Caffeine as a factor influencing the functioning of the human body-friend or foe?

Rodak, Kamil; Kokot, Izabela; Kratz, Ewa Maria

doi:10.3390/nu13093088

Cited by 188Coffee research and impactsAlcohol Consumption and Health EffectsTea Polyphenols and Effects

Caffeine as a factor influencing the functioning of the human body-friend or foe?

Open access

Rodak, Kamil, Kokot, Izabela, Kratz, Ewa Maria·2021·Nutrients

DOI 10.3390/nu13093088PMC PMC8467199

Open this paper in CoChat — free account Open PDF

Abstract

Nowadays, caffeine is one of the most commonly consumed substances, which presents in many plants and products. It has both positive and negative effects on the human body, and its activity concerns a variety of systems including the central nervous system, immune system, digestive system, respiratory system, urinary tract, etc. These effects are dependent on quantity, the type of product in which caffeine is contained, and also on the individual differences among people (sex, age, diet etc.). The main aim of this review was to collect, present, and analyze the available information including the latest discoveries on the impact of caffeine on human health and the functioning of human body systems, taking into account the role of caffeine in individual disease entities. We present both the positive and negative sides of caffeine consumption and the healing properties of this purine alkaloid in diseases such as asthma, Parkinson's disease, and others, not forgetting about the negative effects of excess caffeine (e.g., in people with hypertension, children, adolescents, and the elderly). In summary, we can conclude, however, that caffeine has a multi-directional influence on various organs of the human body, and because of its anti-oxidative properties, it was, and still is, an interesting topic for research studies including those aimed at developing new therapeutic strategies.

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Integrity signals

Registry

Crossref · 10.3390/nu13093088

Cites

204 of 204 references verified0 citation errors · 0 not checkable

Statistics

Claims the paper makes

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

The cut-off time for doses of caffeine contained in a standard cup of coffee or a standard serve of pre-workout supplement occur substantially earlier than anecdotally expected, and well before timings based on the typical half-life of three to six h.
“These fi ndings suggest the cut-off time for doses of caffeine contained in a standard cup of coffee or a standard serve of pre-workout supplement occur substantially earlier than anecdotally expected, and well before timings based on the typical half-life of three to six h [18,86,87].”
From The effect of caffeine on subsequent sleep: A systematic review and meta-analysis (2023) · cites this paper as [86]
Section 1.2, “Metabolism of Caffeine” (page unavailable), gives a metabolic half-life of 3–5 hours, rather than the cited 3–6 hours. The earlier cut-off times are presented as the citing authors’ own findings, not as a finding attributed to this source. (LLM, conf=0.84)
Experimental — accuracy not yet measured

Self-check

Percentages, sums and reported differences re-computed from the paper’s own numbers.

The self-check needs the paper’s full text.

