Oxidative Stress in Neurodegenerative Diseases: From Molecular Mechanisms to Clinical Applications
Open accessAbstract
Increasing numbers of individuals, particularly the elderly, suffer from neurodegenerative disorders. These diseases are normally characterized by progressive loss of neuron cells and compromised motor or cognitive function. Previous studies have proposed that the overproduction of reactive oxygen species (ROS) may have complex roles in promoting the disease development. Research has shown that neuron cells are particularly vulnerable to oxidative damage due to their high polyunsaturated fatty acid content in membranes, high oxygen consumption, and weak antioxidant defense. However, the exact molecular pathogenesis of neurodegeneration related to the disturbance of redox balance remains unclear. Novel antioxidants have shown great potential in mediating disease phenotypes and could be an area of interest for further research. In this review, we provide an updated discussion on the roles of ROS in the pathological mechanisms of Alzheimer’s disease, Huntington’s disease, Parkinson’s disease, amyotrophic lateral sclerosis, and spinocerebellar ataxia, as well as a highlight on the antioxidant‐based therapies for alleviating disease severity.
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Aβ proteins can directly activate nicotinamide adenine dinucleotide phosphate hydrogen (NADPH) oxidase to initiate the synthesis of free radicals.
“Aβ proteins can directly activate nicotinamide adenine dinucleotide phosphate hydrogen (NADPH) oxidase to initiate the synthesis of free radicals [31].”
From Recent Advancements in Pathogenesis, Diagnostics and Treatment of Alzheimer’s Disease (2020) · cites this paper as [31]
A possible linkage between oxidative stress and neurodegenerative disorders such as Huntington disease has been shown in literature.
“A possible linkage between oxidative stress and neurodegenerative disorders such as HD has been shown in literature”
From Nanotechnology: A Promising Approach for Delivery of Neuroprotective Drugs (2020) · cites this paper as Liu et al., 2017
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Reactive oxygen species: Metabolism, oxidative stress, and signal transduction
Apel, K., & Hirt, H. (2004) · Annual Review of Plant Biology · doi:10.1146/annurev.arplant.55.031903.141701 · Cited by 11,723 · see citing works
Polazzi, E., Mengoni, I., Caprini, M., Peña‐Altamira, E., Kurtys, E., & Monti, B. (2012) · Neurosignals · doi:10.1159/000337115 · Cited by 9,023 · see citing works
Mitochondrial Dysfunction and Oxidative Stress in Neurodegenerative Diseases
Lin, M. T., & Beal, M. F. (2006) · Nature · doi:10.1038/nature05292 · Cited by 6,455 · see citing works
Alzheimer's Disease: Genes, Proteins, and Therapy
Selkoe, D. J. (2001) · Physiological Reviews · doi:10.1152/physrev.2001.81.2.741 · Cited by 6,063 · see citing works
2016 Alzheimer's disease facts and figures
Alzheimer's Association (2016) · Alzheimer's & Dementia · doi:10.1016/j.jalz.2016.03.001 · Cited by 5,069 · see citing works
Querfurth, H. W., & LaFerla, F. M. (2010) · New England Journal of Medicine · doi:10.1056/nejmra0909142 · Cited by 4,569 · see citing works
Hereditary Early-Onset Parkinson's Disease Caused by Mutations in <i>PINK1</i>
Valente, E. M., Abou-Sleiman, P. M., Caputo, V., Muqit, M. M. K., Harvey, K., Gispert, S., Ali, Z., Del Turco, D., Bentivoglio, A. R., Healy, D. G., et al. (2004) · Science · doi:10.1126/science.1096284 · Cited by 3,481 · see citing works
Uttara, B., Singh, A., Zamboni, P., & Mahajan, R. (2009) · Current Neuropharmacology · doi:10.2174/157015909787602823 · Cited by 3,378 · see citing works
Adams, J., Dinesh, K., Xiong, M., Tarolli, C. G., Sharma, S., Sheth, N., Aranyosi, A. J., Zhu, W. Y., Goldenthal, S. B., Biglan, K., et al. (2017) · Digital Biomarkers · doi:10.1159/000479018 · Cited by 3,190 · see citing works
Oxidative Stress, Caloric Restriction, and Aging
Sohal, R. S., & Weindruch, R. H. (1996) · Science · doi:10.1126/science.273.5271.59 · Cited by 3,133 · see citing works
Mitochondrial diseases in man and mouse
Wallace, D. C. (1999) · Science · doi:10.1126/science.283.5407.1482 · Cited by 3,060 · see citing works
Kiernan, M. C., Vucic, S., Cheah, B. C., Turner, M. R., Eisen, A., Hardiman, O., Burrell, J. R., & Zoing, M. C. (2011) · The Lancet · doi:10.1016/s0140-6736(10)61156-7 · Cited by 2,603 · see citing works
A Controlled Trial of Selegiline, Alpha-Tocopherol, or Both as Treatment for Alzheimer's Disease
Sano, M., Ernesto, C., Thomas, R. G., Klauber, M. R., Schafer, K., Grundman, M., Woodbury, P., Growdon, J., Cotman, C. W., Pfeiffer, E., et al. (1997) · New England Journal of Medicine · doi:10.1056/nejm199704243361704 · Cited by 2,380 · see citing works
Yang, F., Lim, G. P., Begum, A. N., Ubeda, O. J., Simmons, M. R., Ambegaokar, S. S., Chen, P. P., Kayed, R., Glabe, C. G., Frautschy, S. A., et al. (2005) · Journal of Biological Chemistry · doi:10.1074/jbc.m404751200 · Cited by 2,336 · see citing works
St-Pierre, J., Drori, S., Uldry, M., Silvaggi, J. M., Rhee, J., Jäger, S., Handschin, C., Zheng, K., Lin, J., Yang, W., et al. (2006) · Cell · doi:10.1016/j.cell.2006.09.024 · Cited by 2,233 · see citing works
Davies, S. W., Turmaine, M., Cozens, B. A., DiFiglia, M., Sharp, A. H., Ross, C. A., Scherzinger, E., Wanker, E. E., Mangiarini, L., & Bates, G. P. (1997) · Cell · doi:10.1016/s0092-8674(00)80513-9 · Cited by 2,188 · see citing works
Decoding ALS: from genes to mechanism
Taylor, J. P., Brown, R. H., & Cleveland, D. W. (2016) · Nature · doi:10.1038/nature20413 · Cited by 2,047 · see citing works
The Role of Oxidative Stress in Parkinson's Disease
Dias, V., Junn, E., & Mouradian, M. M. (2013) · Journal of Parkinson’s Disease · doi:10.3233/jpd-130230 · Cited by 1,845 · see citing works
Huntington's disease: from molecular pathogenesis to clinical treatment.
