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Cited by 239Barrier Structure and Function StudiesDementia and Cognitive Impairment ResearchAlzheimer's disease research and treatments

Brain imaging of neurovascular dysfunction in Alzheimer’s disease

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Montagne, Axel, Nation, Daniel A., Pa, Judy, Sweeney, Melanie D., Toga, Arthur W., Zlokovic, Berislav V.·2016·Acta Neuropathologica
DOI 10.1007/s00401-016-1570-0PMC PMC5283382
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Abstract

Neurovascular dysfunction, including blood-brain barrier (BBB) breakdown and cerebral blood flow (CBF) dysregulation and reduction, are increasingly recognized to contribute to Alzheimer's disease (AD). The spatial and temporal relationships between different pathophysiological events during preclinical stages of AD, including cerebrovascular dysfunction and pathology, amyloid and tau pathology, and brain structural and functional changes remain, however, still unclear. Recent advances in neuroimaging techniques, i.e., magnetic resonance imaging (MRI) and positron emission tomography (PET), offer new possibilities to understand how the human brain works in health and disease. This includes methods to detect subtle regional changes in the cerebrovascular system integrity. Here, we focus on the neurovascular imaging techniques to evaluate regional BBB permeability (dynamic contrast-enhanced MRI), regional CBF changes (arterial spin labeling- and functional-MRI), vascular pathology (structural MRI), and cerebral metabolism (PET) in the living human brain, and examine how they can inform about neurovascular dysfunction and vascular pathophysiology in dementia and AD. Altogether, these neuroimaging approaches will continue to elucidate the spatio-temporal progression of vascular and neurodegenerative processes in dementia and AD and how they relate to each other.

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  • Increasing evidence supports that early cerebrovascular dysfunction contributes to AD pathophysiology and cognitive impairment.

    “In addition to the classic hallmark pathology, A 𝛃 plaques, hyperphosphorylated tau neurofibrillary tangles, and neuron loss, increasing evidence supports that early cerebrovascular dysfunction contributes to AD pathophysiology and cognitive impairment (29, 285, 418, 421, 429, 569, 571, 593, 682, 693).”

    From Blood-Brain Barrier: From Physiology to Disease and Back (2019) · cites this paper as [418]

  • Patlak analysis allows detection of subtle changes in BBB permeability.

    “These studies used Patlak analysis (46, 47, 466), which allows detection of subtle changes in BBB permeability (46, 248, 418, 421).”

    From Blood-Brain Barrier: From Physiology to Disease and Back (2019) · cites this paper as [418]

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  1. [1]den Abeelen ASSM Lagro J van Beek AHEA Claassen JAHR Impaired cerebral autoregulation and vasomotor reactivity in sporadic Alzheimer’s disease Curr Alzheimer Res 2014 11 11 17 24251392
  2. [2]Acosta-Cabronero J Williams GB Pengas G Nestor PJ Absolute diffusivities define the landscape of white matter degeneration in Alzheimer’s disease Brain J Neurol 2010 133 529 539 19914928
  3. [3]Alexopoulos P Sorg C Förschler A Grimmer T Skokou M Wohlschläger A Perneczky R Zimmer C Kurz A Preibisch C Perfusion abnormalities in mild cognitive impairment and mild dementia in Alzheimer’s disease measured by pulsed arterial spin labeling MRI Eur Arch Psychiatry Clin Neurosci 2012 262 69 77 21786091
  4. [4]Alsop DC Casement M de Bazelaire C Fong T Press DZ Hippocampal hyperperfusion in Alzheimer’s disease NeuroImage 2008 42 1267 1274 18602481 PMC2675915
  5. [5]Alsop DC Dai W Grossman M Detre JA Arterial spin labeling blood flow MRI: its role in the early characterization of Alzheimer’s disease J Alzheimers Dis JAD 2010 20 871 880 20413865 PMC3643892
  6. [6]Alsop DC Detre JA Grossman M Assessment of cerebral blood flow in Alzheimer’s disease by spin-labeled magnetic resonance imaging Ann Neurol 2000 47 93 100 10632106
  7. [7]Alsop DC Press DZ Activation and baseline changes in functional MRI studies of Alzheimer disease Neurology 2007 69 1645 1646 17954778
  8. [8]Apostolova LG Mosconi L Thompson PM Green AE Hwang KS Ramirez A Mistur R Tsui WH de Leon MJ Sub-regional hippocampal atrophy predicts Alzheimer’s dementia in the cognitively normal Neurobiol Aging 2010 31 1077 1088 18814937 PMC2873083
  9. [9]Armitage PA Farrall AJ Carpenter TK Doubal FN Wardlaw JM Use of dynamic contrast-enhanced MRI to measure subtle blood–brain barrier abnormalities Magn Reson Imaging 2011 29 305 314 21030178 PMC4025605
  10. [11]Atri A O’Brien JL Sreenivasan A Rastegar S Salisbury S DeLuca AN O’Keefe KM LaViolette PS Rentz DM Locascio JJ Sperling RA Test-retest reliability of memory task functional magnetic resonance imaging in Alzheimer disease clinical trials Arch Neurol 2011 68 599 606 21555634 PMC3291175
  11. [13]Bailly M Destrieux C Hommet C Mondon K Cottier J-P Beaufils E Vierron E Vercouillie J Ibazizene M Voisin T Payoux P Barré L Camus V Guilloteau D Ribeiro M-J Precuneus and cingulate cortex atrophy and hypometabolism in patients with Alzheimer’s Disease and mild cognitive impairment: MRI and (18)F-FDG PET quantitative analysis using FreeSurfer BioMed Res Int 2015 2015 583931 26346648 PMC4539420
  12. [14]Barnes SR Ng TSC Montagne A Law M Zlokovic BV Jacobs RE Optimal acquisition and modeling parameters for accurate assessment of low Ktrans blood–brain barrier permeability using dynamic contrast-enhanced MRI Magn Reson Med 2015 PMC4726482 26077645
