The DOI matches its Crossref record; 8 of the 8 references it cites were found in a registry or an index.
The role of variation at AβPP, PSEN1, PSEN2, and MAPT in late onset Alzheimer’s disease
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
In the citing paper
“MAPT also harbors a 3′ UTR Ago2 cluster with a predicted miR-128 binding site which overlaps a previously described tauopathy-associated SNP (Gerrish et al., 2012).”
From Transcriptome-wide Discovery of microRNA Binding Sites in Human Brain (2014) · cites this paper as Gerrish et al., 2012
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
Howie, B. N., Donnelly, P., & Marchini, J. (2009) · PLoS Genetics · doi:10.1371/journal.pgen.1000529 · Cited by 3,928
Harold, D., Abraham, R., Hollingworth, P., Sims, R., Gerrish, A., Hamshere, M. L., Pahwa, J. S., Moskvina, V., Dowzell, K., Williams, A., et al. (2009) · Nature Genetics · doi:10.1038/ng.440 · Cited by 3,326
Self-citationAlzheimer's Disease Neuroimaging Initiative (ADNI)
Petersen, R. C., Aisen, P. S., Beckett, L. A., Donohue, M. C., Gamst, A. C., Harvey, D. J., Jack, C. R., Jagust, W. J., Shaw, L. M., Toga, A. W., et al. (2010) · Neurology · doi:10.1212/wnl.0b013e3181cb3e25 · Cited by 2,572 · cited 2×
“We attempted to impute these variants in two publically available GWAS datasets [23, 39].”
MethodAn improved Bonferroni procedure for multiple tests of significance
SIMES, R. J. (1986) · Biometrika · doi:10.1093/biomet/73.3.751 · Cited by 2,396
Naj, A. C., Jun, G., Beecham, G. W., Wang, L.-S., Vardarajan, B. N., Buros, J., Gallins, P. J., Buxbaum, J. D., Jarvik, G. P., Crane, P. K., et al. (2011) · Nature Genetics · doi:10.1038/ng.801 · Cited by 1,901
Self-citationThe Wellcome Trust Case Control Consortium (2010) · Nature · doi:10.1038/nature08979 · Cited by 807
Corticobasal degeneration and progressive supranuclear palsy share a common tau haplotype
Houlden, H., Baker, M., Morris, H. R., MacDonald, N., Pickering–Brown, S., Adamson, J., Lees, A. J., Rossor, M. N., Quinn, N. P., Kertesz, A., et al. (2001) · Neurology · doi:10.1212/wnl.56.12.1702 · Cited by 409
Self-citationExamination of the current top candidate genes for AD in a genome-wide association study
Feulner, T. M., Laws, S. M., Friedrich, P., Wagenpfeil, S., Wurst, S. H. R., Riehle, C., Kuhn, K. A., Krawczak, M., Schreiber, S., Nikolaus, S., et al. (2010) · Molecular Psychiatry · doi:10.1038/mp.2008.141 · Cited by 128
Flagged first, then by citations
Research works printed but not linked: 38
- [1]Dickson TC Vickers JC 2001 The morphological phenotype of beta-amyloid plaques and associated neuritic changes in Alzheimer’s disease Neuroscience 105 99 107 11483304
- [2]Ertekin-Taner N 2007 Genetics of Alzheimer’s disease: A centennial review Neurol Clin 25 611 667 17659183 PMC2735049
- [3]Zetzsche T Rujescu D Hardy J Hampel H 2010 Advances and perspectives from genetic research: Development of biological markers in Alzheimer’s disease Expert Rev Mol Diagn 10 667 690 20629514
- [4]Selkoe DJ 2001 Alzheimer’s disease: Genes, proteins, and therapy Physiol Rev 81 741 766 11274343