Ross, C., & Tabrizi, S. (2011) · Lancet Neurology · doi:10.1016/s1474-4422(10)70245-3 · Cited by 1,693 · see citing works
The role of oxidative stress in neurodegenerative diseases
Kim, G. H., Kim, J. E., Rhie, S. J., & Yoon, S. (2015) · Experimental Neurobiology · doi:10.5607/en.2015.24.4.325 · Cited by 1,355 · see citing works
Role of pro-inflammatory cytokines released from microglia in Alzheimer's disease.
(2015) · Europe PMC (PubMed Central) · doi:10.3978/j.issn.2305-5839.2015.03.49 · Cited by 1,288 · see citing works
Inflammation in Neurodegenerative Disease—A Double-Edged Sword
Wyss-Coray, T., & Mucke, L. (2002) · Neuron · doi:10.1016/s0896-6273(02)00794-8 · Cited by 1,235 · see citing works
Astrocytes expressing ALS-linked mutated SOD1 release factors selectively toxic to motor neurons
Nagai, M., Re, D. B., Nagata, T., Chalazonitis, A., Jessell, T. M., Wichterle, H., & Przedborski, S. (2007) · Nature Neuroscience · doi:10.1038/nn1876 · Cited by 1,220 · see citing works
Ferrostatins Inhibit Oxidative Lipid Damage and Cell Death in Diverse Disease Models
Skouta, R., Dixon, S. J., Wang, J., Dunn, D. E., Orman, M., Shimada, K., Rosenberg, P. A., Lo, D. C., Weinberg, J. M., Linkermann, A., et al. (2014) · Journal of the American Chemical Society · doi:10.1021/ja411006a · Cited by 1,146 · cited 2× · see citing works
“To counteract this, some small antioxidant molecules, such as ferrostatin-1 (Fer-1), have been developed, which show efficacy in attenuating neurodegenerative symptoms [27, 28].”
BackgroundSystemic inflammation and disease progression in Alzheimer disease
Holmes, C., Cunningham, C., Zotova, E., Woolford, J., Dean, C., Kerr, S., Culliford, D., & Perry, V. H. (2009) · Neurology · doi:10.1212/wnl.0b013e3181b6bb95 · Cited by 1,139 · see citing works
Early mitochondrial calcium defects in Huntington's disease are a direct effect of polyglutamines
Panov, A. V., Gutekunst, C.-A., Leavitt, B. R., Hayden, M. R., Burke, J. R., Strittmatter, W. J., & Greenamyre, J. T. (2002) · Nature Neuroscience · doi:10.1038/nn884 · Cited by 1,030 · see citing works
Role of oxidative stress in Alzheimer’s disease
HUANG, W.-J., ZHANG, X., & CHEN, W.-W. (2016) · Biomedical Reports · doi:10.3892/br.2016.630 · Cited by 1,023 · see citing works
Cui, L., Jeong, H., Borovecki, F., Parkhurst, C. N., Tanese, N., & Krainc, D. (2006) · Cell · doi:10.1016/j.cell.2006.09.015 · Cited by 1,012 · see citing works
Physical activity and risk of neurodegenerative disease: a systematic review of prospective evidence
Hamer, M., & Chida, Y. (2009) · Psychological Medicine · doi:10.1017/s0033291708003681 · Cited by 988 · see citing works
Effects of Coenzyme Q10 in Early Parkinson Disease: Evidence of Slowing of the Functional Decline
Shults, C. W. (2002) · Archives of Neurology · doi:10.1001/archneur.59.10.1541 · Cited by 984 · see citing works
2011 Alzheimer's disease facts and figures
Alzheimer's Association (2011) · Alzheimer s & Dementia · doi:10.1016/j.jalz.2011.02.004 · Cited by 914 · see citing works
Molecular Mechanisms and Potential Therapeutical Targets in Huntington's Disease
Zuccato, C., Valenza, M., & Cattaneo, E. (2010) · Physiological Reviews · doi:10.1152/physrev.00041.2009 · Cited by 848 · see citing works
Gilgun‐Sherki, Y., Melamed, E., & Offen, D. (2001) · Neuropharmacology · doi:10.1016/s0028-3908(01)00019-3 · Cited by 839 · see citing works
McCormack, A. L., Thiruchelvam, M. J., Manning-Bog, A., Thiffault, C., Langston, J. W., Cory‐Slechta, D. A., & Monte, D. A. D. (2002) · Neurobiology of Disease · doi:10.1006/nbdi.2002.0507 · Cited by 838 · see citing works
Hodgson, J., Agopyan, N., Gutekunst, C., Leavitt, B. R., LePiane, F. G., Singaraja, R. R., Smith, D. J., Bissada, N., McCutcheon, K. M., Nasir, J., et al. (1999) · Neuron · doi:10.1016/s0896-6273(00)80764-3 · Cited by 832 · see citing works
Mitochondria, oxidative stress and neurodegeneration
Federico, A., Cardaioli, E., Pozzo, P. D., Formichi, P., Gallus, G. N., & Radi, E. (2012) · Journal of the Neurological Sciences · doi:10.1016/j.jns.2012.05.030 · Cited by 790 · see citing works
Al-Atrache, Z., Cader, A., & Appelt, D. M. (2016) · Alzheimer s & Dementia · doi:10.1016/j.jalz.2016.06.894 · Cited by 765 · see citing works
Frataxin is Reduced in Friedreich Ataxia Patients and is Associated with Mitochondrial Membranes
Campuzano, V., Montermini, L., Lutz, Y., Cova, L., Hindelang, C., Jiralerspong, S., Trottier, Y., Kish, S. J., Faucheux, B. A., Trouillas, P., et al. (1997) · Human Molecular Genetics · doi:10.1093/hmg/6.11.1771 · Cited by 739 · see citing works
Lannfelt, L., Blennow, K., Zetterberg, H., Batsman, S., Ames, D., Harrison, J., Masters, C. L., Targum, S., Bush, A. I., Murdoch, R., et al. (2008) · The Lancet Neurology · doi:10.1016/s1474-4422(08)70167-4 · Cited by 725 · see citing works
