Cognitive Reserve in Midlife is not Associated with Amyloid-β Deposition in Late-Life
Open accessAbstract
We examined associations between cognitive reserve and late-life amyloid-β deposition using florbetapir positron emission tomography (PET). We used data from the Atherosclerosis Risk in Communities (ARIC) and ARIC-PET Study. 330 dementia-free participants underwent PET scans. Mean global cortical standardized uptake value ratio (SUVR) >1.2 was defined as elevated. Midlife cognition was significantly associated with late-life cognition, but not with late-life elevated SUVR; education was not associated with late-life SUVR, but was strongly associated with late-life cognition. Cognitive reserve may reduce dementia risk by mitigating the impact of Alzheimer's disease pathology on the clinical expression of dementia, rather than by altering its pathogenesis.
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More recent research incorporating PET imaging suggests that rather than reducing the risk of developing Alzheimer's brain changes, formal education may help sustain cognitive function in mid- and late life and delay the development of symptoms.
“More recent research incorporating these technological advances suggests that rather than reducing the risk of developing Alzheimer's brain changes, formal education may help sustain cognitive function in mid‐ and late life and delay the development of symptoms.”
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- Authors
- Rawlings, A. M., Sharrett, A. R., Mosley, T. H., Wong, D. F., Knopman, D. S., & Gottesman, R. F.
- Affiliations
- Johns Hopkins University (US)
- University of Mississippi Medical Center (US)
- Mayo Clinic (US)
- Corresponding author
- Gottesman, Rebecca F.
- ORCID
- Venue
- Journal of Alzheimer's Disease
- Publisher
- SAGE Publications
- Published
- 2019-03-29
- Volume
- 68
- Issue
- 2
- Pages
- 517-521
- ISSN
- 1387-2877 (ISSN-L)
- 1875-8908
- PMC
- PMC6443418
- OpenAlex
- W2912361180
- Cited by
- 14
- References
- 15
- Citations by year
- 2026: 2 · 2025: 1 · 2024: 3 · 2023: 4 · 2021: 3 · 2020: 1
- FWCI
- 0.80
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Journal of Alzheimer s Disease (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Institutes of Health (5u01hl096899-08, 5u01hl096902-08)
- National Institute on Aging (R01AG040282, K24AG052573)
- National Heart, Lung, and Blood Institute (HHSN268201700004I, HHSN268201700001I, HHSN268201700005C, HHSN268201700003I, U01HL096814, U01-HL-096899, HHSN268201700005I, U01-HL-096902, HHSN268201700001C, U01HL096917, HHSN268201700002I, HHSN268201700003C, HHSN268201700002C, R01HL070825, HHSN268201700004C, T32HL007024, U01HL096812)
- Topics
- Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
- Health Sciences › Medicine › Physiology › Alzheimer's disease research and treatments
- Health Sciences › Medicine › Pulmonary and Respiratory Medicine › Cancer-related cognitive impairment studies
- Keywords
- cognitive reserve, amyloid-beta deposition
- MeSH terms
- Aged, Aged, 80 and over, Alzheimer Disease, Brain, Educational Status, Female, Humans, Magnetic Resonance Imaging, Male, Middle Aged, Prospective Studies, Cohort Studies, Amyloid beta-Peptides, Positron-Emission Tomography, Cognitive Reserve
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