A novel gene containing a trinucleotide repeat that is expanded and unstable on Huntington's disease chromosomes
MACDONALD, M. (1993) · Cell · doi:10.1016/0092-8674(93)90585-e · Cited by 8,366 · see citing works
Association between Water Intake, Chronic Kidney Disease, and Cardiovascular Disease: A Cross-Sectional Analysis of NHANES Data
Sontrop, J. M., Dixon, S. N., Garg, A. X., Jiménez, I. B., Dohein, O., Huang, S. S., & Clark, W. F. (2013) · American Journal of Nephrology · doi:10.1159/000350377 · Cited by 5,903 · see citing works
Risk Factors for Alzheimer's Disease: A Prospective Analysis from the Canadian Study of Health and Aging
Lindsay, J. (2002) · American Journal of Epidemiology · doi:10.1093/aje/kwf074 · Cited by 1,261 · see citing works
Effects of caffeine on human health
Nawrot, P., Jordan, S., Eastwood, J., Rotstein, J., Hugenholtz, A., & Feeley, M. (2003) · Food Additives and Contaminants · doi:10.1080/0265203021000007840 · Cited by 1,199 · see citing works
Caffeine (1, 3, 7‐trimethylxanthine) in Foods: A Comprehensive Review on Consumption, Functionality, Safety, and Regulatory Matters
Heckman, M. A., Weil, J., & de Mejı́a, E. G. (2010) · Journal of Food Science · doi:10.1111/j.1750-3841.2010.01561.x · Cited by 1,072 · see citing works
Health effects of energy drinks on children, adolescents, and young adults
Seifert, S. M., Schaechter, J. L., Hershorin, E. R., & Lipshultz, S. E. (2011) · Pediatrics · doi:10.1542/peds.2009-3592 · Cited by 893 · see citing works
Molecular Mechanisms and Potential Therapeutical Targets in Huntington's Disease
Zuccato, C., Valenza, M., & Cattaneo, E. (2010) · Physiological Reviews · doi:10.1152/physrev.00041.2009 · Cited by 848 · see citing works
A Review of Caffeine’s Effects on Cognitive, Physical and Occupational Performance
McLellan, T. M., Caldwell, J. A., & Lieberman, H. R. (2016) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2016.09.001 · Cited by 840 · see citing works
Adenosine–dopamine receptor–receptor interactions as an integrative mechanism in the basal ganglia
Ferré, S., Fuxé, K., Fredholm, B. B., Morelli, M., & Popoli, P. (1997) · Trends in Neurosciences · doi:10.1016/s0166-2236(97)01096-5 · Cited by 825 · see citing works
Adenosine in the central nervous system: release mechanisms and extracellular concentrations
Latini, S., & Pedata, F. (2001) · Journal of Neurochemistry · doi:10.1046/j.1471-4159.2001.00607.x · Cited by 779 · see citing works
Association of coffee and caffeine intake with the risk of Parkinson disease
Ross, G. W. (2000) · JAMA · doi:10.1001/jama.283.20.2674 · Cited by 778 · see citing works
Effects of Caffeine on Plasma Renin Activity, Catecholamines and Blood Pressure
Robertson, D., Frölich, J. C., Carr, R. K., Watson, J. T., Hollifield, J. W., Shand, D. G., & Oates, J. A. (1978) · New England Journal of Medicine · doi:10.1056/nejm197801262980403 · Cited by 757 · see citing works
Functional significance of a C–>A polymorphism in intron 1 of the cytochrome P450 CYP1A2 gene tested with caffeine
Sachse, C., Brockmöller, J., Bauer, S., & Roots, I. (1999) · British Journal of Clinical Pharmacology · doi:10.1046/j.1365-2125.1999.00898.x · Cited by 751 · see citing works
Adenosine as a neuromodulator and as a homeostatic regulator in the nervous system: different roles, different sources and different receptors
Cunha, R. A. (2001) · Neurochemistry International · doi:10.1016/s0197-0186(00)00034-6 · Cited by 632 · see citing works
Interindividual Differences in Caffeine Metabolism and Factors Driving Caffeine Consumption
Nehlig, A. (2018) · Pharmacological Reviews · doi:10.1124/pr.117.014407 · Cited by 632 · cited 1× · see citing works
“Gene ADORA2A encodes adenosine receptor A2AR, which plays a role in caffeine metabolism [22].”
Background
Caffeine: Cognitive and Physical Performance Enhancer or Psychoactive Drug?
Cappelletti, S., Daria, P., Sani, G., & Aromatario, M. (2015) · Current Neuropharmacology · doi:10.2174/1570159x13666141210215655 · Cited by 631 · see citing works
Scientific Opinion on the safety of caffeine
EFSA Panel on Dietetic Products, N. A. A. (. (2015) · EFSA Journal · doi:10.2903/j.efsa.2015.4102 · Cited by 613 · see citing works
Adenosine, Adenosine Receptors and the Actions of Caffeine
Fredholm, B. B. (1995) · Pharmacology & Toxicology · doi:10.1111/j.1600-0773.1995.tb00111.x · Cited by 597 · see citing works
Caffeine and Adenosine
Ribeiro, J. A., & Sebastião, A. M. (2010) · Journal of Alzheimer s Disease · doi:10.3233/jad-2010-1379 · Cited by 584 · see citing works
Structure and function of adenosine receptors and their genes
Fredholm, B. B., Arslan, G., Halldner, L., Kull, B., Schulte, G., & Wasserman, W. W. (2000) · Naunyn-Schmiedeberg s Archives of Pharmacology · doi:10.1007/s002100000313 · Cited by 583 · see citing works
The Safety of Ingested Caffeine: A Comprehensive Review
Temple, J. L., Bernard, C., Lipshultz, S. E., Czachor, J. D., Westphal, J. A., & Mestre, M. A. (2017) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2017.00080 · Cited by 557 · see citing works
Neuroprotection by adenosine in the brain: From A1 receptor activation to A2A receptor blockade
Cunha, R. A. (2005) · Purinergic Signalling · doi:10.1007/s11302-005-0649-1 · Cited by 540 · see citing works
Coffee, Caffeine, and Health Outcomes: An Umbrella Review
Grosso, G., Godos, J., Galvano, F., & Giovannucci, E. L. (2017) · Annual Review of Nutrition · doi:10.1146/annurev-nutr-071816-064941 · Cited by 531 · see citing works
Adenosine receptor activation and nociception
Sawynok, J. (1998) · European Journal of Pharmacology · doi:10.1016/s0014-2999(97)01605-1 · Cited by 472 · see citing works
Coffee consumption and risk of type 2 diabetes mellitus
van Dam, R. M., & Feskens, E. J. M. (2002) · The Lancet · doi:10.1016/s0140-6736(02)11436-x · Cited by 444 · see citing works
Nutrients and Oxidative Stress: Friend or Foe?
Tan, B. L., Norhaizan, M. E., & Liew, W.-P.-P. (2018) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2018/9719584 · Cited by 437 · see citing works
Targeting adenosine A2A receptors in Parkinson's disease
Schwarzschild, M. A., Agnati, L. F., Fuxé, K., Chen, J., & Morelli, M. (2006) · Trends in Neurosciences · doi:10.1016/j.tins.2006.09.004 · Cited by 433 · see citing works
Midlife Coffee and Tea Drinking and the Risk of Late-Life Dementia: A Population-Based CAIDE Study
Eskelinen, M. H., Ngandu, T., Tuomilehto, J., Soininen, H., & Kivipelto, M. (2009) · Journal of Alzheimer's Disease · doi:10.3233/jad-2009-0920 · Cited by 428 · see citing works
Dose‐Dependent Pharmacokinetics and Psychomotor Effects of Caffeine in Humans
Kaplan, G. B., Greenblatt, D. J., Ehrenberg, B. L., Goddard, J. E., Cotreau, M. M., Harmatz, J. S., & Shader, R. I. (1997) · The Journal of Clinical Pharmacology · doi:10.1002/j.1552-4604.1997.tb04356.x · Cited by 387 · see citing works
The absolute bioavailability of caffeine in man
Blanchard, J., & Sawers, S. J. A. (1983) · European Journal of Clinical Pharmacology · doi:10.1007/bf00613933 · Cited by 378 · see citing works
Blood pressure response to chronic intake of coffee and caffeine: a meta‐analysis of randomized controlled trials
Noordzij, M., Uiterwaal, C. S., Arends, L. R., Kok, F. J., Grobbee, D. E., & Geleijnse, J. M. (2005) · Journal of Hypertension · doi:10.1097/01.hjh.0000166828.94699.1d · Cited by 376 · see citing works
Caffeine Can Decrease Insulin Sensitivity in Humans
Keijzers, G. B., De Galan, B. E., Tack, C. J., & Smits, P. (2002) · Diabetes Care · doi:10.2337/diacare.25.2.364 · Cited by 358 · see citing works
Does caffeine intake protect from Alzheimer's disease?
Maia, L., & de Mendonça, A. (2002) · European Journal of Neurology · doi:10.1046/j.1468-1331.2002.00421.x · Cited by 357 · see citing works
Adenosine in the spinal cord and periphery: release and regulation of pain
Sawynok, J., & Liu, X. J. (2003) · Progress in Neurobiology · doi:10.1016/s0301-0082(03)00050-9 · Cited by 353 · see citing works
The neuroprotective effects of caffeine: A prospective population study (the Three City Study)
Ritchie, K., Carrière, I., de Mendonça, A., Portet, F., Dartigues, J. F., Rouaud, O., Barberger-Gateau, P., & Ancelin, M. L. (2007) · Neurology · doi:10.1212/01.wnl.0000266670.35219.0c · Cited by 347 · see citing works
Caffeine stimulates hepatic lipid metabolism by the autophagy-lysosomal pathway in mice
Sinha, R. A., Farah, B. L., Singh, B. K., Siddique, M. M., Li, Y., Wu, Y., Ilkayeva, O., Gooding, J. R., Ching, J., Zhou, J., et al. (2013) · Hepatology · doi:10.1002/hep.26667 · Cited by 343 · see citing works
Caffeine use in children: What we know, what we have left to learn, and why we should worry
Temple, J. L. (2009) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2009.01.001 · Cited by 328 · see citing works
Caffeine acts through neuronal adenosine A <sub>2A</sub> receptors to prevent mood and memory dysfunction triggered by chronic stress
Kaster, M. P., Machado, N. J., Silva, H. B., Nunes, A., Ardais, A. P., Santana, M., Baqi, Y., Müller, C. E., Rodrigues, A. L. S., Porciúncula, L. O., et al. (2015) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1423088112 · Cited by 312 · see citing works
The neuroprotective effects of caffeine in neurodegenerative diseases
Kolahdouzan, M., & Hamadeh, M. J. (2017) · CNS Neuroscience & Therapeutics · doi:10.1111/cns.12684 · Cited by 304 · see citing works
Coffee Consumption and Serum Lipids: A Meta-Analysis of Randomized Controlled Clinical Trials
Jee, S. H., He, J., Appel, L. J., Whelton, P. K., Suh, II, & Klag, M. J. (2001) · American Journal of Epidemiology · doi:10.1093/aje/153.4.353 · Cited by 301 · see citing works
Impact of caffeine and coffee on our health
de Mejı́a, E. G., & Ramı́rez-Mares, M. V. (2014) · Trends in Endocrinology and Metabolism · doi:10.1016/j.tem.2014.07.003 · Cited by 300 · see citing works
Effect of Caffeine Ingestion on Muscular Strength and Endurance
Warren, G. L., PARK, N. D., MARESCA, R. D., MCKIBANS, K. I., & MILLARD-STAFFORD, M. L. (2010) · Medicine & Science in Sports & Exercise · doi:10.1249/mss.0b013e3181cabbd8 · Cited by 295 · see citing works
Coffee Consumption and Risk of Type 2 Diabetes Mellitus Among Middle-aged Finnish Men and Women
Tuomilehto, J. O. (2004) · JAMA · doi:10.1001/jama.291.10.1213 · Cited by 281 · see citing works
Increased Caffeine Consumption Is Associated With Reduced Hepatic Fibrosis
Modi, A. A., Feld, J. J., Park, Y., Kleiner, D. E., Everhart, J. E., Liang, J. T., & Hoofnagle, J. H. (2009) · Hepatology · doi:10.1002/hep.23279 · Cited by 279 · see citing works
Beverage Use and Risk for Kidney Stones in Women
Curhan, G. C., Willett, W. C., Speizer, F. E., & Stampfer, M. J. (1998) · Annals of Internal Medicine · doi:10.7326/0003-4819-128-7-199804010-00003 · Cited by 278 · see citing works
Coffee, Caffeine, and Risk of Depression Among Women
Lucas, M. (2011) · Archives of Internal Medicine · doi:10.1001/archinternmed.2011.393 · Cited by 270 · see citing works
Pharmacokinetics and metabolism of natural methylxanthines in animal and man
Arnaud, M. J. (2011) · Handbook of experimental pharmacology · doi:10.1007/978-3-642-13443-2_3 · Cited by 259 · see citing works
Caffeine analogs: biomedical impact
Daly, J. W. (2007) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-007-7051-9 · Cited by 259 · see citing works
Prevalence of caffeine use in elite athletes following its removal from the World Anti-Doping Agency list of banned substances
Del Coso, J., Muñoz, G., & Muñoz-Guerra, J. (2011) · Applied Physiology, Nutrition, and Metabolism · doi:10.1139/h11-052 · Cited by 258 · see citing works
Coffee Reduces Risk for Hepatocellular Carcinoma: An Updated Meta-analysis
Bravi, F., Bosetti, C., Tavani, A., Gallus, S., & Vecchia, C. L. (2013) · Clinical Gastroenterology and Hepatology · doi:10.1016/j.cgh.2013.04.039 · Cited by 252 · see citing works
Nutrition and the Immune System: A Complicated Tango
Venter, C., Eyerich, S., Sarin, T., & Klatt, K. C. (2020) · Nutrients · doi:10.3390/nu12030818 · Cited by 247 · see citing works
Molecular biomarkers of Alzheimer's disease: progress and prospects
Lashley, T., Schott, J. M., Weston, P. S. J., Murray, C. E., Wellington, H., Keshavan, A., Foti, S. C., Foiani, M. S., Toombs, J., Rohrer, J. D., et al. (2018) · Disease Models & Mechanisms · doi:10.1242/dmm.031781 · Cited by 233 · see citing works
The pharmacology of caffeine
Arnaud, M. J. (1987) · Birkhäuser Basel eBooks · doi:10.1007/978-3-0348-9289-6_9 · Cited by 226 · see citing works
Influence of Coffee Drinking on Subsequent Risk of Hepatocellular Carcinoma: A Prospective Study in Japan