- [6]Pittman AM Myers AJ Abou-Sleiman P Fung HC Kaleem M Marlowe L Duckworth J Leung D Williams D Kilford L Thomas N Morris CM Dickson D Wood NW Hardy J Lees AJ de Silva R 2005 Linkage disequilibrium fine mapping and haplotype association analysis of the tau gene in progressive supranuclear palsy and corticobasal degeneration J Med Genet 42 837 846 15792962 PMC1735957
- [7]Simon-Sanchez J Schulte C Bras JM Sharma M Gibbs JR Berg D Paisan-Ruiz C Lichtner P Scholz SW Hernandez DG Kruger R Federoff M Klein C Goate A Perlmutter J Bonin M Nalls MA Illig T Gieger C Houlden H Steffens M Okun MS Racette BA Cookson MR Foote KD Fernandez HH Traynor BJ Schreiber S Arepalli S Zonozi R Gwinn K van der Brug M Lopez G Chanock SJ Schatzkin A Park Y Hollenbeck A Gao J Huang X Wood NW Lorenz D Deuschl G Chen H Riess O Hardy JA Singleton AB Gasser T 2009 Genome-wide association study reveals genetic risk underlying Parkinson’s disease Nat Genet 41 1308 1312 19915575 PMC2787725
- [8]Zhang N Yu JT Yang Y Yang J Zhang W Tan L 2011 Association analysis of GSK3B and MAPT polymorphisms with Alzheimer’s disease in Han Chinese Brain Res 1391 147 153 21443865
- [9]Belbin O Beaumont H Warden D Smith AD Kalsheker N Morgan K 2009 PSEN1 polymorphisms alter the rate of cognitive decline in sporadic Alzheimer’s disease patients Neurobiol Aging 30 1992 1999 18403054
- [11]Guyant-Marechal L Rovelet-Lecrux A Goumidi L Cousin E Hannequin D Raux G Penet C Ricard S Mace S Amouyel P Deleuze JF Frebourg T Brice A Lambert JC Campion D 2007 Variations in the APP gene promoter region and risk of Alzheimer disease Neurology 68 684 687 17325276
- [12]Kwok JB Loy CT Hamilton G Lau E Hallupp M Williams J Owen MJ Broe GA Tang N Lam L Powell JF Lovestone S Schofield PR 2008 Glycogen synthase kinase-3beta and tau genes interact in Alzheimer’s disease Ann Neurol 64 446 454 18991351
- [13]Laws SM Friedrich P Diehl-Schmid J Muller J Eisele T Bauml J Forstl H Kurz A Riemenschneider M 2007 Fine mapping of the MAPT locus using quantitative trait analysis identifies possible causal variants in Alzheimer’s disease Mol Psychiatry 12 510 517 17179995
- [14]Liu Z Jia J 2008 The association of the regulatory region of the presenilin-2 gene with Alzheimer’s disease in the Northern Han Chinese population J Neurol Sci 264 38 42 17727891
- [15]Martinez-Garcia A Aldudo J Recuero M Sastre I Vilella-Cuadrada E Rosich-Estrago M Frank A Valdivieso F Bullido MJ 2008 Presenilin 1 polymorphism associated with Alzheimer’s disease in apolipoprotein E4 carriers Dement Geriatr Cogn Disord 26 440 444 18957849
- [16]Bullido MJ Aldudo J Frank A Coria F Avila J Valdivieso F 2000 A polymorphism in the tau gene associated with risk for Alzheimer’s disease Neurosci Lett 278 49 52 10643798
- [17]Myers AJ Kaleem M Marlowe L Pittman AM Lees AJ Fung HC Duckworth J Leung D Gibson A Morris CM de Silva R Hardy J 2005 The H1c haplotype at the MAPT locus is associated with Alzheimer’s disease Hum Mol Genet 14 2399 2404 16000317
- [18]Seto-Salvia N Clarimon J Pagonabarraga J Pascual-Sedano B Campolongo A Combarros O Mateo JI Regana D Martinez-Corral M Marquie M Alcolea D Suarez-Calvet M Molina-Porcel L Dols O Gomez-Isla T Blesa R Lleo A Kulisevsky J 2011 Dementia risk in Parkinson disease: Disentangling the role of MAPT haplotypes Arch Neurol 68 359 364 21403021
