The DOI matches its Crossref record; 12 of the 12 references it cites were found in a registry or an index.
Caffeine and Adenosine
Open accessAbstract
Caffeine causes most of its biological effects via antagonizing all types of adenosine receptors (ARs): A1, A2A, A3, and A2B and, as does adenosine, exerts effects on neurons and glial cells of all brain areas. In consequence, caffeine, when acting as an AR antagonist, is doing the opposite of activation of adenosine receptors due to removal of endogenous adenosinergic tonus. Besides AR antagonism, xanthines, including caffeine, have other biological actions: they inhibit phosphodiesterases (PDEs) (e.g., PDE1, PDE4, PDE5), promote calcium release from intracellular stores, and interfere with GABA-A receptors. Caffeine, through antagonism of ARs, affects brain functions such as sleep, cognition, learning, and memory, and modifies brain dysfunctions and diseases: Alzheimer's disease, Parkinson's disease, Huntington's disease, Epilepsy, Pain/Migraine, Depression, Schizophrenia. In conclusion, targeting approaches that involve ARs will enhance the possibilities to correct brain dysfunctions, via the universally consumed substance that is caffeine.
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Cites
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“However, in the case of caffeine, the effects seen at very low doses, achieved during normal human consumption, are mostly due to AR antagonism [2].”
InfluentialAssociation of coffee and caffeine intake with the risk of Parkinson disease
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Role of neurotrophic factors in depression
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Adenosine A2A, but not A1, receptors mediate the arousal effect of caffeine
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An Update on the Mechanisms of the Psychostimulant Effects of Caffeine
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“Caffeine improves cognition [1]; however, it also affects sleep [3].”
Doody, R. S. (2001) · Archives of Neurology · doi:10.1001/archneur.58.3.427 · Cited by 362
The neuroprotective effects of caffeine: A prospective population study (the Three City Study)
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Association between A2a receptor gene polymorphisms and caffeine-induced anxiety
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Adenosine: does it have a neuroprotective role after all?
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Self-citation
Cited by
Caffeine: Cognitive and Physical Performance Enhancer or Psychoactive Drug?
Cappelletti, S., Daria, P., Sani, G., & Aromatario, M. (2015) · Current Neuropharmacology · doi:10.2174/1570159x13666141210215655 · Cited by 631
“Caffeine blocks adenosine receptors, mainly A1 and A2A subtypes, competitively antagonizing their action [40, 41] and causing an increased release of dopamine, noradrenalin, and glutamate [42, 43].”
BackgroundPsychostimulants and Cognition: A Continuum of Behavioral and Cognitive Activation
Wood, S., Sage, J. R., Shuman, T., & Anagnostaras, S. G. (2014) · Pharmacological Reviews · doi:10.1124/pr.112.007054 · Cited by 259
Effects of caffeine on sleep and cognition
Snel, J., & Lorist, M. M. (2011) · Progress in brain research · doi:10.1016/b978-0-444-53817-8.00006-2 · Cited by 187
Caffeine as a factor influencing the functioning of the human body-friend or foe?
Rodak, K., Kokot, I., & Kratz, E. M. (2021) · Nutrients · doi:10.3390/nu13093088 · Cited by 188
Adenosine receptor antagonists including caffeine alter fetal brain development in mice
Silva, C. G., Métin, C., Fazeli, W., Machado, N. J., Darmopil, S., Launay, P.-S., Ghestem, A., Nesa, M.-P., Bassot, E., Szabó, E., et al. (2013) · Science Translational Medicine · doi:10.1126/scitranslmed.3006258 · Cited by 177
Metadata
- Authors
- Ribeiro, J. A., & Sebastião, A. M.
- Venue
- Journal of Alzheimer's Disease
- Publisher
- SAGE Publications
- Published
- 2010-04-14
- Volume
- 20
- Issue
- s1
- Pages
- S3-S15
- ISSN
- 1387-2877 (ISSN-L)
- 1875-8908
- OpenAlex
- W2097533515
- Cited by
- 577
- References
- 12
- FWCI
- 13.52
- Type
- journal article
- Language
- en
- Open access
- hybrid
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