A genetic variation in the adenosine A2A receptor gene (ADORA2A) contributes to individual sensitivity to caffeine effects on sleep
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Caffeine is the most widely used stimulant in Western countries. Some people voluntarily reduce caffeine consumption because it impairs the quality of their sleep. Studies in mice revealed that the disruption of sleep after caffeine is mediated by blockade of adenosine A2A receptors. Here we show in humans that (1) habitual caffeine consumption is associated with reduced sleep quality in self-rated caffeine-sensitive individuals, but not in caffeine-insensitive individuals; (2) the distribution of distinct c.1083T>C genotypes of the adenosine A2A receptor gene (ADORA2A) differs between caffeine-sensitive and -insensitive adults; and (3) the ADORA2A c.1083T>C genotype determines how closely the caffeine-induced changes in brain electrical activity during sleep resemble the alterations observed in patients with insomnia. These data demonstrate a role of adenosine A2A receptors for sleep in humans, and suggest that a common variation in ADORA2A contributes to subjective and objective responses to caffeine on sleep.
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Variation in the expression of genes such as CYP1A2 and ADORA2A are suggested to modulate the rate of metabolism and sensitivity.
“Variation in the expression of genes such as cytochrome P450 1A2 (CYP1A2) [91] and adenosine A2A receptor (ADORA2A) [92] are suggested to modulate the rate of metabolism and sensitivity.”
From The effect of caffeine on subsequent sleep: A systematic review and meta-analysis (2023) · cites this paper as [92]
Common variants of the gene encoding for the A2a receptor can disrupt sleep or cause anxiety in some individuals after ingesting caffeine.
“For example, common variants of the gene encoding for the A2a receptor can disrupt sleep (51) or cause anxiety in some individuals (52) after ingesting caffeine.”
From The Safety of Ingested Caffeine: A Comprehensive Review (2017) · cites this paper as [51]
Cites
(1970) · Cited by 24,983 · see citing works
Rechtschaffen, A. (1968) · Medical Entomology and Zoology · Cited by 11,772 · see citing works
Van Dongen, H. P. A., Maislin, G., Mullington, J. M., & Dinges, D. F. (2003) · Sleep · doi:10.1093/sleep/26.2.117 · Cited by 3,173 · see citing works
Fredholm, B. B., Bättig, K., Holmén, J., Nehlig, A., & Zvartau, E. E. (1999) · Pharmacological Reviews · doi:10.1016/s0031-6997(24)01396-6 · Cited by 2,624 · cited 2× · see citing works
“In doses typically contained in coffee, tea, energy drinks, foods, and pharmaceutical formulations,(6) caffeine acts as an adenosine receptor antagonist.(5) Adenosinergic mechanisms appear to be critically involved in wake–sleep processes in humans.”
BackgroundAggressiveness, hypoalgesia and high blood pressure in mice lacking the adenosine A2a receptor
Ledent, C. A., Vaugeois, J., Schiffmann, S. N., Pedrazzini, T., Yacoubi, M. E., Vanderhaeghen, J. J., Costentin, J., Heath, J. K., Vassart, G., & Parmentier, M. (1997) · Nature · doi:10.1038/41771 · Cited by 918 · see citing works
Rajaratnam, S. M., & Arendt, J. (2001) · The Lancet · doi:10.1016/s0140-6736(01)06108-6 · Cited by 711 · see citing works
Barone, J. J., & Roberts, H. R. (1996) · Food and Chemical Toxicology · doi:10.1016/0278-6915(95)00093-3 · Cited by 705 · see citing works
Adenosine A2A, but not A1, receptors mediate the arousal effect of caffeine
Huang, Z.-L., Qu, W.-M., Eguchi, N., Chen, J.-F., Schwarzschild, M. A., Fredholm, B. B., Urade, Y., & Hayaishi, O. (2005) · Nature Neuroscience · doi:10.1038/nn1491 · Cited by 640 · see citing works
Beta/Gamma EEG Activity in Patients with Primary and Secondary Insomnia and Good Sleeper Controls
Perlis, M. L., Smith, M. T., Andrews, P. J., Orff, H. J., & Giles, D. E. (2001) · SLEEP · doi:10.1093/sleep/24.1.110 · Cited by 493 · see citing works
Beta EEG activity and insomnia
Perlis, M. L., Merica, H., Smith, M. T., & Giles, D. E. (2001) · Sleep Medicine Reviews · doi:10.1053/smrv.2001.0151 · Cited by 345 · see citing works