  13. [15]Barnes SR Ng TSC Santa-Maria N Montagne A Zlokovic BV Jacobs RE ROCKETSHIP: a flexible and modular software tool for the planning, processing and analysis of dynamic MRI studies BMC Med Imaging 2015 15 19 26076957 PMC4466867
  14. [16]Basser PJ Jones DK Diffusion-tensor MRI: theory, experimental design and data analysis—a technical review NMR Biomed 2002 15 456 467 12489095
  15. [17]Becker JA Hedden T Carmasin J Maye J Rentz DM Putcha D Fischl B Greve DN Marshall GA Salloway S Marks D Buckner RL Sperling RA Johnson KA Amyloid-β associated cortical thinning in clinically normal elderly Ann Neurol 2011 69 1032 1042 21437929 PMC3117980
  16. [19]Bernard C Helmer C Dilharreguy B Amieva H Auriacombe S Dartigues J-F Allard M Catheline G Time course of brain volume changes in the preclinical phase of Alzheimer’s disease Alzheimers Dement J Alzheimers Assoc 2014 10 143–151 e1 24418054
  17. [21]Bookheimer SY Strojwas MH Cohen MS Saunders AM Pericak-Vance MA Mazziotta JC Small GW Patterns of brain activation in people at risk for Alzheimer’s disease N Engl J Med 2000 343 450 456 10944562 PMC2831477
  18. [22]Bowman GL Kaye JA Quinn JF Dyslipidemia and blood–brain barrier integrity in Alzheimer’s disease Curr Gerontol Geriatr Res 2012 2012 184042 22654903 PMC3359662
  19. [23]Brewer JB Zhao Z Desmond JE Glover GH Gabrieli JD Making memories: brain activity that predicts how well visual experience will be remembered Science 1998 281 1185 1187 9712581
  20. [24]Brown GG Perthen JE Liu TT Buxton RB A primer on functional magnetic resonance imaging Neuropsychol Rev 2007 17 107 125 17468956
  21. [26]Buckner RL Snyder AZ Sanders AL Raichle ME Morris JC Functional brain imaging of young, nondemented, and demented older adults J Cogn Neurosci 2000 12 Suppl 2 24 34 11506645
  22. [27]Buxton RB Uludağ K Dubowitz DJ Liu TT Modeling the hemodynamic response to brain activation NeuroImage 2004 23 Suppl 1 S220 S233 15501093
  23. [28]Calamante F Arterial input function in perfusion MRI: a comprehensive review Prog Nucl Magn Reson Spectrosc 2013 74 1 32 24083460
  24. [29]Canu E Agosta F Spinelli EG Magnani G Marcone A Scola E Falautano M Comi G Falini A Filippi M White matter microstructural damage in Alzheimer’s disease at different ages of onset Neurobiol Aging 2013 34 2331 2340 23623599
  25. [30]Catafau AM Bullich S Amyloid PET imaging: applications beyond Alzheimer’s disease Clin Transl Imaging 2015 3 39 55 25741489 PMC4339781
  26. [31]Celone KA Calhoun VD Dickerson BC Atri A Chua EF Miller SL DePeau K Rentz DM Selkoe DJ Blacker D Albert MS Sperling RA Alterations in memory networks in mild cognitive impairment and Alzheimer’s disease: an independent component analysis J Neurosci Off J Soc Neurosci 2006 26 10222 10231 PMC6674636 17021177
  27. [32]Chao LL Pa J Duarte A Schuff N Weiner MW Kramer JH Miller BL Freeman KM Johnson JK Patterns of cerebral hypoperfusion in amnestic and dysexecutive MCI Alzheimer Dis Assoc Disord 2009 23 245 252 19812467 PMC2760039
  28. [33]Chen J Yao J Thomasson D Automatic determination of arterial input function for dynamic contrast enhanced MRI in tumor assessment Med Image Comput Comput-Assist Interv MICCAI Int Conf Med Image Comput Comput-Assist Interv 2008 11 594 601 PMC2587281 18979795
  29. [34]Chen Y Wolk DA Reddin JS Korczykowski M Martinez PM Musiek ES Newberg AB Julin P Arnold SE Greenberg JH Detre JA Voxel-level comparison of arterial spin-labeled perfusion MRI and FDG-PET in Alzheimer disease Neurology 2011 77 1977 1985 22094481 PMC3235355
  30. [36]Chételat G Villemagne VL Pike KE Ellis KA Bourgeat P Jones G O’Keefe GJ Salvado O Szoeke C Martins RN Ames D Masters CL Rowe CC Australian Imaging Biomarkers and Lifestyle Study of ageing (AIBL) Research Group Independent contribution of temporal beta-amyloid deposition to memory decline in the pre-dementia phase of Alzheimer’s disease Brain J Neurol 2011 134 798 807 21310725
  31. [37]Choo IH Lee DY Oh JS Lee JS Lee DS Song IC Youn JC Kim SG Kim KW Jhoo JH Woo JI Posterior cingulate cortex atrophy and regional cingulum disruption in mild cognitive impairment and Alzheimer’s disease Neurobiol Aging 2010 31 772 779 18687503
  32. [38]Clark CM Schneider JA Bedell BJ Beach TG Bilker WB Mintun MA Pontecorvo MJ Hefti F Carpenter AP Flitter ML Krautkramer MJ Kung HF Coleman RE Doraiswamy PM Fleisher AS Sabbagh MN Sadowsky CH Reiman EP Reiman PEM Zehntner SP Skovronsky DM AV45-A07 Study Group Use of florbetapir-PET for imaging beta-amyloid pathology JAMA 2011 305 275 283 21245183 PMC7041965
  33. [39]Clark LR Nation DA Wierenga CE Bangen KJ Dev SI Shin DD Delano-Wood L Liu TT Rissman RA Bondi MW Elevated cerebrovascular resistance index is associated with cognitive dysfunction in the very-old Alzheimers Res Ther 2015 7 3 27391477 PMC4942967
  34. [40]Clément F Belleville S Test-retest reliability of fMRI verbal episodic memory paradigms in healthy older adults and in persons with mild cognitive impairment Hum Brain Mapp 2009 30 4033 4047 19492301 PMC6871015
  35. [41]Cohen ER Ugurbil K Kim S-G Effect of basal conditions on the magnitude and dynamics of the blood oxygenation level-dependent fMRI response J Cereb Blood Flow Metab Off J Int Soc Cereb Blood Flow Metab 2002 22 1042 1053 12218410
  36. [42]Cramer SP Larsson HBW Accurate determination of blood–brain barrier permeability using dynamic contrast-enhanced T1-weighted MRI: a simulation and in vivo study on healthy subjects and multiple sclerosis patients J Cereb Blood Flow Metab Off J Int Soc Cereb Blood Flow Metab 2014 34 1655 1665 PMC4269724 25074746