Inoue, M., Yoshimi, I., Sobue, T., Tsugane, S., & For the JPHC Study Group (2005) · JNCI Journal of the National Cancer Institute · doi:10.1093/jnci/dji040 · Cited by 225 · see citing works
Shaping of monocyte and macrophage function by adenosine receptors
Haskó, G., Pacher, P., Deitch, E. A., & Vizi, E. S. (2006) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2006.08.003 · Cited by 224 · see citing works
Are the Current Guidelines on Caffeine Use in Sport Optimal for Everyone? Inter-individual Variation in Caffeine Ergogenicity, and a Move Towards Personalised Sports Nutrition
Pickering, C., & Kiely, J. (2017) · Sports Medicine · doi:10.1007/s40279-017-0776-1 · Cited by 221 · see citing works
Association of Coffee, Decaffeinated Coffee and Caffeine Intake from Coffee with Cognitive Performance in Older Adults: National Health and Nutrition Examination Survey (NHANES) 2011–2014.
Dong, X. Z., Li, S., Sun, J., Li, Y., & Zhang, D. (2020) · Nutrients · doi:10.3390/nu12030840 · Cited by 214 · see citing works
Intake of caffeine from all sources and reasons for use by college students
Mahoney, C. R., Giles, G. E., Marriott, B. P., Judelson, D. A., Glickman, E. L., Geiselman, P. J., & Lieberman, H. R. (2018) · Clinical Nutrition · doi:10.1016/j.clnu.2018.04.004 · Cited by 213 · see citing works
Effects of caffeine on bone and the calcium economy
Heaney, R. P. (2002) · Food and Chemical Toxicology · doi:10.1016/s0278-6915(02)00094-7 · Cited by 211 · see citing works
Caffeine as an analgesic adjuvant for acute pain in adults
Derry, C. J., Derry, S., & Moore, R. A. (2014) · Cochrane Database of Systematic Reviews · doi:10.1002/14651858.cd009281.pub3 · Cited by 203 · see citing works
Caffeine Protects Skin from Oxidative Stress-Induced Senescence through the Activation of Autophagy
Li, Y., Ouyang, S., Tu, L., Wang, X., Yuan, W., Wang, G.-E., Wu, Y., Duan, W., Yu, H.-M., Fang, Z., et al. (2018) · Theranostics · doi:10.7150/thno.28778 · Cited by 198 · see citing works
Caffeine counteracts the ergogenic action of muscle creatine loading
Vandenberghe, K., Gillis, N., Van Leemputte, M., Van Hecke, P., Vanstapel, F., & Hespel, P. (1996) · Journal of Applied Physiology · doi:10.1152/jappl.1996.80.2.452 · Cited by 197 · see citing works
Caffeine and risk of Parkinson’s disease in a large cohort of men and women
Palacios, N., Gao, X., McCullough, M. L., Schwarzschild, M. A., Shah, R., Gapstur, S., & Ascherio, A. (2012) · Movement Disorders · doi:10.1002/mds.25076 · Cited by 185 · see citing works
Caffeine induces Ca2+ release by reducing the threshold for luminal Ca2+ activation of the ryanodine receptor
Kong, H., Jones, P. P., Koop, A., Zhang, L., Duff, H. J., & Chen, S. R. W. (2008) · Biochemical Journal · doi:10.1042/bj20080489 · Cited by 184 · see citing works
Associations between coffee consumption and inflammatory markers in healthy persons: the ATTICA study
Zampelas, A., Panagiotakos, D. B., Pitsavos, C. E., Chrysohoou, C. A., & Stefanadis, C. (2004) · American Journal of Clinical Nutrition · doi:10.1093/ajcn/80.4.862 · Cited by 181 · see citing works
Caffeine consumption and self-assessed stress, anxiety, and depression in secondary school children
Richards, G., & Smith, A. (2015) · Journal of Psychopharmacology · doi:10.1177/0269881115612404 · Cited by 179 · see citing works
The influence of a CYP1A2 polymorphism on the ergogenic effects of caffeine
Womack, C. J., Saunders, M. J., Bechtel, M. K., Bolton, D. J., Martin, M., Luden, N. D., Dunham, W., & Hancock, M. (2012) · Journal of the International Society of Sports Nutrition · doi:10.1186/1550-2783-9-7 · Cited by 178 · see citing works
Coffee Consumption and Oxidative Stress: A Review of Human Intervention Studies
Martini, D., Bo’, C. D., Tassotti, M., Riso, P., Rio, D. D., Brighenti, F., & Porrini, M. (2016) · Molecules · doi:10.3390/molecules21080979 · Cited by 178 · see citing works
Caffeine Intake, Smoking, and Risk of Parkinson Disease in Men and Women
Liu, R., Guo, X., Park, Y., Huang, X., Sinha, R. R., Freedman, N. D., Hollenbeck, A. R., Blair, A. E., & Chen, H. (2012) · American Journal of Epidemiology · doi:10.1093/aje/kwr451 · Cited by 171 · see citing works
Dietary caffeine intake and the risk for detrusor instability: a case-control study
Arya, L. A. (2000) · Obstetrics and Gynecology · doi:10.1016/s0029-7844(00)00808-5 · Cited by 170 · see citing works
Acute and long-term cardiovascular effects of coffee: Implications for coronary heart disease
Riksen, N. P., Rongen, G. A. P. J. M., & Smits, P. (2008) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2008.10.006 · Cited by 166 · see citing works
Coffee and Gastrointestinal Function: Facts and Fiction: A Review
J. Boekema, M. S. (1999) · Scandinavian Journal of Gastroenterology · doi:10.1080/003655299750025525 · Cited by 164 · see citing works
A meta‐analysis of coffee, myocardial infarction, and coronary death
Greenland, S. (1993) · Epidemiology · doi:10.1097/00001648-199307000-00013 · Cited by 163 · see citing works
Human Consumption of Caffeine
Barone, J., & Roberts, H. R. (1984) · Springer eBooks · doi:10.1007/978-3-642-69823-1_4 · Cited by 162 · see citing works
Coffee consumption and risk of type 2 diabetes, cardiovascular diseases, and cancer
van Dam, R. M. (2008) · Applied Physiology, Nutrition, and Metabolism · doi:10.1139/h08-120 · Cited by 161 · see citing works
Coffee and incidence of diabetes in Swedish women: a prospective 18‐year follow‐up study
Rosengren, A., Dotevall, A., Wilhelmsen, L., Thelle, D. S., & Johansson, S. (2003) · Journal of Internal Medicine · doi:10.1046/j.1365-2796.2003.01260.x · Cited by 157 · see citing works
A Prospective Study of Coffee Drinking and Suicide in Women
Kawachi, I. I. (1996) · Archives of Internal Medicine · doi:10.1001/archinte.1996.00440050067008 · Cited by 155 · see citing works
Caffeine improves neuromuscular function during maximal dynamic exercise
Bazzucchi, I., Felici, F., Montini, M., Figura, F., & Sacchetti, M. (2011) · Muscle & Nerve · doi:10.1002/mus.21995 · Cited by 149 · see citing works
The Relationship Between Caffeine, Sleep, and Behavior in Children
Watson, E. J., Banks, S., Coates, A. M., & Kohler, M. J. (2017) · Journal of Clinical Sleep Medicine · doi:10.5664/jcsm.6536 · Cited by 145 · see citing works
A Brief Outline of the Immune System
Tomar, N., & De, R. K. (2014) · Methods in molecular biology · doi:10.1007/978-1-4939-1115-8_1 · Cited by 140 · see citing works
Caffeine ingestion elevates plasma insulin response in humans during an oral glucose tolerance test
Graham, T. E., Sathasivam, P., Rowland, M., Marko, N., Greer, F., & Battram, D. (2001) · Canadian Journal of Physiology and Pharmacology · doi:10.1139/y01-026 · Cited by 135 · see citing works
Caffeine as symptomatic treatment for Parkinson disease (Café-PD): A randomized trial
Postuma, R. B., Anang, J., Pelletier, A., Joseph, L., Moscovich, M., Grimes, D., Furtado, S., Munhoz, R. P., Appel-Cresswell, S., Moro, A., et al. (2017) · Neurology · doi:10.1212/wnl.0000000000004568 · Cited by 135 · see citing works
Is Coffee a Colonie Stimulant?
Rao, S. S. C., Welcher, K., Zimmerman, B., & Stumbo, P. (1998) · European Journal of Gastroenterology & Hepatology · doi:10.1097/00042737-199802000-00003 · Cited by 133 · see citing works
Requirement of Intact Adenosine A1 Receptors for the Diuretic and Natriuretic Action of the Methylxanthines Theophylline and Caffeine
Rieg, T., Steigele, H., Schnermann, J., Richter, K., Osswald, H., & Vallon, V. (2005) · The Journal of Pharmacology and Experimental Therapeutics · doi:10.1124/jpet.104.080432 · Cited by 133 · see citing works
Adenosine receptors and Huntington's disease: implications for pathogenesis and therapeutics
Blum, D. L., Hourez, R., Galas, M., Popoli, P., & Schiffmann, S. N. (2003) · The Lancet Neurology · doi:10.1016/s1474-4422(03)00411-3 · Cited by 131 · see citing works
Effect of caffeine on bladder function in patients with overactive bladder symptoms
Lohsiriwat, S., Hirunsai, M., & Chaiyaprasithi, B. (2011) · Urology Annals · doi:10.4103/0974-7796.75862 · Cited by 129 · see citing works
Caffeine-Related Deaths: Manner of Deaths and Categories at Risk
Cappelletti, S., Piacentino, D., Fineschi, V., Frati, P., Cipolloni, L., & Aromatario, M. (2018) · Nutrients · doi:10.3390/nu10050611 · Cited by 123 · see citing works
The Role of Caffeine in Pain Management: A Brief Literature Review
Baratloo, A., Rouhipour, A., Forouzanfar, M. M., Safari, S., Amiri, M., & Negida, A. (2015) · Anesthesiology and Pain Medicine · doi:10.5812/aapm.33193 · Cited by 121 · see citing works
Caffeine Inhibits Acetylcholinesterase, But Not Butyrylcholinesterase
Pohanka, M., & Dobes, P. (2013) · International Journal of Molecular Sciences · doi:10.3390/ijms14059873 · Cited by 120 · see citing works
Inverse association between caffeine intake and depressive symptoms in US adults: Data from National Health and Nutrition Examination Survey (NHANES) 2005–2006
Iranpour, S., & Sabour, S. (2019) · Psychiatry Research · doi:10.1016/j.psychres.2018.11.004 · Cited by 115 · see citing works
Caffeine for asthma
Welsh, E. J., Bara, A., Barley, E. A., & Cates, C. J. (2010) · Cochrane Database of Systematic Reviews · doi:10.1002/14651858.cd001112.pub2 · Cited by 114 · see citing works
Role of adenosine receptors in caffeine tolerance.
Holtzman, S. G., Mante, S., & Minneman, K. P. (1990) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1016/s0022-3565(25)23061-0 · Cited by 114 · see citing works
Caffeine Consumption and Sleep Quality in Australian Adults
Watson, E., Coates, A., Kohler, M., & Banks, S. (2016) · Nutrients · doi:10.3390/nu8080479 · Cited by 109 · see citing works
Consumption of coffee associated with reduced risk of liver cancer: a meta-analysis
Sang, L.-X., Chang, B., Li, X., & Jiang, M. (2013) · BMC Gastroenterology · doi:10.1186/1471-230x-13-34 · Cited by 107 · see citing works
Caffeine and 3‐km cycling performance: Effects of mouth rinsing, genotype, and time of day
Pataky, M. W., Womack, C. J., Saunders, M., Goffe, J. L., D’Lugos, A. C., El‐Sohemy, A., & Luden, N. D. (2015) · Scandinavian Journal of Medicine and Science in Sports · doi:10.1111/sms.12501 · Cited by 105 · see citing works
The Role of Adenosine in Alzheimers Disease
Rahman, A. (2009) · Current Neuropharmacology · doi:10.2174/157015909789152119 · Cited by 104 · see citing works
Molecular Bases Underlying the Hepatoprotective Effects of Coffee
Salomone, F., Galvano, F., & Volti, G. L. (2017) · Nutrients · doi:10.3390/nu9010085 · Cited by 104 · see citing works
Coffee, caffeine, and risk of completed suicide: Results from three prospective cohorts of American adults
Lucas, M., O’Reilly, E. J., Pan, A., Mirzaei, F., Willett, W. C., Okereke, O. I., & Ascherio, A. (2014) · The World Journal of Biological Psychiatry · doi:10.3109/15622975.2013.795243 · Cited by 103 · see citing works
Caffeine Intake, and the Risk of Stress, Urgency and Mixed Urinary Incontinence
Jura, Y. H., Townsend, M. K., Curhan, G. C., Resnick, N. M., & Grodstein, F. (2011) · The Journal of Urology · doi:10.1016/j.juro.2011.01.003 · Cited by 101 · see citing works
Serum caffeine and metabolites are reliable biomarkers of early Parkinson disease
Fujimaki, M., Saiki, S., Li, Y., Kaga, N., Taka, H., Hatano, T., Ishikawa, K., Oji, Y., Mori, A., Okuzumi, A., et al. (2018) · Neurology · doi:10.1212/wnl.0000000000004888 · Cited by 100 · see citing works
Long-Term Coffee Consumption is Associated with Fecal Microbial Composition in Humans
González, S., Salazar, N., Ruiz-Saavedra, S., Gómez‐Martín, M., Reyes‐Gavilán, C. G. D. L., & Gueimonde, M. (2020) · Nutrients · doi:10.3390/nu12051287 · Cited by 100 · see citing works
Consumption of coffee or caffeine and serum concentration of inflammatory markers: A systematic review
Paiva, C., Beserra, B. T. S., Reis, C., Dórea, J. G., Costa, T. D., & Amato, A. A. (2017) · Critical Reviews in Food Science and Nutrition · doi:10.1080/10408398.2017.1386159 · Cited by 99 · see citing works
Does Coffee Protect Against Liver Cirrhosis?
Gallus, S., Tavani, A., Negri, E., & Vecchia, C. L. (2002) · Annals of Epidemiology · doi:10.1016/s1047-2797(01)00304-0 · Cited by 97 · see citing works
Caffeine intake, toxicity and dependence and lifetime risk for psychiatric and substance use disorders: An epidemiologic and co-twin control analysis
KENDLER, K. S., MYERS, J., & O. GARDNER, C. (2006) · Psychological Medicine · doi:10.1017/s0033291706008622 · Cited by 96 · cited 1× · see citing works
“[94] analyzed data from the Virginia Twin Registry of about 3600 adult twins and reported that the risk of developing anxiety increased after consumption of >6 cups of caffeinated coffee per day.”
Method