Spectral characteristics of sleep EEG in chronic insomnia
Merica, H., Blois, R., & Jm, G. (1998) · European Journal of Neuroscience · doi:10.1046/j.1460-9568.1998.00189.x · Cited by 345 · see citing works
Association between A2a receptor gene polymorphisms and caffeine-induced anxiety
Alsene, K., Deckert, J., Sand, P., & de Wit, H. (2003) · Neuropsychopharmacology · doi:10.1038/sj.npp.1300232 · Cited by 334 · see citing works
Prevalence and Patterns of Problematic Sleep Among Older Adolescents
Ohayon, M. M., ROBERTS, R. E., Zulley, J., Smirne, S., & Priest, R. G. (2000) · Journal of the American Academy of Child & Adolescent Psychiatry · doi:10.1097/00004583-200012000-00019 · Cited by 324 · see citing works
Rétey, J., Adam, M., Honegger, E., Khatami, R., Luhmann, U. F. O., Jung, H. H., Berger, W., & Landolt, H. (2005) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0505414102 · Cited by 260 · see citing works
Self-citationErlich, H. A., Gelfand, D. H., & Saiki, R. K. (1988) · Nature · doi:10.1038/331461a0 · Cited by 254 · see citing works
Foster, F., & Wulff, K. (2005) · Nature reviews. Neuroscience · doi:10.1038/nrn1670 · Cited by 243 · see citing works
Rasmussen (2002) · Pharmacogenetics · doi:10.1097/00008571-200208000-00008 · Cited by 241 · see citing works
Caffeine Use as a Model of Acute and Chronic Insomnia
Bonnet, M. H., & Arand, D. L. (1992) · SLEEP · doi:10.1093/sleep/15.6.526 · Cited by 236 · see citing works
Caffeine Attenuates Waking and Sleep Electroencephalographic Markers of Sleep Homeostasis in Humans
Landolt, H., Rétey, J., Tönz, K., Gottselig, J. M., Khatami, R., Buckelmüller, I., & Achermann, P. (2004) · Neuropsychopharmacology · doi:10.1038/sj.npp.1300526 · Cited by 211 · see citing works
Self-citationCaffeine intake (200 mg) in the morning affects human sleep and EEG power spectra at night
Landolt, H.-P., Werth, E., Borbély, A. A., & Dijk, D.-J. (1995) · Brain Research · doi:10.1016/0006-8993(95)00040-w · Cited by 209 · see citing works
Self-citationCaffeine Reduces Low-Frequency Delta Activity in the Human Sleep EEG
Landolt, H. (1995) · Neuropsychopharmacology · doi:10.1016/0893-133x(94)00079-f · Cited by 198 · see citing works
Self-citationInvolvement of DARPP-32 phosphorylation in the stimulant action of caffeine
Lindskog, M., Svenningsson, P., Pozzi, L., Kim, Y. D., Fienberg, A. A., Bibb, J. A., Fredholm, B. B., Nairn, A. C., Greengard, P., & Fisone, G. (2002) · Nature · doi:10.1038/nature00817 · Cited by 180 · see citing works
Bonnet, M., Balkin, T., Dinges, D., Roehrs, T., Rogers, N., & Wesensten, N. (2005) · Sleep · doi:10.1093/sleep/28.9.1163 · Cited by 171 · see citing works
Genetic and Environmental Influences on Insomnia, Daytime Sleepiness, and Obesity in Twins
Watson, N. F., Goldberg, J. H., Arguelles, L., & Buchwald, D. (2006) · SLEEP · doi:10.1093/sleep/29.5.645 · Cited by 166 · see citing works
Deckert, J., Nöthen, M. M., Franke, P. E., Delmo, C. D., Fritze, J., Knapp, M., Maier, W., Beckmann, H., & Propping, P. (1998) · Molecular Psychiatry · doi:10.1038/sj.mp.4000345 · Cited by 162 · see citing works
Age-Related Changes in the Time Course of Vigilant Attention During 40 Hours Without Sleep in Men
Adam, M., Rétey, J., Khatami, R., & Landolt, H. (2006) · SLEEP · doi:10.1093/sleep/29.1.55 · Cited by 154 · see citing works
Self-citationEvidence for Genetic Linkage Between a Polymorphism in the Adenosine 2A Receptor and Panic Disorder
Hamilton, S. P., Slager, S. L., Baisre, A., Heiman, G. A., Klein, D. F., Hodge, S. E., Weissman, M. M., Fyer, A. J., & Knowles, J. A. (2003) · Neuropsychopharmacology · doi:10.1038/sj.npp.1300311 · Cited by 147 · see citing works
Caffeine Self-administration, Withdrawal, and Adverse Effects Among Coffee Drinkers
Hughes, J. R. (1991) · Archives of General Psychiatry · doi:10.1001/archpsyc.1991.01810310029006 · Cited by 140 · see citing works
Interindividual Variation in Sleep Duration and Its Association With Sleep Debt in Young Adults
Klerman, E. B., & Dijk, D. (2005) · SLEEP · doi:10.1093/sleep/28.10.1253 · Cited by 138 · see citing works
Low-dose caffeine discrimination in humans.
