Lower Serum Antibodies Against Tau Protein and Heavy Neurofilament in Alzheimer’s Disease
Abstract
BACKGROUND: Unlike antibodies against amyloid-β, little is known about serum antibodies to neuron-specific cytoskeletal proteins in patients with Alzheimer's disease (AD). OBJECTIVE: We aimed to study IgG autoantibodies against tau protein, light (NFL) and heavy subunits (NFH) of neurofilaments in serum of AD patients and elderly controls and to explore the evolution of antineurocytoskeletal antibody levels over time. METHODS: Antibodies against three targets (tau, NFL, and NFH) were measured using ELISA in 100 serum samples from 51 cognitively normal elderly controls and 49 patients with AD. Our primary cross-sectional design was further extended to monitor fluctuations over 1-2 years in a subset of individuals. RESULTS: The AD patients had lower levels of anti-tau antibodies (p = 0.03) and even lower anti-NFH antibodies (p = 0.005) than those in the control group at baseline. On the contrary, anti-NFL antibodies or total IgG concentrations in serum did not differ. All three antibodies remained stable in both groups except for a selective and significant anti-tau decline in AD patients (p = 0.03). CONCLUSIONS: The different responses to these antigens suggest some antibody selectivity in AD. The significant decline was observed for only serum anti-tau antibodies in AD patients over time and it corresponds to lower anti-tau levels in these patients. Our findings indicate a special feature of disease-relevant antigens and humoral autoimmunity in AD.
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Naturally occurring anti-tau antibodies are detected in both AD patients and healthy controls without significant inter-group differences in their levels or correlation with cognitive decline.
“naturally occurring anti-tau antibodies are detected in both AD patients and healthy controls without significant inter-group differences in their levels or correlation with cognitive decline”
From Is there a role for B cells in Alzheimer's disease? (2026) · cites this paper as [100]
Cites
McKhann, G. M., Knopman, D. S., Chertkow, H., Hyman, B. T., Jack, C. R., Kawas, C. H., Klunk, W. E., Koroshetz, W. J., Manly, J. J., Mayeux, R., et al. (2011) · Alzheimer's & Dementia · doi:10.1016/j.jalz.2011.03.005 · Cited by 18,657 · see citing works
A compendium of neuropsychological tests: administration, norms, and commentary
(1991) · Choice Reviews Online · doi:10.5860/choice.29-2400 · Cited by 6,117 · see citing works
Mioshi, E., Dawson, K., Mitchell, J., Arnold, R., & Hodges, J. R. (2006) · International Journal of Geriatric Psychiatry · doi:10.1002/gps.1610 · Cited by 2,016 · see citing works
Scheltens, P., Leys, D., Barkhof, F., Huglo, D. G., Weinstein, H. C., Vermersch, P., Kuiper, M. A., Steinling, M., Wolters, E. C., & Valk, J. (1992) · Journal of Neurology Neurosurgery & Psychiatry · doi:10.1136/jnnp.55.10.967 · Cited by 1,781 · see citing works
Himmler, A., Drechsel, D. N., Kirschner, M. W., & Martin, D. W. (1989) · Molecular and Cellular Biology · doi:10.1128/mcb.9.4.1381-1388.1989 · Cited by 535 · see citing works
Asuni, A. A., Boutajangout, A., Quartermain, D., & Sigurdsson, E. M. (2007) · The Journal of Neuroscience · doi:10.1523/jneurosci.2361-07.2007 · Cited by 506 · see citing works
Antibodies and neuronal autoimmune disorders of the CNS
Graus, F., Saiz, A., & Dalmau, J. O. (2009) · Journal of Neurology · doi:10.1007/s00415-009-5431-9 · Cited by 388 · see citing works
Novák, P., Schmidt, R., Kontseková, E., Žilka, N., Kováčech, B., Škrabana, R., Kazmerova, Z., Katina, S., Fialová, Ľ., Prčina, M., et al. (2016) · The Lancet Neurology · doi:10.1016/s1474-4422(16)30331-3 · Cited by 306 · see citing works
Immunotherapy Targeting Pathological Tau Prevents Cognitive Decline in a New Tangle Mouse Model
Boutajangout, A., Quartermain, D., & Sigurdsson, E. M. (2010) · The Journal of Neuroscience · doi:10.1523/jneurosci.4363-10.2010 · Cited by 272 · see citing works
Paired helical filaments from Alzheimer disease patients contain cytoskeletal components.
