The DOI matches its Crossref record; 38 of the 39 references it cites were found in a registry or an index.
Combined volumetry and DTI in subcortical structures of mild cognitive impairment and Alzheimer’s disease patients.
Abstract
The aim of this work was to investigate the hypothesis that multimodal MRI is able to detect the progressive disruption of volume and microstructure of subcortical structures in patients with amnestic mild cognitive impairment (a-MCI) and mild Alzheimer's disease (AD) in comparison with healthy controls (CTRL). We combined volumetric and diffusion tensor imaging (DTI) techniques in a cross-sectional study including 30 a-MCI, 30 AD patients, and 30 age-matched CTRL. We employed a fully automated model-based segmentation algorithm on 3 Tesla MRI anatomical images and accurate coregistration of DTI to anatomical images to extract regional values of DTI parameters. Both the hippocampi significantly and progressively decreased in volume from CTRL through MCI to AD. Both the thalami showed a progressive and significant decrease in volume from CTRL to AD. Mean diffusivity (MD) values increased progressively across the three groups in the bilateral hippocampus, amygdala, and in the right caudate. No differences in fractional anisotropy (FA) values were found. Two distinct but overlapping patterns of progression of structural (i.e., atrophy) and microstructural (i.e., MD increase) damage were observed. Particularly, the pattern of atrophy was mirrored by the increasing value of the averaged MD, which provided a further indicator of subtle tissue disruption in the hippocampal structure in mild AD patients. Combining different MRI modalities can allow identifying sensitive indicators of the subtle pathogenic mechanisms that occur in subcortical areas of AD patients.
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“Reduced FA and increased MD in hippocampus were reported in many of these human studies, probably attributed to increased extracellular space volume and neurodegeneration (Muller et al., 2007; Cherubini et al., 2010; Hong et al., 2013; Nowrangi et al., 2013).”
From Age-dependent microstructure alterations in 5xFAD mice by high-resolution diffusion tensor imaging (2022) · cites this paper as Cherubini et al., 2010
In the citing paper
“However, most of the studies using DTI data of healthy older and AD participants did not consider PVE at all (Cherubini et al., 2010, Douaud et al., 2013, Eustache et al., 2016, Müller et al., 2007).”
From Mean diffusivity in cortical gray matter in Alzheimer's disease: The importance of partial volume correction (2018) · cites this paper as Cherubini et al., 2010
In the citing paper
“Previous studies on GM MD in AD reported increases of hippocampal MD and whole brain GM MD in subjects with mild cognitive impairment (MCI) as compared to healthy controls (Cherubini et al., 2010, Eustache et al., 2016, Fellgiebel et al., 2004, Müller et al., 2005, Scola et al., 2010)”
From Mean diffusivity in cortical gray matter in Alzheimer's disease: The importance of partial volume correction (2018) · cites this paper as Cherubini et al., 2010
In the citing paper
“Left and right hippocampi as well as the posterior cingulate cortex (PCC) were chosen as regions of interest following the literature on peak differences in regional MD and volumes in AD (Cherubini et al., 2010, Eustache et al., 2016, Rose et al., 2008).”
From Mean diffusivity in cortical gray matter in Alzheimer's disease: The importance of partial volume correction (2018) · cites this paper as Cherubini et al., 2010
In the citing paper
“As a limitation, the MCI subjects of our sample were not uniquely amnestic MCI. Thus, our sample is more heterogeneous than the MCI subgroups in other studies”
From Mean diffusivity in cortical gray matter in Alzheimer's disease: The importance of partial volume correction (2018) · cites this paper as Cherubini et al., 2010
Citations
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Cited by
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Brain imaging of neurovascular dysfunction in Alzheimer’s disease
Montagne, A., Nation, D. A., Pa, J., Sweeney, M. D., Toga, A. W., & Zlokovic, B. V. (2016) · Acta Neuropathologica · doi:10.1007/s00401-016-1570-0 · Cited by 239
“Similarly, other studies of late onset or sporadic AD have also found increased MD within the hippocampus of mildly demented subjects [35, 193].”
