Cited by 810Redox biology and oxidative stressAntioxidant Activity and Oxidative StressAlzheimer's disease research and treatments

Oxidative Stress in Neurodegenerative Diseases: From Molecular Mechanisms to Clinical Applications

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Liu, Zewen, Zhou, Tingyang, Ziegler, Alexander C., Dimitrion, Peter, Zuo, Li·2017·Oxidative Medicine and Cellular Longevity

Abstract

Increasing numbers of individuals, particularly the elderly, suffer from neurodegenerative disorders. These diseases are normally characterized by progressive loss of neuron cells and compromised motor or cognitive function. Previous studies have proposed that the overproduction of reactive oxygen species (ROS) may have complex roles in promoting the disease development. Research has shown that neuron cells are particularly vulnerable to oxidative damage due to their high polyunsaturated fatty acid content in membranes, high oxygen consumption, and weak antioxidant defense. However, the exact molecular pathogenesis of neurodegeneration related to the disturbance of redox balance remains unclear. Novel antioxidants have shown great potential in mediating disease phenotypes and could be an area of interest for further research. In this review, we provide an updated discussion on the roles of ROS in the pathological mechanisms of Alzheimer’s disease, Huntington’s disease, Parkinson’s disease, amyotrophic lateral sclerosis, and spinocerebellar ataxia, as well as a highlight on the antioxidant‐based therapies for alleviating disease severity.

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  • Aβ proteins can directly activate nicotinamide adenine dinucleotide phosphate hydrogen (NADPH) oxidase to initiate the synthesis of free radicals.

    “Aβ proteins can directly activate nicotinamide adenine dinucleotide phosphate hydrogen (NADPH) oxidase to initiate the synthesis of free radicals [31].”
  • A possible linkage between oxidative stress and neurodegenerative disorders such as Huntington disease has been shown in literature.

    “A possible linkage between oxidative stress and neurodegenerative disorders such as HD has been shown in literature”

    From Nanotechnology: A Promising Approach for Delivery of Neuroprotective Drugs (2020) · cites this paper as Liu et al., 2017

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Authors
Liu, Z., Zhou, T., Ziegler, A. C., Dimitrion, P., & Zuo, L.
Affiliations
  • The Ohio State University Wexner Medical Center (US)
  • Johns Hopkins University (US)
Corresponding author
Zuo, Li
Venue
Oxidative Medicine and Cellular Longevity
Publisher
Wiley
Published
2017-01
Volume
2017
Issue
1
Pages
2525967-2525967
ISSN
  • 1942-0994 (ISSN-L)
  • 1942-0900
OpenAlex
W2735791958
Cited by
810
References
149
Citations by year
2026: 31 · 2025: 87 · 2024: 95 · 2023: 96 · 2022: 100 · 2021: 106 · 2020: 130 · 2019: 96 · 2018: 60 · 2017: 9
FWCI
7.54
Type
journal article
Language
en
Open access
Locations
  • Oxidative Medicine and Cellular Longevity (publishedVersion, cc-by)
  • Europe PMC (PubMed Central) (publishedVersion, cc-by)
  • PubMed Central (publishedVersion, cc-by)
  • PubMed (publishedVersion)
  • DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
Topics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Redox biology and oxidative stress
  • Health Sciences › Medicine › Biochemistry › Antioxidant Activity and Oxidative Stress
  • Health Sciences › Medicine › Physiology › Alzheimer's disease research and treatments
Keywords
oxidative stress, neurodegenerative diseases, reactive oxygen species, redox homeostasis, antioxidant therapy, Alzheimer's disease, Huntington's disease, Parkinson's disease, amyotrophic lateral sclerosis, spinocerebellar ataxia, neuronal vulnerability, polyunsaturated fatty acids, antioxidant defense
MeSH terms
Animals, Humans, Reactive Oxygen Species, Oxidative Stress, Neurodegenerative Diseases

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