Griffiths, R. R., Evans, S. M., Heishman, S. J., Preston, K. L., Sannerud, C. A., Wolf, B., & Woodson, P. P. (1990) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1016/s0022-3565(25)20216-6 · Cited by 133 · see citing works
Rétey, J., Adam, M., Gottselig, J. M., Khatami, R., Dürr, R., Achermann, P., & Landolt, H. (2006) · Journal of Neuroscience · doi:10.1523/jneurosci.1538-06.2006 · Cited by 119 · see citing works
Self-citationThe Use of Caffeine Versus Prophylactic Naps in Sustained Performance
Bonnet, M. H., Gomez, S. A., Wirth, O., & Arand, D. L. (1995) · SLEEP · doi:10.1093/sleep/18.2.97 · Cited by 117 · see citing works
Drapeau, C., Hamel-Hébert, I., Robillard, R., Selmaoui, B., Filipini, D., & Carrier, J. (2006) · Journal of Sleep Research · doi:10.1111/j.1365-2869.2006.00518.x · Cited by 115 · see citing works
Goldstein, A., Warren, R. A., & Kaizer, S. (1965) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1016/s0022-3565(25)27091-4 · Cited by 112 · see citing works
PSYCHOTROPIC EFFECTS OF CAFFEINE IN MAN. II. ALERTNESS, PSYCHOMOTOR COORDINATION, AND MOOD
Goldstein, A., Kaizer, S., & Warren, R. A. (1965) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1016/s0022-3565(25)27160-9 · Cited by 109 · see citing works
Reinforcing and subjective effects of caffeine in normal human volunteers
Stern, K., Chait, L. D., & Johanson, C. E. (1989) · Psychopharmacology · doi:10.1007/bf00442010 · Cited by 101 · see citing works
Enhanced stimulant and metabolic effects of combined ephedrine and caffeine*1
HALLER, C. (2004) · Clinical Pharmacology & Therapeutics · doi:10.1016/j.clpt.2003.11.375 · Cited by 86 · see citing works
Neurophysiological aspects of primary insomnia: Implications for its treatment
Cortoos, A., Verstraeten, E., & Cluydts, R. (2006) · Sleep Medicine Reviews · doi:10.1016/j.smrv.2006.01.002 · Cited by 69 · see citing works
Caffeine metabolism and coffee-attributed sleep disturbances
Levy, M., & Zylber‐Katz, E. (1983) · Clinical Pharmacology & Therapeutics · doi:10.1038/clpt.1983.105 · Cited by 66 · see citing works
Gottselig, J. M., Adam, M., Rétey, J., Khatami, R., Achermann, P., & Landolt, H. (2006) · Journal of Sleep Research · doi:10.1111/j.1365-2869.2006.00497.x · Cited by 66 · see citing works
Self-citationPharmacokinetic and pharmacodynamic responses to caffeine in poor and normal sleepers
Tiffin, P. A., Ashton, H., Marsh, R., Kamali, F., Ashton, H., & Marsh, R. (1995) · Psychopharmacology · doi:10.1007/bf02246500 · Cited by 54 · see citing works
Reasons for changing caffeinated coffee consumption: the Rancho Bernardo Study.
Soroko, S. B., Chang, J. C., & Barrett-Connor, E. L. (1996) · Journal of the American College of Nutrition · doi:10.1080/07315724.1996.10718571 · Cited by 44 · see citing works
Dose-related caffeine discrimination in normal volunteers
Evans, S., & Griffiths, R. R. (1991) · Behavioural Pharmacology · doi:10.1097/00008877-199109000-00011 · Cited by 41 · see citing works
Factors influencing the subjective response to caffeine
Chait, L. D. (1992) · Behavioural Pharmacology · doi:10.1097/00008877-199206000-00005 · Cited by 31 · see citing works
The Influence of Caffein Alkaloid on the Quality and Amount of Sleep
Hollingworth, H. L. (1912) · The American Journal of Psychology · doi:10.2307/1413116 · Cited by 17 · see citing works
Arousal and Behavior: Biopsychological Effects of Caffeine
Nehlig, A. (2004) · CRC Press eBooks · doi:10.1201/9780203618851-10 · Cited by 12 · see citing works
Bastien, C., & Bonnet, M. H. (2001) · Sleep Medicine Reviews · doi:10.1053/smrv.2001.0169 · Cited by 9 · see citing works
Flagged first, then by citations
1 of the 48 references couldn’t be matched to a known paper.
Cited by
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Neurocognitive consequences of sleep deprivation
Goel, N., Rao, H., Durmer, J., & Dinges, D. (2009) · Seminars in Neurology · doi:10.1055/s-0029-1237117 · Cited by 2,154 · see citing works
Control of sleep and wakefulness
Brown, R. E., Basheer, R., McKenna, J. T., Strecker, R. E., & McCarley, R. W. (2012) · Physiological Reviews · doi:10.1152/physrev.00032.2011 · Cited by 1,477 · see citing works
Fredholm, B. B., IJzerman, A. P., Jacobson, K. A., Linden, J. M., & Müller, C. E. (2011) · Pharmacological Reviews · doi:10.1124/pr.110.003285 · Cited by 1,307 · see citing works
<i>Sleep Deprivation and Vigilant Attention</i>
Lim, J., & Dinges, D. F. (2008) · Annals of the New York Academy of Sciences · doi:10.1196/annals.1417.002 · Cited by 1,213 · see citing works
Caffeinated energy drinks a growing problem
Reissig, C. J., Strain, E. C., & Griffiths, R. R. (2009) · Drug and Alcohol Dependence · doi:10.1016/j.drugalcdep.2008.08.001 · Cited by 1,026 · see citing works
The role of sleep hygiene in promoting public health: a review of empirical evidence
Irish, L. A., Kline, C. E., Gunn, H. E., Buysse, D. J., & Hall, M. H. (2015) · Sleep Medicine Reviews · doi:10.1016/j.smrv.2014.10.001 · Cited by 931 · see citing works
Adenosine receptors as drug targets — what are the challenges?