Mitochondrial Defects and Oxidative Stress in Alzheimer Disease and Parkinson Disease
Yan, M. H., Wang, X., & Zhu, X. (2013) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2012.11.014 · Cited by 718 · see citing works
Genetics of Parkinson disease: paradigm shifts and future prospects
Farrer, M. J. (2006) · Nature Reviews Genetics · doi:10.1038/nrg1831 · Cited by 709 · see citing works
Complexity of dopamine metabolism
Meiser, J., Weindl, D., & Hiller, K. (2013) · Cell Communication and Signaling · doi:10.1186/1478-811x-11-34 · Cited by 665 · see citing works
Protein Oxidation in Aging and Age‐Related Diseases
Stadtman, E. R. (2001) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.2001.tb05632.x · Cited by 660 · see citing works
Curtain, C. C., Ali, F. E. A., Volitakis, I., Cherny, R. A., Norton, R. S., Beyreuther, K. T., Barrow, C. J., Masters, C. L., Bush, A. I., & Barnham, K. J. (2001) · Journal of Biological Chemistry · doi:10.1074/jbc.m100175200 · Cited by 653 · see citing works
Weydt, P., Pineda, V. V., Torrence, A. E., Libby, R. T., Satterfield, T. F., Lazarowski, E. R., Gilbert, M. L., Morton, G. J., Bammler, T. K., Strand, A. D., et al. (2006) · Cell Metabolism · doi:10.1016/j.cmet.2006.10.004 · Cited by 562 · see citing works
de Rijk, M. C., Launer, L. J., Berger, K., Breteler, M. M. B., Dartigues, J. F., Baldereschi, M., Fratiglioni, L., Lobo, A., Martinez-Lage, J., Trenkwalder, C., et al. (2000) · PubMed · Cited by 528 · see citing works
Prevalence of Parkinson's disease in Europe : A collaborative study of population-based cohorts
de Rijk, M. C., Launer, L. J., Berger, K., Breteler, M. M. B., Dartigues, J. F., Baldereschi, M., Fratiglioni, L., Lobo, A., Martínez‐Lage, J. M., Trenkwalder, C., et al. (2000) · EUR Research Repository (Erasmus University Rotterdam) · Cited by 514 · see citing works
Oxidative stress in Huntington’s disease
Browne, S. E., Ferrante, R. J., & Beal, M. F. (1999) · Brain Pathology · doi:10.1111/j.1750-3639.1999.tb00216.x · Cited by 508 · see citing works
Oxidative stress in Alzheimer disease: A possibility for prevention
Bonda, D., Wang, X., Perry, G. L., Nunomura, A., Tabaton, M., Zhu, X., & Smith, M. A. (2010) · Neuropharmacology · doi:10.1016/j.neuropharm.2010.04.005 · Cited by 481 · see citing works
Rego, A. C., & Oliveira, C. R. (2003) · Neurochemical Research · doi:10.1023/a:1025682611389 · Cited by 472 · see citing works
Risk factors for amyotrophic lateral sclerosis
Fang, F., Ingre, C., Roos, P. M., Kamel, F., & Piehl, F. (2015) · Clinical Epidemiology · doi:10.2147/clep.s37505 · Cited by 470 · see citing works
Adam-Vizi, V. (2005) · Antioxidants & Redox Signaling · doi:10.1089/ars.2005.7.1140 · Cited by 439 · see citing works
Biological and physiological role of reactive oxygen species - the good, the bad and the ugly
Zuo, L., Zhou, T., Pannell, B. K., Ziegler, A. C., & Best, T. M. (2015) · Acta Physiologica · doi:10.1111/apha.12515 · Cited by 430 · see citing works
Self-citationNeuroprotective strategies involving ROS in Alzheimer disease
Dumont, M., & Beal, M. F. (2011) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2010.11.026 · Cited by 402 · see citing works
Smith, M. A., Zhu, X., Tabaton, M., Liu, G., McKeel, D. W., Cohen, M. L., Wang, X., Siedlak, S. L., Dwyer, B. E., Hayashi, T., et al. (2010) · Journal of Alzheimer s Disease · doi:10.3233/jad-2010-1239 · Cited by 400 · see citing works
Neuroinflammation, oxidative stress, and the pathogenesis of Parkinson’s disease
Mosley, R. L., Benner, E. J., Kadiu, I., Thomas, M., Boska, M. D., Hasan, K. M., Laurie, C. D., & Gendelman, H. E. (2006) · Clinical Neuroscience Research · doi:10.1016/j.cnr.2006.09.006 · Cited by 388 · see citing works
NLRP3 inflammasome is expressed and functional in mouse brain microglia but not in astrocytes
Gustin, A., Kirchmeyer, M., Koncina, E., Felten, P., Losciuto, S., Heurtaux, T., Tardivel, A., Heuschling, P., & Dostert, C. (2015) · PLoS ONE · doi:10.1371/journal.pone.0130624 · Cited by 369 · see citing works
Huntington's disease: underlying molecular mechanisms and emerging concepts
Labbadia, J. P., & Morimoto, R. I. (2013) · Trends in Biochemical Sciences · doi:10.1016/j.tibs.2013.05.003 · Cited by 368 · see citing works
Johnstone, M., Gearing, A., & Miller, K. (1999) · Journal of Neuroimmunology · doi:10.1016/s0165-5728(98)00226-4 · Cited by 353 · see citing works
Bonora, M., Wieckowski, M. R., Chinopoulos, C., Kepp, O., Kroemer, G., Galluzzi, L., & Pinton, P. (2015) · Oncogene · doi:10.1038/onc.2014.96 · Cited by 330 · see citing works
Clinical perspective on oxidative stress in sporadic amyotrophic lateral sclerosis
D’Amico, E., Factor-Litvak, P. R., Santella, R. M., & Mitsumoto, H. (2013) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2013.06.029 · Cited by 324 · see citing works
Is SOD1 loss of function involved in amyotrophic lateral sclerosis?
