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Lipid Peroxidation and Oxidative imbalance: Early functional events in Alzheimer's disease
Abstract
Alzheimer's disease (AD) is a growing public health problem worldwide. Clinically, AD is a progressive neurodegenerative disorder characterized by a global cognitive decline. Accumulating evidence indicates that reactive oxygen species-mediated reactions, particularly of neuronal lipids, are extensive in those AD brain areas directly involved in the disease processes. Traditional views claim that oxidative-mediated tissue injury in the AD brain is the result of neurodegeneration. In recent years, numerous investigations have pointed to the functional importance of oxidative imbalance as a crucial event in mediating AD pathogenesis. The availability of specific and sensitive markers to monitor in vivo oxidative stress, in combination with studies performed in living patients with clinical diagnosis of AD are helping us to elucidate these issues. The evidence we have accumulated so far clearly indicates that oxidative imbalance and subsequent oxidative stress are early events during the evolution of the disease, and secondary to specific mechanism(s) present in AD but not in other neurodegenerative diseases. These new concepts implicate that this phenomenon may play a more important role in AD pathogenesis than previously anticipated, and that any therapeutic intervention targeting oxidative stress should be initiated at the earliest possible stage of the disease.
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“the brain contains the high levels of polyunsaturated fatty acids (PUFAs) in its membrane rich architecture”
In the citing paper
“lipid peroxidation could be a major feature of ferroptosis in AD”
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Items 201–230 of 230
Ferroptosis in Nervous System Diseases
Wan, J., Yang, X., & Wang, J. (2019) · Springer eBooks · doi:10.1007/978-3-030-26780-3_10 · Cited by 5
Quiney, C., Finnegan, S., Groeger, G., & Cotter, T. G. (2010) · Springer eBooks · doi:10.1007/978-1-4419-6382-6_3 · Cited by 5
Song, B., Yue, D., Yan, H., Feng, L., & Li, M. (2025) · Drug Design Development and Therapy · doi:10.2147/dddt.s531909 · Cited by 3
“149 Furthermore, glycosylation of AGEs at the N-terminal of tau protein, the microtubule binding site, results in microtubule instability.”
Kahraman, Ç., Gönülalan, E. M., Koçak, E., Gökmen, F. Ş., Gündüz, M. G., Nemutlu, E., & Çankaya, İ. İ. T. (2025) · Journal of Ethnopharmacology · doi:10.1016/j.jep.2025.120692 · Cited by 3
Core Ferroptosis-Related Biomarkers and miRNA Regulatory Networks in Alzheimer’s Disease
Liu, W., Rao, X., & Yu, L. (2026) · Genes · doi:10.3390/genes17020224 · Cited by 2
“Ferroptosis markers, such as lipid peroxidation and disrupted iron metabolism, have been consistently observed in the brains of AD patients [8,9].”
Nicotine: A Possible Neuroprotector in Brain Disorders
Alkadhi, K. A., Salim, S., & Alzoubi, K. H. (2025) · Springer eBooks · doi:10.1007/978-3-642-36202-6_178-1 · Cited by 2
An update on using vitamin E in Alzheimer's disease
Kontush, A., & Schekatolina, S. (2008) · Expert Opinion on Drug Discovery · doi:10.1517/17460441.3.2.261 · Cited by 2
“Increased susceptibility of CSF to in vitro oxidation [31] and elevated CSF markers of in vivo lipid peroxidation (F2-isoprostanes) [14,36] paralleled the decreases in vitamin E levels in AD patients, suggesting a role of oxidative stress in the vitamin E depletion.”