Chen, J., Eltzschig, H. K., & Fredholm, B. B. (2013) · Nature Reviews Drug Discovery · doi:10.1038/nrd3955 · Cited by 899 · see citing works
International society of sports nutrition position stand: caffeine and performance
Goldstein, E. R., Ziegenfuss, T., Kalman, D., Kreider, R., Campbell, B., Wilborn, C., Taylor, L., Willoughby, D., Stout, J., Graves, B. S., et al. (2010) · Journal of the International Society of Sports Nutrition · doi:10.1186/1550-2783-7-5 · Cited by 686 · see citing works
International Society of Sports Nutrition Position Stand: Caffeine and Exercise Performance
Guest, N. S., VanDusseldorp, T. A., Nelson, M. T., Grgic, J., Schoenfeld, B. J., Jenkins, N. D. M., Arent, S. M., Antonio, J., Stout, J. R., Trexler, E. T., et al. (2021) · Journal of the International Society of Sports Nutrition · doi:10.1186/s12970-020-00383-4 · Cited by 665 · see citing works
Interindividual Differences in Caffeine Metabolism and Factors Driving Caffeine Consumption
Nehlig, A. (2018) · Pharmacological Reviews · doi:10.1124/pr.117.014407 · Cited by 632 · see citing works
Scientific Opinion on the safety of caffeine
EFSA Panel on Dietetic Products, N. A. A. (. (2015) · EFSA Journal · doi:10.2903/j.efsa.2015.4102 · Cited by 613 · see citing works
“, 2010) and in the effects of caffeine on sleep (Retey et al., 2007; Byrne et al., 2012).”
BackgroundRibeiro, J. A., & Sebastião, A. M. (2010) · Journal of Alzheimer s Disease · doi:10.3233/jad-2010-1379 · Cited by 584 · see citing works
The Safety of Ingested Caffeine: A Comprehensive Review
Temple, J. L., Bernard, C., Lipshultz, S. E., Czachor, J. D., Westphal, J. A., & Mestre, M. A. (2017) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2017.00080 · Cited by 557 · see citing works
Clark, I., & Landolt, H. P. (2017) · Sleep Medicine Reviews · doi:10.1016/j.smrv.2016.01.006 · Cited by 499 · see citing works
Self-citationComorbidity of insomnia and depression
Staner, L. (2010) · Sleep Medicine Reviews · doi:10.1016/j.smrv.2009.09.003 · Cited by 481 · see citing works
Purinergic signalling: From normal behaviour to pathological brain function
Burnstock, G., Krügel, U., Abbracchio, M. P., & Illés, P. (2011) · Progress in Neurobiology · doi:10.1016/j.pneurobio.2011.08.006 · Cited by 394 · see citing works
Adenosine, energy metabolism and sleep homeostasis
Porkka-Heiskanen, T., & Kalinchuk, A. V. (2011) · Sleep Medicine Reviews · doi:10.1016/j.smrv.2010.06.005 · Cited by 328 · see citing works
Caffeine use in children: What we know, what we have left to learn, and why we should worry
Temple, J. L. (2009) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2009.01.001 · Cited by 328 · see citing works
The effect of caffeine on subsequent sleep: A systematic review and meta-analysis
Gardiner, C., Weakley, J., Burke, L. M., Roach, G. D., Sargent, C., Maniar, N., Townshend, A., & Halson, S. L. (2023) · Sleep Medicine Reviews · doi:10.1016/j.smrv.2023.101764 · Cited by 315 · see citing works
Genetics of caffeine consumption and responses to caffeine
Yang, A., Palmer, A. A., & de Wit, H. (2010) · Psychopharmacology · doi:10.1007/s00213-010-1900-1 · Cited by 310 · see citing works
Sleep homeostasis: a role for adenosine in humans?
Landolt, H.-P. (2008) · Biochemical Pharmacology · doi:10.1016/j.bcp.2008.02.024 · Cited by 290 · see citing works
Self-citationEffects of caffeine on the human circadian clock in vivo and in vitro
Burke, T. M., Markwald, R. R., McHill, A. W., Chinoy, E. D., Snider, J. A., Bessman, S. C., Jung, C. M., O’Neill, J. S., & Wright, K. P. (2015) · Science Translational Medicine · doi:10.1126/scitranslmed.aac5125 · Cited by 283 · see citing works
Adenosine Receptors and the Central Nervous System
Sebastião, A. M., & Ribeiro, J. A. (2009) · Handbook of experimental pharmacology · doi:10.1007/978-3-540-89615-9_16 · Cited by 271 · see citing works
Cunha, R. A., & Agostinho, P. M. (2010) · Journal of Alzheimer s Disease · doi:10.3233/jad-2010-1408 · Cited by 233 · see citing works
The Role of Adenosine in the Regulation of Sleep
Huang, Z., Urade, Y., & Hayaishi, O. (2011) · Current Topics in Medicinal Chemistry · doi:10.2174/156802611795347654 · Cited by 216 · see citing works
Caffeine and cardiovascular health
Turnbull, D., Rodricks, J. V., Mariano, G. F., & Chowdhury, F. (2017) · Regulatory Toxicology and Pharmacology · doi:10.1016/j.yrtph.2017.07.025 · Cited by 216 · see citing works
Caffeine Use Disorder: A Comprehensive Review and Research Agenda
Meredith, S. E., Juliano, L. M., Hughes, J. R., & Griffiths, R. R. (2013) · Journal of Caffeine Research · doi:10.1089/jcr.2013.0016 · Cited by 210 · see citing works
Pickering, C., & Kiely, J. (2017) · Sports Medicine · doi:10.1007/s40279-017-0776-1 · Cited by 221 · see citing works
Effects of coffee/caffeine on brain health and disease: What should I tell my patients?
