Alzheimer’s disease
Zhang, X., Li, J., Ma, L., Xu, H., Cao, Y., Liang, W., Ma, J., Wang, Z. P., & Li, Y. (2021) · Cell Death Discovery · doi:10.1038/s41420-021-00435-x · Cited by 28 · see citing works
Self-citationLi, Z.-R., Fan, Z.-X., & Zhang, Q. (2024) · Journal of Alzheimer's Disease · doi:10.3233/jad-230799 · Cited by 21 · see citing works
Tu, L. M. T. P. P. L. M., & Cho, S. (2022) · Biomedicines · doi:10.3390/biomedicines10010093 · Cited by 25 · see citing works
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Nguyen, T. T., Ta, Q. T. H., Nguyen, T. K. O., Nguyen, T. K. O., & Giau, V. V. (2020) · Diagnostics · doi:10.3390/diagnostics10050326 · Cited by 25 · see citing works
Santos, J. R. F., Bauer, C., Schuchhardt, J., Wedekind, D., Waniek, K., Lachmann, I., Wiltfang, J., & Vogelgsang, J. (2019) · Journal of Neural Transmission · doi:10.1007/s00702-019-01982-5 · Cited by 26 · see citing works
Giampietri, L., Belli, E., Beatino, M. F., Giannoni, S., Palermo, G., Campese, N., Tognoni, G., Siciliano, G., Ceravolo, R., Luca, C. D., et al. (2022) · Diagnostics · doi:10.3390/diagnostics12040796 · Cited by 22 · see citing works
Blessing, E., Parekh, A., Betensky, R. A., Babb, J. S., Saba, N., Debure, L., Varga, A. W., Ayappa, I. A., Rapoport, D. M., Butler, T., et al. (2022) · Neurobiology of Disease · doi:10.1016/j.nbd.2022.105748 · Cited by 22 · see citing works
Self-citationChu, T., Shu, Y., Qu, Y., Gao, S., & Zhang, L. (2018) · Europe PMC (PubMed Central) · Cited by 18 · see citing works
Plasma Biomarkers of Alzheimer Disease in Women With and Without HIV
Li, X., Yucel, R. M., Clervius, H., Kamalakar, K., Zetterberg, H., Blennow, K., Zhang, J., Adimora, A. A., Collins, L. F., Fischl, M. A., et al. (2023) · JAMA Network Open · doi:10.1001/jamanetworkopen.2023.44194 · Cited by 16 · see citing works
Self-citationCognitive phenotype and neurodegeneration associated with Tau in Huntington's disease
Martínez‐Horta, S., Pérez‐Pérez, J., Pérez‐González, R., Sampedro, F., Horta‐Barba, A., Campolongo, A., Rivas‐Asensio, E., Puig‐Davi, A., Pagonabarraga, J., & Kulisevsky, J. (2024) · Annals of Clinical and Translational Neurology · doi:10.1002/acn3.52031 · Cited by 13 · see citing works
Required improvements for cerebrospinal fluid-based biomarker tests of Alzheimer’s disease
Gaetani, L., Chiasserini, D., Paoletti, F. P., Bellomo, G., & Parnetti, L. (2023) · Expert Review of Molecular Diagnostics · doi:10.1080/14737159.2023.2276918 · Cited by 10 · see citing works
Alzheimer's Disease and Other Neurodegenerative Diseases
Fuller, S. J., Sohrabi, H. R., Goozee, K. G., Sankaranarayanan, A., & Martins, R. N. (2019) · doi:10.1002/9781119356752.ch2 · Cited by 8 · see citing works
Babür, E., Tufan, E., Barutçu, Ö., Aslan-Gülpınar, E., Tan, B., Süer, C., & Dursun, N. (2022) · Brain Research Bulletin · doi:10.1016/j.brainresbull.2022.02.007 · Cited by 7 · see citing works
Statistical Parametric Mapping in Amyloid Positron Emission Tomography
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Nabizadeh, F., Salehi, N., Ramezannezhad, E., Sadeghmousavi, S., & Khalili, E. (2022) · Annals of Indian Academy of Neurology · doi:10.4103/aian.aian_77_22 · Cited by 5 · see citing works
Tau profiling across Alzheimer’s disease staging reveals vulnerability to disease pathophysiology
Bezgin, G., Pascoal, T. A., Therriault, J., Lussier, F. Z., Servaes, S., Kang, M. S., Savard, M., Tissot, C., Stevenson, J., Wang, Y.-T., et al. (2025) · European Journal of Nuclear Medicine and Molecular Imaging · doi:10.1007/s00259-025-07257-4 · Cited by 4 · see citing works
Self-citationTatar, A.-S., Colniță, A., Brezeștean, I.-A., & Boca, S. (2026) · Biophysical Reviews · doi:10.1007/s12551-026-01428-9 · Cited by 2 · see citing works
