Cited by 25Alzheimer's disease research and treatmentsNeuroinflammation and Neurodegeneration MechanismsNeuroscience and Neuropharmacology Research

Astrocytic transporters in Alzheimer's disease

Ugbode, Chris, Hu, Yuhan, Whalley, Benjamin, Peers, Chris, Rattray, Marcus, Dallas, Mark L.·2017·Biochemical Journal

Abstract

Astrocytes play a fundamental role in maintaining the health and function of the central nervous system. Increasing evidence indicates that astrocytes undergo both cellular and molecular changes at an early stage in neurological diseases, including Alzheimer's disease (AD). These changes may reflect a change from a neuroprotective to a neurotoxic phenotype. Given the lack of current disease-modifying therapies for AD, astrocytes have become an interesting and viable target for therapeutic intervention. The astrocyte transport system covers a diverse array of proteins involved in metabolic support, neurotransmission and synaptic architecture. Therefore, specific targeting of individual transporter families has the potential to suppress neurodegeneration, a characteristic hallmark of AD. A small number of the 400 transporter superfamilies are expressed in astrocytes, with evidence highlighting a fraction of these are implicated in AD. Here, we review the current evidence for six astrocytic transporter subfamilies involved in AD, as reported in both animal and human studies. This review confirms that astrocytes are indeed a viable target, highlights the complexities of studying astrocytes and provides future directives to exploit the potential of astrocytes in tackling AD.

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Registry

Crossref · 10.1042/bcj20160505

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268 of 268 references verified0 citation errors · 0 not checkable

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Authors
Ugbode, C., Hu, Y., Whalley, B., Peers, C., Rattray, M., & Dallas, M. L.
Affiliations
  • University of York (GB)
  • University of Reading (GB)
  • University of Leeds (GB)
  • University of Bradford (GB)
Venue
Biochemical Journal
Published
2017-01-20
Volume
474
Issue
3
Pages
333-355
ISSN
  • 0264-6021 (ISSN-L)
  • 1470-8728
OpenAlex
W2573504574
Cited by
25
References
270
Citations by year
2025: 4 · 2024: 1 · 2022: 7 · 2021: 3 · 2020: 5 · 2018: 1 · 2017: 4
FWCI
0.34
Type
journal article
Language
en
Open access
closed
Locations
  • Biochemical Journal (publishedVersion)
  • PubMed (publishedVersion)
  • Bradford Scholars (University of Bradford) (acceptedVersion)
  • CentAUR (University of Reading) (acceptedVersion)
Funders
Biotechnology and Biological Sciences Research Council (1090392)
Topics
  • Health Sciences › Medicine › Physiology › Alzheimer's disease research and treatments
  • Life Sciences › Neuroscience › Neurology › Neuroinflammation and Neurodegeneration Mechanisms
  • Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
Keywords
astrocytes, Alzheimer's disease, neurodegeneration, astrocyte phenotype, therapeutic target, metabolic support, neurotransmission, synaptic structure
MeSH terms
Sodium-Potassium-Exchanging ATPase, Alzheimer Disease, Animals, Astrocytes, Gene Expression Regulation, Multigene Family, Humans, Signal Transduction, ATP-Binding Cassette Transporters, Membrane Transport Proteins, GABA Plasma Membrane Transport Proteins, Serotonin Plasma Membrane Transport Proteins, Glycine Plasma Membrane Transport Proteins, Glutamate Plasma Membrane Transport Proteins, Glucose Transport Proteins, Facilitative

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