Nehlig, A. (2015) · Practical Neurology · doi:10.1136/practneurol-2015-001162 · Cited by 206 · see citing works
Harvey, C., Gehrman, P., & Espie, C. A. (2013) · Sleep Medicine Reviews · doi:10.1016/j.smrv.2013.11.004 · Cited by 201 · see citing works
Effects of caffeine on sleep and cognition
Snel, J., & Lorist, M. M. (2011) · Progress in brain research · doi:10.1016/b978-0-444-53817-8.00006-2 · Cited by 187 · see citing works
Potential Therapeutic Interest of Adenosine A2A Receptors in Psychiatric Disorders
Cunha, R. A., Ferré, S., Vaugeois, J., & Chen, J. (2008) · Current Pharmaceutical Design · doi:10.2174/138161208784480090 · Cited by 187 · see citing works
Sleep in the United States Military
Good, C. H., Brager, A. J., Capaldi, V. F., & Mysliwiec, V. (2019) · Neuropsychopharmacology · doi:10.1038/s41386-019-0431-7 · Cited by 191 · see citing works
Adenosine, caffeine, and sleep–wake regulation: state of the science and perspectives
Reichert, C. F., Deboer, T., & Landolt, H. (2022) · Journal of Sleep Research · doi:10.1111/jsr.13597 · Cited by 183 · see citing works
“…caffeine, theophylline, and paraxanthine act as adenosine receptor antagonists (Biaggioni et al., 1991), and that the trait-like individual differences in the effects of caffeine on sleep have a biological basis in genetic variants coding for adenosine receptors (Retey et al., 2007).”
BackgroundInfluentialSelf-citationSport Nutrigenomics: Personalized Nutrition for Athletic Performance
Guest, N. S., Horne, J. R., Vanderhout, S. M., & El‐Sohemy, A. (2019) · Frontiers in Nutrition · doi:10.3389/fnut.2019.00008 · Cited by 184 · see citing works
Caffeine and Exercise: What Next?
Pickering, C., & Grgić, J. (2019) · Sports Medicine · doi:10.1007/s40279-019-01101-0 · Cited by 178 · see citing works
The effect of caffeine on energy balance
Harpaz, E., Tamir, S., Weinstein, A., & Weinstein, Y. (2016) · Journal of Basic and Clinical Physiology and Pharmacology · doi:10.1515/jbcpp-2016-0090 · Cited by 160 · see citing works
Sleep, its regulation and possible mechanisms of sleep disturbances
Porkka‐Heiskanen, T., Zitting, K. ‐., & Wigren, H. ‐. (2013) · Acta Physiologica · doi:10.1111/apha.12134 · Cited by 157 · see citing works
Archer, S. N., Viola, A., Kyriakopoulou, V., von Schantz, M., & Dijk, D. (2008) · SLEEP · doi:10.1093/sleep/31.5.608 · Cited by 156 · see citing works
Wei, C. J., Li, W., & Chen, J. (2010) · Biochimica et Biophysica Acta (BBA) - Biomembranes · doi:10.1016/j.bbamem.2010.12.018 · Cited by 151 · see citing works
Roles of Adenosine and Its Receptors in Sleep–Wake Regulation
Huang, Z., Zhang, Z., & Qu, W. (2014) · International review of neurobiology · doi:10.1016/b978-0-12-801022-8.00014-3 · Cited by 148 · see citing works
Thorn, C. F., Aklillu, E., McDonagh, E. M., Klein, T. E., & Altman, R. B. (2012) · Pharmacogenetics and Genomics · doi:10.1097/fpc.0b013e3283505d5e · Cited by 125 · see citing works
Cholinergic augmentation modulates visual task performance in sleep-deprived young adults
Chuah, L. Y. M., & Chee, M. W. L. (2008) · The Journal of Neuroscience · doi:10.1523/jneurosci.4045-08.2008 · Cited by 118 · see citing works
Bodenmann, S., Hohoff, C., Freitag, C. M., Deckert, J., Rétey, J., Bachmann, V., & Landolt, H. (2011) · British Journal of Pharmacology · doi:10.1111/j.1476-5381.2011.01689.x · Cited by 118 · see citing works
Self-citationIndividual Differences in Vulnerability to Sleep Loss in the Work Environment
Dongen, H. P. A. V., & Belenky, G. L. (2009) · Industrial Health · doi:10.2486/indhealth.47.518 · Cited by 114 · see citing works
Early effects of caffeinated and decaffeinated coffee on subjective state and gender differences
Adan, A., Prat, G., Fabbri, M., & Sànchez-Turet, M. (2008) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2008.07.005 · Cited by 113 · see citing works
Adenosine, Caffeine, and Performance: From Cognitive Neuroscience of Sleep to Sleep Pharmacogenetics
Urry, E., & Landolt, H. (2014) · Current topics in behavioral neurosciences · doi:10.1007/7854_2014_274 · Cited by 108 · see citing works
Self-citationFunctional ADA Polymorphism Increases Sleep Depth and Reduces Vigilant Attention in Humans
Bachmann, V., Klaus, F., Bodenmann, S., Schäfer, N., Brugger, P., Huber, S., Berger, W., & Landolt, H. (2011) · Cerebral Cortex · doi:10.1093/cercor/bhr173 · Cited by 107 · see citing works