Saccon, R. A., Bunton-Stasyshyn, R. K. A., Fisher, E., & Fratta, P. (2013) · Brain · doi:10.1093/brain/awt097 · Cited by 318 · see citing works
The Genetics of Parkinson Disease
Bekris, L. M., Mata, I. F., & Zabetian, C. P. (2010) · Journal of Geriatric Psychiatry and Neurology · doi:10.1177/0891988710383572 · Cited by 307 · see citing works
Redox imbalance in Parkinson's disease
Chinta, S. J., & Andersen, J. K. (2008) · Biochimica et Biophysica Acta (BBA) - General Subjects · doi:10.1016/j.bbagen.2008.02.005 · Cited by 302 · see citing works
Proteomic and oxidative stress analysis in human brain samples of Huntington disease
Sorolla, M. A., Reverter‐Branchat, G., Tamarit, J., Ferrer, I., Ros, J., & Cabiscol, E. (2008) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2008.05.014 · Cited by 300 · see citing works
Mitochondrial dysfunction and oxidative stress in aging and neurodegenerative disease
Albers, D. S., & Beal, M. F. (2000) · Springer eBooks · doi:10.1007/978-3-7091-6781-6_16 · Cited by 297 · see citing works
The Potential of HDAC Inhibitors as Cognitive Enhancers
Gräff, J., & Tsai, L. (2013) · The Annual Review of Pharmacology and Toxicology · doi:10.1146/annurev-pharmtox-011112-140216 · Cited by 297 · see citing works
Ganguly, G., Chakrabarti, S., Chatterjee, U., & Saso, L. (2017) · Drug Design Development and Therapy · doi:10.2147/dddt.s130514 · Cited by 295 · see citing works
Mitochondria: A therapeutic target in neurodegeneration
Moreira, P. I., Zhu, X., Wang, X., Lee, H., Nunomura, A., Petersen, R. B., Perry, G. L., & Smith, M. A. (2009) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/j.bbadis.2009.10.007 · Cited by 286 · see citing works
Shelat, P. B., Chalimoniuk, M., Wang, J., Strosznajder, J. B., Lee, J. C., Sun, A. Y., Simonyi, Á., & Sun, G. Y. (2008) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.2008.05347.x · Cited by 283 · see citing works
The wide spectrum of spinocerebellar ataxias (SCAs)
Manto, M. (2008) · Cerebellum · doi:10.1080/14734220510007914 · Cited by 281 · see citing works
Reactive Oxygen Species: Stuck in the Middle of Neurodegeneration
Patten, D. A., Germain, M., Kelly, M., & Slack, R. S. (2010) · Journal of Alzheimer s Disease · doi:10.3233/jad-2010-100498 · Cited by 280 · see citing works
Intake of vitamin E, vitamin C, and carotenoids and the risk of Parkinson's disease: a meta-analysis
Etminan, M., Gill, S. S., & Samii, A. (2005) · The Lancet Neurology · doi:10.1016/s1474-4422(05)70097-1 · Cited by 279 · see citing works
Mutant huntingtin and mitochondrial dysfunction
Bossy‐Wetzel, E., Petrilli, A. M., & Knott, A. B. (2008) · Trends in Neurosciences · doi:10.1016/j.tins.2008.09.004 · Cited by 269 · see citing works
Giraldo, E., Lloret, A., Fuchsberger, T., & Viña, J. (2014) · Redox Biology · doi:10.1016/j.redox.2014.03.002 · Cited by 268 · cited 1× · see citing works
“An abnormal accumulation of hyperphosphorylated tau proteins can lead to intracellular NFT formation (Figure 1) [41, 42].”