- [19]Abraham R Sims R Carroll L Hollingworth P O’Donovan MC Williams J Owen MJ 2009 An association study of common variation at the MAPT locus with late-onset Alzheimer’s disease Am J Med Genet B Neuropsychiatr Genet 150B 1152 1155 19308965
- [20]Cousin E Mace S Rocher C Dib C Muzard G Hannequin D Pradier L Deleuze JF Genin E Brice A Campion D 2011 No replication of genetic association between candidate polymorphisms and Alzheimer’s disease Neurobiol Aging 32 1443 1451 19889475
- [21]Mukherjee O Kauwe JS Mayo K Morris JC Goate AM 2007 Haplotype-based association analysis of the MAPT locus in late onset Alzheimer’s disease BMC Gene 8 3 PMC1800865 17266761
- [22]Nowotny P Simcock X Bertelsen S Hinrichs AL Kauwe JS Mayo K Smemo S Morris JC Goate A 2007 Association studies testing for risk for late-onset Alzheimer’s disease with common variants in the beta-amyloid precursor protein (APP) Am J Med Genet B Neuropsychiatr Genet 144B 469 474 17427190
- [23]Reiman EM Webster JA Myers AJ Hardy J Dunckley T Zismann VL Joshipura KD Pearson JV Hu-Lince D Huentelman MJ Craig DW Coon KD Liang WS Herbert RH Beach T Rohrer KC Zhao AS Leung D Bryden L Marlowe L Kaleem M Mastroeni D Grover A Heward CB Ravid R Rogers J Hutton ML Melquist S Petersen RC Alexander GE Caselli RJ Kukull W Papassotiropoulos A Stephan DA 2007 GAB2 alleles modify Alzheimer’s risk in APOE epsilon4 carriers Neuron 54 713 720 17553421 PMC2587162
- [24]Kwon JM Nowotny P Shah PK Chakraverty S Norton J Morris JC Goate AM 2000 Tau polymorphisms are not associated with Alzheimer’s disease Neurosci Lett 284 77 80 10771166
- [26]McKhann G Drachman D Folstein M Katzman R Price D Stadlan EM 1984 Clinical diagnosis of Alzheimer’s disease: Report of the NINCDS-ADRDA Work Group under the auspices of Department of Health and Human Services Task Force on Alzheimer’s Disease Neurology 34 939 944 6610841
- [27]Mirra SS Heyman A McKeel D Sumi SM Crain BJ Brownlee LM Vogel FS Hughes JP van Belle G Berg L 1991 The Consortium to Establish a Registry for Alzheimer’s Disease (CERAD). Part II. Standardization of the neuropathologic assessment of Alzheimer’s disease Neurology 41 479 486 2011243
- [28]Wichmann HE Gieger C Illig T 2005 KORA-gen–resource for population genetics, controls and a broad spectrum of disease phenotypes Gesundheitswesen 67 Suppl 1 S26 S30 16032514
- [29]Birnbaum S Ludwig KU Reutter H Herms S Steffens M Rubini M Baluardo C Ferrian M Almeida de Assis N Alblas MA Barth S Freudenberg J Lauster C Schmidt G Scheer M Braumann B Berge SJ Reich RH Schiefke F Hemprich A Potzsch S Steegers-Theunissen RP Potzsch B Moebus S Horsthemke B Kramer FJ Wienker TF Mossey PA Propping P Cichon S Hoffmann P Knapp M Nothen MM Mangold E 2009 Key susceptibility locus for nonsyndromic cleft lip with or without cleft palate on chromosome 8q24 Nat Genet 41 473 477 19270707
- [30]Hillmer AM Brockschmidt FF Hanneken S Eigelshoven S Steffens M Flaquer A Herms S Becker T Kortum AK Nyholt DR Zhao ZZ Montgomery GW Martin NG Muhleisen TW Alblas MA Moebus S Jockel KH Brocker-Preuss M Erbel R Reinartz R Betz RC Cichon S Propping P Baur MP Wienker TF Kruse R Nothen MM 2008 Susceptibility variants for male-pattern baldness on chromosome 20p11 Nat Genet 40 1279 1281 18849994