Self-citationWaldowski, R. A., Franken, P., & Tafti, M. (2008) · Annual Review of Genetics · doi:10.1146/annurev.genet.42.110807.091541 · Cited by 105 · see citing works
Martin, V. T., & Vij, B. (2016) · Headache The Journal of Head and Face Pain · doi:10.1111/head.12953 · Cited by 107 · see citing works
Sleep Loss Produces False Memories
Diekelmann, S., Landolt, H.-P., Lahl, O., Born, J., & Wagner, U. (2008) · PLoS ONE · doi:10.1371/journal.pone.0003512 · Cited by 103 · see citing works
Self-citationBenarroch, E. E. (2008) · Neurology · doi:10.1212/01.wnl.0000297939.18236.ec · Cited by 95 · see citing works
Byrne, E. M., Johnson, J., McRae, A. F., Nyholt, D. R., Medland, S. E., Gehrman, P., Heath, A. C., Madden, P. A. F., Montgomery, G. W., Chenevix‐Trench, G., et al. (2012) · SLEEP · doi:10.5665/sleep.1962 · Cited by 96 · see citing works
Multi-ingredient, Caffeine-containing Dietary Supplements: History, Safety, and Efficacy
Gurley, B. J., Steelman, S. C., & Thomas, S. L. (2014) · Clinical Therapeutics · doi:10.1016/j.clinthera.2014.08.012 · Cited by 96 · see citing works
<i>DQB1*0602</i> predicts interindividual differences in physiologic sleep, sleepiness, and fatigue
Goel, N., Banks, S., Mignot, E., & Dinges, D. F. (2010) · Neurology · doi:10.1212/wnl.0b013e3181f9615d · Cited by 92 · see citing works
Elmenhorst, D., Elmenhorst, E.-M., Hennecke, E., Kroll, T., Matusch, A., Aeschbach, D., & Bauer, A. (2017) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1614677114 · Cited by 92 · see citing works
The pharmacogenetics of natural products: A pharmacokinetic and pharmacodynamic perspective
Rao, T., Tan, Z., Peng, J., Guo, Y., Chen, Y., Zhou, H., & Ouyang, D. (2019) · Pharmacological Research · doi:10.1016/j.phrs.2019.104283 · Cited by 92 · see citing works
Lazarus, M., Chen, J., Huang, Z., Urade, Y., & Fredholm, B. B. (2017) · Handbook of experimental pharmacology · doi:10.1007/164_2017_36 · Cited by 93 · see citing works
Bodenmann, S., Xu, S., Luhmann, U., Arand, M., Berger, W., Jung, H., & Landolt, H. (2009) · Clinical Pharmacology & Therapeutics · doi:10.1038/clpt.2008.222 · Cited by 85 · see citing works
Self-citationEffects of caffeine on daytime recovery sleep: A double challenge to the sleep–wake cycle in aging
Carrier, J., Paquet, J., Fernandez-Bolanos, M., Girouard, L., Roy, J., Selmaoui, B., & Filipini, D. (2009) · Sleep Medicine · doi:10.1016/j.sleep.2009.01.001 · Cited by 82 · see citing works
Rodent models of insomnia: A review of experimental procedures that induce sleep disturbances
Revel, F. G., Gottowik, J., Gatti, S., Wettstein, J. G., & Moreau, J. (2009) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2009.03.002 · Cited by 82 · see citing works
Salinero, J. J., Lara, B., Ruiz-Vicente, D., Areces, F., Puente, C., Gallo–Salazar, C., Pascual, T., & Coso, J. D. (2017) · Nutrients · doi:10.3390/nu9030269 · Cited by 82 · see citing works
The Role of Genetics in Moderating the Inter-Individual Differences in the Ergogenicity of Caffeine
Southward, K., Rutherfurd-Markwick, K., Badenhorst, C., & Ali, A. (2018) · Nutrients · doi:10.3390/nu10101352 · Cited by 81 · see citing works
Czeisler, C. A. (2009) · PubMed Central · Cited by 79 · see citing works
Holst, S. C., & Landolt, H. (2018) · Sleep Medicine Clinics · doi:10.1016/j.jsmc.2018.03.002 · Cited by 75 · see citing works
Self-citationGutiérrez‐Hellín, J., & Varillas‐Delgado, D. (2021) · Nutrients · doi:10.3390/nu13030715 · Cited by 75 · see citing works
Wei, Y., Xu, J., Miao, S., Wei, K., Peng, L., Wang, Y., & Wei, X. (2022) · Critical Reviews in Food Science and Nutrition · doi:10.1080/10408398.2022.2048291 · Cited by 73 · see citing works
Neurobehavioral Effects and Biomarkers of Sleep Loss in Healthy Adults
Goel, N. (2017) · Current Neurology and Neuroscience Reports · doi:10.1007/s11910-017-0799-x · Cited by 74 · see citing works
Dopaminergic Role in Regulating Neurophysiological Markers of Sleep Homeostasis in Humans
Holst, S. C., Bersagliere, A., Bachmann, V., Berger, W., Achermann, P., & Landolt, H. (2014) · Journal of Neuroscience · doi:10.1523/jneurosci.4128-13.2014 · Cited by 70 · see citing works
