Improvement of Main Cognitive Functions in Patients with Alzheimer’s Disease after Treatment with Coconut Oil Enriched Mediterranean Diet: A Pilot Study
Open accessAbstract
BACKGROUND: Alzheimer's disease (AD) is the most prevalent neurodegenerative disorder (mainly in women), and new therapies are needed. In this way, ketone bodies are a direct source of cellular energy and can be obtained from coconut oil, postulating that coconut oil could be a new non-pharmacological alternative in AD patients. OBJECTIVE: The aim of this study is to detect changes in the main cognitive functions of patients with AD after following a coconut oil enriched Mediterranean diet, and to determine whether there are differences in function of stage or sex. METHODS: A prospective, longitudinal, qualitative, analytic, experimental study was carried out in 44 patients with AD, who were randomly divided into two homogenous groups of 22 patients each: an experimental group of patients who followed a coconut oil enriched Mediterranean diet for 21 days and a control group. In order to determine the cognitive changes after the intervention, we carried out the 7 Minute Screen, which analyses temporal orientation, visuospatial and visuoconstructive abilities, and semantic and episodic memory. RESULTS: After intervention with coconut oil, improvements in episodic, temporal orientation, and semantic memory were observed, and it seems that the positive effect is more evident in women with mild-moderate state, although other improvements in males and severe state were also shown. CONCLUSIONS: The isocaloric coconut oil enriched Mediterranean diet seems to improve cognitive functions in patients with AD, with differences according to patient sex and degree of severity of the disease, although more studies in this line are needed.
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VCO can accelerate wound healing, attributed to its antioxidant properties and its ability to promote collagen synthesis and re-epithelialization.
“Studies have indicated that VCO can accelerate wound healing. This is attributed to its antioxidant properties, which reduce oxidative stress at the wound site, and its ability to promote collagen synthesis and re-epithelialization [154].”
From Nutritional composition and bioactive properties of tropical coconut palm fruit with functional food applications (2025) · cites this paper as [154]
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Mediterranean diet nutrients to turn the tide against insulin resistance and related diseases
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Current opinion on dietary advice in order to preserve fat-free mass during a low-calorie diet
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“This is attributed to its antioxidant properties, which reduce oxidative stress at the wound site, and its ability to promote collagen synthesis and re-epithelialization [154].”
- Authors
- de la Rubia Ortí, J. E., García-Pardo, M. P., Drehmer, E., Sancho Cantus, D., Julián Rochina, M., Aguilar, M. A., & Hu Yang, I.
- Affiliations
- Faculty of Nursing, Catholic University of Valencia, Valencia, Spain
- Universitat Jaume I (ES)
- Valencia Catholic University Saint Vincent Martyr (ES)
- Faculty of Psychology, Catholic University of Valencia, Valencia, Spain
- Faculty of Nursing and Podiatry, University of Valencia, Valencia, Spain
- Universitat de València (ES)
- Corresponding author
- García-Pardo, María Pilar
- Venue
- Journal of Alzheimer’s Disease
- Publisher
- SAGE Publications
- Published
- 2018-07-20
- Volume
- 65
- Issue
- 2
- Pages
- 577-587
- ISSN
- 1387-2877 (ISSN-L)
- 1875-8908
- OpenAlex
- W2883253765
- Cited by
- 116
- References
- 2
- Citations by year
- 2026: 6 · 2025: 14 · 2024: 14 · 2023: 20 · 2022: 25 · 2021: 15 · 2020: 14 · 2019: 8
- FWCI
- 7.27
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Journal of Alzheimer s Disease (publishedVersion)
- PubMed (publishedVersion)
- RIUCV (Universidad Católica de Valencia San Vicente Martír) (submittedVersion, cc-by-nc-nd)
- Hispana (submittedVersion, cc-by-nc-nd)
- Topics
- Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
- Physical Sciences › Chemistry › Inorganic Chemistry › Coconut Research and Applications
- Health Sciences › Medicine › Physiology › Diet and metabolism studies
- Keywords
- Alzheimer's disease, coconut oil
- MeSH terms
- Coconut Oil, Aged, Aged, 80 and over, Alzheimer Disease, Cognition, Female, Humans, Longitudinal Studies, Male, Memory, Severity of Illness Index, Sex Factors, Time Perception, Treatment Outcome, Qualitative Research, Diet, Mediterranean
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