Perry, G. L., Rizzuto, N., AUTILIO‐GAMBETTI, L., & Gambetti, P. L. (1985) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.82.11.3916 · Cited by 215 · see citing works
Tauopathy-like Abnormalities and Neurologic Deficits in Mice Immunized With Neuronal Tau Protein
Rosenmann, H., Grigoriadis, N., Karussis, D., Boimel, M., Touloumi, O., Ovadia, H., & Abramsky, O. (2006) · Archives of Neurology · doi:10.1001/archneur.63.10.1459 · Cited by 178 · see citing works
Efficacy and safety of immunization with phosphorylated tau against neurofibrillary tangles in mice
Boimel, M., Grigoriadis, N., Lourbopoulos, A., Haber, E., Abramsky, O., & Rosenmann, H. (2010) · Experimental Neurology · doi:10.1016/j.expneurol.2010.05.010 · Cited by 174 · see citing works
van Zwam, M., Huizinga, R., Melief, M., Wierenga‐Wolf, A. F., van Meurs, M., Voerman, J. S. A., Biber, K. P. H., Boddeke, H. W. G. M., Höpken, U. E., Meisel, C., et al. (2008) · Journal of Molecular Medicine · doi:10.1007/s00109-008-0421-4 · Cited by 144 · see citing works
Patients with progressive multiple sclerosis have elevated antibodies to neurofilament subunit
Silber, E., Semra, Y. K., Gregson, N. A., & Sharief, M. K. (2002) · Neurology · doi:10.1212/wnl.58.9.1372 · Cited by 143 · see citing works
Stefánsson, K., Marton, L. S., Dieperink, M. E., Molnar, G. K., Schlaepfer, W. W., & Helgason, C. M. (1985) · Science · doi:10.1126/science.4039466 · Cited by 117 · see citing works
Levin, E. C., Acharya, N. K., Han, M. C., Zavareh, S., Sedeyn, J. C., Venkataraman, V., & Nagele, R. G. (2010) · Brain Research · doi:10.1016/j.brainres.2010.05.038 · Cited by 113 · see citing works
Mruthinti, S., Buccafusco, J. J., Hill, W., Waller, J. L., Jackson, T. W., ZAMRINI, E. Y., & Schade, R. (2004) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2003.11.001 · Cited by 113 · see citing works
Add Alzheimer's disease to the list of autoimmune diseases
D’Andrea, M. R. (2005) · Medical Hypotheses · doi:10.1016/j.mehy.2004.08.024 · Cited by 113 · see citing works
A Systematic Review and Meta-Analysis of CSF Neurofilament Protein Levels as Biomarkers in Dementia
Petzold, A., Keir, G., Warren, J. D., Fox, N. C., & Rossor, M. N. (2007) · Neurodegenerative Diseases · doi:10.1159/000101843 · Cited by 112 · see citing works
Алексеевна, Г. М., Davidova, T. B., Mališauskas, M., Sewell, R. D. E., Voskresenskaya, N. I., Wilhelm, K., Elistratova, E. I., Sherstnev, V. V., & Morozova‐Roche, L. A. (2007) · Journal of Neuroimmunology · doi:10.1016/j.jneuroim.2007.03.023 · Cited by 112 · see citing works
Natural human antibodies to amyloid beta peptide
Szabo, P., Relkin, N. R., & Weksler, M. E. (2008) · Autoimmunity Reviews · doi:10.1016/j.autrev.2008.03.007 · Cited by 107 · see citing works
Autoantibodies in Neurodegenerative Diseases: Antigen-Specific Frequencies and Intrathecal Analysis
Terryberry, J. W., Thor, G. T., & Peter, J. B. (1998) · Neurobiology of Aging · doi:10.1016/s0197-4580(98)00049-9 · Cited by 105 · see citing works
Tau as a Therapeutic Target for Alzheimers Disease
Boutajangout, A., Sigurdsson, E. M., & Krishnamurthy, P. K. (2011) · Current Alzheimer Research · doi:10.2174/156720511796717195 · Cited by 97 · see citing works
Jianming, W., & Ling, L. (2016) · The Journal of Biomedical Research · doi:10.7555/jbr.30.20150131 · Cited by 87 · see citing works
Rosenmann, H., Meiner, Z., Geylis, V., Abramsky, O., & Steinitz, M. (2006) · Neuroscience Letters · doi:10.1016/j.neulet.2006.01.072 · Cited by 77 · see citing works
Use of cerebrospinal fluid biomarkers in diagnosis of dementia across Europe
Hort, J., Bartoš, A., Pirttilä, T., & Scheltens, P. (2009) · European Journal of Neurology · doi:10.1111/j.1468-1331.2009.02753.x · Cited by 73 · see citing works
CSF Biomarkers for Amyloid and Tau Pathology in Alzheimer's Disease