Self-citationMairs, L., & Mullan, B. A. (2015) · International Journal of Behavioral Medicine · doi:10.1007/s12529-015-9467-1 · Cited by 68 · see citing works
Caffeine Consuming Children and Adolescents Show Altered Sleep Behavior and Deep Sleep
Aepli, A., Kurth, S., Tesler, N., Jenni, O. G., & Huber, R. (2015) · Brain Sciences · doi:10.3390/brainsci5040441 · Cited by 67 · see citing works
Genetic determination of sleep EEG profiles in healthy humans
Landolt, H.-P. (2011) · Progress in Brain Research · doi:10.1016/b978-0-444-53839-0.00004-1 · Cited by 67 · see citing works
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Gonzalez, D. E., McAllister, M. J., Waldman, H. S., Ferrando, A. A., Joyce, J., Barringer, N., Dawes, J. J., Kieffer, A. J., Harvey, T. M., Kerksick, C. M., et al. (2022) · Journal of the International Society of Sports Nutrition · doi:10.1080/15502783.2022.2086017 · Cited by 68 · see citing works
Genotype-Dependent Differences in Sleep, Vigilance, and Response to Stimulants
Landolt, H. (2008) · Current Pharmaceutical Design · doi:10.2174/138161208786549344 · Cited by 63 · see citing works
Self-citationLoy, B. D., O’Connor, P. J., Lindheimer, J. B., & Covert, S. F. (2015) · Journal of Caffeine Research · doi:10.1089/jcr.2014.0035 · Cited by 62 · see citing works
Carswell, A. T., Howland, K., Martinez-Gonzalez, B., Baron, P., & Davison, G. (2020) · European Journal of Applied Physiology · doi:10.1007/s00421-020-04384-8 · Cited by 61 · see citing works
Domschke, K., Gajewska, A., Winter, B., Herrmann, M. J., Warrings, B., Mühlberger, A., Wosnitza, K., Glotzbach, E., Conzelmann, A., Dlugos, A. M., et al. (2011) · Neuropsychopharmacology · doi:10.1038/npp.2011.253 · Cited by 61 · see citing works
Kinetic and Dynamic Description of Caffeine
Alsabri, S. G., Mari, W. O., Younes, S., Elsadawi, M., & Oroszi, T. L. (2018) · Journal of Caffeine and Adenosine Research · doi:10.1089/caff.2017.0011 · Cited by 61 · see citing works
How to Keep the Brain Awake? The Complex Molecular Pharmacogenetics of Wake Promotion
Hasan, S., Pradervand, S., Ahnaou, A., Drinkenburg, W. H. I. M., Tafti, M., & Franken, P. (2009) · Neuropsychopharmacology · doi:10.1038/npp.2009.3 · Cited by 59 · see citing works
Goel, N., Banks, S., Lin, L., Mignot, E., & Dinges, D. F. (2011) · PLoS ONE · doi:10.1371/journal.pone.0029283 · Cited by 58 · see citing works
Sleep-Wake Regulation and Its Impact on Working Memory Performance: The Role of Adenosine
Reichert, C., Maire, M., Schmidt, C., & Cajochen, C. (2016) · Biology · doi:10.3390/biology5010011 · Cited by 56 · see citing works
Caffeine intake in children in the United States and 10-y trends: 2001-2010
Ahluwalia, N., Herrick, K., Moshfegh, A., & Rybak, M. (2014) · The American Journal of Clinical Nutrition · doi:10.3945/ajcn.113.082172 · Cited by 56 · see citing works
The CYP1A2 -163C>A polymorphism does not alter the effects of caffeine on basketball performance
Puente, C., Abián‐Vicén, J., Coso, J. D., Lara, B., & Salinero, J. J. (2018) · PLoS ONE · doi:10.1371/journal.pone.0195943 · Cited by 56 · see citing works
Caffeine Concentrations in Coffee, Tea, Chocolate, and Energy Drink Flavored E-liquids
Lisko, J. G., Lee, G. E., Kimbrell, J. B., Rybak, M. E., Valentín-Blasini, L., & Watson, C. H. (2016) · Nicotine & Tobacco Research · doi:10.1093/ntr/ntw192 · Cited by 55 · see citing works
PER 3 and ADORA 2 A polymorphisms impact neurobehavioral performance during sleep restriction
Rupp, T. L., Wesensten, N. J., Newman, R., & Balkin, T. J. (2012) · Journal of Sleep Research · doi:10.1111/j.1365-2869.2012.01062.x · Cited by 54 · see citing works
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Urry, E., Jetter, A., & Landolt, H. (2016) · Nutrition & Metabolism · doi:10.1186/s12986-016-0126-6 · Cited by 54 · see citing works
Self-citationSleep is more sensitive to high doses of caffeine in the middle years of life
Robillard, R., Bouchard, M., Cartier, A., Nicolau, L., & Carrier, J. (2015) · Journal of Psychopharmacology · doi:10.1177/0269881115575535 · Cited by 53 · see citing works
The impact of daily caffeine intake on nighttime sleep in young adult men
Weibel, J., Lin, Y.-S., Landolt, H.-P., Kistler, J., Rehm, S., Rentsch, K. M., Slawik, H., Borgwardt, S., Cajochen, C., & Reichert, C. F. (2021) · Scientific Reports · doi:10.1038/s41598-021-84088-x · Cited by 52 · see citing works
