Calcium and ROS: A mutual interplay

Görlach, Agnes; Bertram, Katharina; Hudecova, Sona; Krizanova, Olga

doi:10.1016/j.redox.2015.08.010

Cited by 1,546Redox biology and oxidative stressCalcium signaling and nucleotide metabolismIon Channels and Receptors

Calcium and ROS: A mutual interplay

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Görlach, Agnes, Bertram, Katharina, Hudecova, Sona, Krizanova, Olga·2015·Redox Biology

DOI 10.1016/j.redox.2015.08.010PMC PMC4556774

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Abstract

Calcium is an important second messenger involved in intra- and extracellular signaling cascades and plays an essential role in cell life and death decisions. The Ca(2+) signaling network works in many different ways to regulate cellular processes that function over a wide dynamic range due to the action of buffers, pumps and exchangers on the plasma membrane as well as in internal stores. Calcium signaling pathways interact with other cellular signaling systems such as reactive oxygen species (ROS). Although initially considered to be potentially detrimental byproducts of aerobic metabolism, it is now clear that ROS generated in sub-toxic levels by different intracellular systems act as signaling molecules involved in various cellular processes including growth and cell death. Increasing evidence suggests a mutual interplay between calcium and ROS signaling systems which seems to have important implications for fine tuning cellular signaling networks. However, dysfunction in either of the systems might affect the other system thus potentiating harmful effects which might contribute to the pathogenesis of various disorders.

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Sustained elevation in cellular calcium signal stimulates higher mitochondrial ROS generation due to enhanced electron flow through respiratory chain and subsequent inhibition of complexes I and III of ubiquinone cycle.
“However, sustained elevation in the cellular calcium signal stimulates higher mitochondrial reactive oxygen species (ROS) generation (28) due to enhanced electron flow through respiratory chain and subsequent inhibition of complexes I and III of ubiquinone (Q) cycle.”
From Mechanistic inferences on metabolic dysfunction in posttraumatic stress disorder from an integrated model and multiomic analysis: role of glucocorticoid receptor sensitivity (2019) · cites this paper as [28]
In “Calcium and mitochondrial ROS generation” (page unavailable), the review says calcium overload might increase mitochondrial ROS, but it also says calcium uptake can decrease ROS or leave it unchanged depending on mitochondrial conditions. It suggests increased respiratory-chain electron leakage as one possible explanation; it does not say sustained calcium elevation subsequently inhibits complexes I and III. Instead, it describes increased ROS when those complexes were inhibited by pharmacological agents. (LLM, conf=0.88)
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[29]Camello-Almaraz C. Gomez-Pinilla P.J. Pozo M.J. Camello P.J. Mitochondrial reactive oxygen species and Ca2+ signaling Am. J. Physiol. Cell Physiol. 291 2006 1082 1088 16760264

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Authors: Görlach, A., Bertram, K., Hudecova, S., & Krizanova, O.
Affiliations: German Centre for Cardiovascular Research (DE)
Deutsches Herzzentrum München (DE)
Corresponding author: Görlach, Agnes
ORCID: Görlach, Agnes
Venue: Redox Biology
Publisher: Elsevier BV
Published: 2015-12
Volume: 6
Pages: 260-271
ISSN: 2213-2317 (ISSN-L)
DOI: 10.1016/j.redox.2015.08.010
PMC: PMC4556774
OpenAlex: W1165140024
Cited by: 1,546
References: 180
Citations by year: 2026: 128 · 2025: 188 · 2024: 195 · 2023: 184 · 2022: 177 · 2021: 179 · 2020: 141 · 2019: 133 · 2018: 115 · 2017: 72 · 2016: 30 · 2015: 3
FWCI: 7.11
Type: journal article
Language: en
Open access: gold
doi.org
Licence: cc-by-nc-nd
www.elsevier.com/tdm/userlicense/1.0/ (tdm)
www.elsevier.com/legal/tdmrep-license (tdm)
creativecommons.org/licenses/by-nc-nd/4.0/ (vor)
Locations: Redox Biology (publishedVersion, cc-by-nc-nd)
Europe PMC (PubMed Central) (publishedVersion, cc-by-nc-nd)
PubMed (publishedVersion)
mediaTUM (Technical University of Munich) (submittedVersion)
Funders: Bundesministerium für Bildung und Forschung (SAV 2/0074)
Deutsches Zentrum für Herz-Kreislaufforschung
Deutsche Forschungsgemeinschaft (DFG-GO709/4-5)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Redox biology and oxidative stress
Life Sciences › Biochemistry, Genetics and Molecular Biology › Physiology › Calcium signaling and nucleotide metabolism
Life Sciences › Neuroscience › Sensory Systems › Ion Channels and Receptors
Keywords: calcium signaling, reactive oxygen species, second messengers, cell death, cell signaling networks, redox signaling, intracellular calcium stores
MeSH terms: Animals, Calcium, Cell Membrane, Endoplasmic Reticulum, Eukaryotic Cells, Gene Expression Regulation, Humans, Mitochondria, Calcium Channels, Cell Death, Reactive Oxygen Species, Oxidative Stress, NADPH Oxidases, Calcium Signaling, Plasma Membrane Calcium-Transporting ATPases

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Calcium and ROS: A mutual interplay

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