Rosenmann, H. (2011) · Journal of Molecular Neuroscience · doi:10.1007/s12031-011-9665-5 · Cited by 68 · see citing works
Huizinga, R., Heijmans, N., Schubert, P., Gschmeissner, S., Hart, B. A. ‘., Herrmann, H. O., & Amor, S. (2007) · Journal of Neuropathology & Experimental Neurology · doi:10.1097/nen.0b013e318040ad5c · Cited by 65 · see citing works
Алексеевна, Г. М., Davudova, T. B., Mališauskas, M., Zamotin, V., Sewell, R. D. E., Voskresenskaya, N. I., Kostanyan, I. A., Sherstnev, V. V., & Morozova‐Roche, L. A. (2004) · Dementia and Geriatric Cognitive Disorders · doi:10.1159/000079197 · Cited by 65 · see citing works
Nagele, R. G., Clifford, P. M., Siu, G., Levin, E. C., Acharya, N. K., Han, M. C., Kosciuk, M. C., Venkataraman, V., Zavareh, S., Zarrabi, S., et al. (2011) · Journal of Alzheimer s Disease · doi:10.3233/jad-2011-110098 · Cited by 65 · see citing works
Colasanti, T., Barbati, C., Rosano, G. M. C., Malorni, W., & Ortona, E. (2010) · Autoimmunity Reviews · doi:10.1016/j.autrev.2010.07.008 · Cited by 61 · see citing works
Elevated intrathecal antibodies against the medium neurofilament subunit in multiple sclerosis
Bartoš, A., Fialová, L., Soukupová, J., Kukal, J., Malbohan, I. M., & Piťha, J. (2007) · Journal of Neurology · doi:10.1007/s00415-006-0185-0 · Cited by 55 · see citing works
Self-citationBartoš, A., & Raisová, M. (2016) · Dementia and Geriatric Cognitive Disorders · doi:10.1159/000446426 · Cited by 47 · see citing works
Antibodies against light neurofilaments in multiple sclerosis patients
Bartoš, A., Fialová, L., Soukupová, J., Kukal, J., Malbohan, I. M., & ha, J. P. (2007) · Acta Neurologica Scandinavica · doi:10.1111/j.1600-0404.2006.00794.x · Cited by 45 · see citing works
Self-citationResistance is futile: antineuronal autoimmunity in multiple sclerosis.
Huizinga, R., Linington, C., & Amor, S. (2008) · Trends in immunology · doi:10.1016/j.it.2007.11.002 · Cited by 43 · see citing works
Low Avidity and Level of Serum Anti-A?? Antibodies in Alzheimer Disease
Lv, J., Yao, Z., Wei, Q., Zhikai, C., Jie, X., & Jinbiao, L. (2006) · Alzheimer Disease & Associated Disorders · doi:10.1097/00002093-200607000-00001 · Cited by 42 · see citing works
The innate and adaptive immunological aspects in neurodegenerative diseases
Rodrigues, M. C. O., Sanberg, P. R., Cruz, L. E. G., & Garbuzova-Davis, S. N. (2013) · Journal of Neuroimmunology · doi:10.1016/j.jneuroim.2013.09.020 · Cited by 41 · see citing works
Papuć, E., Kurys-Denis, E., Krupski, W., Tatara, M. R., & Rejdak, K. (2015) · Journal of Alzheimer s Disease · doi:10.3233/jad-150309 · Cited by 33 · see citing works
Antibodies to the neuronal cytoskeleton are elicited by Alzheimer paired helical filament fractions
Perry, G. L., Friedman, R., Kang, D. H., Manetto, V., AUTILIO‐GAMBETTI, L., & Gambetti, P. L. (1987) · Brain Research · doi:10.1016/0006-8993(87)91243-1 · Cited by 33 · see citing works
Marcello, A., Wirths, O., Schneider-Axmann, T., Degerman-Gunnarsson, M., Lannfelt, L., & Bayer, T. A. (2009) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2009.08.011 · Cited by 29 · see citing works
Naturally Occurring Autoantibodies against Tau Protein Are Reduced in Parkinson's Disease Dementia
Kronimus, Y., Albus, A., Balzer‐Geldsetzer, M., Straub, S., Semler, E., Otto, M., Klotsche, J., Dodel, R. C., & Mengel, D. (2016) · PLoS ONE · doi:10.1371/journal.pone.0164953 · Cited by 26 · see citing works
Soussan, L., Tchernakov, K., Lavi, O., Yuvan, T., Wertman, E., & Michaelson, D. M. (1994) · Molecular Neurobiology · doi:10.1007/bf02816107 · Cited by 26 · see citing works
Increased Intrathecal High-Avidity Anti-Tau Antibodies in Patients with Multiple Sclerosis
Fialová, L., Bartoš, A., Švarcová, J., & Malbohan, I. M. (2011) · PLoS ONE · doi:10.1371/journal.pone.0027476 · Cited by 25 · see citing works
Self-citationNew directions towards safer and effective vaccines for Alzheimer's disease.