Self-citationElmenhorst, E.-M., Elmenhorst, D., Benderoth, S., Kroll, T., Bauer, A., & Aeschbach, D. (2018) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1803770115 · Cited by 51 · see citing works
Landolt, H., Rétey, J., & Adam, M. (2012) · Frontiers in Neurology · doi:10.3389/fneur.2012.00062 · Cited by 53 · see citing works
Self-citationDishman, R. K., Thom, N. J., Puetz, T. W., O’Connor, P. J., & Clementz, B. A. (2010) · Psychophysiology · doi:10.1111/j.1469-8986.2010.01014.x · Cited by 54 · see citing works
Sleep Homeostasis, Metabolism, and Adenosine
Holst, S. C., & Landolt, H. (2015) · Current Sleep Medicine Reports · doi:10.1007/s40675-014-0007-3 · Cited by 50 · see citing works
Self-citationErblang, M., Drogou, C., Gomez-Mérino, D., Metlaine, A., Boland, A., Deleuze, J., Thomas, C., Sauvet, F., & Chennaoui, M. (2019) · Genes · doi:10.3390/genes10121021 · Cited by 50 · see citing works
Caffeine Gum Minimizes Sleep Inertia
Newman, R. A., Kamimori, G., Wesensten, N., Picchioni, D., & Balkin, T. (2013) · Perceptual and Motor Skills · doi:10.2466/29.22.25.pms.116.1.280-293 · Cited by 55 · see citing works
Effects of Modafinil on the Sleep EEG Depend on Val158Met Genotype of COMT
Bodenmann, S., & Landolt, H. (2010) · SLEEP · doi:10.1093/sleep/33.8.1027 · Cited by 49 · see citing works
Self-citationSleep Pharmacogenetics: Personalized Sleep-Wake Therapy
Holst, S. C., Valomon, A., & Landolt, H. (2015) · The Annual Review of Pharmacology and Toxicology · doi:10.1146/annurev-pharmtox-010715-103801 · Cited by 47 · see citing works
Self-citationHolst, S. C., & Landolt, H. (2022) · Sleep Medicine Clinics · doi:10.1016/j.jsmc.2022.03.002 · Cited by 51 · see citing works
Self-citationReichert, C., Veitz, S., Bühler, M., Gruber, G., Deuring, G., Rehm, S., Rentsch, K., Garbazza, C., Meyer, M., Slawik, H. C., et al. (2020) · Biochemical Pharmacology · doi:10.1016/j.bcp.2020.114283 · Cited by 50 · see citing works
Chapman, J. L., Serinel, Y., Marshall, N. S., & Grunstein, R. R. (2016) · Sleep Medicine Clinics · doi:10.1016/j.jsmc.2016.05.005 · Cited by 44 · see citing works
Spaeth, A. M., Goel, N., & Dinges, D. F. (2014) · Nutrition Reviews · doi:10.1111/nure.12151 · Cited by 44 · see citing works
- Authors
- Rétey, J. V., Adam, M., Khatami, R., Luhmann, U. F. O., Jung, H. H., Berger, W., & Landolt, H.-P.
- Affiliations
- University of Zurich (CH)
- University Hospital Zurich (CH)
- Corresponding author
- Landolt, H-P
- Venue
- Clinical Pharmacology & Therapeutics
- Publisher
- Wiley
- Published
- 2007-02-28
- Volume
- 81
- Issue
- 5
- Pages
- 692-698
- ISSN
- 0009-9236 (ISSN-L)
- 1532-6535
- OpenAlex
- W2035474281
- Cited by
- 278
- References
- 48
- Citations by year
- 2026: 11 · 2025: 11 · 2024: 12 · 2023: 14 · 2022: 8 · 2021: 12 · 2020: 22 · 2019: 17 · 2018: 13 · 2017: 13 · 2016: 16 · 2015: 17 · 2014: 14 · 2013: 10 · 2012: 26
- FWCI
- 9.75
- Type
- journal article
- Language
- en
- Open access
- green
- doi.org
- Locations
- Clinical Pharmacology & Therapeutics (publishedVersion)
- PubMed (publishedVersion)
- Zurich Open Repository and Archive (University of Zurich) (acceptedVersion)
- UCL Discovery (University College London) (submittedVersion)
- Zurich Open Repository and Archive (University of Zurich) (submittedVersion)
- Zurich Open Repository and Archive (University of Zurich)
- Funders
- Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung
- Topics
- Health Sciences › Medicine › Pharmacology › Coffee research and impacts
- Social Sciences › Psychology › Experimental and Cognitive Psychology › Sleep and related disorders
- Life Sciences › Neuroscience › Cognitive Neuroscience › Sleep and Wakefulness Research
- Keywords
- caffeine, adenosine A2A receptor, caffeine sensitivity, sleep quality, genetic variation, insomnia, habitual caffeine consumption
- MeSH terms
- Adult, Aged, Alleles, Central Nervous System Stimulants, Caffeine, Data Interpretation, Statistical, DNA, Electroencephalography, Female, Genotype, Humans, Male, Middle Aged, Surveys and Questionnaires, Sleep, Genetic Variation, Polysomnography, Reverse Transcriptase Polymerase Chain Reaction, Internet, Receptor, Adenosine A2A
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