Major Components of Energy Drinks (Caffeine, Taurine, and Guarana) Exert Cytotoxic Effects on Human Neuronal SH-SY5Y Cells by Decreasing Reactive Oxygen Species Production
Zeidán‐Chuliá, F., Gelain, D. P., Kolling, E. A., Rybarczyk-Filho, J. L., Ambrosi, P., Terra, S. R., Pires, A. S., da Rocha, J. B. T., Behr, G. A., & Moreira, J. C. F. (2013) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2013/791795 · Cited by 95 · see citing works
The Acute Effects of Caffeinated Black Coffee on Cognition and Mood in Healthy Young and Older Adults
Haskell‐Ramsay, C. F., Jackson, P. A., Forster, J. S., Dodd, F. L., Bowerbank, S. L., & Kennedy, D. O. (2018) · Nutrients · doi:10.3390/nu10101386 · Cited by 95 · see citing works
Pathophysiological roles for purines
Morelli, M., Carta, A. R., Kachroo, A., & Schwarzschild, M. A. (2010) · Progress in brain research · doi:10.1016/s0079-6123(10)83010-9 · Cited by 94 · see citing works
Caffeine decreases exhaled nitric oxide
Bruce, C. (2002) · Thorax · doi:10.1136/thorax.57.4.361 · Cited by 93 · see citing works
Coffee consumption and risk of type 2 diabetes in Finnish twins
Carlsson, S. (2004) · International Journal of Epidemiology · doi:10.1093/ije/dyh185 · Cited by 93 · see citing works
Coffee Consumption and Risk of Colorectal Cancer: A Meta-Analysis of Observational Studies
Li, G., Ma, D., Zhang, Y., Zheng, W., & Wang, P. (2013) · Public Health Nutrition · doi:10.1017/s1368980012002601 · Cited by 91 · see citing works
Methylxanthines, Seizures, and Excitotoxicity
Boison, D. (2010) · Handbook of experimental pharmacology · doi:10.1007/978-3-642-13443-2_9 · Cited by 90 · see citing works
Caffeine Modulates TNF-α Production by Cord Blood Monocytes: The Role of Adenosine Receptors
Chavez‐Valdez, R., Wills-Karp, M. A., Ahlawat, R., Cristofalo, E. A., Nathan, A. T., & Gauda, E. B. (2009) · Pediatric Research · doi:10.1203/pdr.0b013e31818d66b1 · Cited by 89 · see citing works
Roasted Coffees High in Lipophilic Antioxidants and Chlorogenic Acid Lactones Are More Neuroprotective than Green Coffees
Chu, Y.-F., Brown, P. H., Lyle, B. J., Chen, Y., Black, R. M., Williams, C. E., Lin, Y.-C., Hsu, C.-W., & Cheng, I. H. (2009) · Journal of Agricultural and Food Chemistry · doi:10.1021/jf902095z · Cited by 89 · see citing works
Association of Tea Consumption with Risk of Alzheimer’s Disease and Anti-Beta-Amyloid Effects of Tea
Polito, C. A., Cai, Z., Shi, Y., Li, X.-M., Yang, R., Shi, M., Li, Q., Ma, S., Xiang, L., Wang, K., et al. (2018) · Nutrients · doi:10.3390/nu10050655 · Cited by 89 · see citing works
Caffeine and urinary incontinence in US women
Gleason, J. L., Richter, H. E., Redden, D. T., Goode, P. S., Burgio, K. L., & Markland, A. D. (2012) · International Urogynecology Journal · doi:10.1007/s00192-012-1829-5 · Cited by 88 · see citing works
Adenosine Enhances Sweet Taste through A2B Receptors in the Taste Bud
Dando, R., Dvoryanchikov, G. A., Pereira, E., Chaudhari, N., & Roper, S. D. (2012) · Journal of Neuroscience · doi:10.1523/jneurosci.4070-11.2012 · Cited by 87 · see citing works
Coffee, tea, mate, methylxanthines and methylglyoxal. IARC Working Group on the Evaluation of Carcinogenic Risks to Humans. Lyon, 27 February to 6 March 1990.
(1991) · PubMed Central · Cited by 86 · see citing works
Reflex sympathoexcitation by cardiac sympathetic afferents during myocardial ischemia. Role of adenosine.
Thames, M. D., Kinugawa, T., & Dibner‐Dunlap, M. E. (1993) · Circulation · doi:10.1161/01.cir.87.5.1698 · Cited by 82 · see citing works
CYP1A2 Genotype Variations Do Not Modify the Benefits and Drawbacks of Caffeine during Exercise: A Pilot Study
Salinero, J. J., Lara, B., Ruiz-Vicente, D., Areces, F., Puente, C., Gallo–Salazar, C., Pascual, T., & Coso, J. D. (2017) · Nutrients · doi:10.3390/nu9030269 · Cited by 82 · see citing works
Neuroprotective Effects of Synaptic Modulation in Huntington's Disease R6/2 Mice
Stack, E. C., Dedeoglu, A., Smith, K. M., Cormier, K., Kubilus, J. K., Bogdanov, M. B., Matson, W. R., Yang, L., Jenkins, B. G., Luthi‐Carter, R., et al. (2007) · Journal of Neuroscience · doi:10.1523/jneurosci.4318-07.2007 · Cited by 80 · see citing works
The Effects of High Doses of Caffeine on Maximal Strength and Muscular Endurance in Athletes Habituated to Caffeine
Wilk, M., Krzysztofik, M., Filip, A., Zając, A., & Coso, J. D. (2019) · Nutrients · doi:10.3390/nu11081912 · Cited by 80 · see citing works
Opposite actions of caffeine and creatine on muscle relaxation time in humans
Hespel, P., ‘t Eijnde, B. O., & Van Leemputte, M. (2002) · Journal of Applied Physiology · doi:10.1152/japplphysiol.00255.2001 · Cited by 78 · see citing works
High consumption of coffee is associated with decreased multiple sclerosis risk; results from two independent studies
Hedström, A. K., Mowry, E. M., Gianfrancesco, M. A., Shao, X., Schaefer, C. A., Shen, L., Olsson, T., Barcellos, L. F., & Alfredsson, L. (2016) · Journal of Neurology, Neurosurgery & Psychiatry · doi:10.1136/jnnp-2015-312176 · Cited by 77 · see citing works
Caffeine induces sustained apoptosis of human gastric cancer cells by activating the caspase-9/caspase-3 signalling pathway
Liu, H., Zhou, Y., & Tang, L. (2017) · Molecular Medicine Reports · doi:10.3892/mmr.2017.6894 · Cited by 77 · see citing works
Coffee consumption and risk of cardiovascular events and all-cause mortality among women with type 2 diabetes
Zhang, W. L., López‐García, E., Li, T. Y., Hu, F. B., & van Dam, R. M. (2009) · Diabetologia · doi:10.1007/s00125-009-1311-1 · Cited by 76 · see citing works
Association between caffeine intake and age at onset in Huntington's disease
Simonin, C., Duru, C., Salleron, J., Hincker, P., Charles, P., Delval, A., Youssov, K., Burnouf, S., Azulay, J., Verny, C., et al. (2013) · Neurobiology of Disease · doi:10.1016/j.nbd.2013.05.013 · Cited by 73 · see citing works
Caffeine prevents kidney stone formation by translocation of apical surface annexin A1 crystal-binding protein into cytoplasm: In vitro evidence
Peerapen, P., & Thongboonkerd, V. (2016) · Scientific Reports · doi:10.1038/srep38536 · Cited by 73 · see citing works
Coffee consumption and decreased serum γ-glutamyltransferase: a study of middle-aged Japanese men
Nakanishi, N., Nakamura, K., Nakajima, K., Suzuki, K., & Tatara, K. (2000) · European Journal of Epidemiology · doi:10.1023/a:1007683626665 · Cited by 72 · see citing works
Effect of Caffeine Intake on Pain Perception During High-Intensity Exercise
Astorino, T. A., Terzi, M. N., Roberson, D. W., & Burnett, T. R. (2011) · International Journal of Sport Nutrition and Exercise Metabolism · doi:10.1123/ijsnem.21.1.27 · Cited by 71 · see citing works
A Randomised Placebo-Controlled Trial to Differentiate the Acute Cognitive and Mood Effects of Chlorogenic Acid from Decaffeinated Coffee
Camfield, D., Silber, B. Y., Scholey, A. B., Nolidin, K., Goh, A. W.-T., & Stough, C. K. K. (2013) · PLoS ONE · doi:10.1371/journal.pone.0082897 · Cited by 71 · see citing works
Caffeine Targets SIRT3 to Enhance SOD2 Activity in Mitochondria
Xu, H., Gan, C., Gao, Z., Huang, Y., Wu, S., Zhang, D., Wang, X., & Sheng, J. (2020) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2020.00822 · Cited by 71 · see citing works
Effect of caffeine on control of breathing in infantile apnea
Aranda, J. V., Türmen, T., Davis, J. M., Trippenbach, T., Grondin, D., Zinman, R., & Watters, G. V. (1983) · The Journal of Pediatrics · doi:10.1016/s0022-3476(83)80735-5 · Cited by 70 · see citing works
The effects of caffeine and theophylline on diaphragm contractility.
Supinski, G. S., Deal, E. C., & Kelsen, S. G. (1984) · PubMed · doi:10.1164/arrd.1984.130.3.429 · Cited by 68 · see citing works
Effect of caffeine on respiratory muscle strength and lung function in prematurely born, ventilated infants
Kassim, Z., Greenough, A., & Rafferty, G. F. (2009) · European Journal of Pediatrics · doi:10.1007/s00431-009-0961-9 · Cited by 67 · see citing works
Adenosine for pain control
Sollevi, A. (1997) · Acta Anaesthesiologica Scandinavica · doi:10.1111/j.1399-6576.1997.tb05532.x · Cited by 66 · see citing works
Is Caffeine Addictive?—A Review of the Literature
Satel, S. L. (2006) · The American Journal of Drug and Alcohol Abuse · doi:10.1080/00952990600918965 · Cited by 65 · see citing works
Heavy coffee drinking and the risk of suicide
Tanskanen, A. J., Tuomilehto, J., Viinamäki, H. T., Vartiainen, E. A., Lehtonen, J., & Puska, P. (2000) · European Journal of Epidemiology · doi:10.1023/a:1007614714579 · Cited by 63 · see citing works
Effect of decaffeinated versus regular coffee on blood pressure. A 12-week, double-blind trial.
Dusseldorp, M., Smits, P., Thien, T. A., & Katan, M. (1989) · Hypertension · doi:10.1161/01.hyp.14.5.563 · Cited by 63 · see citing works
Caffeine Is Ergogenic for Adenosine A 2A Receptor Gene ( ADORA2A ) T Allele Homozygotes: A Pilot Study
Loy, B. D., O’Connor, P. J., Lindheimer, J. B., & Covert, S. F. (2015) · Journal of Caffeine Research · doi:10.1089/jcr.2014.0035 · Cited by 62 · see citing works
Effect of caffeine on biomarkers of oxidative stress in lenses of rats with streptozotocin-induced diabetes
Kaczmarczyk‐Sedlak, I., Folwarczna, J., Sedlak, L., Zych, M., Wojnar, W., Szumińska, I., Wyględowska‐Promieńska, D., & Mrukwa–Kominek, E. (2019) · Archives of Medical Science · doi:10.5114/aoms.2019.85461 · Cited by 62 · see citing works
The effect of caffeine on cognitive performance is influenced by CYP1A2 but not ADORA2A genotype, yet neither genotype affects exercise performance in healthy adults
Carswell, A. T., Howland, K., Martinez-Gonzalez, B., Baron, P., & Davison, G. (2020) · European Journal of Applied Physiology · doi:10.1007/s00421-020-04384-8 · Cited by 61 · see citing works
A Combination of Caffeine, Arginine, Soy Isoflavones, and l-Carnitine Enhances Both Lipolysis and Fatty Acid Oxidation in 3T3-L1 and HepG2 Cells in Vitro and in KK Mice in Vivo
Murosaki, S., Lee, T. R., Muroyama, K., Shin, E. S., Cho, S. Y., Yamamoto, Y., & Lee, S. J. (2007) · Journal of Nutrition · doi:10.1093/jn/137.10.2252 · Cited by 60 · see citing works
Changes in pulmonary mechanics following caffeine administration in infants with bronchopulmonary dysplasia
Davis, J. M., Bhutani, V. K., Stefano, J. L., Fox, W. W., & Spitzer, A. R. (1989) · Pediatric Pulmonology · doi:10.1002/ppul.1950060112 · Cited by 60 · see citing works
Acute caffeine intake increases muscle oxygen saturation during a maximal incremental exercise test
Ruíz‐Moreno, C., Lara, B., de Souza, D. B., Gutiérrez‐Hellín, J., Romero‐Moraleda, B., Cuéllar-Rayo, Á., & Coso, J. D. (2019) · British Journal of Clinical Pharmacology · doi:10.1111/bcp.14189 · Cited by 53 · see citing works
Caffeine in the Treatment of Pain
Tavares, C., & Sakata, R. K. (2012) · Brazilian Journal of Anesthesiology · doi:10.1016/s0034-7094(12)70139-3 · Cited by 52 · see citing works
Coffee Consumption and Risk of Colorectal Cancer: A Dose-Response Analysis of Observational Studies
Tian, C., Wang, W., Hong, Z., & Zhang, X. (2013) · Cancer Causes & Control · doi:10.1007/s10552-013-0200-6 · Cited by 51 · see citing works
Different roles of adenosine A1, A2A and A3 receptors in controlling kainate-induced toxicity in cortical cultured neurons
Rebola, N., Rodrigues, R. J., Oliveira, C. R., & Cunha, R. A. (2005) · Neurochemistry International · doi:10.1016/j.neuint.2005.05.009 · Cited by 50 · see citing works
Caffeine relaxes smooth muscle through actin depolymerization
Tazzeo, T., Bates, G., Roman, H. N., Lauzon, A., Khasnis, M. D., Eto, M., & Janssen, L. J. (2012) · American Journal of Physiology-Lung Cellular and Molecular Physiology · doi:10.1152/ajplung.00103.2012 · Cited by 48 · see citing works
Caffeine toxicity in forensic practice: possible effects and under-appreciated sources
Musgrave, I., Farrington, R., Hoban, C. L., & Byard, R. W. (2016) · Forensic Science Medicine and Pathology · doi:10.1007/s12024-016-9786-9 · Cited by 48 · see citing works
Caffeine affects HFD-induced hepatic steatosis by multifactorial intervention
Helal, M. G., Ayoub, S., Elkashefand, W., & Ibrahim, T. (2017) · Human & Experimental Toxicology · doi:10.1177/0960327117747026 · Cited by 48 · see citing works
Coffee increases state anxiety in males but not in females
Botella, P., & Parra, A. (2003) · Human Psychopharmacology Clinical and Experimental · doi:10.1002/hup.444 · Cited by 47 · see citing works
Caffeine Intake and Mental Health in College Students
Bertasi, R. A. O., Humeda, Y., Bertasi, T. G. O., Zins, Z., Kimsey, J., & Pujalte, G. G. A. (2021) · Cureus · doi:10.7759/cureus.14313 · Cited by 47 · see citing works
Associations Between Black Tea and Coffee Consumption and Risk of Lung Cancer Among Current and Former Smokers
