Cited by 25Alzheimer's disease research and treatmentsDementia and Cognitive Impairment ResearchNeuroinflammation and Neurodegeneration Mechanisms

Lower Serum Antibodies Against Tau Protein and Heavy Neurofilament in Alzheimer’s Disease

Bartos, Ales, Fialová, Lenka, Švarcová, Jana·2018·Journal of Alzheimer's Disease

Abstract

BACKGROUND: Unlike antibodies against amyloid-β, little is known about serum antibodies to neuron-specific cytoskeletal proteins in patients with Alzheimer's disease (AD). OBJECTIVE: We aimed to study IgG autoantibodies against tau protein, light (NFL) and heavy subunits (NFH) of neurofilaments in serum of AD patients and elderly controls and to explore the evolution of antineurocytoskeletal antibody levels over time. METHODS: Antibodies against three targets (tau, NFL, and NFH) were measured using ELISA in 100 serum samples from 51 cognitively normal elderly controls and 49 patients with AD. Our primary cross-sectional design was further extended to monitor fluctuations over 1-2 years in a subset of individuals. RESULTS: The AD patients had lower levels of anti-tau antibodies (p = 0.03) and even lower anti-NFH antibodies (p = 0.005) than those in the control group at baseline. On the contrary, anti-NFL antibodies or total IgG concentrations in serum did not differ. All three antibodies remained stable in both groups except for a selective and significant anti-tau decline in AD patients (p = 0.03). CONCLUSIONS: The different responses to these antigens suggest some antibody selectivity in AD. The significant decline was observed for only serum anti-tau antibodies in AD patients over time and it corresponds to lower anti-tau levels in these patients. Our findings indicate a special feature of disease-relevant antigens and humoral autoimmunity in AD.

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Registry

Crossref · 10.3233/jad-180039

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  • Naturally occurring anti-tau antibodies are detected in both AD patients and healthy controls without significant inter-group differences in their levels or correlation with cognitive decline.

    “naturally occurring anti-tau antibodies are detected in both AD patients and healthy controls without significant inter-group differences in their levels or correlation with cognitive decline”

    From Is there a role for B cells in Alzheimer's disease? (2026) · cites this paper as [100]

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Authors
Bartos, A., Fialová, L., & Švarcová, J.
Affiliations
  • National Institute of Mental Health, Klecany, Czech Republic
  • Charles University (CZ)
  • University Hospital in Motol (CZ)
Venue
Journal of Alzheimer's Disease
Published
2018-07-03
Volume
64
Issue
3
Pages
751-760
ISSN
  • 1387-2877 (ISSN-L)
  • 1875-8908
OpenAlex
W2810945462
Cited by
25
References
54
Citations by year
2026: 4 · 2025: 3 · 2024: 1 · 2023: 7 · 2022: 2 · 2021: 3 · 2020: 3 · 2019: 2
FWCI
1.38
Type
journal article
Language
en
Open access
closed
Locations
  • Journal of Alzheimer s Disease (publishedVersion)
  • PubMed (publishedVersion)
Funders
  • Všeobecná Fakultní Nemocnice v Praze
  • National Institutes of Health
  • National Institute of Mental Health
Topics
  • Health Sciences › Medicine › Physiology › Alzheimer's disease research and treatments
  • Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
  • Life Sciences › Neuroscience › Neurology › Neuroinflammation and Neurodegeneration Mechanisms
Keywords
Alzheimer's disease, anti-tau antibodies
MeSH terms
Aged, Aged, 80 and over, Alzheimer Disease, Female, Humans, Immunoglobulin G, Male, Middle Aged, tau Proteins, Neurofilament Proteins

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