BackgroundResultTranscriptional Factor Modulation by Lipid Peroxidation-Derived Aldehydes
Saxena, A., Sonowal, H., & Ramana, K. V. (2018) · Elsevier eBooks · doi:10.1016/b978-0-12-811297-7.00032-9 · Cited by 2
The Principal Inferior Olivary Nucleus in Aging and Alzheimer's Disease
Lasn, H. (2006) · Figshare · Cited by 2
Zheng, W., Wang, Y. X., Zhu, E., Xu, R., & Zhu, L. (2025) · Medicine · doi:10.1097/md.0000000000045048 · Cited by 1
Fatke, B., & Förstl, H. (2013) · Springer eBooks · doi:10.1007/978-3-642-29908-7_19 · Cited by 1
Insulin resistance and Alzheimer’s disease
Farooqui, A. A. (2020) · Elsevier eBooks · doi:10.1016/b978-0-12-819603-8.00006-7 · Cited by 1
Alzheimer’s disease: from pathogenesis to novel therapeutic approaches
Scarpini, E. A., & Galimberti, D. (2009) · Therapy · doi:10.2217/14750708.6.2.259 · Cited by 1
Senegenin rescues PC12 cells with oxidative damage through inhibition of ferroptosisPreprint
Zhang, H., Zhou, W. J., Li, J., et al. (2022) · Research Square · doi:10.21203/rs.3.rs-1729531/v1 · Cited by 1
Effec ts of hyperoxia in alzheimers transgenic mice
Cox, A. (2005) · Digital Commons - University of South Florida (University of South Florida)
Title : Novel perspectives for progesterone in HRT, with special reference to the nervous system
Schumacher, M., Guennoun, R., Ghoumari, A. M., Massaad, C., Robert, F., Akwa, Y., Rajkowski, K. M., & Baulieu, É.-É. (2007)
Fujihara, S. (2012) · Americanae (AECID Library)
Bioscience Frontiers in Neuromedical Interventions Following Brain Injury
Ashley, M. J., Weintraub, A. H., & Ripley, D. L. (2010) · CRC Press eBooks · doi:10.1201/9781439849828-c12
Modulation of PrP Aggregation and Cellular Prion Transfer
Fontaine, S. N. (2010) · The University of Bath Online Publications Store (The University of Bath)
Petruski‐Ivleva, N. (2017) · Carolina Digital Repository (University of North Carolina at Chapel Hill) · doi:10.17615/j7sy-9s93
Patel, S. (2019) · TSpace (University of Toronto)
Aged-Related Physiological Changes: CNS Function
Miot, S., Chancel, R., & Blain, H. (2022) · Lessons from the ICU · doi:10.1007/978-3-030-94133-8_3
Sharma, A., & Kaur, G. (2023) · BENTHAM SCIENCE PUBLISHERS eBooks · doi:10.2174/9789815040197123010009
Phytochemicals for neurodegeneration and neuroinflammation: medicine of the future or a mirage?
Mythri, R. B. (2023) · Elsevier eBooks · doi:10.1016/b978-0-443-19084-1.00006-5
Ferroptosis Modulators: A Potential Therapeutic Target in Alzheimer’s Disease
Singh, G., Rana, N. K., Mishra, I., & Modi, G. P. (2023) · Springer eBooks · doi:10.1007/978-981-99-6038-5_14
Barrington, J. H. (2013) · University of Bedfordshire Repository (University of Bedfordshire)
Jiang, P., Peng, S., Huang, Y., Wang, L., Lan, Y., Li, Y., Wang, C., Feng, C., Xie, H., Liu, L., et al. (2026) · Journal of Alzheimer s Disease · doi:10.1177/13872877261476713
“32 – 34 More studies have con fi rmed that a de fi ciency in GPX4 leads to ferroptosis in AD through the accumulation of lipid peroxides.”
Lysosomal Involvement in the Pathogenesis of Alzheimer's Disease
Zheng, L. P. (2012) · DiVA (Linkoping University)
Metadata
- Authors
- Praticò, D., & Sung, S.
- Affiliations
- University of Pennsylvania (US)
- Corresponding author
- Praticò, Domenico
- ORCID
- Praticò, Domenico
- Venue
- Journal of Alzheimer s Disease
- Publisher
- SAGE Publications
- Published
- 2004-04-13
- Volume
- 6
- Issue
- 2
- Pages
- 171-175
- ISSN
- 1387-2877 (ISSN-L)
- 1875-8908
- OpenAlex
- W1889306845
- Cited by
- 229
- References
- 0
- Citations by year
- 2026: 3 · 2025: 7 · 2024: 7 · 2023: 12 · 2022: 15 · 2021: 14 · 2020: 10 · 2019: 5 · 2018: 9 · 2017: 8 · 2016: 12 · 2015: 12 · 2014: 8 · 2013: 11 · 2012: 15
- FWCI
- 8.22
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Journal of Alzheimer s Disease (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institutes of Health
- National Institute on Aging (P01AG011542, AG 11542)
- Topics
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Alzheimer's disease research and treatments
- Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
- Health Sciences › Medicine › Biochemistry (medical) › Antioxidant Activity and Oxidative Stress
- Keywords
- Alzheimer's disease, lipid peroxidation
- MeSH terms
- Alzheimer Disease, Cognition Disorders, Frontal Lobe, Humans, Temporal Lobe, Time Factors, Lipid Peroxidation, Oxidative Stress, Isoprostanes
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