Baker, J. A., McCann, S. E., Reid, M. E., Nowell, S. A., Beehler, G. P., & Moysich, K. B. (2005) · Nutrition and Cancer · doi:10.1207/s15327914nc5201_2 · Cited by 45 · see citing works
The Role of Adenosine Tone and Adenosine Receptors in Huntington's Disease
Blum, D. L., Chern, Y., Domenici, M. R., Buée, L., Lin, C., Rea, W. P., Ferré, S., & Popoli, P. (2018) · Journal of Caffeine and Adenosine Research · doi:10.1089/caff.2018.0006 · Cited by 45 · see citing works
The influence of different food components on thein vitroavailability of iron, zinc and calcium from a composed meal
Dyck, K. V., Tas, S., Robberecht, H. J., & Deelstra, H. A. (1996) · International Journal of Food Sciences and Nutrition · doi:10.3109/09637489609031879 · Cited by 44 · see citing works
The Effects of a Polymorphism in the Cytochrome P450 CYP1A2 Gene on Performance Enhancement with Caffeine in Recreational Cyclists
AlGrain, H. A., Thomas, R. M., Carrillo, A. E., Ryan, E. J., Kim, C.-H., Lettan, R. B. I., & Ryan, E. J. (2015) · Journal of Caffeine Research · doi:10.1089/jcr.2015.0029 · Cited by 44 · see citing works
Autophagy mediated by endoplasmic reticulum stress enhances the caffeine-induced apoptosis of hepatic stellate cells
Li, Y., Chen, Y., Huang, H., Shi, M., Yang, W., Kuang, J., & Yan, J. (2017) · International Journal of Molecular Medicine · doi:10.3892/ijmm.2017.3145 · Cited by 44 · see citing works
Caffeine Consumption and Mortality in Diabetes: An Analysis of NHANES 1999–2010
Neves, J. S., Leitão, L., Magriço, R., Vieira, M. B., Dias, C. V., Oliveira, A. B. F. D., Carvalho, D. M., & Claggett, B. L. (2018) · Frontiers in Endocrinology · doi:10.3389/fendo.2018.00547 · Cited by 43 · see citing works
Caffeine Intake and Risk of Urinary Incontinence Progression Among Women
Townsend, M. K., Resnick, N. M., & Grodstein, F. (2012) · Obstetrics and Gynecology · doi:10.1097/aog.0b013e31824fc604 · Cited by 42 · see citing works
Are caffeine’s performance-enhancing effects partially driven by its bitter taste?
Pickering, C. (2019) · Medical Hypotheses · doi:10.1016/j.mehy.2019.109301 · Cited by 41 · see citing works
Mécanismes de l’effet diurétique de la caféine
Marx, B., Scuvée, É., Scuvée‐Moreau, J., Seutin, V., & Jouret, F. (2016) · médecine/sciences · doi:10.1051/medsci/20163205015 · Cited by 40 · see citing works
Caffeine-Induced Effects on Human Skeletal Muscle Contraction Time and Maximal Displacement Measured by Tensiomyography
Domaszewski, P., Pakosz, P., Konieczny, M., Bączkowicz, D., & Sadowska‐Krępa, E. (2021) · Nutrients · doi:10.3390/nu13030815 · Cited by 39 · see citing works
Caffeinated and decaffeinated coffee consumption and risk of all‐cause mortality: a dose–response meta‐analysis of cohort studies
Li, Q., Liu, Y., Sun, X., Yin, Z., Li, H., Cheng, C., Liu, L., Zhang, R., Liu, F., Zhou, Q., et al. (2019) · Journal of Human Nutrition and Dietetics · doi:10.1111/jhn.12633 · Cited by 38 · see citing works
Coffee and tea consumption and risk of lung cancer: A dose–response analysis of observational studies
Wang, Y., Yu, X., Wu, Y., & Zhang, D. (2012) · Lung Cancer · doi:10.1016/j.lungcan.2012.08.009 · Cited by 37 · see citing works
Caffeine inhibits hypoxia-induced renal fibroblast activation by antioxidant mechanism
Nilnumkhum, A., Kanlaya, R., Yoodee, S., & Thongboonkerd, V. (2019) · Cell Adhesion & Migration · doi:10.1080/19336918.2019.1638691 · Cited by 36 · see citing works
Caffeine Augments The Instruction of Anti-Inflammatory Macrophages by The Conditioned Medium of Mesenchymal Stem Cells.
Shushtari, N., & Froushani, S. M. A. (2017) · PubMed Central · doi:10.22074/cellj.2017.4364 · Cited by 36 · see citing works
The Effect of Caffeine on Performance in Collegiate Tennis Players
Klein, C. S., Clawson, A. J., Martin, M., Saunders, M. J., Flohr, J. A., Bechtel, M. K., Dunham, W., Hancock, M., & Womack, C. J. (2012) · Journal of Caffeine Research · doi:10.1089/jcr.2012.0019 · Cited by 35 · see citing works
Caffeine: Implications for Alertness in Athletes
Rogers, N. L., & Dinges, D. F. (2005) · Clinics in Sports Medicine · doi:10.1016/j.csm.2004.12.012 · Cited by 35 · see citing works
Caffeine, Through Adenosine A3 Receptor-Mediated Actions, Suppresses Amyloid-β Protein Precursor Internalization and Amyloid-β Generation
Li, S., Geiger, N. H., Soliman, M. L., Hui, L., Geiger, J. D., & Chen, X. (2015) · Journal of Alzheimer s Disease · doi:10.3233/jad-142223 · Cited by 35 · see citing works
Untitled work
(2015) · PubMed · Cited by 35 · see citing works
Association Between Caffeine Intake and All-Cause and Cause-Specific Mortality: A Population-Based Prospective Cohort Study
Tsujimoto, T., Kajio, H., & Sugiyama, T. (2017) · Mayo Clinic Proceedings · doi:10.1016/j.mayocp.2017.03.010 · Cited by 34 · see citing works
Effect of caffeine on lower esophageal sphincter pressure in Thai healthy volunteers
Lohsiriwat, S., Puengna, N., & Leelakusolvong, S. (2006) · Diseases of the Esophagus · doi:10.1111/j.1442-2050.2006.00562.x · Cited by 30 · see citing works
A dose–response meta-analysis of coffee consumption and bladder cancer
Zhou, Y., Tian, C., & Jia, C. (2012) · Preventive Medicine · doi:10.1016/j.ypmed.2012.04.020 · Cited by 30 · see citing works
Caffeine and Progression of Parkinson Disease
Simon, D. K., Wu, C., Tilley, B. C., Wills, A.-M. A., Aminoff, M. J., Bainbridge, J. L., Hauser, R. A., Schneider, J. S., Sharma, S., Singer, C., et al. (2015) · Clinical Neuropharmacology · doi:10.1097/wnf.0000000000000102 · Cited by 29 · see citing works
Potential Role of Caffeine in the Treatment of Parkinson’s Disease
Roshan, M. H. K., Tambo, A., & Pace, N. P. (2016) · The Open Neurology Journal · doi:10.2174/1874205x01610010042 · Cited by 29 · see citing works
Selected health and lifestyle factors, cytosine‐adenine‐guanine status, and phenoconversion in Huntington's disease
Tanner, C. M., Marder, K. S., Eberly, S. W., Biglan, K., Oakes, D., Shoulson, I., & on behalf of the Huntington Study Group Prospective Huntington At‐Risk Observational Study Investigators (2018) · Movement Disorders · doi:10.1002/mds.27239 · Cited by 29 · see citing works
Caffeine consumption and mortality in chronic kidney disease: a nationally representative analysis
Vieira, M. B., Magriço, R., Dias, C. V., Leitão, L., & Neves, J. S. (2018) · Nephrology Dialysis Transplantation · doi:10.1093/ndt/gfy234 · Cited by 29 · see citing works
The effects of a caffeine-like supplement, TeaCrine®, on muscular strength, endurance and power performance in resistance-trained men
Cesareo, K. R., Mason, J., Saracino, P. G., Morrissey, M. C., & Ormsbee, M. J. (2019) · Journal of the International Society of Sports Nutrition · doi:10.1186/s12970-019-0316-5 · Cited by 29 · see citing works
In-vitro examination of the positive inotropic effect of caffeine and taurine, the two most frequent active ingredients of energy drinks
Chaban, R., Kornberger, A., Branski, N., Buschmann, K., Stumpf, N., Beiras-Fernández, A., & Vahl, C. (2017) · BMC Cardiovascular Disorders · doi:10.1186/s12872-017-0625-z · Cited by 28 · see citing works
Mechanisms of modulation of cytokine release by human cord blood monocytes exposed to high concentrations of caffeine
Chavez‐Valdez, R., Ahlawat, R., Wills-Karp, M. A., & Gauda, E. B. (2016) · Pediatric Research · doi:10.1038/pr.2016.50 · Cited by 27 · see citing works
Effect of single caffeine intake on neuropsychological functions in healthy volunteers: A double-blind placebo-controlled study
Konishi, Y., Hori, H., Ide, K., Katsuki, A., Atake, K., Igata, R., Kubo, T., Tominaga, H., Beppu, H., Asahara, T., et al. (2018) · PLoS ONE · doi:10.1371/journal.pone.0202247 · Cited by 26 · see citing works
Higher habitual dietary caffeine consumption is related to lower experimental pain sensitivity in a community-based sample
Overstreet, D. S., Penn, T. M., Cable, S. T., Aroke, E. N., & Goodin, B. R. (2018) · Psychopharmacology · doi:10.1007/s00213-018-5016-3 · Cited by 23 · see citing works
Acute doses of caffeine shift nervous system cell expression profiles toward promotion of neuronal projection growth
Yu, N. Y., Bieder, A., Raman, A., Mileti, E., Katayama, S., Einarsdottir, E., Fredholm, B., Falk, A., Tapia-Páez, I., Daub, C. O., et al. (2017) · Scientific Reports · doi:10.1038/s41598-017-11574-6 · Cited by 22 · see citing works
Caffeine impairs gastrointestinal function in newborn rats
Welsh, C., Pan, J., & Belik, J. (2015) · Pediatric Research · doi:10.1038/pr.2015.65 · Cited by 21 · see citing works
Caffeine affects the biological responses of human hematopoietic cells of myeloid lineageviadownregulation of the mTOR pathway and xanthine oxidase activity
Gibbs, B. F., Silva, I. G., Prokhorov, A., Abooali, M., Yasinska, I. M., Casely‐Hayford, M. A., Berger, S., Fasler‐Kan, E., & Sumbayev, V. V. (2015) · Oncotarget · doi:10.18632/oncotarget.5212 · Cited by 20 · see citing works
Taste Perception and Caffeine Consumption: An fMRI Study
Gramling, L., Kapoulea, E. A., & Murphy, C. (2018) · Nutrients · doi:10.3390/nu11010034 · Cited by 20 · see citing works
Caffeine and NAD+ Improve Motor Neural Integrity of Dissociated Wobbler Cells In Vitro
Zwilling, M., Theiß, C., & Matschke, V. (2020) · Antioxidants · doi:10.3390/antiox9060460 · Cited by 20 · see citing works
Exploring the Association between Urine Caffeine Metabolites and Urine Flow Rate: A Cross-Sectional Study
Wu, S. E., & Chen, W. (2020) · Nutrients · doi:10.3390/nu12092803 · Cited by 20 · see citing works
High doses of caffeine reduce in vivo osteogenic activity in prepubertal rats
Shin, J., Choi, Y., Kim, J., Yu, A., Shin, J., Choi, Y. Y., & Roh, J. (2015) · Journal of Anatomy · doi:10.1111/joa.12332 · Cited by 18 · see citing works
Caffeine May Reduce Perceived Sweet Taste in Humans, Supporting Evidence That Adenosine Receptors Modulate Taste
Choo, E., Picket, B., & Dando, R. (2017) · Journal of Food Science · doi:10.1111/1750-3841.13836 · Cited by 17 · see citing works
Pharmacologic immunosuppression of mononuclear phagocyte phagocytosis by caffeine
Steck, R., Hill, S. L., Weagel, E. G., Weber, K. S., Robison, R. A., & O'Neill, K. L. (2015) · Pharmacology Research & Perspectives · doi:10.1002/prp2.180 · Cited by 16 · see citing works
Caffeine Targets G6PDH to Disrupt Redox Homeostasis and Inhibit Renal Cell Carcinoma Proliferation
Xu, H., Hu, L., Liu, T., Chen, F., Li, J., Xu, J., Jiang, L., Xiang, Z., Wang, X., & Sheng, J. (2020) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2020.556162 · Cited by 15 · see citing works
Is Caffeine Intake Associated With Urinary Incontinence in Japanese Adults?
Hirayama, F., & Lee, A. H. (2012) · Journal of Preventive Medicine and Public Health · doi:10.3961/jpmph.2012.45.3.204 · Cited by 14 · see citing works
Caffeine increases myoglobin expression via the cyclic AMP pathway in L6 myotubes
Yokokawa, T., Hashimoto, T., & Iwanaka, N. (2021) · Physiological Reports · doi:10.14814/phy2.14869 · Cited by 13 · see citing works
Caffeine Suppresses GABA Receptor-Mediated Current in Rat Primary Sensory Neurons via Inhibition of Intracellular Phosphodiesterase
Yang, J. Y., Yang, G., Ren, J. T., Zhao, J., & Li, S. (2015) · Neurophysiology · doi:10.1007/s11062-015-9506-1 · Cited by 12 · see citing works
The mechanism of caffeine-enhanced glucose stimulation of liver glycogen synthase phosphatase activity
Gilboe, D. P. (1986) · Biochemical Pharmacology · doi:10.1016/0006-2952(86)90576-9 · Cited by 12 · see citing works
Effects of upper respiratory tract illnesses, ibuprofen and caffeine on reaction time and alertness
Smith, A. P., & Nutt, D. (2013) · Psychopharmacology · doi:10.1007/s00213-013-3339-7 · Cited by 12 · see citing works
Impact of caffeine on myocardial perfusion reserve assessed by semiquantitative adenosine stress perfusion cardiovascular magnetic resonance
Seitz, A., Kaesemann, P., Chatzitofi, M., Löbig, S., Tauscher, G., Bekeredjian, R., Sechtem, U. P., Mahrholdt, H., & Greulich, S. (2019) · Journal of Cardiovascular Magnetic Resonance · doi:10.1186/s12968-019-0542-7 · Cited by 12 · see citing works
Caffeine Intake and the Risk of Chronic Obstructive Pulmonary Disease in Japanese Adults
Hirayama, F., Lee, A. H., Yasukawa, K., Ishihara, Y., & Shinjo, M. (2012) · Journal of Caffeine Research · doi:10.1089/jcr.2012.0029 · Cited by 10 · see citing works
Caffeine Increases Apolipoprotein A-1 and Paraoxonase-1 but not Paraoxonase-3 Protein Levels in Human-Derived Liver (HepG2) Cells
Özgün, G. S., Özgün, E., Tabakçioğlu, K., Gökmen, S. S., Eskiocak, S., & Çakır, E. (2017) · Balkan Medical Journal · doi:10.4274/balkanmedj.2016.1217 · Cited by 8 · see citing works