BackgroundButterfield, D. A., & Debra Boyd-kimball, A. (2004) · Biochimica et Biophysica Acta (BBA) - Proteins and Proteomics · doi:10.1016/j.bbapap.2004.10.014 · Cited by 267 · see citing works
Pang, T. Y. C., Stam, N. C., Nithianantharajah, J., Howard, M. L., & Hannan, A. J. (2006) · Neuroscience · doi:10.1016/j.neuroscience.2006.04.013 · Cited by 265 · see citing works
Nuclear factor erythroid 2-related factor 2 protects against beta amyloid
Kanninen, K. M., Malm, T., Jyrkkänen, H.-K., Goldsteins, G., Keksa-Goldsteine, V., Tanila, H., Yamamoto, M. P., Ylä‐Herttuala, S., Levonen, A., & Koıstınaho, J. (2008) · Molecular and Cellular Neuroscience · doi:10.1016/j.mcn.2008.07.010 · Cited by 256 · see citing works
Redox Roles of Reactive Oxygen Species in Cardiovascular Diseases
He, F. J., & Zuo, L. (2015) · International Journal of Molecular Sciences · doi:10.3390/ijms161126059 · Cited by 240 · see citing works
Self-citationParkin protects human dopaminergic neuroblastoma cells against dopamine-induced apoptosis
Jiang, H., Ren, Y., Zhao, J., & Feng, J. (2004) · Human Molecular Genetics · doi:10.1093/hmg/ddh180 · Cited by 239 · see citing works
Oxidative Stress and Huntington’s Disease: The Good, the Bad, and the Ugly
Kumar, A., & Ratan, R. R. (2016) · Journal of Huntington s Disease · doi:10.3233/jhd-160205 · Cited by 236 · see citing works
Lodi, R., Hart, P. E., Rajagopalan, B., Taylor, D. J., Crilley, J. G., Bradley, J. L., Blamire, A. M., Manners, D. N., Styles, P., Schapira, A. H. V., et al. (2001) · Annals of Neurology · doi:10.1002/ana.1001 · Cited by 235 · see citing works
Environmental factors and unhealthy lifestyle influence oxidative stress in humans—an overview
Aseervatham, G. S. B., Thilagar, S., Jeyadevi, R., & Ananth, D. A. (2013) · Environmental Science and Pollution Research · doi:10.1007/s11356-013-1748-0 · Cited by 230 · see citing works
Zoghbi, H., & Orr, H. (2009) · Journal of Biological Chemistry · doi:10.1074/jbc.r800041200 · Cited by 228 · see citing works
Minocycline affects microglia activation, Aβ deposition, and behavior in APP‐tg mice
Seabrook, T. J., Jiang, L., Maier, M., & Lemere, C. A. (2006) · Glia · doi:10.1002/glia.20338 · Cited by 223 · see citing works
Nakamura, T., & Lipton, S. A. (2011) · Cell Death and Differentiation · doi:10.1038/cdd.2011.65 · Cited by 222 · see citing works
Energy deficit in Huntington disease: why it matters
Mochel, F., & Haller, R. G. (2011) · Journal of Clinical Investigation · doi:10.1172/jci45691 · Cited by 220 · see citing works
Ferreiro, E. B., Oliveira, C. R., & Pereira, C. (2008) · Neurobiology of Disease · doi:10.1016/j.nbd.2008.02.003 · Cited by 219 · see citing works
Oxidative damage to mitochondrial DNA in Huntington's disease parietal cortex
Polidori, M. C., Mecocci, P., Browne, S. E., Senin, U., & Beal, M. F. (1999) · Neuroscience Letters · doi:10.1016/s0304-3940(99)00578-9 · Cited by 211 · see citing works
A pilot trial of high-dose alpha-tocopherol and ascorbate in early Parkinson's disease
Fahn, S. (1992) · Annals of Neurology · doi:10.1002/ana.410320722 · Cited by 211 · see citing works
DATATOP: A decade of neuroprotective inquiry
Shoulson, I., & Parkinson Study Group (1998) · Annals of Neurology · doi:10.1002/ana.410440724 · Cited by 202 · see citing works
NADPH oxidase as a therapeutic target in Alzheimer's disease
Block, M. L. (2008) · BMC Neuroscience · doi:10.1186/1471-2202-9-s2-s8 · Cited by 202 · see citing works
The impact of reactive oxygen species and genetic mitochondrial mutations in Parkinson's disease
Zuo, L., & Motherwell, M. S. (2013) · Gene · doi:10.1016/j.gene.2013.07.085 · Cited by 194 · see citing works
Self-citationKlepac, N., Relja, M., Klepac, R., Hecimovic, S. K., Babić, T., & Trkulja, V. (2007) · Journal of Neurology · doi:10.1007/s00415-007-0611-y · Cited by 181 · see citing works
Yao, Z., Drieu, K., & Papadopoulos, V. (2001) · Brain Research · doi:10.1016/s0006-8993(00)03131-0 · Cited by 181 · see citing works
Gangemi, S., Gofiţă, E., Costa, C., Teodoro, M., Briguglio, G., Nikitovic, D., Tzanakakis, G. N., Tsatsakis, A. M., Wilks, M. F., Spandidos, D. A., et al. (2016) · International Journal of Molecular Medicine · doi:10.3892/ijmm.2016.2728 · Cited by 181 · see citing works
Hensley, K., Mhatre, M., Mou, S., Pye, Q. N., Stewart, C. A., West, M. S., & Williamson, K. S. (2006) · Antioxidants and Redox Signaling · doi:10.1089/ars.2006.8.2075 · Cited by 168 · see citing works
The Cu, Zn Superoxide Dismutase: Not Only a Dismutase Enzyme
Mondola, P., Damiano, S., Sasso, A., & Santillo, M. (2016) · Frontiers in Physiology · doi:10.3389/fphys.2016.00594 · Cited by 166 · see citing works
Perfeito, R., Cunha‐Oliveira, T., & Rego, A. C. (2013) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2013.05.042 · Cited by 165 · see citing works
Bonora, M., Wieckowsk, M. R., Chinopoulos, C., Kepp, O., Kroemer, G., Galluzzi, L., & Pinton, P. (2015) · Oncogene · doi:10.1038/onc.2014.462 · Cited by 163 · see citing works
Astrocytes and Microglia as Non-cell Autonomous Players in the Pathogenesis of ALS
Lee, J.-H., Hyeon, S. J., Im, H., Ryu, H., Kim, Y., & Ryu, H. (2016) · Experimental Neurobiology · doi:10.5607/en.2016.25.5.233 · Cited by 155 · see citing works
Shoulson, I. (1998) · PubMed · Cited by 154 · see citing works
Isoprostanes and Neuroprostanes as Biomarkers of Oxidative Stress in Neurodegenerative Diseases
Miller, E. D., Morel, A., Saso, L., & Saluk, J. (2014) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2014/572491 · Cited by 154 · see citing works
Antioxidants as therapies: can we improve on nature?