  37. [43]Dai W Lopez OL Carmichael OT Becker JT Kuller LH Gach HM Mild cognitive impairment and alzheimer disease: patterns of altered cerebral blood flow at MR imaging Radiology 2009 250 856 866 19164119 PMC2680168
  38. [45]Dani M Brooks DJ Edison P Tau imaging in neurodegenerative diseases Eur J Nucl Med Mol Imaging 2015 PMC4844651 26572762
  39. [47]D’Esposito M Deouell LY Gazzaley A Alterations in the BOLD fMRI signal with ageing and disease: a challenge for neuroimaging Nat Rev Neurosci 2003 4 863 872 14595398
  40. [48]Detre JA Rao H Wang DJJ Chen YF Wang Z Applications of arterial spin labeled MRI in the brain J Magn Reson Imaging JMRI 2012 35 1026 1037 22246782 PMC3326188
  41. [49]Detre JA Wang J Technical aspects and utility of fMRI using BOLD and ASL Clin Neurophysiol Off J Int Fed Clin Neurophysiol 2002 113 621 634 11976042
  42. [50]Diaz-de-Grenu LZ Acosta-Cabronero J Chong YFV Pereira JMS Sajjadi SA Williams GB Nestor PJ A brief history of voxel-based grey matter analysis in Alzheimer’s disease J Alzheimers Dis JAD 2014 38 647 659 24037033
  43. [51]Dickerson BC Salat DH Bates JF Atiya M Killiany RJ Greve DN Dale AM Stern CE Blacker D Albert MS Sperling RA Medial temporal lobe function and structure in mild cognitive impairment Ann Neurol 2004 56 27 35 15236399 PMC4335689
  44. [52]Dickerson BC Salat DH Greve DN Chua EF Rand-Giovannetti E Rentz DM Bertram L Mullin K Tanzi RE Blacker D Albert MS Sperling RA Increased hippocampal activation in mild cognitive impairment compared to normal aging and AD Neurology 2005 65 404 411 16087905 PMC4335677
  45. [53]Drzezga A Becker JA Van Dijk KRA Sreenivasan A Talukdar T Sullivan C Schultz AP Sepulcre J Putcha D Greve D Johnson KA Sperling RA Neuronal dysfunction and disconnection of cortical hubs in non-demented subjects with elevated amyloid burden Brain J Neurol 2011 134 1635 1646 PMC3102239 21490054
  46. [54]Dumas A Dierksen GA Gurol ME Halpin A Martinez-Ramirez S Schwab K Rosand J Viswanathan A Salat DH Polimeni JR Greenberg SM Functional magnetic resonance imaging detection of vascular reactivity in cerebral amyloid angiopathy Ann Neurol 2012 72 76 81 22829269 PMC3408630
  47. [57]Firbank MJ He J Blamire AM Singh B Danson P Kalaria RN O’Brien JT Cerebral blood flow by arterial spin labeling in poststroke dementia Neurology 2011 76 1478 1484 21518997 PMC3087466
  48. [59]Fjell AM McEvoy L Holland D Dale AM Walhovd KB Alzheimer’s Disease Neuroimaging Initiative Brain changes in older adults at very low risk for Alzheimer’s disease J Neurosci Off J Soc Neurosci 2013 33 8237 8242 PMC4050197 23658162
  49. [60]Fleisher AS Houston WS Eyler LT Frye S Jenkins C Thal LJ Bondi MW Identification of Alzheimer disease risk by functional magnetic resonance imaging Arch Neurol 2005 62 1881 1888 16344346
  50. [61]Fleisher AS Podraza KM Bangen KJ Taylor C Sherzai A Sidhar K Liu TT Dale AM Buxton RB Cerebral perfusion and oxygenation differences in Alzheimer’s disease risk Neurobiol Aging 2009 30 1737 1748 18325636 PMC2746874
  51. [62]de Flores R La Joie R Chételat G Structural imaging of hippocampal subfields in healthy aging and Alzheimer’s disease Neuroscience 2015 309 29 50 26306871
  52. [63]de Flores R La Joie R Landeau B Perrotin A Mézenge F de La Sayette V Eustache F Desgranges B Chételat G Effects of age and Alzheimer’s disease on hippocampal subfields: comparison between manual and FreeSurfer volumetry Hum Brain Mapp 2015 36 463 474 25231681 PMC6869780
  53. [64]Fox PT Raichle ME Focal physiological uncoupling of cerebral blood flow and oxidative metabolism during somatosensory stimulation in human subjects Proc Natl Acad Sci USA 1986 83 1140 1144 3485282 PMC323027
  54. [66]Ganguli M Dodge HH Shen C DeKosky ST Mild cognitive impairment, amnestic type: an epidemiologic study Neurology 2004 63 115 121 15249620
  55. [67]Girouard H Iadecola C Neurovascular coupling in the normal brain and in hypertension, stroke, and Alzheimer disease J Appl Physiol Bethesda Md 1985 2006 100 328 335 16357086
  56. [68]Golby A Silverberg G Race E Gabrieli S O’Shea J Knierim K Stebbins G Gabrieli J Memory encoding in Alzheimer’s disease: an fMRI study of explicit and implicit memory Brain J Neurol 2005 128 773 787 15705615
  57. [69]Grady CL McIntosh AR Beig S Keightley ML Burian H Black SE Evidence from functional neuroimaging of a compensatory prefrontal network in Alzheimer’s disease J Neurosci Off J Soc Neurosci 2003 23 986 993 PMC6741917 12574428
  58. [72]Greicius MD Srivastava G Reiss AL Menon V Default-mode network activity distinguishes Alzheimer’s disease from healthy aging: evidence from functional MRI Proc Natl Acad Sci USA 2004 101 4637 4642 15070770 PMC384799
  59. [73]Guo CC Kurth F Zhou J Mayer EA Eickhoff SB Kramer JH Seeley WW One-year test–retest reliability of intrinsic connectivity network fMRI in older adults NeuroImage 2012 61 1471 1483 22446491 PMC4226138
  60. [74]Gusnard DA Raichle ME Raichle ME Searching for a baseline: functional imaging and the resting human brain Nat Rev Neurosci 2001 2 685 694 11584306
  61. [75]Halliday MR Pomara N Sagare AP Mack WJ Frangione B Zlokovic BV Relationship between cyclophilin a levels and matrix metalloproteinase 9 activity in cerebrospinal fluid of cognitively normal apolipoprotein e4 carriers and blood–brain barrier breakdown JAMA Neurol 2013 70 1198 1200 24030206 PMC4047029
