Prospective evaluation of behavioral scales in the behavioral variant of frontotemporal dementia
Abstract
BACKGROUND: The Neuropsychiatric Inventory (NPI) and the Frontal Behavioral Inventory (FBI) are widely used in patients with the behavioral variant of frontotemporal dementia (bvFTD). Yet, few data are available on the long-term relevance of these scales. MATERIAL AND METHODS: Based on a bvFTD population that participated in the Memantine Clinical Trial (NCT00200538), we studied the evolution and correlation between scores obtained on behavioral scales (NPI and FBI), cognitive scales [Mini-Mental State Examination (MMSE) and Mattis Dementia Rating Scale (MDRS)] and a burden scale [Zarit Burden Inventory (ZBI)]. The assessments were performed at 1 year in 41 patients and at 2 years in 23 patients who agreed to participate in this open-label study. RESULTS: The 2-year scores obtained on the FBI were significantly higher than the scores at inclusion while those obtained on the NPI did not change. There were significant correlations between the FBI, and the MDRS and MMSE, especially regarding the negative items. The ZBI correlated with behavioral scales at all stages for positive items. CONCLUSIONS: This study based on a large population shows that the FBI is a better tool than the NPI for the long-term assessment of bvFTD patients. Moreover, the FBI allows a distinction to be made between behavioral disturbances that involve cognitive functions from those which have an important impact on caregiver burden.
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The FBI and CBI-R were sensitive to progression in sporadic and genetic bvFTD (C9ORF72) more consistently than the NPI, over varying follow-up time (1-4 years).
“Literature showed the FBI and the CBI-R to be sensitive to progression in sporadic and genetic bvFTD (C9ORF72) more consistently than the NPI, over varying follow-up time (1–4 years), despite one study stating comparable decline of FBI and NPI (Marczinski et al., 2004; Boutoleau-Bretonniere et al., 2012; Linds et al., 2015; O’Connor et al., 2016; Floeter et al., 2017; Reus et al., 2018).”
From The pursuit for markers of disease progression in behavioral variant frontotemporal dementia: a scoping review to optimize outcome measures for clinical trials (2024) · cites this paper as Boutoleau-Bretonniere et al., 2012
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Self-citation
- Authors
- Boutoleau-Bretonnière, C., Lebouvier, T., Volteau, C., Jaulin, P., Lacomblez, L., Damier, P., Thomas-Anterion, C., & Vercelletto, M.
- Affiliations
- Inserm (FR)
- Venue
- Dementia and Geriatric Cognitive Disorders
- Publisher
- S. Karger AG
- Published
- 2012
- Volume
- 34
- Issue
- 2
- Pages
- 75-82
- ISSN
- 1420-8008 (ISSN-L)
- 1421-9824
- OpenAlex
- W2039393379
- Cited by
- 19
- References
- 26
- Citations by year
- 2024: 2 · 2023: 2 · 2022: 1 · 2021: 3 · 2020: 1 · 2019: 1 · 2018: 1 · 2017: 4 · 2016: 1 · 2015: 3
- FWCI
- 0.68
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Dementia and Geriatric Cognitive Disorders (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
- Social Sciences › Psychology › Clinical Psychology › Historical and Modern Theater Studies
- Health Sciences › Medicine › Physiology › Alzheimer's disease research and treatments
- Keywords
- behavioral variant frontotemporal dementia, Neuropsychiatric Inventory, Frontal Behavioral Inventory, behavior rating scales, caregiver burden, Zarit Burden Inventory, cognitive impairment, long-term outcomes, scale correlation
- MeSH terms
- Aged, Cross-Sectional Studies, Female, Humans, Longitudinal Studies, Male, Middle Aged, Neuropsychological Tests, Prospective Studies, Psychometrics, Severity of Illness Index, Disease Progression, Frontotemporal Dementia
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