Murphy, M. P. (2013) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2013.04.010 · Cited by 148 · see citing works
Zaitone, S. A., Abo–Elmatty, D. M., & Shaalan, A. A. M. (2011) · Pharmacology Biochemistry and Behavior · doi:10.1016/j.pbb.2011.09.002 · Cited by 141 · see citing works
Hakonen, A. H., Goffart, S., Marjavaara, S. K., Paetau, A. E., Cooper, H., Mattila, K., Lampinen, M., Sajantila, A., Lönnqvist, T. R. I., Spelbrink, J. N., et al. (2008) · Human Molecular Genetics · doi:10.1093/hmg/ddn280 · Cited by 135 · see citing works
Autosomal dominant cerebellar ataxias: a systematic review of clinical features
Rossi, M., Perez‐Lloret, S., Doldan, L., et al. (2014) · European Journal of Neurology · doi:10.1111/ene.12350 · Cited by 134 · see citing works
Consensus Paper: Pathological Mechanisms Underlying Neurodegeneration in Spinocerebellar Ataxias
Matilla‐Dueñas, A., Ashizawa, T., Brice, A., Magri, S., McFarland, K. N., Pandolfo, M., Pulst, S. M., Rieß, O., Rubinsztein, D. C., Schmidt, J., et al. (2013) · The Cerebellum · doi:10.1007/s12311-013-0539-y · Cited by 128 · see citing works
Butterfield, D. A. (2014) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2014.06.006 · Cited by 126 · see citing works
Hamilton, A., & Hölscher, C. (2012) · Brain Research · doi:10.1016/j.brainres.2012.02.015 · Cited by 121 · see citing works
Bolaños, J. P., Moro, M. Á., Lizasoaín, I., & Almeida, Á. (2009) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2009.05.009 · Cited by 119 · see citing works
Zuo, L., Hemmelgarn, B. T., Chuang, C., & Best, T. M. (2015) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2015/604658 · Cited by 118 · see citing works
Self-citationCase-Control Study of Early Life Dietary Factors in Parkinson's Disease
Golbe, L. I., Farrell, T. M., & Davis, P. H. (1988) · Archives of Neurology · doi:10.1001/archneur.1988.00520360068014 · Cited by 115 · see citing works
Reagan, L. P., Magariños, A. M., Yee, D. K., Swzeda, L. I., Bueren, A. M. V., McCall, A. L., & McEwen, B. S. (2000) · Brain Research · doi:10.1016/s0006-8993(00)02212-5 · Cited by 114 · see citing works
Spinocerebellar ataxia: relationship between phenotype and genotype – a review
Sun, Y.-M., Lu, C., & Wu, Z.-Y. (2016) · Clinical Genetics · doi:10.1111/cge.12808 · Cited by 113 · see citing works
Perfeito, R., Cunha‐Oliveira, T., & Rego, A. C. (2012) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2012.08.569 · Cited by 108 · see citing works
Awasthi, A., Matsunaga, Y., & Yamada, T. (2005) · Experimental Neurology · doi:10.1016/j.expneurol.2005.08.001 · Cited by 102 · see citing works
The role of oxidative stress in Huntington’s disease: Are antioxidants good therapeutic candidates?
Gil-Mohapel, J., Brocardo, P., & Christie, B. (2014) · Current Drug Targets · doi:10.2174/1389450115666140115113734 · Cited by 101 · see citing works
Dávila, D., & Torres‐Alemán, I. (2008) · Molecular Biology of the Cell · doi:10.1091/mbc.e07-08-0811 · Cited by 96 · see citing works
Li, Q., Spencer, N. Y., Pantazis, N. J., & Engelhardt, J. F. (2011) · Journal of Biological Chemistry · doi:10.1074/jbc.m111.279711 · Cited by 95 · see citing works
Important Role of Oxidative Stress Biomarkers in Huntington’s Disease
Túnez, I., Sánchez‐López, F., Agüera, E., Fernández‐Bolaños, R., Sánchez, F. M., & Tasset-Cuevas, I. (2011) · Journal of Medicinal Chemistry · doi:10.1021/jm200605a · Cited by 93 · see citing works
Nakamura, T., & Lipton, S. A. (2010) · Cell Calcium · doi:10.1016/j.ceca.2009.12.009 · Cited by 92 · see citing works
The genetics of Parkinson's disease
de Silva, H. R. (2000) · Current Opinion in Genetics & Development · doi:10.1016/s0959-437x(00)00082-4 · Cited by 92 · see citing works
Gámez, J., Corbera‐Bellalta, M., Nogales‐Gadea, G., et al. (2006) · Journal of the Neurological Sciences · doi:10.1016/j.jns.2006.03.006 · Cited by 82 · see citing works
Alpha-tocopherol in the ventricular cerebrospinal fluid of Parkinson's disease patients
Pappert, E. J., Tangney, C., Goetz, C. G., Ling, Z. D., Lipton, J. W., Stebbins, G. T., & Carvey, P. M. (1996) · Neurology · doi:10.1212/wnl.47.4.1037 · Cited by 77 · see citing works
Overactivation of calcineurin induced by amyloid-beta and prion proteins
Agostinho, P. M., Lopes, J. P., Velez, Z., & Oliveira, C. R. (2008) · Neurochemistry International · doi:10.1016/j.neuint.2008.01.005 · Cited by 76 · see citing works
Nizzari, M., Thellung, S., Corsaro, A., Villa, V., Pagano, A., Porcile, C., Russo, C., & Florio, T. (2012) · Journal of Toxicology · doi:10.1155/2012/187297 · Cited by 70 · see citing works
Stucki, D., Ruegsegger, C., Steiner, S., Radecke, J., Murphy, M. P., Zuber, B., & Saxena, S. (2016) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2016.07.005 · Cited by 70 · see citing works
Motor neuron impairment mediated by a sumoylated fragment of the glial glutamate transporter EAAT2
Foran, E., Bogush, A. I., Goffredo, M., Roncaglia, P., Gustincich, S., Pasinelli, P., & Trotti, D. (2011) · Glia · doi:10.1002/glia.21218 · Cited by 66 · see citing works