Goñi, F., & Sigurdsson, E. M. (2005) · PubMed · Cited by 25 · see citing works
Harnessing the Immune System for Treatment and Detection of Tau Pathology
Congdon, E. E., Krishnaswamy, S., & Sigurdsson, E. M. (2014) · Journal of Alzheimer s Disease · doi:10.3233/jad-132435 · Cited by 20 · see citing works
SERUM IgG BRAIN REACTIVE ANTIBODIES IN ALZHEIMER DISEASE AND DOWN SYNDROME
Kumar, M., Cohén, D., & Eisdorfer, C. (1988) · Alzheimer Disease & Associated Disorders · doi:10.1097/00002093-198802010-00006 · Cited by 20 · see citing works
Immunotherapy for Conformational Diseases
Sigurdsson, E. M. (2006) · Current Pharmaceutical Design · doi:10.2174/138161206777698837 · Cited by 19 · see citing works
Vickers, J. C., Kirkcaldie, M., Phipps, A. J., & King, A. E. (2016) · Brain Research Bulletin · doi:10.1016/j.brainresbull.2016.07.012 · Cited by 18 · see citing works
Neurofilaments and tau proteins in cerebrospinal fluid and serum in dementias and neuroinflammation
Fialová, L., Bartoš, A., & Švarcová, J. (2017) · Biomedical Papers · doi:10.5507/bp.2017.038 · Cited by 15 · see citing works
Self-citationPapuć, E., Krupski, W., Kurys-Denis, E., & Rejdak, K. (2015) · Journal of Neural Transmission · doi:10.1007/s00702-015-1477-2 · Cited by 9 · see citing works
Serum antibodies to cholinergic neurons in Alzheimer's disease.
Michaelson, D. M., Chapman, J., Bachar, O., Korczyn, A. D., & Wertman, E. (1989) · PubMed · Cited by 9 · see citing works
Paraneoplastische Degeneration des Kleinhirns bei Ovarialkarzinom
Bartoš, A., Štourač, P., Rusina, R., Šejdová, M., & Velenská, Z. (2002) · Der Nervenarzt · doi:10.1007/s00115-002-1371-7 · Cited by 7 · see citing works
SERUM ANTIBODIES TO CHOLINERGIC NEURONS IN ALZHEIMER??S DISEASE
Michaelson, D. M., Chapman, J., Bachar, O., Feldon, J., Korczyn, A. D., & Wertman, E. (1988) · Alzheimer Disease & Associated Disorders · doi:10.1097/00002093-198802030-00025 · Cited by 5 · see citing works
Avidity of antineurocytoskeletal antibodies in Alzheimer's disease patients
Nosková, L., Fialová, L., Bartoš, A., & Zima, T. (2017) · Biomedical Papers · doi:10.5507/bp.2017.017 · Cited by 4 · see citing works
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Autoantibodies targeting neuronal proteins as biomarkers for neurodegenerative diseases
Kocurova, G., Říčný, J., & Ovsepian, S. V. (2022) · Theranostics · doi:10.7150/thno.72126 · Cited by 29 · see citing works
Nataf, S., Guillen, M., & Pays, L. (2019) · Frontiers in Immunology · doi:10.3389/fimmu.2019.02704 · Cited by 25 · see citing works
Lavi, Y. B., Vojdani, A., Halpert, G., Sharif, Κ., Ostrinski, Y., Zyskind, I., Lattin, M. T., Zimmerman, J., Silverberg, J. I., Rosenberg, A. Z., et al. (2023) · Diagnostics · doi:10.3390/diagnostics13040687 · Cited by 26 · see citing works
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Garmendia, J. V., Sanctis, C. V. D., Das, V., Annadurai, N., Hajdúch, M., & Sanctis, J. B. D. (2023) · Current Neuropharmacology · doi:10.2174/1570159x22666231017141636 · Cited by 27 · see citing works
Blood Neurofilament Light Chain in Different Types of Dementia
Gu, L., Shu, H., Wang, Y., & Wang, P. (2023) · Current Alzheimer Research · doi:10.2174/1567205020666230601123123 · Cited by 16 · see citing works
Hromádková, L., & Ovsepian, S. V. (2019) · Journal of Immunology Research · doi:10.1155/2019/7406810 · Cited by 17 · see citing works
Chatanaka, M. K., Sohaei, D., Diamandis, E. P., & Prassas, I. (2023) · Critical Reviews in Clinical Laboratory Sciences · doi:10.1080/10408363.2023.2187342 · Cited by 15 · see citing works
