The DOI matches its Crossref record; 84 of the 84 references it cites were found in a registry or an index.
Exercise Plays a Preventive Role Against Alzheimer's Disease
Abstract
Alzheimer's disease (AD) is a progressive neurodegenerative disorder affecting the elderly population. It is predicted that the incidence of AD will be increased in the future making this disease one of the greatest medical, social, and economic challenges for individuals, families, and the health care system worldwide. The etiology of AD is multifactorial. It features increased oxidative state and deposition of amyloid plaques and neurofibrillary tangles of protein tau in the central cortex and limbic system of the brain. Here we provide an overview of the positive impacts of exercise on this challenging disease. Regular physical activity increases the endurance of cells and tissues to oxidative stress, vascularization, energy metabolism, and neurotrophin synthesis, all important in neurogenesis, memory improvement, and brain plasticity. Although extensive studies are required to understand the mechanism, it is clear that physical exercise is beneficial in the prevention of AD and other age-associated neurodegenerative disorders.
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1 retracted
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RetractedRunning increases cell proliferation and neurogenesis in the adult mouse dentate gyrus
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Exercise enhances learning and hippocampal neurogenesis in aged mice
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Apolipoprotein E and its receptors in Alzheimer's disease: pathways, pathogenesis and therapy
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Aerobic fitness is associated with hippocampal volume in elderly humans
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Physical Activity, Diet, and Risk of Alzheimer Disease
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Evidence for a release of brain-derived neurotrophic factor from the brain during exercise
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Cited by
Choi, S. H., Bylykbashi, E., Chatila, Z. K., Lee, S. W., Pulli, B., Clemenson, G. D., Kim, E., Rompala, A., Oram, M. K., Asselin, C., et al. (2018) · Science · doi:10.1126/science.aan8821 · Cited by 802
Groot, C., Hooghiemstra, A. M., Raijmakers, P. G. H. M., van Berckel, B. N. M., Scheltens, P., Scherder, E. J. A., van der Flier, W. M., & Ossenkoppele, R. (2016) · Ageing Research Reviews · doi:10.1016/j.arr.2015.11.005 · Cited by 616
Physical exercise and cognitive performance in the elderly: Current perspectives.
Kirk-Sanchez, N., & McGough, E. (2013) · Clinical Interventions in Aging · doi:10.2147/cia.s39506 · Cited by 465
Santos, C. Y., Snyder, P. J., Wu, W., Zhang, M., Echeverria, A., & Alber, J. (2017) · Alzheimer's & Dementia: Diagnosis, Assessment & Disease Monitoring · doi:10.1016/j.dadm.2017.01.005 · Cited by 431
Exercise Attenuates the Major Hallmarks of Aging
Garatachea, N., Pareja-Galeano, H., Sanchis-Gomar, F., Santos-Lozano, A., Fiuza-Luces, C., Morán, M., Emanuele, E., Joyner, M. J., & Lucia, A. (2015) · Rejuvenation Research · doi:10.1089/rej.2014.1623 · Cited by 413
Metadata
- Authors
- Radak, Z., Hart, N., Sarga, L., Koltai, E., Atalay, M., Ohno, H., & Boldogh, I.
- Venue
- Journal of Alzheimer's Disease
- Publisher
- SAGE Publications
- Published
- 2010-05-26
- Volume
- 20
- Issue
- 3
- Pages
- 777-783
- ISSN
- 1387-2877 (ISSN-L)
- 1875-8908
- OpenAlex
- W2125186396
- Cited by
- 316
- References
- 84
- FWCI
- 10.37
- Type
- journal article
- Language
- en
- Open access
- closed
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- Radak, Z., Hart, N., Sarga, L., Koltai, E., Atalay, M., Ohno, H., & Boldogh, I. (2010). Exercise Plays a Preventive Role Against Alzheimer's Disease. Journal of Alzheimer's Disease. https://doi.org/10.3233/jad-2010-091531
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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