Energy defects in Huntington's disease: Why “in vivo” evidence matters
Liot, G., Valette, J., Pépin, J., Flament, J., & Brouillet, E. (2016) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2016.09.065 · Cited by 65 · see citing works
Vitamin E and memantine in Alzheimer's disease: Clinical trial methods and baseline data
Dysken, M. W., Guarino, P., Vertrees, J. E., Asthana, S., Sano, M. C., Llorente, M. D., Pallaki, M., Love, S. B., Schellenberg, G. D., McCarten, J. R., et al. (2013) · Alzheimer s & Dementia · doi:10.1016/j.jalz.2013.01.014 · Cited by 59 · see citing works
Mondola, P., Ruggiero, G., Serù, R., Damiano, S., Grimaldi, S., Garbi, C., Monda, M., Greco, D., & Santillo, M. (2003) · Molecular Brain Research · doi:10.1016/s0169-328x(02)00583-1 · Cited by 57 · see citing works
(2000) · Neurology · doi:10.1212/wnl.54.11.21a · Cited by 57 · see citing works
New links between SOD1 and metabolic dysfunction from a yeast model of amyotrophic lateral sclerosis
Bastow, E. L., Peswani, A. R., Tarrant, D., et al. (2016) · Journal of Cell Science · doi:10.1242/jcs.190298 · Cited by 56 · see citing works
Characterization of reactive nitrogen species in allergic asthma
Zuo, L., Koozechian, M., & Chen, L. L. (2013) · Annals of Allergy Asthma & Immunology · doi:10.1016/j.anai.2013.10.007 · Cited by 53 · see citing works
Self-citationLi, K., Hala, T. J., Seetharam, S., Poulsen, D. J., Wright, M. C., & Lepore, A. C. (2015) · Neurobiology of Disease · doi:10.1016/j.nbd.2015.03.010 · Cited by 49 · see citing works
Covarrubias‐Pinto, A., Moll, P., Solís‐Maldonado, M., Acuña, A. I., Riveros, A., Miró, M. P., Papic, E., Beltrán, F. A., Cepeda, C., Concha, I. I., et al. (2015) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2015.09.024 · Cited by 48 · see citing works
Medicinal Plants as Protective Strategies Against Parkinson's Disease
Mazo, N. A., Echeverrı́a, V., Cabezas, R., et al. (2017) · Current Pharmaceutical Design · doi:10.2174/1381612823666170316142803 · Cited by 44 · see citing works
Mondola, P., Annella, T., Serù, R., et al. (1998) · Brain Research Bulletin · doi:10.1016/s0361-9230(97)00438-3 · Cited by 43 · see citing works
Caspase substrates and neurodegenerative diseases
Bulat, N., & Widmann, C. (2009) · Brain Research Bulletin · doi:10.1016/j.brainresbull.2009.07.007 · Cited by 41 · see citing works
Zuo, L., Shiah, A. A., Roberts, W. J., Chien, M. T., Wagner, P. D., & Hogan, M. C. (2013) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.00563.2012 · Cited by 39 · see citing works
Self-citationJeon, S., Hur, J., Jeong, H. J., Koo, B., & Pak, S. C. (2011) · The American Journal of Chinese Medicine · doi:10.1142/s0192415x11009305 · Cited by 38 · see citing works
Mondola, P., Santillo, M., Serù, R., Damiano, S., Alvino, C. G., Ruggiero, G., Formisano, P., Terrazzano, G., Secondo, A., & Annunziato, L. (2004) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2004.09.131 · Cited by 35 · see citing works
Qin, L., Tan, J., Zhang, H., Kousar, R., Lu, J., Tang, J., Jiang, B., Shen, X., Guo, J., Tang, B., et al. (2017) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2017/5094934 · Cited by 30 · see citing works
Damiano, S., Petrozziello, T., Ucci, V., Amente, S., Santillo, M., & Mondola, P. (2012) · Molecular and Cellular Neuroscience · doi:10.1016/j.mcn.2012.11.001 · Cited by 29 · see citing works
Ciancarelli, I. (2015) · Functional Neurology · doi:10.11138/fneur/2015.30.1.047 · Cited by 28 · see citing works
Role of Physical Exercise as Complementary Treatment for Epilepsy and other Brain Disorders
Arida, R. M., Scorza, F. A., & Cavalheiro, É. A. (2013) · Current Pharmaceutical Design · doi:10.2174/1381612811319380004 · Cited by 28 · see citing works
Yu, Q. J., & Yang, Y. (2016) · Life Sciences · doi:10.1016/j.lfs.2016.02.005 · Cited by 22 · see citing works
Neuroprotective effect of antioxidant compounds
Skouta, R. (2016) · Neural Regeneration Research · doi:10.4103/1673-5374.180738 · Cited by 8 · see citing works
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An Overview of Oxidative Stress, Neuroinflammation, and Neurodegenerative Diseases
Teleanu, D. M., Niculescu, A.-G., Lungu, I. I., Radu, C. I., Vladâcenco, O., Roza, E., Costăchescu, B., Grumezescu, A. M., & Teleanu, R. I. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms23115938 · Cited by 1,085 · see citing works
Recent Advancements in Pathogenesis, Diagnostics and Treatment of Alzheimer’s Disease
Khan, S., Barve, K. H., & Kumar, M. S. (2020) · Current Neuropharmacology · doi:10.2174/1570159x18666200528142429 · Cited by 820 · see citing works
“Aβ proteins can directly activate nicotinamide adenine dinucleotide phosphate hydrogen (NADPH) oxidase to initiate the synthesis of free radicals [31].”
BackgroundExercise-induced oxidative stress: Friend or foe?
Powers, S. K., Deminice, R., Ozdemir, M., Yoshihara, T., Bomkamp, M. P., & Hyatt, H. (2020) · Journal of Sport and Health Science · doi:10.1016/j.jshs.2020.04.001 · Cited by 655 · see citing works
Ageing, age-related diseases and oxidative stress: What to do next?