  62. [77]Hanyu H Asano T Tanaka Y Iwamoto T Takasaki M Abe K Increased blood–brain barrier permeability in white matter lesions of Binswanger’s disease evaluated by contrast-enhanced MRI Dement Geriatr Cogn Disord 2002 14 1 6 12053125
  63. [78]Harrington GS Tomaszewski Farias S Buonocore MH Yonelinas AP The intersubject and intrasubject reproducibility of FMRI activation during three encoding tasks: implications for clinical applications Neuroradiology 2006 48 495 505 16703360
  64. [79]Hillman EMC Coupling mechanism and significance of the BOLD signal: a status report Annu Rev Neurosci 2014 37 161 181 25032494 PMC4147398
  65. [80]Hillman EMC Devor A Bouchard MB Dunn AK Krauss GW Skoch J Bacskai BJ Dale AM Boas DA Depth-resolved optical imaging and microscopy of vascular compartment dynamics during somatosensory stimulation NeuroImage 2007 35 89 104 17222567 PMC1994243
  66. [81]Hultman K Strickland S Norris EH The APOE ε4/ε4 genotype potentiates vascular fibrin(ogen) deposition in amyloid-laden vessels in the brains of Alzheimer’s disease patients J Cereb Blood Flow Metab Off J Int Soc Cereb Blood Flow Metab 2013 33 1251 1258 PMC3734776 23652625
  67. [82]Hu WT Wang Z Lee VM-Y Trojanowski JQ Detre JA Grossman M Distinct cerebral perfusion patterns in FTLD and AD Neurology 2010 75 881 888 20819999 PMC2938974
  68. [83]Hyder F Neuroimaging with calibrated FMRI Stroke J Cereb Circ 2004 35 2635 2641 15388903
  69. [84]Iadecola C Regulation of the cerebral microcirculation during neural activity: is nitric oxide the missing link? Trends Neurosci 1993 16 206 214 7688160
  70. [85]Iadecola C Cerebrovascular effects of amyloid-beta peptides: mechanisms and implications for Alzheimer’s dementia Cell Mol Neurobiol 2003 23 681 689 14514024 PMC11530195
  71. [86]Jack CR Knopman DS Jagust WJ Petersen RC Weiner MW Aisen PS Shaw LM Vemuri P Wiste HJ Weigand SD Lesnick TG Pankratz VS Donohue MC Trojanowski JQ Tracking pathophysiological processes in Alzheimer’s disease: an updated hypothetical model of dynamic biomarkers Lancet Neurol 2013 12 207 216 23332364 PMC3622225
  72. [87]Jack CR Wiste HJ Knopman DS Vemuri P Mielke MM Weigand SD Senjem ML Gunter JL Lowe V Gregg BE Pankratz VS Petersen RC Rates of β-amyloid accumulation are independent of hippocampal neurodegeneration Neurology 2014 82 1605 1612 24706010 PMC4013810
  73. [88]Jagust W Time for tau Brain J Neurol 2014 137 1570 1571 24736306
  74. [89]Jagust W Is amyloid-β harmful to the brain? Insights from human imaging studies Brain J Neurol 2015 PMC4990654 26614753
  75. [90]Jagust WJ Bandy D Chen K Foster NL Landau SM Mathis CA Price JC Reiman EM Skovronsky D Koeppe RA Alzheimer’s Disease Neuroimaging Initiative The Alzheimer’s Disease Neuroimaging Initiative positron emission tomography core Alzheimers Dement J Alzheimers Assoc 2010 6 221 229 PMC2920531 20451870
  76. [91]Jedynak BM Lang A Liu B Katz E Zhang Y Wyman BT Raunig D Jedynak CP Caffo B Prince JL Alzheimer’s Disease Neuroimaging Initiative A computational neurodegenerative disease progression score: method and results with the Alzheimer’s disease Neuroimaging Initiative cohort NeuroImage 2012 63 1478 1486 22885136 PMC3472161
  77. [92]Johnson KA Gregas M Becker JA Kinnecom C Salat DH Moran EK Smith EE Rosand J Rentz DM Klunk WE Mathis CA Price JC Dekosky ST Fischman AJ Greenberg SM Imaging of amyloid burden and distribution in cerebral amyloid angiopathy Ann Neurol 2007 62 229 234 17683091
  78. [93]Johnson KA Schultz A Betensky RA Becker JA Sepulcre J Rentz D Mormino E Chhatwal J Amariglio R Papp K Marshall G Albers M Mauro S Pepin L Alverio J Judge K Philiossaint M Shoup T Yokell D Dickerson B Gomez-Isla T Hyman B Vasdev N Sperling R Tau PET imaging in aging and early Alzheimer’s disease Ann Neurol 2015 PMC4738026 26505746
  79. [94]Johnson NA Jahng G-H Weiner MW Miller BL Chui HC Jagust WJ Gorno-Tempini ML Schuff N Pattern of cerebral hypoperfusion in Alzheimer disease and mild cognitive impairment measured with arterial spin-labeling MR imaging: initial experience Radiology 2005 234 851 859 15734937 PMC1851934
  80. [95]Johnson SC Schmitz TW Trivedi MA Ries ML Torgerson BM Carlsson CM Asthana S Hermann BP Sager MA The influence of Alzheimer disease family history and apolipoprotein E epsilon4 on mesial temporal lobe activation J Neurosci Off J Soc Neurosci 2006 26 6069 6076 PMC2684824 16738250
  81. [96]Kasischke KA Vishwasrao HD Fisher PJ Zipfel WR Webb WW Neural activity triggers neuronal oxidative metabolism followed by astrocytic glycolysis Science 2004 305 99 103 15232110
  82. [97]Kato T Knopman D Liu H Dissociation of regional activation in mild AD during visual encoding: a functional MRI study Neurology 2001 57 812 816 11552009
  83. [98]Kerchner GA Berdnik D Shen JC Bernstein JD Fenesy MC Deutsch GK Wyss-Coray T Rutt BK APOE ε4 worsens hippocampal CA1 apical neuropil atrophy and episodic memory Neurology 2014 82 691 697 24453080 PMC3945665
  84. [99]Klunk WE Engler H Nordberg A Wang Y Blomqvist G Holt DP Bergström M Savitcheva I Huang G Estrada S Ausén B Debnath ML Barletta J Price JC Sandell J Lopresti BJ Wall A Koivisto P Antoni G Mathis CA Långström B Imaging brain amyloid in Alzheimer’s disease with Pittsburgh Compound-B Ann Neurol 2004 55 306 319 14991808
  85. [100]Knopman DS Diagnostic tests for Alzheimer disease: FDG-PET imaging is a player in search of a role Neurol Clin Pract 2012 2 151 153 23634363 PMC3613199