Flagged first, then by citations

1 of the 205 references couldn’t be matched to a known paper.

Sorted by citations

The effect of caffeine on subsequent sleep: A systematic review and meta-analysis
Gardiner, C., Weakley, J., Burke, L. M., Roach, G. D., Sargent, C., Maniar, N., Townshend, A., & Halson, S. L. (2023) · Sleep Medicine Reviews · doi:10.1016/j.smrv.2023.101764 · Cited by 315 · see citing works
A review on the influence of nutraceuticals and functional foods on health
Vignesh, A., Amal, T. C., Sarvalingam, A., & Vasanth, K. (2024) · Food Chemistry Advances · doi:10.1016/j.focha.2024.100749 · Cited by 200 · see citing works
Caffeine and Its Antioxidant Properties—It Is All about Dose and Source
Ősz, B.-E., Jîtcă, G., Ștefănescu, R., Puşcaş, A., Tero-Vescan, A., & Vari, C.-E. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms232113074 · Cited by 146 · see citing works
The medicinal and aromatic plants as ingredients in functional beverage production
Maleš, I., Pedišić, S., Zorić, Z., Garofulić, I. E., Repajić, M., You, L., Vladimir‐Knežević, S., Butorac, D., & Dragović‐Uzelac, V. (2022) · Journal of Functional Foods · doi:10.1016/j.jff.2022.105210 · Cited by 127 · see citing works
Bioactive compounds in coffee and their role in lowering the risk of major public health consequences: A review
Urugo, M. M., Tola, Y. B., Ogah, O., & Endale, F. (2023) · Food Science & Nutrition · doi:10.1002/fsn3.3848 · Cited by 114 · see citing works
A Review on Natural Antioxidants for Their Role in the Treatment of Parkinson’s Disease
Mittal, P., Dhankhar, S., Chauhan, S., Garg, N., Bhattacharya, T., Ali, M., Chaudhary, A. A., Rudayni, H. A., Al-Zharani, M. M., Ahmad, W., et al. (2023) · Pharmaceuticals · doi:10.3390/ph16070908 · Cited by 82 · see citing works
Composing functional food from agro-forest wastes: Selectively extracting bioactive compounds using supercritical fluid extraction
Qu, A., Cui, D., Li, Y., Zhige, W., Wu, Y., Minfen, Y., Li, D., Ruan, X., & Qiang, W. (2024) · Food Chemistry · doi:10.1016/j.foodchem.2024.139848 · Cited by 71 · see citing works
Neurodegenerative Diseases: Can Caffeine Be a Powerful Ally to Weaken Neuroinflammation?
Ruggiero, M., Calvello, R., Porro, C., Messina, G., Cianciulli, A., & Panaro, M. A. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms232112958 · Cited by 58 · see citing works
Common questions and misconceptions about caffeine supplementation: what does the scientific evidence really show?
António, J., Newmire, D. E., Stout, J. R., Antonio, B. B., Gibbons, M., Lowery, L. M., Harper, J., Willoughby, D. S., Evans, C., Anderson, D., et al. (2024) · Journal of the International Society of Sports Nutrition · doi:10.1080/15502783.2024.2323919 · Cited by 48 · see citing works
Plant Alkaloids: Production, Extraction, and Potential Therapeutic Properties
Pereira, A. G., Cassani, L., Garcia‐Oliveira, P., Otero, P., Mansoor, S., Echave, J., Xiao, J., Simal‐Gándara, J., & Prieto, M. A. (2023) · Springer eBooks · doi:10.1007/978-3-031-18587-8_6 · Cited by 42 · see citing works
Potential Benefits of Coffee Consumption on Improving Biomarkers of Oxidative Stress and Inflammation in Healthy Individuals and Those at Increased Risk of Cardiovascular Disease
Dludla, P. V., Cirilli, I., Marcheggiani, F., Silvestri, S., Orlando, P., Muvhulawa, N., Moetlediwa, M. T., Nkambule, B. B., Mazibuko-Mbeje, S. E., Hlengwa, N., et al. (2023) · Molecules · doi:10.3390/molecules28186440 · Cited by 39 · see citing works
Caffeine for Prevention of Alzheimer’s Disease: Is the A2A Adenosine Receptor Its Target?
Merighi, S., Travagli, A., Nigro, M., Pasquini, S., Cappello, M., Contri, C., Varani, K., Vincenzi, F., Borea, P. A., & Gessi, S. (2023) · Biomolecules · doi:10.3390/biom13060967 · Cited by 34 · see citing works
Current therapeutic targets and multifaceted physiological impacts of caffeine
Song, X., Kirtipal, N., Lee, S., Malý, P., & Bharadwaj, S. (2023) · Phytotherapy Research · doi:10.1002/ptr.8000 · Cited by 33 · see citing works
Caffeinated Beverages—Unveiling Their Impact on Human Health
Čižmárová, B., Kraus, V., & Birková, A. (2025) · Beverages · doi:10.3390/beverages11010018 · Cited by 32 · see citing works
Update to the Treatment of Parkinson’s Disease Based on the Gut-Brain Axis Mechanism
Sun, X., Li, X., Wang, Z., & Xie, A. (2022) · Frontiers in Neuroscience · doi:10.3389/fnins.2022.878239 · Cited by 26 · see citing works
Anti-Inflammatory Effect of Caffeine on Muscle under Lipopolysaccharide-Induced Inflammation
Eichwald, T., Solano, A. F., Souza, J., de Miranda, T. B., Carvalho, L. B., Sanna, P. L. D. S., da Silva, R. A., & Latini, A. (2023) · Antioxidants · doi:10.3390/antiox12030554 · Cited by 26 · see citing works
Effects of front-of-package caffeine and sweetener disclaimers in Mexico: cross-sectional results from the 2020 International Food Policy Study
Arellano‐Gómez, L. P., Jáuregui, A., Nieto, C., Contreras‐Manzano, A., Quevedo, K. L., White, C. M., Thrasher, J. F., Davis, R. E., Hammond, D. G., & Barquera, S. (2023) · Public Health Nutrition · doi:10.1017/s1368980023002100 · Cited by 26 · see citing works
Green synthesis by extraction of caffeine for cosmeceutical application: A review
Watts, S. S., Pal, K., Asthana, N., Bhattu, M., & Verma, M. (2024) · Journal of Molecular Structure · doi:10.1016/j.molstruc.2024.137733 · Cited by 26 · see citing works
Impact of coffee intake on human aging: Epidemiology and cellular mechanisms
Lopes, C. R., & Cunha, R. A. (2024) · Ageing Research Reviews · doi:10.1016/j.arr.2024.102581 · Cited by 26 · see citing works
Caffeine, Paraxanthine, Theophylline, and Theobromine Content in Human Milk
Purkiewicz, A., Pietrzak‐Fiećko, R., Sörgel, F., & Kinzig, M. (2022) · Nutrients · doi:10.3390/nu14112196 · Cited by 25 · see citing works
Association of caffeine intake with all-cause and cardiovascular mortality in elderly patients with hypertension
Chen, S., Li, J., Gao, M., Li, D., Shen, R., Lyu, L., Shen, J., Shen, X., Fu, G., Wei, T., et al. (2022) · Frontiers in Nutrition · doi:10.3389/fnut.2022.1023345 · Cited by 24 · see citing works
Association of Coffee and Tea Consumption with the Risk of Asthma: A Prospective Cohort Study from the UK Biobank
Lin, F., Zhu, Y., Liang, H., Li, D., Jing, D., Liu, H., Pan, P., & Zhang, Y. (2022) · Nutrients · doi:10.3390/nu14194039 · Cited by 22 · see citing works
The Effects of Caffeine on Blood Platelets and the Cardiovascular System through Adenosine Receptors
Marcinek, K., Luzak, B., & Różalski, M. (2024) · International Journal of Molecular Sciences · doi:10.3390/ijms25168905 · Cited by 21 · see citing works
Much More than Nutrients: The Protective Effects of Nutraceuticals on the Blood–Brain Barrier in Diseases
Kocsis, A. E., Kucsápszky, N., Santa-Maria, A. R., Hunyadi, A., Deli, M. A., & Walter, F. R. (2025) · Nutrients · doi:10.3390/nu17050766 · Cited by 21 · see citing works
Timing Matters: Time of Day Impacts the Ergogenic Effects of Caffeine—A Narrative Review
Zhang, Y., Yang, W., Xue, Y., Hou, D., Chen, S., Xu, Z., Peng, S., Zhao, H., Wang, C., & Liu, C. (2024) · Nutrients · doi:10.3390/nu16101421 · Cited by 20 · see citing works
Deep eutectic solvents based on sugars for oral applications
Lomba, L., Polo, A., Werner, Á., Lafuente, C., & Giner, B. (2023) · European Journal of Pharmaceutics and Biopharmaceutics · doi:10.1016/j.ejpb.2023.08.007 · Cited by 20 · see citing works
Target and Nontarget Screening to Support Capacity Scaling for Substance Use Assessment through a Statewide Wastewater Surveillance Network in New York
Vogel, E., Neyra, M., Larsen, D. A., & Zeng, T. (2024) · Environmental Science & Technology · doi:10.1021/acs.est.4c01251 · Cited by 19 · see citing works
Precision caffeine therapy for apnea of prematurity and circadian rhythms: New possibilities open up
Dai, H., Guo, H., Hu, Y., Xu, J., Ding, X., Cheng, R., & Chen, F. (2022) · Frontiers in Pharmacology · doi:10.3389/fphar.2022.1053210 · Cited by 17 · see citing works
Coffee, antioxidants, and brain inflammation
Rai, S. P., Ansari, A. H., Singh, D., & Singh, S. (2024) · Progress in brain research · doi:10.1016/bs.pbr.2024.06.005 · Cited by 19 · see citing works
Effects of dietary approaches to prevent hypertension and enhance cardiovascular health
Vignesh, A., Amal, T. C., Shanmugam, A., Vasanth, K., & Selvakumar, S. (2025) · Discover Food · doi:10.1007/s44187-025-00278-w · Cited by 16 · see citing works
Effect of Caffeine in Hypertension
Islam, R., Ahmed, M., Ullah, W., Tahir, Y. B., Gul, S., Hussain, N., Islam, H., & Anjum, M. U. (2023) · Current Problems in Cardiology · doi:10.1016/j.cpcardiol.2023.101892 · Cited by 16 · see citing works
Wastewater surveillance of high risk substances in Southern Nevada: Sucralose normalization to translate data for potential public health action
Gerrity, D. W., Crank, K. C., Oh, E. C. T., Quiñones, O., Trenholm, R. A., & Vanderford, B. J. (2023) · The Science of The Total Environment · doi:10.1016/j.scitotenv.2023.168369 · Cited by 13 · see citing works
Deep Supramolecular Language Processing for Co‐Crystal Prediction
Birolo, R., Özçelik, R., Aramini, A., Gobetto, R., Chierotti, M. R., & Grisoni, F. (2025) · Angewandte Chemie International Edition · doi:10.1002/anie.202507835 · Cited by 13 · see citing works
Determination of L-theanine and caffeine contents in tea infusions with different fermentation degrees and brewing conditions using the chromatographic method
Ayakdaş, G., & Ağagündüz, D. (2025) · Foods · doi:10.3390/foods14132313 · Cited by 12 · see citing works
Effect of processing method (natural, washed, honey, fermentation, maceration) on the availability of heavy metals in specialty coffee
Várady, M., Boržíková, J., & Popelka, P. (2024) · Heliyon · doi:10.1016/j.heliyon.2024.e25563 · Cited by 12 · see citing works
The Role of Caffeine in Enhancing Physical Performance: From Metabolism to Muscle Function
Szerej, K., Dorobek, W., Stankiewicz, K., & Świeczkowski-Feiz, J. (2024) · Journal of Education Health and Sport · doi:10.12775/jehs.2024.59.010 · Cited by 12 · see citing works
Role of Caffeine in the Age-related Neurodegenerative Diseases: A Review
Pohanka, M. (2022) · Mini-Reviews in Medicinal Chemistry · doi:10.2174/1389557522666220413103529 · Cited by 11 · see citing works
Caffeine causes cell cycle arrest at G0/G1 and increases of ubiquitinated proteins, ATP and mitochondrial membrane potential in renal cells
Kanlaya, R., Subkod, C., Nanthawuttiphan, S., & Thongboonkerd, V. (2023) · Computational and Structural Biotechnology Journal · doi:10.1016/j.csbj.2023.09.023 · Cited by 10 · see citing works
Obesity as an influencing factor for the occurrence of caffeine-induced effects in women
Domaszewski, P., Konieczny, M., Pakosz, P., Matuska, J., Skorupska, E., & Santafé, M. M. (2024) · Nutrition Metabolism and Cardiovascular Diseases · doi:10.1016/j.numecd.2024.103836 · Cited by 10 · see citing works
Evaluation of Non-Alcoholic Beverages and the Risk Related to Consumer Health among the Romanian Population
Mititelu, M., Oancea, C. N., Neacșu, S. M., Olteanu, G., Cîrţu, A., Hîncu, L., Gheonea, T. C., Stanciu, T. I., Rogoveanu, I., Hashemi, F., et al. (2023) · Nutrients · doi:10.3390/nu15173841 · Cited by 10 · see citing works
Limited caffeine consumption as first-line treatment in managing primary monosymptomatic enuresis in children: how effective is it? A randomised clinical trial
Rezakhaniha, S., Rezakhaniha, B., & Siroosbakht, S. (2023) · BMJ Paediatrics Open · doi:10.1136/bmjpo-2023-001899 · Cited by 10 · see citing works
Detection of Adulterants in Herbal Weight Loss Supplements
Gheorghiu, O. R. C., Ciobanu, A.-M., Guțu, C. M., Dănilă, G.-M., Nițescu, G. V., Rohnean, Ș., & Baconi, D. L. (2025) · Journal of Mind and Medical Sciences · doi:10.3390/jmms12010023 · Cited by 9 · see citing works
Advancements in Modified Electrodes with Electrochemical Sensors for Detecting Acetaminophen and Caffeine: An Update
Meenakshi, S., Saviour, J. S. S., Balakrishnan, S., Kannaiyan, P., & Gopinath, S. C. B. (2025) · Critical Reviews in Analytical Chemistry · doi:10.1080/10408347.2025.2496506 · Cited by 9 · see citing works
Caffeine removal in wastewater: a comprehensive review of current treatment plants and small-scale innovations
Yang, Y., Wan, Y., Chen, H., Li, Y. C., Muñoz‐Carpena, R., Zheng, Y., Huang, J., Zhang, Y., & Gao, B. (2025) · Environmental Technology Reviews · doi:10.1080/21622515.2025.2512483 · Cited by 9 · see citing works
Caffeine Consumption Patterns, Health Impacts, and Media Influence: A Narrative Review
Rauf, M. A., Sharma, L., Essiet, E., Elhassan, O., Fahim, R., Irem-Oko, F., & Sreedharan, J. (2025) · Cureus · doi:10.7759/cureus.86215 · Cited by 9 · see citing works
Caffeine in Aging Brains: Cognitive Enhancement, Neurodegeneration, and Emerging Concerns About Addiction
Carbone, M. G., Pagni, G., Tagliarini, C., Maremmani, I., & Maremmani, A. G. I. (2025) · International Journal of Environmental Research and Public Health · doi:10.3390/ijerph22081171 · Cited by 9 · see citing works
The Examination of the Influence of Caffeinated Coffee Consumption on the Concentrations of Serum Prolactin and Selected Parameters of the Oxidative‐Antioxidant Balance in Young Adults: A Preliminary Report
Rodak, K., Kokot, I., Kryla, A., & Kratz, E. M. (2022) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2022/1735204 · Cited by 9 · see citing works
The Interplay of Nutrition, Exercise, and Dietary Intervention for Enhanced Performance of Athletes and General Well-Being of Non-Athletes: A Review
Emakpor, O. L., Edo, G. I., Yousif, E., Samuel, P. O., Jikah, A. N., Zainulabdeen, K., Mohammed, A. A., Ndudi, W., Nwachukwu, S. C., Ugbune, U., et al. (2024) · OBM Integrative and Complementary Medicine · doi:10.21926/obm.icm.2402038 · Cited by 9 · see citing works
The influence of physical office environments on physiological stress: A PRISMA systematic scoping review
Schuller, S., Bergefurt, L., de Kort, Y. A. W., & Appel‐Meulenbroek, R. (2025) · Journal of Environmental Psychology · doi:10.1016/j.jenvp.2025.102642 · Cited by 10 · see citing works
Evaluating the Neuroprotective Potential of Caffeinated Coffee in the Context of Aluminum-Induced Neurotoxicity: Insights from a PC12 Cell Culture Model
