The DOI matches its Crossref record; 24 of the 24 references it cites were found in a registry or an index.
Calcium and Mitochondrial Reactive Oxygen Species Generation: How to Read the Facts
Open accessAbstract
A number of recent discoveries indicate that abnormal Ca2+ signaling, oxidative stress, and mitochondrial dysfunction are involved in the neuronal damage in Alzheimer's disease. However, the literature on the interactions between these factors is controversial especially in the interpretation of the cause-effect relationship between mitochondrial damage induced by Ca2+ overload and the production of reactive oxygen species (ROS). In this review, we survey the experimental observations on the Ca2+-induced mitochondrial ROS production, explain the sources of controversy in interpreting these results, and discuss the different molecular mechanisms underlying the effect of Ca2+ on the ROS emission by brain mitochondria.
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Citations
Cites
How mitochondria produce reactive oxygen species
Murphy, M. P. (2009) · Biochemical Journal · doi:10.1042/bj20081386 · Cited by 8,207
Soluble protein oligomers in neurodegeneration: lessons from the Alzheimer's amyloid β-peptide
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Calcium, ATP, and ROS: a mitochondrial love-hate triangle
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The mitochondrial permeability transition pore and its role in cell death
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Oxidative Damage Is the Earliest Event in Alzheimer Disease
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ABAD Directly Links Aß to Mitochondrial Toxicity in Alzheimer's Disease
Lustbader, J. W., Cirilli, M., Lin, C., Xu, H. W., Takuma, K., Wang, N., Caspersen, C., Chen, X., Pollak, S., Chaney, M., et al. (2004) · Science · doi:10.1126/science.1091230 · Cited by 1,303
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The role of mitochondria in reactive oxygen species metabolism and signaling
Starkov, A. A. (2008) · Annals of the New York Academy of Sciences · doi:10.1196/annals.1427.015 · Cited by 846 · cited 3×
“The highest ROS producing capacity in brain mitochondria has been demonstrated for complex I and complex III of the respiratory chain [64] [65] [66] [67] and the enzyme dihydrolipoamide dehydrogenase [68] [69] [70].”
BackgroundSelf-citationPraticò, D., Uryu, K., Leight, S., Trojanoswki, J. Q., & Lee, V. M.-Y. (2001) · The Journal of Neuroscience · doi:10.1523/jneurosci.21-12-04183.2001 · Cited by 777
Cited by
Calcium and ROS: A mutual interplay
Görlach, A., Bertram, K., Hudecova, S., & Krizanova, O. (2015) · Redox Biology · doi:10.1016/j.redox.2015.08.010 · Cited by 1,546
Kohli, S. K., Khanna, K., Bhardwaj, R., Abd_Allah, E. F., Ahmad, P., & Corpas, F. J. (2019) · Antioxidants · doi:10.3390/antiox8120641 · Cited by 447
Oxidative & nitrosative stress in depression: Why so much stress?
Moylan, S., Berk, M., Dean, O. M., Samuni, Y., Williams, L. J., O’Neil, A., Hayley, A. C., Pasco, J. A., Anderson, G., Jacka, F. N., et al. (2014) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2014.05.007 · Cited by 403
Kann, O., Papageorgiou, I. E., & Draguhn, A. (2014) · Journal of Cerebral Blood Flow & Metabolism · doi:10.1038/jcbfm.2014.104 · Cited by 295
Mitochondrial Calcium: Effects of Its Imbalance in Disease
Matuz-Mares, D., González-Andrade, M., Araiza-Villanueva, M. G., Vilchis-Landeros, M. M., & Vázquez-Meza, H. (2022) · Antioxidants · doi:10.3390/antiox11050801 · Cited by 266
Metadata
- Authors
- Adam-Vizi, V., & Starkov, A. A.
- Venue
- Journal of Alzheimer's Disease
- Publisher
- SAGE Publications
- Published
- 2010-06-03
- Volume
- 20
- Issue
- s2
- Pages
- S413-S426
- ISSN
- 1387-2877 (ISSN-L)
- 1875-8908
- OpenAlex
- W1509344561
- Cited by
- 246
- References
- 24
- FWCI
- 2.72
- Type
- journal article
- Language
- en
- Open access
- hybrid
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- Adam-Vizi, V., & Starkov, A. A. (2010). Calcium and Mitochondrial Reactive Oxygen Species Generation: How to Read the Facts. Journal of Alzheimer's Disease. https://doi.org/10.3233/jad-2010-100465
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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