The Modified Frontal Behavioral Inventory (FBI-mod) for patients with frontotemporal lobar degeneration, Alzheimer’s disease, and mild cognitive impairment
Abstract
While behavioral symptoms are both early and prevalent features of behavioral variant frontotemporal dementia (bvFTD), they can be present in other types of dementia as well, including Alzheimer's disease (AD) and even mild cognitive impairment (MCI). The Frontal Behavioral Inventory (FBI) was specifically developed to capture the behavioral and personality changes in bvFTD; it has also been modified into a self-administered caregiver questionnaire (FBI-mod). We examined the utility of the FBI-mod in differentiating bvFTD (n = 26), primary progressive aphasia (PPA) (n = 7), AD (n = 53), and MCI (n = 50) patients, and investigated how the FBI-mod may be associated with neuropsychological measures. The bvFTD patients scored significantly higher as compared to all other patient groups on the FBI-mod Total (p < 0.005), Negative (p < 0.005), and Positive (p < 0.01) scores. The cut-off point for the FBI-mod Total score that best discriminated the bvFTD and AD patients in our sample was 16, thus substantially lower than reported for the original FBI. For the bvFTD group, only mild correlations emerged between the FBI-mod and the cognitive measures. However, significant correlations between the FBI-mod and depressive symptoms as measured by the BDI-II were found for bvFTD. This suggests that while behavioral symptoms appear independent from cognitive deficits in bvFTD, they may nevertheless be interrelated with depressive symptoms. We conclude that the FBI-mod is an easily administer…
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The Frontal Behavioral Inventory (FBI) overall score does not distinguish bvFTD from PPD.
“the overall score does not distinguish bvFTD from PPD (Kertesz et al. , 2000; Alberici et al. , 2007; Milan et al. , 2008; Krudop et al. , 2015; Dols et al. , 2016; Suhonen et al. , 2017).”
From Recommendations to distinguish behavioural variant frontotemporal dementia from psychiatric disorders (2020) · cites this paper as Suhonen et al., 2017
Cites
Mild cognitive impairment: a concept in evolution
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Prospective evaluation of behavioral scales in the behavioral variant of frontotemporal dementia
Boutoleau-Bretonnière, C., Lebouvier, T., Volteau, C., Jaulin, P., Lacomblez, L., Damier, P., Thomas-Anterion, C., & Vercelletto, M. (2012) · Dementia and Geriatric Cognitive Disorders · doi:10.1159/000341784 · Cited by 19 · see citing works
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Ducharme, S., Dols, A., Laforce, R., Devenney, E., Kumfor, F., van den Stock, J., Dallaire-Théroux, C., Seelaar, H., Gossink, F., Vijverberg, E., et al. (2020) · Brain · doi:10.1093/brain/awaa018 · Cited by 320 · see citing works
- Authors
- Suhonen, N.-M., Hallikainen, I., Hänninen, T., Jokelainen, J., Krüger, J., Hall, A., Pikkarainen, M., Soininen, H., & Remes, A. M.
- Affiliations
- Oulu University Hospital (FI)
- University of Eastern Finland (FI)
- Kuopio University Hospital (FI)
- Corresponding author
- Remes, Anne M.
- Venue
- Journal of Alzheimer’s Disease
- Publisher
- SAGE Publications
- Published
- 2017-01-20
- Volume
- 56
- Issue
- 4
- Pages
- 1241-1251
- ISSN
- 1387-2877 (ISSN-L)
- 1875-8908
- OpenAlex
- W2571805574
- Cited by
- 14
- References
- 4
- Citations by year
- 2026: 1 · 2025: 1 · 2024: 2 · 2023: 1 · 2022: 3 · 2021: 2 · 2020: 1 · 2019: 3
- FWCI
- 0.90
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Journal of Alzheimer s Disease (publishedVersion)
- PubMed (publishedVersion)
- UEF eRepo (University of Eastern Finland) (acceptedVersion)
- UEF eRepo (University of Eastern Finland) (submittedVersion)
- Topics
- Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
- Social Sciences › Psychology › Clinical Psychology › Historical and Modern Theater Studies
- Health Sciences › Medicine › Physiology › Alzheimer's disease research and treatments
- Keywords
- Frontal Behavioral Inventory, behavioral variant frontotemporal dementia
- MeSH terms
- Mental Status and Dementia Tests, Aged, Alzheimer Disease, Cognition, Diagnosis, Differential, Female, Humans, Male, Middle Aged, Psychiatric Status Rating Scales, Sensitivity and Specificity, Aphasia, Primary Progressive, Frontotemporal Lobar Degeneration, Cognitive Dysfunction
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