The DOI matches its Crossref record; 83 of the 83 references it cites were found in a registry or an index.
Increased Iron and Free Radical Generation in Preclinical Alzheimer Disease and Mild Cognitive Impairment
Open accessAbstract
It is now established that oxidative stress is one of the earliest, if not the earliest, change that occurs in the pathogenesis of Alzheimer's disease (AD). Consistent with this, mild cognitive impairment (MCI), the clinical precursor of AD, is also characterized by elevations in oxidative stress. Since such stress does not operate in vacuo, in this study we sought to determine whether redox-active iron, a potent source of free radicals, was elevated in MCI and preclinical AD as compared to cognitively-intact age-matched control patients. Increased iron was found at the highest levels both in the cortex and cerebellum from the pre-clinical AD/MCI cases. Interestingly, glial accumulations of redox-active iron in the cerebellum were also evident in preclinical AD patients and tended to increase as patients became progressively cognitively impaired. Our findings suggests that an imbalance in iron homeostasis is a precursor to the neurodegenerative processes leading to AD and that iron imbalance is not necessarily unique to affected regions. In fact, an understanding of iron deposition in other regions of the brain may provide insights into neuroprotective strategies. Iron deposition at the preclinical stage of AD may be useful as a diagnostic tool, using iron imaging methods, as well as a potential therapeutic target, through metal ion chelators.
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Cites
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Oxidative Damage Is the Earliest Event in Alzheimer Disease
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Self-citationMitochondrial abnormalities in Alzheimer's disease
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Iron accumulation in Alzheimer disease is a source of redox-generated free radicals
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Self-citationSynaptic Targeting by Alzheimer's-Related Amyloid β Oligomers
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Self-citationRNA Oxidation Is a Prominent Feature of Vulnerable Neurons in Alzheimer’s Disease
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Cited by
The development of the concept of ferroptosis
Hirschhorn, T., & Stockwell, B. R. (2019) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2018.09.043 · Cited by 1,052
Oxidative Stress in Neurodegenerative Diseases: From Molecular Mechanisms to Clinical Applications
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Iron neurochemistry in Alzheimer's disease and Parkinson's disease: targets for therapeutics
Belaidi, A. A., & Bush, A. I. (2016) · Journal of Neurochemistry · doi:10.1111/jnc.13425 · Cited by 578
Metal Toxicity Links to Alzheimer's Disease and Neuroinflammation
Huat, T. J., Camats-Perna, J., Newcombe, E. A., Valmas, N., Kitazawa, M., & Medeiros, R. (2019) · Journal of Molecular Biology · doi:10.1016/j.jmb.2019.01.018 · Cited by 470
Current understanding of metal ions in the pathogenesis of Alzheimer’s disease
Wang, L., Yin, Y.-L., Liu, X.-Z., Shen, P., Zheng, Y.-G., Lan, X.-R., Lu, C.-B., & Wang, J.-Z. (2020) · Translational Neurodegeneration · doi:10.1186/s40035-020-00189-z · Cited by 454
Metadata
- Authors
- Smith, M. A., Zhu, X., Tabaton, M., Liu, G., McKeel, D. W., Cohen, M. L., Wang, X., Siedlak, S. L., Dwyer, B. E., Hayashi, T., Nakamura, M., Nunomura, A., & Perry, G.
- Venue
- Journal of Alzheimer's Disease
- Publisher
- SAGE Publications
- Published
- 2010-01-06
- Volume
- 19
- Issue
- 1
- Pages
- 363-372
- ISSN
- 1387-2877 (ISSN-L)
- 1875-8908
- OpenAlex
- W2110464595
- Cited by
- 401
- References
- 83
- FWCI
- 25.49
- Type
- journal article
- Language
- en
- Open access
- green
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- Smith, M. A., Zhu, X., Tabaton, M., Liu, G., McKeel, D. W., Cohen, M. L., Wang, X., Siedlak, S. L., Dwyer, B. E., Hayashi, T., Nakamura, M., Nunomura, A., & Perry, G. (2010). Increased Iron and Free Radical Generation in Preclinical Alzheimer Disease and Mild Cognitive Impairment. Journal of Alzheimer's Disease. https://doi.org/10.3233/jad-2010-1239
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