Longitudinal memory profiles in behavioral-variant frontotemporal dementia and Alzheimer’s disease
Abstract
BACKGROUND: Alzheimer's disease (AD) and behavioral-variant of frontotemporal dementia (bvFTD) can present with an overlapping neuropsychological profile, which often hinders their clinical differentiation. OBJECTIVE: To compare changes over time in memory, general cognition tasks, and functional scales between bvFTD and AD. METHODS: Consecutive cases diagnosed with probable bvFTD (n = 22) and typical AD (n = 31) with at least two clinical visits were selected. Of these, 13 (9 AD, 4 bvFTD) underwent Pittsburgh compound B PET scan, which supported the clinical diagnosis in all cases. Mixed-model regressions were used to estimate the differential rate of decline on selected tasks between cohorts. RESULTS: Analyses demonstrated that, despite equivalent baseline performance, bvFTD patients experienced a more rapid functional deterioration and a steeper decline in global cognition than AD patients. At baseline, both groups were impaired on executive function and memory tasks compared to controls, but these deficits were more marked in the bvFTD group. In addition, performance on these domains continued to decline more rapidly in this group. CONCLUSIONS: Neither the initial neuropsychological assessment nor projected performances can reliably distinguish the totality of bvFTD and AD individuals. Nevertheless, annual rates of progression on cognitive tasks provide valuable information and will potentially help establish the impact of future therapeutic treatments in these dementia syndromes.
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Longitudinal studies on FTD-FRS captured a multi-domain deterioration over time in sporadic and genetic bvFTD (1-5 years).
“Longitudinal studies on FTD-FRS captured a multi-domain deterioration over time in sporadic and genetic bvFTD (1–5 years) (Devenney et al., 2015; Schubert et al., 2016; Lima-Silva et al., 2021).”
From The pursuit for markers of disease progression in behavioral variant frontotemporal dementia: a scoping review to optimize outcome measures for clinical trials (2024) · cites this paper as Schubert et al., 2016
Due to its comprehensive, yet feasible design, the ACE-R is a more valid cognitive progression screener for bvFTD, with marked rates of decline over follow-up (1-5 years).
“Due to its comprehensive, yet feasible design, the ACE-R is a more valid cognitive progression screener for bvFTD, with marked rates of decline over follow-up (1–5 years) (Mioshi and Hodges, 2009; Devenney et al., 2015; Schubert et al., 2016).”
From The pursuit for markers of disease progression in behavioral variant frontotemporal dementia: a scoping review to optimize outcome measures for clinical trials (2024) · cites this paper as Schubert et al., 2016
Literature demonstrated declines of MMSE, FAB and ACE-R total scores in bvFTD.
“Literature demonstrated declines of MMSE, FAB and ACE-R total scores in bvFTD (Mioshi and Hodges, 2009; Devenney et al., 2015; Schubert et al., 2016; Reus et al., 2018), but a principal component analysis of these measures (reflecting global cognitive status) showed no association with mortality (Lansdall et al., 2019).”
From The pursuit for markers of disease progression in behavioral variant frontotemporal dementia: a scoping review to optimize outcome measures for clinical trials (2024) · cites this paper as Schubert et al., 2016
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- Authors
- Schubert, S., Leyton, C. E., Hodges, J. R., & Piguet, O.
- Affiliations
- Neuroscience Research Australia (AU)
- The University of Sydney (AU)
- UNSW Sydney (AU)
- Corresponding author
- Piguet, Olivier
- Venue
- Journal of Alzheimer's Disease
- Publisher
- SAGE Publications
- Published
- 2016-03-30
- Volume
- 51
- Issue
- 3
- Pages
- 775-782
- ISSN
- 1387-2877 (ISSN-L)
- 1875-8908
- OpenAlex
- W2281205902
- Cited by
- 37
- References
- 29
- Citations by year
- 2026: 2 · 2025: 3 · 2024: 2 · 2023: 2 · 2022: 4 · 2021: 5 · 2020: 2 · 2019: 4 · 2018: 2 · 2017: 7 · 2016: 4
- FWCI
- 5.03
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Journal of Alzheimer s Disease (publishedVersion)
- PubMed (publishedVersion)
- Funders
- University of New South Wales
- Australian Research Council
- National Health and Medical Research Council
- Topics
- Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
- Health Sciences › Medicine › Physiology › Alzheimer's disease research and treatments
- Health Sciences › Medicine › Neurology › Amyotrophic Lateral Sclerosis Research
- Keywords
- behavioral variant frontotemporal dementia, Alzheimer's disease
- MeSH terms
- Alzheimer Disease, Aniline Compounds, Brain, Diagnosis, Differential, Female, Follow-Up Studies, Humans, Longitudinal Studies, Male, Memory, Middle Aged, Neuropsychological Tests, Thiazoles, Disease Progression, Radiopharmaceuticals, Positron-Emission Tomography, Executive Function, Frontotemporal Dementia
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