  86. [101]Lacalle-Aurioles M Mateos-Pérez JM Guzmán-De-Villoria JA Olazarán J Cruz-Orduña I Alemán-Gómez Y Martino M-E Desco M Cerebral blood flow is an earlier indicator of perfusion abnormalities than cerebral blood volume in Alzheimer’s disease J Cereb Blood Flow Metab Off J Int Soc Cereb Blood Flow Metab 2014 34 654 659 PMC3982085 24424381
  87. [102]Landau SM Harvey D Madison CM Koeppe RA Reiman EM Foster NL Weiner MW Jagust WJ Alzheimer’s Disease Neuroimaging Initiative Associations between cognitive, functional, and FDG-PET measures of decline in AD and MCI Neurobiol Aging 2011 32 1207 1218 19660834 PMC2891865
  88. [103]Larsson HBW Courivaud F Rostrup E Hansen AE Measurement of brain perfusion, blood volume, and blood–brain barrier permeability, using dynamic contrast-enhanced T(1)-weighted MRI at 3 tesla Magn Reson Med 2009 62 1270 1281 19780145
  89. [104]Lavini C Verhoeff JJC Reproducibility of the gadolinium concentration measurements and of the fitting parameters of the vascular input function in the superior sagittal sinus in a patient population Magn Reson Imaging 2010 28 1420 1430 20817379
  90. [105]Li J Pan P Huang R Shang H A meta-analysis of voxel-based morphometry studies of white matter volume alterations in Alzheimer’s disease Neurosci Biobehav Rev 2012 36 757 763 22192882
  91. [106]Liu TT Brown GG Measurement of cerebral perfusion with arterial spin labeling: Part 1. Methods J Int Neuropsychol Soc JINS 2007 13 517 525 17445301
  92. [107]Logothetis NK Neurovascular uncoupling: much ado about nothing Front Neuroenergetics 2010 PMC2912029 20725519
  93. [108]Machulda MM Ward HA Borowski B Gunter JL Cha RH O’Brien PC Petersen RC Boeve BF Knopman D Tang-Wai DF Ivnik RJ Smith GE Tangalos EG Jack CR Comparison of memory fMRI response among normal, MCI, and Alzheimer’s patients Neurology 2003 61 500 506 12939424 PMC2744465
  94. [109]Mackic JB Bading J Ghiso J Walker L Wisniewski T Frangione B Zlokovic BV Circulating amyloid-beta peptide crosses the blood–brain barrier in aged monkeys and contributes to Alzheimer’s disease lesions Vascul Pharmacol 2002 38 303 313 12529925
  95. [110]Malonek D Dirnagl U Lindauer U Yamada K Kanno I Grinvald A Vascular imprints of neuronal activity: relationships between the dynamics of cortical blood flow, oxygenation, and volume changes following sensory stimulation Proc Natl Acad Sci USA 1997 94 14826 14831 9405698 PMC25122
  96. [111]Mann GE Zlokovic BV Yudilevich DL Evidence for a lactate transport system in the sarcolemmal membrane of the perfused rabbit heart: kinetics of unidirectional influx, carrier specificity and effects of glucagon Biochim Biophys Acta 1985 819 241 248 4041458
  97. [112]Marquié M Normandin MD Vanderburg CR Costantino IM Bien EA Rycyna LG Klunk WE Mathis CA Ikonomovic MD Debnath ML Vasdev N Dickerson BC Gomperts SN Growdon JH Johnson KA Frosch MP Hyman BT Gómez-Isla T Validating novel tau positron emission tomography tracer [F-18]-AV-1451 (T807) on postmortem brain tissue Ann Neurol 2015 78 787 800 26344059 PMC4900162
  98. [113]Miller SL Fenstermacher E Bates J Blacker D Sperling RA Dickerson BC Hippocampal activation in adults with mild cognitive impairment predicts subsequent cognitive decline J Neurol Neurosurg Psychiatry 2008 79 630 635 17846109 PMC2683145
  99. [116]Montagne A Pa J Zlokovic BV Vascular plasticity and cognition during normal aging and dementia JAMA Neurol 2015 72 495 496 25751405 PMC4428924
  100. [117]Montagne A Toga AW Zlokovic BV Blood–brain barrier permeability and gadolinium: benefits and potential pitfalls in research JAMA Neurol 2015 PMC4736734 26524294
  101. [118]Mormino EC Betensky RA Hedden T Schultz AP Ward A Huijbers W Rentz DM Johnson KA Sperling RA Alzheimer’s Disease Neuroimaging Initiative, Australian Imaging Biomarkers and Lifestyle Flagship Study of Ageing, Harvard Aging Brain Study Amyloid and APOE ε4 interact to influence short-term decline in preclinical Alzheimer disease Neurology 2014 82 1760 1767 24748674 PMC4035706
  102. [120]Nation DA Wierenga CE Clark LR Dev SI Stricker NH Jak AJ Salmon DP Delano-Wood L Bangen KJ Rissman RA Liu TT Bondi MW Cortical and subcortical cerebrovascular resistance index in mild cognitive impairment and Alzheimer’s disease J Alzheimers Dis JAD 2013 36 689 698 23666173 PMC4089500
  103. [122]O’Brien JL O’Keefe KM LaViolette PS DeLuca AN Blacker D Dickerson BC Sperling RA Longitudinal fMRI in elderly reveals loss of hippocampal activation with clinical decline Neurology 2010 74 1969 1976 20463288 PMC2905893
  104. [124]Okamura N Harada R Furumoto S Arai H Yanai K Kudo Y Tau PET imaging in Alzheimer’s disease Curr Neurol Neurosci Rep 2014 14 500 25239654
  105. [125]Østergaard L Aamand R Gutiérrez-Jiménez E Ho Y-CL Blicher JU Madsen SM Nagenthiraja K Dalby RB Drasbek KR Møller A Brændgaard H Mouridsen K Jespersen SN Jensen MS West MJ The capillary dysfunction hypothesis of Alzheimer’s disease Neurobiol Aging 2013 34 1018 1031 23084084
  106. [126]Østergaard L Jespersen SN Engedahl T Gutiérrez Jiménez E Ashkanian M Hansen MB Eskildsen S Mouridsen K Capillary dysfunction: its detection and causative role in dementias and stroke Curr Neurol Neurosci Rep 2015 15 37 25956993 PMC4441906
  107. [127]Pariente J Cole S Henson R Clare L Kennedy A Rossor M Cipoloti L Puel M Demonet JF Chollet F Frackowiak RSJ Alzheimer’s patients engage an alternative network during a memory task Ann Neurol 2005 58 870 879 16315273
  108. [128]Parkes LM Rashid W Chard DT Tofts PS Normal cerebral perfusion measurements using arterial spin labeling: reproducibility, stability, and age and gender effects Magn Reson Med 2004 51 736 743 15065246
