Astrocytic transporters in Alzheimer's disease
Abstract
Astrocytes play a fundamental role in maintaining the health and function of the central nervous system. Increasing evidence indicates that astrocytes undergo both cellular and molecular changes at an early stage in neurological diseases, including Alzheimer's disease (AD). These changes may reflect a change from a neuroprotective to a neurotoxic phenotype. Given the lack of current disease-modifying therapies for AD, astrocytes have become an interesting and viable target for therapeutic intervention. The astrocyte transport system covers a diverse array of proteins involved in metabolic support, neurotransmission and synaptic architecture. Therefore, specific targeting of individual transporter families has the potential to suppress neurodegeneration, a characteristic hallmark of AD. A small number of the 400 transporter superfamilies are expressed in astrocytes, with evidence highlighting a fraction of these are implicated in AD. Here, we review the current evidence for six astrocytic transporter subfamilies involved in AD, as reported in both animal and human studies. This review confirms that astrocytes are indeed a viable target, highlights the complexities of studying astrocytes and provides future directives to exploit the potential of astrocytes in tackling AD.
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From Gliovascular alterations in sporadic and familial Alzheimer's disease: <scp><i>APOE3</i></scp> Christchurch homozygote glioprotection (2023) · cites this paper as [114]
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Glucose metabolism and astrocyte–neuron interactions in the neonatal brain
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New views of glutamate transporter structure and function: advances and challenges
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Flagged first, then by citations
2 of the 270 references couldn’t be matched to a known paper.
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YKL-40 in the brain and cerebrospinal fluid of neurodegenerative dementias
Llorens, F., Thüne, K., Tahir, W., Kanata, E., Diaz-Lucena, D., Xanthopoulos, K., Kovatsi, E., Pleschka, C., Garcia-Esparcia, P., Schmitz, M., et al. (2017) · Molecular Neurodegeneration · doi:10.1186/s13024-017-0226-4 · Cited by 249 · see citing works
Stress-Induced Depression and Alzheimer’s Disease: Focus on Astrocytes
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A Novel Concept is Needed for Combating Alzheimer's Disease and NeuroHIV
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Astrocyte-specific druggable protein as PET-ligand target for early detection of Alzheimer's disease
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Plasma Human Cartilage Glycoprotein‐39 and Cognitive Impairment After Acute Ischemic Stroke
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- Authors
- Ugbode, C., Hu, Y., Whalley, B., Peers, C., Rattray, M., & Dallas, M. L.
- Affiliations
- University of York (GB)
- University of Reading (GB)
- University of Leeds (GB)
- University of Bradford (GB)
- Venue
- Biochemical Journal
- Publisher
- Portland Press Ltd.
- Published
- 2017-01-20
- Volume
- 474
- Issue
- 3
- Pages
- 333-355
- ISSN
- 0264-6021 (ISSN-L)
- 1470-8728
- OpenAlex
- W2573504574
- Cited by
- 25
- References
- 270
- Citations by year
- 2025: 4 · 2024: 1 · 2022: 7 · 2021: 3 · 2020: 5 · 2018: 1 · 2017: 4
- FWCI
- 0.34
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Biochemical Journal (publishedVersion)
- PubMed (publishedVersion)
- Bradford Scholars (University of Bradford) (acceptedVersion)
- CentAUR (University of Reading) (acceptedVersion)
- Funders
- Biotechnology and Biological Sciences Research Council (1090392)
- Topics
- Health Sciences › Medicine › Physiology › Alzheimer's disease research and treatments
- Life Sciences › Neuroscience › Neurology › Neuroinflammation and Neurodegeneration Mechanisms
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Keywords
- astrocytes, Alzheimer's disease, neurodegeneration, astrocyte phenotype, therapeutic target, metabolic support, neurotransmission, synaptic structure
- MeSH terms
- Sodium-Potassium-Exchanging ATPase, Alzheimer Disease, Animals, Astrocytes, Gene Expression Regulation, Multigene Family, Humans, Signal Transduction, ATP-Binding Cassette Transporters, Membrane Transport Proteins, GABA Plasma Membrane Transport Proteins, Serotonin Plasma Membrane Transport Proteins, Glycine Plasma Membrane Transport Proteins, Glutamate Plasma Membrane Transport Proteins, Glucose Transport Proteins, Facilitative
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
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