Rodak, K., Bęben, D., Birska, M., Siwiela, O., Kokot, I., Moreira, H., Radajewska, A., Szyjka, A., & Kratz, E. M. (2024) · Antioxidants · doi:10.3390/antiox13030342 · Cited by 8 · see citing works
Effect of ADORA2A Gene Polymorphism and Acute Caffeine Supplementation on Hormonal Response to Resistance Exercise: A Double-Blind, Crossover, Placebo-Controlled Study
Rahimi, R., Semenova, E. A., John, G., Fallah, F., Larin, A. K., Generozov, E. V., & Ahmetov, I. I. (2024) · Nutrients · doi:10.3390/nu16121803 · Cited by 9 · see citing works
Caffeine - a substance well known or still researched
Balawejder-Biśto, A., & Pyka, A. (2022) · Farmacja Polska · doi:10.32383/farmpol/155158 · Cited by 8 · see citing works
Maternal Caffeine Consumption and Its Impact on the Fetus: A Review
Lakin, H., Sheehan, P., & Soti, V. (2023) · Cureus · doi:10.7759/cureus.48266 · Cited by 10 · see citing works
Effect Solvent and Extraction Method on the Characteristics of Green Bean Robusta Coffee
Winarsih, S., Sukardi, S., Wachid, M., & Ismayawati, A. D. (2024) · BIO Web of Conferences · doi:10.1051/bioconf/202410400043 · Cited by 7 · see citing works
Respiratory Responses to a Single Oral Dose of Caffeine in Male Sprague–Dawley Rats
Cho, S.-H., Kim, M., Doo, M., & Ha, J. (2024) · Journal of Medicinal Food · doi:10.1089/jmf.2024.k.0229 · Cited by 7 · see citing works
Association of Coffee and Energy Drink Intake with Suicide Attempts and Suicide Ideation: A Systematic Review and Meta-Analysis
Low, C. E., Chew, N. S. M., Loke, S., Tan, J. Y., Phee, S., Lee, A. R. Y. B., & Ho, C. S. H. (2025) · Nutrients · doi:10.3390/nu17111911 · Cited by 7 · see citing works
The Influence of Lifestyle Factors on the Occurrence and Severity of Premature Ventricular Contractions: A Comprehensive Review
Tungar, I. M., Reddy, M. M. R. K., Flores, S. M., Pokhrel, P., & Ibrahim, A. D. (2023) · Current Problems in Cardiology · doi:10.1016/j.cpcardiol.2023.102072 · Cited by 7 · see citing works
Coffee and Alzheimer's disease
Mirzaei, F., Agbaria, L., Bhatnagar, K., Sirimanne, N., A'amar, N. O., Jindal, V., Thilagendra, A. G., & Raba, F. T. (2024) · Progress in brain research · doi:10.1016/bs.pbr.2024.06.002 · Cited by 7 · see citing works
Associations of black and sugar-sweetened coffee consumption with depressive symptoms: A longitudinal study of Chinese adolescents
Liu, Q., Peng, S., Jiang, W., He, Y., Lu, C., Wang, W., Li, Y., & Guo, L. (2024) · Journal of Affective Disorders · doi:10.1016/j.jad.2024.10.008 · Cited by 8 · see citing works
Synthesis, In vitro Cytotoxicity, Molecular docking of Few Quinazolinone Incorporated Naphthyl Chalcones: As Potential Dual Targeting Anticancer Agents to Treat Lung Cancer and Colorectal Cancer
Arora, P. K., Kumar, S., Bansal, S. K., & Sharma, P. C. (2023) · Oriental Journal Of Chemistry · doi:10.13005/ojc/390202 · Cited by 6 · see citing works
Quantification of skin penetration of caffeine and propylene glycol applied topically in a mixture by tailored multivariate curve resolution‐alternating least squares of depth‐resolved Raman spectra
Choe, C., Pak, G. J., Ascencio, S. M., & Darvin, M. E. (2023) · Journal of Biophotonics · doi:10.1002/jbio.202300146 · Cited by 7 · see citing works
Use of Hansen solubility parameters to select supercritical carbon dioxide cosolvents for improved extraction selectivity: Case study on green tea decaffeination
del Valle, J. M., Cuéllar, L. M., Canales, R. I., de la Fuente, J. C., & Núñez, G. A. (2025) · Journal of Food Engineering · doi:10.1016/j.jfoodeng.2025.112538 · Cited by 6 · see citing works
Effects of caffeine on neuroinflammation in anxiety and depression: a systematic review of rodent studies
Neves, L. D. S., de Mattos, G. V. R. M., Oliveira-Nazareth, Y., da Silva, R. S., & Campello-Costa, P. (2025) · Translational Psychiatry · doi:10.1038/s41398-025-03668-x · Cited by 9 · see citing works
Unraveling the complexities of caffeine: metabolism, genetics, evolution, and health
Liu, X., & Xu, S. (2026) · Hereditas · doi:10.1186/s41065-026-00648-z · Cited by 6 · see citing works
Mid-Infrared Photothermal Spectroscopy for the Detection of Caffeine in Beverages
Ricchiuti, G., Riedlsperger, L., Dabrowska, A., Rosenberg, E., O’Faoláin, L., & Lendl, B. (2024) · Sensors · doi:10.3390/s24061974 · Cited by 6 · see citing works
Synthetic and Natural Radioprotective Agents: Recent Status and their Underlying Mechanism of Action
Mishra, J., Poonia, N., Lather, V., Nishad, D. K., & Pandita, D. (2024) · Current Pharmaceutical Biotechnology · doi:10.2174/0113892010293722240522071042 · Cited by 5 · see citing works
Unraveling tea and coffee consumption effects on cardiovascular diseases risk factors: A narrative review
Santoso, L. F. A. S., Nasr, K., Roumani, A. M., Zeid, H. K. A., & Dabbous, M. S. (2024) · Health Science Reports · doi:10.1002/hsr2.70105 · Cited by 5 · see citing works
Sustained Release of Liposomal Caffeine Using Novel Natural Fiber Interlaced Liposomal Technology: Development and Structural Characterisation
Sharma, V. M., Valsaraj, T., Sudeep, H. V., Shyamprasad, K., & Jacob, J. (2024) · Journal of Pharmaceutical Innovation · doi:10.1007/s12247-024-09874-2 · Cited by 5 · see citing works
The Effects of Coffee/Caffeine in Patients with Multiple Sclerosis; A Systematic Review
Salekzamani, S., Baharomid, S., Pakkhesal, S., Balafkandeh, M., Gholipour-khalili, E., Talebi, M., Sanaie, S., & Naseri, A. (2024) · Journal of Evidence-Based Integrative Medicine · doi:10.1177/2515690x241293114 · Cited by 5 · see citing works
Synergetic Effects of Coffea liberica and Curcuma zanthorrhiza: Study of Sensory Profile, Proximate, and Chemical Compound
Latief, M., Muntasir, R. W., Wijaya, D. E., Tarigan, I. L., & Sutrisno, S. (2025) · Beverages · doi:10.3390/beverages11010009 · Cited by 4 · see citing works
Progress in Methylxanthine Biosynthesis: Insights into Pathways and Engineering Strategies
Jiang, T., Zuo, S., Liu, C. Y., Xing, W., & Wang, P. (2025) · International Journal of Molecular Sciences · doi:10.3390/ijms26041510 · Cited by 4 · see citing works
The association between urinary caffeine and caffeine metabolites and diabetic retinopathy in individuals with diabetes: NHANES 2009–2014
Chen, X., Guo, Q., Li, J., Xu, N., Miao, H., & Huang, L. (2025) · Scientific Reports · doi:10.1038/s41598-025-01088-x · Cited by 4 · see citing works
Improving flavor, safety, and sustainability of coffee substitute: Challenges and future research directions
Adi, P., Mulyani, R., Yudhistira, B., Punthi, F., Listyaningrum, R. S., Chang, C., Gavahian, M., & Hsieh, C. (2025) · Trends in Food Science & Technology · doi:10.1016/j.tifs.2025.105083 · Cited by 4 · see citing works
Continuous removal of caffeine in a horizontal-flow anaerobic immobilized biomass bioreactor: identification of transformation products
Martins, G. S., Rodrigues, T. A., Lamarca, R. S., Ayala-Durán, S. C., da Silva, B. F., & Gomes, P. C. F. D. L. (2023) · Environmental Science and Pollution Research · doi:10.1007/s11356-023-29875-x · Cited by 4 · see citing works
Injectables Pharmacotherapies for Obesity: Mechanisms, Efficacy, and Aesthetic Implications
Gomes, J. M., Ferreira, A. C. M., & Barbosa, A. D. P. (2025) · Obesities · doi:10.3390/obesities5020022 · Cited by 5 · see citing works
Energy Drinks—Trend or Awareness Choice? A Mini-Review
Górka, K., Kruczyńska, A., Lenard, T., Banach, A., Sochaczewska, A., Mencfel, R., Kuźniar, A., & Czarnek, K. (2025) · Journal of Nutrition · doi:10.1016/j.tjnut.2025.06.033 · Cited by 4 · see citing works
From Science to Dressing Room: Dietary Supplements for Elite Soccer Performance
Bongiovanni, T., Genovesi, F., Carling, C., Greco, G., & Jäger, R. (2025) · Journal of Functional Morphology and Kinesiology · doi:10.3390/jfmk10040408 · Cited by 3 · see citing works
Hybrid Deep Learning Models for Analyzing Histological Images of the Zebrafish Intestine Under Oxidative Stress
Pavel, C. D., Moldovanu, S., Pavel, I. A., Dragostin, O.-M., Chițescu, C. L., & Zamfir, C. L. (2025) · Diagnostics · doi:10.3390/diagnostics15222859 · Cited by 3 · see citing works
Coffee intake is associated with telomere length in severe mental disorders
Mlakar, V., Forti, M. D., Halff, E. F., Srivastava, D. P., Akkouh, I. A., Djurovic, S., Martin-Ruiz, C. M., Quintana, D. S., Birkenæs, V., Steen, N. E., et al. (2025) · BMJ Mental Health · doi:10.1136/bmjment-2025-301700 · Cited by 3 · see citing works
Effect of caffeine on the cardiovascular system and performance: A systematic review
Bjelica, B., Aksović, N., Zelenović, M., Pržulj, R., & Radenković, O. (2023) · Turkish Journal of Kinesiology · doi:10.31459/turkjkin.1263307 · Cited by 3 · see citing works
Nonrestorative sleep and its associated factors in Chinese adolescents and the moderation effects of coffee or tea consumption
Li, S., Fong, D., Wang, Y. Z., Lin, Z., Shang, X., & Gong, W. J. (2024) · BMC Public Health · doi:10.1186/s12889-024-19936-2 · Cited by 3 · see citing works
The Effects of Caffeine on Exercise in Hot Environments: A Bibliometric Study
Li, H., Yang, Y., Liu, Q., Liu, L., Zhang, G., Zhang, X., Yin, M., & Cao, Y. (2024) · Nutrients · doi:10.3390/nu16213692 · Cited by 3 · see citing works
Unravelling the myth: A cross-sectional study on coffee consumption among anesthesiologists in France
Barnawi, M. I., Alawadi, D., Alzahrani, K., Samargandi, R., & Boutros, M. (2024) · Medicine · doi:10.1097/md.0000000000040762 · Cited by 3 · see citing works
Chlorogenic acid-rich fraction from Coffea canaphora attenuates periodontal bacteria growth and lipopolysaccharide-stimulated oral squamous cell carcinoma progression
Panyathep, A., Makeudom, A., Kantrong, N., Punturee, K., & Chewonarin, T. (2025) · Food Bioscience · doi:10.1016/j.fbio.2025.106489 · Cited by 3 · see citing works
A Hands-on Experiment of Caffeine Extraction from Tea Leaves Using Direct Sublimation: Learning Effectiveness for Secondary School Students
Horimatsu, S., Mizutani, M., Miura, H., & Ohkoshi, E. (2025) · Journal of Chemical Education · doi:10.1021/acs.jchemed.4c00933 · Cited by 3 · see citing works
Mastalgia in Fibrocystic Changes; From the Diagnosis Bench to Innovative Therapy: A Narrative Review
Nori, W., Zghair, M. A. G., Abdulqader, S. K., & Jaber, R. A. (2025) · The Open Medicinal Chemistry Journal · doi:10.2174/0118741045371715250404073206 · Cited by 3 · see citing works
Influence of the CYP1A2 genotype on the exercise performance of physically active individuals under caffeine supplementation: a systematic review
Messenburger, G. P., Nuñez, F. F., Porepp, O. D. S. C., Collares, L. F., Delpino, F. M., Barros, C. C., & Pieniz, S. (2025) · Nutrition Research · doi:10.1016/j.nutres.2025.10.005 · Cited by 4 · see citing works
The Use of Caffeine Products in Saudi Arabia
Rara, R., Alhindi, R., Alotaibi, M., Shaykhayn, Y., Alnakhli, A. M., Albar, H. T., Alshanberi, A. M., Alhindi, Y. Z., & Alsanosi, S. (2023) · Pharmacognosy Research · doi:10.5530/pres.15.4.068 · Cited by 3 · see citing works
The Effect of Bacterial Enzymes on Reducing Chlorogenic Acid Levels in Cascara Robusta Coffee (Coffea canephora L.)
Utami, N. F., Elya, B., Hayun, H., Kusmardi, K., & Nur, S. (2024) · Pharmacognosy Journal · doi:10.5530/pj.2024.16.50 · Cited by 3 · see citing works
Energy drinks, depression, insomnia, and stress in palestinian adolescents: a cross-sectional study
Maraqa, B. N., Fasfoos, A., Alami, M., Banat, N., Amr, O., & Saraheen, A. (2025) · International Journal of Adolescent Medicine and Health · doi:10.1515/ijamh-2024-0178 · Cited by 3 · see citing works
Comparative Analysis of Caffeine Content in Cold and Hot Brewed Robusta Coffee Using High-Performance Liquid Chromatography (HPLC)
Rahmawati, I., & Asrori, S. H. (2024) · JKPK (Jurnal Kimia dan Pendidikan Kimia) · doi:10.20961/jkpk.v9i1.84991 · Cited by 2 · see citing works
Acute Cardiovascular Effects of Turkish Coffee Assessed by VO2 Test: A Randomized Crossover Trial
Elsahoryi, N. A., Ibrahim, M. O., Alhaj, O. A., & Hammouh, F. (2025) · Nutrients · doi:10.3390/nu17050823 · Cited by 2 · see citing works
Caffeine Intake Attenuates the Association of Cadmium Exposure with Cardiovascular Disease: National Health and Nutrition Examination Survey (NHANES) 2003–2016
Chen, S., Zhang, H., Su, Q., Lin, X., Kang, K., Zhou, Z., Zeng, L., Lin, Y., Wang, H.-S., Peng, F., et al. (2025) · Cardiovascular Toxicology · doi:10.1007/s12012-025-10031-5 · Cited by 2 · see citing works
Caffeine Use in Sport: A Systematic Review and Meta-analysis of Acute Side Effects and Implications for Athlete Health and Safety
Negaresh, R., Al-Riyami, S. A. A., Ghahfarrokhi, M. M., Coso, J. D., Karimi, Z., Yaghoobi, M., & Bagheri, R. (2026) · Sports Medicine · doi:10.1007/s40279-026-02441-4 · Cited by 3 · see citing works
Ferrocenyl Hydroxy Methyl Coupled Caffeine Synthesis, Density Functional Theory, ADME Prediction and Docking Analysis of It's Binding Interactions to Coronavirus Main Protease
Almahmoud, S. A. J., Cariello, M., & Elzupir, A. O. (2023) · Oriental Journal Of Chemistry · doi:10.13005/ojc/390201 · Cited by 2 · see citing works
Coffee and brain health: An introductory overview
Raza, M. L. (2024) · Progress in brain research · doi:10.1016/bs.pbr.2024.06.010 · Cited by 2 · see citing works
Recording of hippocampal activity on the effect of convulsant doses of caffeine.
Eiró-Quirino, L., Yoshino, F. K., Amorim, G. C. D., de Araújo, D. B., Barbosa, G., de Souza, L. V., dos Santos, M. F., Hamoy, M., dos Santos, R. D., Amóras, L., et al. (2024) · Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie · doi:10.1016/j.biopha.2024.117148 · Cited by 1 · see citing works
Photophysical Properties, Fluorescence Quenching of Metformin Hydrochloride by Caffeine, and its Docking with the AMP-activated protein kinase receptor
Asemare, S., Belay, A., Kebede, A., Sherefedin, U., Gurumurthi, T., & Hurrisa, T. F. (2025) · Journal of Fluorescence · doi:10.1007/s10895-024-04128-3 · Cited by 2 · see citing works
Exploring energy drink consumption among nursing students: A qualitative study
Higbee, M. R., & Gipson, C. S. (2025) · Teaching and learning in nursing · doi:10.1016/j.teln.2025.02.030 · Cited by 2 · see citing works
Deep Supramolecular Language Processing for Co‐Crystal Prediction
Birolo, R., Özçelik, R., Aramini, A., Gobetto, R., Chierotti, M. R., & Grisoni, F. (2025) · Angewandte Chemie · doi:10.1002/ange.202507835 · Cited by 2 · see citing works