  109. [129]Patlak CS Blasberg RG Fenstermacher JD Graphical evaluation of blood-to-brain transfer constants from multiple-time uptake data J Cereb Blood Flow Metab Off J Int Soc Cereb Blood Flow Metab 1983 3 1 7 6822610
  110. [130]Pauling L Coryell CD The magnetic properties and structure of hemoglobin, oxyhemoglobin and carbonmonoxyhemoglobin Proc Natl Acad Sci USA 1936 22 210 216 16577697 PMC1076743
  111. [132]Peterson EC Wang Z Britz G Regulation of cerebral blood flow Int J Vasc Med 2011 2011 823525 21808738 PMC3144666
  112. [133]Popa-Wagner A Buga A-M Popescu B Muresanu D Vascular cognitive impairment, dementia, aging and energy demand. A vicious cycle J Neural Transm Vienna Austria 1996 122 Suppl 1 S47 S54 24337666
  113. [134]Putcha D O’Keefe K LaViolette P O’Brien J Greve D Rentz DM Locascio J Atri A Sperling R Reliability of functional magnetic resonance imaging associative encoding memory paradigms in non-demented elderly adults Hum Brain Mapp 2011 32 2027 2044 21259385 PMC3551453
  114. [136]Raichle ME MacLeod AM Snyder AZ Powers WJ Gusnard DA Shulman GL A default mode of brain function Proc Natl Acad Sci USA 2001 98 676 682 11209064 PMC14647
  115. [137]Raz N Lindenberger U Rodrigue KM Kennedy KM Head D Williamson A Dahle C Gerstorf D Acker JD Regional brain changes in aging healthy adults: general trends, individual differences and modifiers Cereb Cortex N Y N 1991 2005 15 1676 1689 15703252
  116. [138]Rémy F Mirrashed F Campbell B Richter W Verbal episodic memory impairment in Alzheimer’s disease: a combined structural and functional MRI study NeuroImage 2005 25 253 266 15734360
  117. [139]Ringman JM O’Neill J Geschwind D Medina L Apostolova LG Rodriguez Y Schaffer B Varpetian A Tseng B Ortiz F Fitten J Cummings JL Bartzokis G Diffusion tensor imaging in preclinical and presymptomatic carriers of familial Alzheimer’s disease mutations Brain J Neurol 2007 130 1767 1776 17522104
  118. [140]Roe CM Fagan AM Grant EA Hassenstab J Moulder KL Maue Dreyfus D Sutphen CL Benzinger TLS Mintun MA Holtzman DM Morris JC Amyloid imaging and CSF biomarkers in predicting cognitive impairment up to 7.5 years later Neurology 2013 80 1784 1791 23576620 PMC3719431
  119. [141]Rombouts SA Barkhof F Veltman DJ Machielsen WC Witter MP Bierlaagh MA Lazeron RH Valk J Scheltens P Functional MR imaging in Alzheimer’s disease during memory encoding AJNR Am J Neuroradiol 2000 21 1869 1875 11110539 PMC7974309
  120. [143]Ryan NS Keihaninejad S Shakespeare TJ Lehmann M Crutch SJ Malone IB Thornton JS Mancini L Hyare H Yousry T Ridgway GR Zhang H Modat M Alexander DC Rossor MN Ourselin S Fox NC Magnetic resonance imaging evidence for presymptomatic change in thalamus and caudate in familial Alzheimer’s disease Brain J Neurol 2013 136 1399 1414 PMC3634199 23539189
  121. [144]Schabel MC Parker DL Uncertainty and bias in contrast concentration measurements using spoiled gradient echo pulse sequences Phys Med Biol 2008 53 2345 2373 18421121 PMC2894639
  122. [145]Schmidt R Schmidt H Haybaeck J Loitfelder M Weis S Cavalieri M Seiler S Enzinger C Ropele S Erkinjuntti T Pantoni L Scheltens P Fazekas F Jellinger K Heterogeneity in age-related white matter changes Acta Neuropathol (Berl) 2011 122 171 185 21706175
  123. [146]Schmithorst VJ Hernandez-Garcia L Vannest J Rajagopal A Lee G Holland SK Optimized simultaneous ASL and BOLD functional imaging of the whole brain J Magn Reson Imaging JMRI 2014 39 1104 1117 24115454 PMC3964152
  124. [147]Schuff N Matsumoto S Kmiecik J Studholme C Du A Ezekiel F Miller BL Kramer JH Jagust WJ Chui HC Weiner MW Cerebral blood flow in ischemic vascular dementia and Alzheimer’s disease, measured by arterial spin-labeling magnetic resonance imaging Alzheimers Dement J Alzheimers Assoc 2009 5 454 462 PMC2802181 19896584
  125. [148]Seeley WW Crawford RK Zhou J Miller BL Greicius MD Neurodegenerative diseases target large-scale human brain networks Neuron 2009 62 42 52 19376066 PMC2691647
  126. [149]Sestini S Castagnoli A Mansi L The new FDG brain revolution: the neurovascular unit and the default network Eur J Nucl Med Mol Imaging 2010 37 913 916 20033155
  127. [150]Sheline YI Raichle ME Resting state functional connectivity in preclinical Alzheimer’s disease Biol Psychiatry 2013 74 340 347 23290495 PMC3537262
  128. [151]Shulman GL Fiez JA Corbetta M Buckner RL Miezin FM Raichle ME Petersen SE Common blood flow changes across visual tasks: II. Decreases in cerebral cortex J Cogn Neurosci 1997 9 648 663 23965122
  129. [152]Sirotin YB Das A Anticipatory haemodynamic signals in sensory cortex not predicted by local neuronal activity Nature 2009 457 475 479 19158795 PMC2705195
  130. [153]Small SA Perera GM DeLaPaz R Mayeux R Stern Y Differential regional dysfunction of the hippocampal formation among elderly with memory decline and Alzheimer’s disease Ann Neurol 1999 45 466 472 10211471
  131. [154]Smith CD Andersen AH Gold BT Alzheimer’s Disease Neuroimaging Initiative Structural brain alterations before mild cognitive impairment in ADNI: validation of volume loss in a predefined antero-temporal region J Alzheimers Dis JAD 2012 31 Suppl 3 S49 S58 22460332 PMC3652624
  132. [155]Solé-Padullés C Bartrés-Faz D Junqué C Vendrell P Rami L Clemente IC Bosch B Villar A Bargalló N Jurado MA Barrios M Molinuevo JL Brain structure and function related to cognitive reserve variables in normal aging, mild cognitive impairment and Alzheimer’s disease Neurobiol Aging 2009 30 1114 1124 18053618