Mohammed, H. E., Haseeb, M. E., Nasser, M., Hanen, G., Abdelkader, M., Yaser, H., Yaser, S., Samir, A., Arafeh, Y., Wagdy, M., et al. (2026) · Acta Neurologica Belgica · doi:10.1007/s13760-026-03107-8 · Cited by 1 · see citing works
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Yanagisawa, D., Ohgita, T., Kawashima, H., Yoshikawa, H., Saito, H., Tooyama, I., & Takata, K. (2026) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2026.109084 · Cited by 1 · see citing works
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Ahmadian, N., Talebi, M., Mahmoudi, J., Etegad, S. S., & Aghili, A. (2019) · Basic and Clinical Neuroscience Journal · doi:10.32598/bcn.9.10.445 · Cited by 1 · see citing works
Wojdała, A. L., Bellomo, G., Gaetani, L., Shan, D., Parnetti, L., & Chiasserini, D. (2023) · medRxiv · doi:10.1101/2023.06.08.23291128 · Cited by 1 · see citing works
Headbutting goats self-inflict traumatic brain injuryPreprint
Oyadeyi, A., Smith, C., Willeford, B. V., Grissett-Hardwick, G., Fizzano, K. M., Ws, R., Sorace, A. G., Osborne, A., Samuel, S., Campbell, I., et al. (2026) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.64898/2026.06.26.734585 · Cited by 1 · see citing works
Ueland, T. E., Horst, S., Shroder, M. M., Ye, F., Bai, K., McCoy, A. B., Bachmann, J. M., & Hawkins, A. T. (2024) · Journal of Gastrointestinal Surgery · doi:10.1016/j.gassur.2024.05.027
- Authors
- Spiegel, J., Pirraglia, E., Osorio, R. S., Glodzik, L., Li, Y., Tsui, W., Saint Louis, L. A., Randall, C., Butler, T., Xu, J., Zinkowski, R. P., Zetterberg, H., Fortea, J., Fossati, S., Wisniewski, T., Davies, P., Blennow, K., & de Leon, M. J.
- Affiliations
- New York University (US)
- Manhattan Diagnostic Radiology, New York, NY, USA
- Pioneer BioSolutions Inc., Grayslake, IL, USA
- University of Gothenburg (SE)
- Universitat Autònoma de Barcelona (ES)
- New York University, School of Medicine, Department of Neurology, New York, NY, USA
- Feinstein Institute for Medical Research (US)
- New York University, School of Medicine, Center for Brain Health, New York, NY, USA
- ORCID
- Venue
- Journal of Alzheimer's Disease
- Publisher
- SAGE Publications
- Published
- 2015-11-03
- Volume
- 49
- Issue
- 1
- Pages
- 93-100
- ISSN
- 1387-2877 (ISSN-L)
- 1875-8908
- PMC
- PMC4694576
- OpenAlex
- W2235546933
- Cited by
- 45
- References
- 37
- Citations by year
- 2026: 4 · 2025: 1 · 2024: 5 · 2023: 3 · 2022: 9 · 2021: 3 · 2020: 6 · 2019: 6 · 2018: 4 · 2017: 2 · 2016: 2
- FWCI
- 2.17
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Journal of Alzheimer s Disease (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- The HKU Scholars Hub (University of Hong Kong) (submittedVersion)
- Funders
- National Institutes of Health
- National Institute on Aging (AG035137, AG022374, R01AG022374, AG 12101, R01AG012101, R21AG049348, P30AG008051, AG032554, AG 08051, R21AG032554, R01AG022102, R01AG013616, R01AG035137, AG 13616)
- National Heart, Lung, and Blood Institute (R01HL118624, HL111724, R01HL111724)
- Topics
- Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
- Health Sciences › Medicine › Physiology › Alzheimer's disease research and treatments
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Cerebrospinal fluid and hydrocephalus
- Keywords
- Alzheimer's disease, cerebrospinal fluid
- MeSH terms
- Aged, Aged, 80 and over, Alzheimer Disease, Cross-Sectional Studies, Female, Humans, Male, Middle Aged, Phosphorylation, ROC Curve, Sensitivity and Specificity, Biomarkers, Logistic Models, Case-Control Studies, Amyloid beta-Peptides, tau Proteins
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