Amlien, I. K., & Fjell, A. M. (2014) · Neuroscience · doi:10.1016/j.neuroscience.2014.02.017 · Cited by 219
Dyrba, M., Grothe, M. J., Kirste, T., & Teipel, S. J. (2015) · Human Brain Mapping · doi:10.1002/hbm.22759 · Cited by 188
“…independent patterns of group differences using DTI data and tissue volume [Canu et al., 2010, 2011; Yoon et al., 2011], but also high correlation between MD and volume in medial temporal lobe areas such as the hippocampus [Canu et al., 2010, 2011; Cherubini et al., 2010; O’Dwyer et al., 2011].”
MethodAderghal, K., Khvostikov, A. V., Крылов, А., Benois‐Pineau, J., Afdel, K., & Catheline, G. (2018) · Proceedings - IEEE Symposium on Computer-Based Medical Systems · doi:10.1109/cbms.2018.00067 · Cited by 154
“The affine transformation between sMRI and MD was estimated using mutual information criterion [21], implemented with Statistical Parametric Mapping software (SPM8, Wellcome Trust Centre for Neuroimaging at UCL, London, UK)4”
MethodAutomatic morphometry in Alzheimer's disease and mild cognitive impairment
Heckemann, R. A., Shiva Keihaninejad, A., Aljabar, P., Gray, K. R., Nielsen, C. F., Rueckert, D., Hajnal, J. V., & Hammers, A. (2011) · NeuroImage · doi:10.1016/j.neuroimage.2011.03.014 · Cited by 140
Metadata
- Authors
- Cherubini, A., Péran, P., Spoletini, I., Di Paola, M., Di Iulio, F., Hagberg, G. E., Sancesario, G., Gianni, W., Bossù, P., Caltagirone, C., Sabatini, U., & Spalletta, G.
- Affiliations
- Fondazione Santa Lucia (IT)
- IRCCS Santa Lucia Foundation, Rome, Italy
- University of Rome Tor Vergata (IT)
- Istituti di Ricovero e Cura a Carattere Scientifico (IT)
- Corresponding author
- Spalletta, Gianfranco
- ORCID
- Venue
- Journal of Alzheimer s Disease
- Publisher
- SAGE Publications
- Published
- 2010-03-11
- Volume
- 19
- Issue
- 4
- Pages
- 1273-1282
- ISSN
- 1387-2877 (ISSN-L)
- 1875-8908
- OpenAlex
- W1666202957
- Semantic Scholar
- 5c44f8e52617fb5f84a38643587267c93f788b5d
- Cited by
- 123
- References
- 39
- Citations by year
- 2026: 3 · 2025: 3 · 2024: 3 · 2023: 7 · 2022: 4 · 2021: 4 · 2020: 7 · 2019: 5 · 2018: 9 · 2017: 11 · 2016: 7 · 2015: 15 · 2014: 9 · 2013: 13 · 2012: 13
- FWCI
- 7.85
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Journal of Alzheimer s Disease (publishedVersion)
- PubMed (publishedVersion)
- HAL (submittedVersion)
- Cineca Institutional Research Information System (Tor Vergata University) (submittedVersion)
- Funders
- Ministero della Salute
- Topics
- Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
- Health Sciences › Medicine › Radiology, Nuclear Medicine and Imaging › Advanced Neuroimaging Techniques and Applications
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Alzheimer's disease research and treatments
- Keywords
- amnestic mild cognitive impairment, Alzheimer's disease
- MeSH terms
- Aged, Alzheimer Disease, Atrophy, Brain, Cognition Disorders, Female, Humans, Functional Laterality, Male, Neuropsychological Tests, Severity of Illness Index, Thalamus, Diffusion Tensor Imaging
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