  133. [156]Sourbron S Ingrisch M Siefert A Reiser M Herrmann K Quantification of cerebral blood flow, cerebral blood volume, and blood-brain-barrier leakage with DCE-MRI Magn Reson Med 2009 62 205 217 19449435
  134. [157]Sourbron SP Buckley DL On the scope and interpretation of the Tofts models for DCE-MRI Magn Reson Med 2011 66 735 745 21384424
  135. [158]Sourbron SP Buckley DL Classic models for dynamic contrast-enhanced MRI NMR Biomed 2013 26 1004 1027 23674304
  136. [159]Sperling RA Bates JF Chua EF Cocchiarella AJ Rentz DM Rosen BR Schacter DL Albert MS fMRI studies of associative encoding in young and elderly controls and mild Alzheimer’s disease J Neurol Neurosurg Psychiatry 2003 74 44 50 12486265 PMC1738201
  137. [160]Sperling RA Johnson KA Doraiswamy PM Reiman EM Fleisher AS Sabbagh MN Sadowsky CH Carpenter A Davis MD Lu M Flitter M Joshi AD Clark CM Grundman M Mintun MA Skovronsky DM Pontecorvo MJ AV45-A05 Study Group Amyloid deposition detected with florbetapir F 18 ((18)F-AV-45) is related to lower episodic memory performance in clinically normal older individuals Neurobiol Aging 2013 34 822 831 22878163 PMC3518678
  138. [161]Sperling RA Laviolette PS O’Keefe K O’Brien J Rentz DM Pihlajamaki M Marshall G Hyman BT Selkoe DJ Hedden T Buckner RL Becker JA Johnson KA Amyloid deposition is associated with impaired default network function in older persons without dementia Neuron 2009 63 178 188 19640477 PMC2738994
  139. [162]Sperling R Greve D Dale A Killiany R Holmes J Rosas HD Cocchiarella A Firth P Rosen B Lake S Lange N Routledge C Albert M Functional MRI detection of pharmacologically induced memory impairment Proc Natl Acad Sci USA 2002 99 455 460 11756667 PMC117581
  140. [163]Starr JM Farrall AJ Armitage P McGurn B Wardlaw J Blood–brain barrier permeability in Alzheimer’s disease: a case-control MRI study Psychiatry Res 2009 171 232 241 19211227
  141. [164]Stern CE Corkin S González RG Guimaraes AR Baker JR Jennings PJ Carr CA Sugiura RM Vedantham V Rosen BR The hippocampal formation participates in novel picture encoding: evidence from functional magnetic resonance imaging Proc Natl Acad Sci USA 1996 93 8660 8665 8710927 PMC38729
  142. [165]Stricker NH Chang Y-L Fennema-Notestine C Delano-Wood L Salmon DP Bondi MW Dale AM Alzheimer’s Disease Neuroimaging Initiative Distinct profiles of brain and cognitive changes in the very old with Alzheimer disease Neurology 2011 77 713 721 21832223 PMC3164395
  143. [167]Taheri S Gasparovic C Huisa BN Adair JC Edmonds E Prestopnik J Grossetete M Shah NJ Wills J Qualls C Rosenberg GA Blood–brain barrier permeability abnormalities in vascular cognitive impairment Stroke J Cereb Circ 2011 42 2158 2163 PMC3584170 21719768
  144. [168]Taheri S Gasparovic C Shah NJ Rosenberg GA Quantitative measurement of blood–brain barrier permeability in human using dynamic contrast-enhanced MRI with fast T1 mapping Magn Reson Med 2011 65 1036 1042 21413067 PMC4950947
  145. [169]Tambini A Davachi L Persistence of hippocampal multivoxel patterns into postencoding rest is related to memory Proc Natl Acad Sci USA 2013 110 19591 19596 24218550 PMC3845130
  146. [170]Tekes A Mohamed MA Browner NM Calhoun VD Yousem DM Effect of age on visuomotor functional MR imaging Acad Radiol 2005 12 739 745 15935972
  147. [171]Thomsen HS Morcos SK Almén T Bellin M-F Bertolotto M Bongartz G Clement O Leander P Heinz-Peer G Reimer P Stacul F van der Molen A Webb JAW ESUR Contrast Medium Safety Committee Nephrogenic systemic fibrosis and gadolinium-based contrast media: updated ESUR Contrast Medium Safety Committee guidelines Eur Radiol 2013 23 307 318 22865271
  148. [173]Tian P Teng IC May LD Kurz R Lu K Scadeng M Hillman EMC De Crespigny AJ D’Arceuil HE Mandeville JB Marota JJA Rosen BR Liu TT Boas DA Buxton RB Dale AM Devor A Cortical depth-specific microvascular dilation underlies laminar differences in blood oxygenation level-dependent functional MRI signal Proc Natl Acad Sci USA 2010 107 15246 15251 20696904 PMC2930564
  149. [174]Tofts PS Brix G Buckley DL Evelhoch JL Henderson E Knopp MV Larsson HB Lee TY Mayr NA Parker GJ Port RE Taylor J Weisskoff RM Estimating kinetic parameters from dynamic contrast-enhanced T(1)-weighted MRI of a diffusable tracer: standardized quantities and symbols J Magn Reson Imaging JMRI 1999 10 223 232 10508281
  150. [175]Tondelli M Wilcock GK Nichelli P De Jager CA Jenkinson M Zamboni G Structural MRI changes detectable up to ten years before clinical Alzheimer’s disease Neurobiol Aging 2012 33 825 e25 e36 21782287
  151. [176]Tosto G Zimmerman ME Hamilton JL Carmichael OT Brickman AM Alzheimer’s Disease Neuroimaging Initiative The effect of white matter hyperintensities on neurodegeneration in mild cognitive impairment Alzheimers Dement J Alzheimers Assoc 2015 PMC4677059 26079417
  152. [178]Umutlu L Kraff O Orzada S Fischer A Kinner S Maderwald S Antoch G Quick HH Forsting M Ladd ME Lauenstein TC Dynamic contrast-enhanced renal MRI at 7 Tesla: preliminary results Invest Radiol 2011 46 425 433 21317791
  153. [179]Uspenskaia O Liebetrau M Herms J Danek A Hamann GF Aging is associated with increased collagen type IV accumulation in the basal lamina of human cerebral microvessels BMC Neurosci 2004 5 37 15387892 PMC523851
  154. [180]Villemagne VL Burnham S Bourgeat P Brown B Ellis KA Salvado O Szoeke C Macaulay SL Martins R Maruff P Ames D Rowe CC Masters CL Australian Imaging Biomarkers and Lifestyle (AIBL) Research Group Amyloid β deposition, neurodegeneration, and cognitive decline in sporadic Alzheimer’s disease: a prospective cohort study Lancet Neurol 2013 12 357 367 23477989