Luo, J., Mills, K., le Cessie, S., Noordam, R., & van Heemst, D. (2020) · Ageing Research Reviews · doi:10.1016/j.arr.2019.100982 · Cited by 581 · see citing works
Health benefits of resveratrol: Evidence from clinical studies
Singh, A. P., Singh, R., Verma, S. S., Rai, V., Kaschula, C. H., Maiti, P., & Gupta, S. C. (2019) · Medicinal Research Reviews · doi:10.1002/med.21565 · Cited by 523 · see citing works
Nanotechnology: A Promising Approach for Delivery of Neuroprotective Drugs
Naqvi, S., Panghal, A., & Flora, S. J. S. (2020) · Frontiers in Neuroscience · doi:10.3389/fnins.2020.00494 · Cited by 305 · see citing works
Neuroprotective Natural Products for Alzheimer’s Disease
Chen, X., Drew, J., Berney, W., & Lei, W. (2021) · Cells · doi:10.3390/cells10061309 · Cited by 236 · see citing works
Oxidant/Antioxidant Imbalance in Alzheimer’s Disease: Therapeutic and Diagnostic Prospects
Wojsiat, J., Zoltowska, K. M., Laskowska-Kaszub, K., & Wojda, U. (2018) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2018/6435861 · Cited by 221 · see citing works
Griñán-Ferré, C., Bellver-Sanchis, A., Izquierdo, V., Corpas, R., Roig-Soriano, J., Chillón, M., Andres-Lacueva, C., Somogyvári, M., Sőti, C., Sanfeliu, C., et al. (2021) · Ageing Research Reviews · doi:10.1016/j.arr.2021.101271 · Cited by 208 · see citing works
Neurotheranostics as Personalized Medicines
Kevadiya, B. D., Ottemann, B. M., Thomas, M. B., Mukadam, I., Nigam, S., McMillan, J., Gorantla, S., Bronich, T. K., Edagwa, B., & Gendelman, H. E. (2019) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2018.10.011 · Cited by 124 · see citing works
Palasz, E., Niewiadomski, W., Gasiorowska, A., Wysocka, A., Stepniewska, A., & Niewiadomska, G. (2019) · Frontiers in Neurology · doi:10.3389/fneur.2019.01143 · Cited by 95 · see citing works
Lodato, M. A., & Walsh, C. A. (2019) · Human Molecular Genetics · doi:10.1093/hmg/ddz191 · Cited by 56 · see citing works
Angeloni, S., Freschi, M., Marrazzo, P., Hrelia, S., Beghelli, D., Juan-García, A., Juan, C., Caprioli, G., Sagratini, G., & Angeloni, C. (2021) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2021/6620913 · Cited by 50 · see citing works
Kim, W. S., Kim, Y.-E., Cho, E.-J., Byun, E.-B., Park, W. Y., Song, H.-Y., Kim, K., Park, S.-H., & Byun, E.-H. (2020) · Bioscience, Biotechnology, and Biochemistry · doi:10.1080/09168451.2020.1715201 · Cited by 37 · see citing works
Stefanova, N. A., Ershov, N. I., & Kolosova, N. G. (2019) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2019/3984906 · Cited by 40 · see citing works
Gu, Y., Zhang, Q., Huang, H., Ho, K. H. W., Zhang, Y., Yi, C., Zheng, Y., Chang, R. C. C., Wang, E. S., & Yang, M. (2024) · Theranostics · doi:10.7150/thno.98462 · Cited by 27 · see citing works
Bacci, A., Runfola, M., Sestito, S., & Rapposelli, S. (2021) · Antioxidants · doi:10.3390/antiox10030367 · Cited by 23 · see citing works
Kumar, S., Yadav, A., Verma, R. K., Kumar, A., Gupta, P. K., & Shukla, R. (2025) · Molecular Pharmaceutics · doi:10.1021/acs.molpharmaceut.5c00386 · Cited by 14 · see citing works
Tsap, M. I., Yatsenko, A. S., Hegermann, J., Beckmann, B., Tsikas, D., & Shcherbata, H. R. (2024) · eLife · doi:10.7554/elife.98020 · Cited by 8 · see citing works
- Authors
- Liu, Z., Zhou, T., Ziegler, A. C., Dimitrion, P., & Zuo, L.
- Affiliations
- The Ohio State University Wexner Medical Center (US)
- Johns Hopkins University (US)
- Corresponding author
- Zuo, Li
- Venue
- Oxidative Medicine and Cellular Longevity
- Publisher
- Wiley
- Published
- 2017-01
- Volume
- 2017
- Issue
- 1
- Pages
- 2525967-2525967
- ISSN
- 1942-0994 (ISSN-L)
- 1942-0900
- PMC
- PMC5529664
- OpenAlex
- W2735791958
- Cited by
- 810
- References
- 149
- Citations by year
- 2026: 31 · 2025: 87 · 2024: 95 · 2023: 96 · 2022: 100 · 2021: 106 · 2020: 130 · 2019: 96 · 2018: 60 · 2017: 9
- FWCI
- 7.54
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Locations
- Oxidative Medicine and Cellular Longevity (publishedVersion, cc-by)
- Europe PMC (PubMed Central) (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Redox biology and oxidative stress
- Health Sciences › Medicine › Biochemistry › Antioxidant Activity and Oxidative Stress
- Health Sciences › Medicine › Physiology › Alzheimer's disease research and treatments
- Keywords
- oxidative stress, neurodegenerative diseases, reactive oxygen species, redox homeostasis, antioxidant therapy, Alzheimer's disease, Huntington's disease, Parkinson's disease, amyotrophic lateral sclerosis, spinocerebellar ataxia, neuronal vulnerability, polyunsaturated fatty acids, antioxidant defense
- MeSH terms
- Animals, Humans, Reactive Oxygen Species, Oxidative Stress, Neurodegenerative Diseases
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