Pharmacology of caffeine
Maheshwari, R. A., Sen, D. B., Shah, U., Upaganlawar, A., & Sen, A. K. (2024) · Tea in Health and Disease Prevention · doi:10.1016/b978-0-443-14158-4.00038-5 · Cited by 1 · see citing works
COFFEE AND HEALTH - WHAT DOES MEDICINE KNOW ABOUT ONE OF THE MOST LOVED BEVERAGES OF THE WORLD? A LITERATURE REVIEW
Pelc, J., Czerny, I., Daniszewski, S., Cieślik-Porębska, M., Cieślik, A., Cichocka, A., Miecznikowska, A., & Gąbka, M. (2026) · International Journal of Innovative Technologies in Social Science · doi:10.31435/ijitss.3(51).2026.6161
Current therapeutic targets and multifaceted physiological impacts of caffeine
Song, X., Kirtipal, N., Lee, S., Malý, P., & Bharadwaj, S. (2023) · Phytotherapy Research · doi:10.1002/ptr.8000 · Cited by 33 · see citing works
Caffeinated Beverages—Unveiling Their Impact on Human Health
Čižmárová, B., Kraus, V., & Birková, A. (2025) · Beverages · doi:10.3390/beverages11010018 · Cited by 32 · see citing works
Food-derived caffeine in human nutrition
Glibowski, P., Spodymek, A., Gazda, P., Siłka, Ł., & Rząd, Z. (2023) · Journal of Food and Nutrition Research · doi:10.64122/dlmn3672

Authors: Rodak, K., Kokot, I., & Kratz, E. M.
Affiliations: Wroclaw Medical University (PL)
Corresponding author: Rodak, Kamil
Kratz, Ewa Maria
ORCID: Rodak, Kamil
Kokot, Izabela
Kratz, Ewa Maria
Venue: Nutrients
Publisher: MDPI AG
Published: 2021-09-02
Volume: 13
Issue: 9
Pages: 3088
ISSN: 2072-6643 (ISSN-L)
DOI: 10.3390/nu13093088
PMC: PMC8467199
OpenAlex: W3198497028
Cited by: 188
References: 205
Citations by year: 2026: 27 · 2025: 64 · 2024: 49 · 2023: 33 · 2022: 15
FWCI: 3.07
Type: journal article
Language: en
Open access: gold
doi.org
Licence: cc-by
creativecommons.org/licenses/by/4.0/ (vor)
Locations: Nutrients (publishedVersion, cc-by)
Europe PMC (PubMed Central) (publishedVersion, other-oa)
PubMed Central (publishedVersion, cc-by)
PubMed (publishedVersion)
DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
Topics: Health Sciences › Medicine › Pharmacology › Coffee research and impacts
Health Sciences › Medicine › Pathology and Forensic Medicine › Alcohol Consumption and Health Effects
Health Sciences › Medicine › Pathology and Forensic Medicine › Tea Polyphenols and Effects
Keywords: caffeine, purine alkaloids, caffeine consumption, health effects of caffeine, central nervous system, immune system, digestive system, respiratory system, urinary tract, asthma, Parkinson's disease, hypertension, children and adolescents, older adults, antioxidant activity
MeSH terms: Adolescent, Adult, Central Nervous System Stimulants, Analgesics, Animals, Antioxidants, Mental Disorders, Caffeine, Cardiovascular System, Child, Digestive System, Humans, Immune System, Respiratory System, Urinary Tract, Receptors, Purinergic P1, Neurodegenerative Diseases

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

Caffeine as a factor influencing the functioning of the human body-friend or foe?

Abstract

Integrity signals

Claims the paper makes

Claims other papers make about this one

Self-check

Cites

Cited by

Related

Record

About these checks