Miteva, D., Vasilev, G., & Velikova, T. V. (2023) · Antibodies · doi:10.3390/antib12040081 · Cited by 14 · see citing works
Kapadia, M., Mian, M. F., Ma, D., Hutton, C. P., Azam, A., Narkaj, K., Cao, C., Brown, B., Michalski, B., Morgan, D., et al. (2021) · Alzheimer's Research & Therapy · doi:10.1186/s13195-020-00745-9 · Cited by 14 · see citing works
TDP-43–specific Autoantibody Decline in Patients With Amyotrophic Lateral Sclerosis
Nielsen, A. K., Folke, J., Owczarek, S., Svenstrup, K., Winge, K., Pakkenberg, B., Aznar, S., & Brudek, T. (2020) · Neurology Neuroimmunology & Neuroinflammation · doi:10.1212/nxi.0000000000000937 · Cited by 14 · see citing works
Anti-neurofilament antibodies and neurodegeneration: Markers and generators
Zmira, O., Halpern, A. I., & Drori, T. (2020) · Journal of Neuroimmunology · doi:10.1016/j.jneuroim.2020.577248 · Cited by 13 · see citing works
Detection of antibodies against the huntingtin protein in human plasma
Denis, H. L., Alpaugh, M., Alvarez, C., Fenyi, A., Barker, R. A., Chouinard, S., Arrowsmith, C. H., Melki, R., Labib, R., Harding, R., et al. (2023) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-023-04687-x · Cited by 6 · see citing works
CMV as a factor in the development of Alzheimer’s disease?
Blanck, G., Huda, T. I., Chobrutskiy, B. I., & Chobrutskiy, A. (2023) · Medical Hypotheses · doi:10.1016/j.mehy.2023.111140 · Cited by 5 · see citing works
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Magalhães, A. D., Emmenegger, M., Cecco, E. D., Carta, M. C., Frontzek, K., Chincisan, A., Guo, J., Hornemann, S., & Aguzzi, A. (2021) · medRxiv · doi:10.1101/2021.11.24.21266833 · Cited by 4 · see citing works
Adult Neurogenesis in the Gut, Homeostatic Autoimmunity and Neurodegenerative Disease Biomarkers
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The role of autoantibodies in Alzheimer's disease: Pathogenetic connections or epiphenomena?
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Self-citationKapadia, M., Mian, M. F., Ma, D., Hutton, C. P., Azam, A. B., Narkaj, K., Cao, C., Brown, B., Michalski, B., Morgan, D., et al. (2021) · Figshare · doi:10.6084/m9.figshare.13619932
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- Authors
- Bartos, A., Fialová, L., & Švarcová, J.
- Affiliations
- National Institute of Mental Health, Klecany, Czech Republic
- Charles University (CZ)
- University Hospital in Motol (CZ)
- ORCID
- Fialová, Lenka
- Venue
- Journal of Alzheimer's Disease
- Publisher
- SAGE Publications
- Published
- 2018-07-03
- Volume
- 64
- Issue
- 3
- Pages
- 751-760
- ISSN
- 1387-2877 (ISSN-L)
- 1875-8908
- OpenAlex
- W2810945462
- Cited by
- 25
- References
- 54
- Citations by year
- 2026: 4 · 2025: 3 · 2024: 1 · 2023: 7 · 2022: 2 · 2021: 3 · 2020: 3 · 2019: 2
- FWCI
- 1.38
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Journal of Alzheimer s Disease (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Všeobecná Fakultní Nemocnice v Praze
- National Institutes of Health
- National Institute of Mental Health
- Topics
- Health Sciences › Medicine › Physiology › Alzheimer's disease research and treatments
- Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
- Life Sciences › Neuroscience › Neurology › Neuroinflammation and Neurodegeneration Mechanisms
- Keywords
- Alzheimer's disease, anti-tau antibodies
- MeSH terms
- Aged, Aged, 80 and over, Alzheimer Disease, Female, Humans, Immunoglobulin G, Male, Middle Aged, tau Proteins, Neurofilament Proteins
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