Structural anatomical investigation of long term memory deficit in behavioral frontotemporal dementia
Open accessAbstract
Although a growing body of work has shown that behavioral variant frontotemporal dementia (bvFTD) could present with severe amnesia in approximately half of cases, memory assessment is currently the clinical standard to distinguish bvFTD from Alzheimer’s disease (AD). Thus, the concept of “relatively preserved episodic memory” in bvFTD remains the basis of its clinical distinction from AD and a criterion for bvFTD’s diagnosis. This view is supported by the idea that bvFTD is not characterized by genuine amnesia and hippocampal degeneration, by contrast to AD. In this multicenter study, we aimed to investigate the neural correlates of memory performance in bvFTD as assessed by the Free and Cued Selective Reminding Test (FCSRT). Imaging explorations followed a two-step procedure, first relying on a visual rating of atrophy of 35 bvFTD and 34 AD patients’ MRI, contrasted with 29 controls; and then using voxel-based morphometry (VBM) in a subset of bvFTD patients. Results showed that 43% of bvFTD patients presented with a genuine amnesia. Data-driven analysis on visual rating data showed that, in bvFTD, memory recall & storage performances were significantly predicted by atrophy in rostral prefrontal and hippocampal/perihippocampal regions, similar to mild AD. VBM results in bvFTD (p FWE <0.05) showed similar prefrontal and hippocampal regions in addition to striatal and lateral temporal involvement. Our findings showed the involvement of prefrontal as well as medial/lateral temporal atrophy in memory deficits of bvFTD patients. This contradicts the common view that only frontal deficits explain memory impairment in this disease and plead for an updated view on memory dysfunctions in bvFTD.
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10% of pathologically-confirmed bvFTD subjects show marked episodic memory deficits at initial presentation.
“Furthermore, 10% of pathologically-confirmed bvFTD subjects show marked episodic memory deficits at initial presentation, contrary to current diagnostic criteria (Hodges et al. , 2004; Hornberger and Piguet, 2012; Bertoux et al. , 2018).”
From Recommendations to distinguish behavioural variant frontotemporal dementia from psychiatric disorders (2020) · cites this paper as Bertoux et al. , 2018
The Introduction says episodic memory impairment is not contemplated as a bvFTD presentation in current diagnostic criteria, and the paper reports genuine amnesia in some bvFTD patients. But its Participants section describes clinically diagnosed, probable bvFTD—not pathologically confirmed cases—and its Abstract reports 43% with genuine amnesia, not 10%. The cited passages do not establish that the deficits were present at initial presentation. Page numbers are unavailable in our copy. (LLM, conf=0.88)
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Précis of Elements of episodic memory
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Ducharme, S., Dols, A., Laforce, R., Devenney, E., Kumfor, F., van den Stock, J., Dallaire-Théroux, C., Seelaar, H., Gossink, F., Vijverberg, E., et al. (2020) · Brain · doi:10.1093/brain/awaa018 · Cited by 320 · see citing works
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- Authors
- Bertoux, M., Flanagan, E. C., Hobbs, M., Ruiz-Tagle, A., Delgado, C., Miranda, M., Ibáñez, A., Slachevsky, A., & Hornberger, M.
- Affiliations
- University of East Anglia (GB)
- Laboratorio de Neurosciencas, Centro de Investigación Avanzada en Educación, Universidad de Chile, Santiago, Chile
- University of Chile (CL)
- Clínica Las Condes (CL)
- The University of Sydney (AU)
- Corresponding author
- Bertoux, Maxime
- ORCID
- Venue
- Journal of Alzheimer’s Disease
- Publisher
- SAGE Publications
- Published
- 2018-03-24
- Volume
- 62
- Issue
- 4
- Pages
- 1887-1900
- ISSN
- 1387-2877 (ISSN-L)
- 1875-8908
- OpenAlex
- W2794678786
- Cited by
- 28
- References
- 7
- Citations by year
- 2026: 1 · 2024: 4 · 2023: 3 · 2022: 3 · 2021: 9 · 2020: 3 · 2019: 5
- FWCI
- 1.81
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Journal of Alzheimer s Disease (publishedVersion)
- PubMed (publishedVersion)
- UEA Digital Repository (University of East Anglia) (submittedVersion)
- HAL (submittedVersion)
- Universidad de Chile (submittedVersion, cc-by-nc-nd)
- CONICET Digital (CONICET) (submittedVersion, cc-by-nc-sa)
- Funders
- Fundación INECO (15150012)
- Consejo Nacional de Investigaciones Científicas y Técnicas (1170010, 15150012, CONICYT/FONDAP 15150012)
- Comisión Nacional de Investigación Científica y Tecnológica (1170010, FONDAP-15150012, 15150012)
- Fondo para la Investigación Científica y Tecnológica (2012-0412, 2012‐1309)
- Fondo de Financiamiento de Centros de Investigación en Áreas Prioritarias (15150012)
- Topics
- Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
- Health Sciences › Medicine › Physiology › Alzheimer's disease research and treatments
- Health Sciences › Medicine › Neurology › Amyotrophic Lateral Sclerosis Research
- Keywords
- behavioral variant frontotemporal dementia, long-term memory deficits
- MeSH terms
- Aged, Alzheimer Disease, Atrophy, Brain, Humans, Magnetic Resonance Imaging, Memory Disorders, Mental Recall, Frontotemporal Dementia, Memory, Long-Term, Memory, Episodic, Gray Matter
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