  155. [182]Viswanathan A Greenberg SM Cerebral amyloid angiopathy in the elderly Ann Neurol 2011 70 871 880 22190361 PMC4004372
  156. [183]Wagner AD Schacter DL Rotte M Koutstaal W Maril A Dale AM Rosen BR Buckner RL Building memories: remembering and forgetting of verbal experiences as predicted by brain activity Science 1998 281 1188 1191 9712582
  157. [184]Wahlund LO Bronge L Contrast-enhanced MRI of white matter lesions in patients with blood–brain barrier dysfunction Ann N Y Acad Sci 2000 903 477 481 10818541
  158. [185]Wang H Golob EJ Su M-Y Vascular volume and blood–brain barrier permeability measured by dynamic contrast enhanced MRI in hippocampus and cerebellum of patients with MCI and normal controls J Magn Reson Imaging JMRI 2006 24 695 700 16878309
  159. [186]Wang L Kittaka M Sun N Schreiber SS Zlokovic BV Chronic nicotine treatment enhances focal ischemic brain injury and depletes free pool of brain microvascular tissue plasminogen activator in rats J Cereb Blood Flow Metab Off J Int Soc Cereb Blood Flow Metab 1997 17 136 146 9040492
  160. [187]Wang L Zang Y He Y Liang M Zhang X Tian L Wu T Jiang T Li K Changes in hippocampal connectivity in the early stages of Alzheimer’s disease: evidence from resting state fMRI NeuroImage 2006 31 496 504 16473024
  161. [189]Weiner MW Veitch DP Aisen PS Beckett LA Cairns NJ Cedarbaum J Donohue MC Green RC Harvey D Jack CR Jagust W Morris JC Petersen RC Saykin AJ Shaw L Thompson PM Toga AW Trojanowski JQ Alzheimer’s Disease Neuroimaging Initiative Impact of the Alzheimer’s Disease Neuroimaging Initiative, 2004 to 2014 Alzheimers Dement J Alzheimers Assoc 2015 11 865 884 PMC4659407 26194320
  162. [190]Wierenga CE Bondi MW Use of functional magnetic resonance imaging in the early identification of Alzheimer’s disease Neuropsychol Rev 2007 17 127 143 17476598 PMC2084460
  163. [191]Wierenga CE Dev SI Shin DD Clark LR Bangen KJ Jak AJ Rissman RA Liu TT Salmon DP Bondi MW Effect of mild cognitive impairment and APOE genotype on resting cerebral blood flow and its association with cognition J Cereb Blood Flow Metab Off J Int Soc Cereb Blood Flow Metab 2012 32 1589 1599 PMC3421098 22549621
  164. [192]Xu G Antuono PG Jones J Xu Y Wu G Ward D Li S-J Perfusion fMRI detects deficits in regional CBF during memory-encoding tasks in MCI subjects Neurology 2007 69 1650 1656 17954780
  165. [193]Yakushev I Müller MJ Lorscheider M Schermuly I Weibrich C Dellani PR Hammers A Stoeter P Fellgiebel A Increased hippocampal head diffusivity predicts impaired episodic memory performance in early Alzheimer’s disease Neuropsychologia 2010 48 1447 1453 20109475
  166. [194]Yassa MA Stark SM Bakker A Albert MS Gallagher M Stark CEL High-resolution structural and functional MRI of hippocampal CA3 and dentate gyrus in patients with amnestic Mild Cognitive Impairment NeuroImage 2010 51 1242 1252 20338246 PMC2909476
  167. [195]Yoshiura T Hiwatashi A Yamashita K Ohyagi Y Monji A Takayama Y Nagao E Kamano H Noguchi T Honda H Simultaneous measurement of arterial transit time, arterial blood volume, and cerebral blood flow using arterial spin-labeling in patients with Alzheimer disease AJNR Am J Neuroradiol 2009 30 1388 1393 19342545 PMC7051557
  168. [196]Zanto TP Pa J Gazzaley A Reliability measures of functional magnetic resonance imaging in a longitudinal evaluation of mild cognitive impairment NeuroImage 2014 84 443 452 24018304 PMC3855402
  169. [197]Zlokovic BV Cerebrovascular permeability to peptides: manipulations of transport systems at the blood–brain barrier Pharm Res 1995 12 1395 1406 8584471
  170. [199]Zlokovic BV Begley DJ Chain-Eliash DG Blood–brain barrier permeability to leucine-enkephalin, d-alanine2-d-leucine5-enkephalin and their N-terminal amino acid (tyrosine) Brain Res 1985 336 125 132 3891014

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Authors
Montagne, A., Nation, D. A., Pa, J., Sweeney, M. D., Toga, A. W., & Zlokovic, B. V.
Affiliations
University of Southern California (US)
ORCID
Venue
Acta Neuropathologica
Publisher
Springer Science and Business Media LLC
Published
2016-04-01
Volume
131
Issue
5
Pages
687-707
ISSN
  • 0001-6322 (ISSN-L)
  • 1432-0533
DOI
10.1007/s00401-016-1570-0
PMC
PMC5283382
OpenAlex
W2334742858
Cited by
239
References
30
Citations by year
2026: 13 · 2025: 25 · 2024: 22 · 2023: 20 · 2022: 22 · 2021: 33 · 2020: 31 · 2019: 25 · 2018: 17 · 2017: 18 · 2016: 13
FWCI
2.13
Type
journal article
Language
en
Open access
Licence
Locations
  • Acta Neuropathologica (publishedVersion)
  • PubMed (publishedVersion)
  • PubMed Central (acceptedVersion)
  • eScholarship (California Digital Library) (submittedVersion)
Funders
  • National Institutes of Health (R37NS34467, R37AG23084, R01AG039452, R01AG046928, P41EB015922)
  • Alzheimer's Association (NIRP12259277)
Topics
  • Life Sciences › Neuroscience › Neurology › Barrier Structure and Function Studies
  • Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
  • Health Sciences › Medicine › Physiology › Alzheimer's disease research and treatments
Keywords
Alzheimer's disease, neurovascular dysfunction, blood-brain barrier permeability, cerebral blood flow, cerebrovascular dysfunction, amyloid pathology, tau pathology, dynamic contrast-enhanced MRI, arterial spin labeling, functional MRI, brain metabolism, dementia, preclinical Alzheimer's disease, vascular pathophysiology
MeSH terms
Alzheimer Disease, Animals, Blood-Brain Barrier, Brain, Humans, Central Nervous System Vascular Malformations, Neuroimaging

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