- [31]Landers JE Melki J Meininger V Glass JD van den Berg LH van Es MA Sapp PC van Vught PW McKenna-Yasek DM Blauw HM Cho TJ Polak M Shi L Wills AM Broom WJ Ticozzi N Silani V Ozoguz A Rodriguez-Leyva I Veldink JH Ivinson AJ Saris CG Hosler BA Barnes-Nessa A Couture N Wokke JH Kwiatkowski TJ Jr Ophoff RA Cronin S Hardiman O Diekstra FP Leigh PN Shaw CE Simpson CL Hansen VK Powell JF Corcia P Salachas F Heath S Galan P Georges F Horvitz HR Lathrop M Purcell S Al-Chalabi A Brown RH Jr 2009 Reduced expression of the Kinesin-Associated Protein 3 (KIFAP3) gene increases survival in sporadic amyotrophic lateral sclerosis Proc Natl Acad Sci U S A 106 9004 9009 19451621 PMC2683883
- [33]Devlin B Roeder K 1999 Genomic control for association studies Biometrics 55 997 1004 11315092
- [34]Pe’er I Yelensky R Altshuler D Daly MJ 2008 Estimation of the multiple testing burden for genomewide association studies of nearly all common variants Genet Epidemiol 32 381 385 18348202
- [36]Price AL Patterson NJ Plenge RM Weinblatt ME Shadick NA Reich D 2006 Principal components analysis corrects for stratification in genome-wide association studies Nat Genet 38 904 909 16862161
- [38]Li Y Willer CJ Ding J Scheet P Abecasis GR 2010 MaCH: Using sequence and genotype data to estimate haplotypes and unobserved genotypes Genet Epidemiol 34 816 834 21058334 PMC3175618
- [40]Hiltunen M Helisalmi S Mannermaa A Alafuzoff I Koivisto AM Lehtovirta M Pirskanen M Sulkava R Verkkoniemi A Soininen H 2000 Identification of a novel 4.6-kb genomic deletion in presenilin-1 gene which results in exclusion of exon 9 in a Finnish early onset Alzheimer’s disease family: An Alu core sequence-stimulated recombination? Eur J Hum Genet 8 259 266 10854108
- [41]Prihar G Verkkoniem A Perez-Tur J Crook R Lincoln S Houlden H Somer M Paetau A Kalimo H Grover A Myllykangas L Hutton M Hardy J Haltia M 1999 Alzheimer disease PS-1 exon 9 deletion defined Nat Me 5 1090 10502791
- [42]Neale BM Sham PC 2004 The future of association studies: Gene-based analysis and replication Am J Hum Genet 75 353 362 15272419 PMC1182015
- [43]Moskvina V Craddock N Holmans P Nikolov I Pahwa JS Green E Owen MJ O’Donovan MC 2009 Gene-wide analyses of genome-wide association data sets: Evidence for multiple common risk alleles for schizophrenia and bipolar disorder and for overlap in genetic risk Mol Psychiatry 14 252 260 19065143 PMC3970088
- [44]Lambert JC Heath S Even G Campion D Sleegers K Hiltunen M Combarros O Zelenika D Bullido MJ Tavernier B Letenneur L Bettens K Berr C Pasquier F Fievet N Barberger-Gateau P Engelborghs S De Deyn P Mateo I Franck A Helisalmi S Porcellini E Hanon O de Pancorbo MM Lendon C Dufouil C Jaillard C Leveillard T Alvarez V Bosco P Mancuso M Panza F Nacmias B Bossu P Piccardi P Annoni G Seripa D Galimberti D Hannequin D Licastro F Soininen H Ritchie K Blanche H Dartigues JF Tzourio C Gut I Van Broeckhoven C Alperovitch A Lathrop M Amouyel P 2009 Genome-wide association study identifies variants at CLU and CR1 associated with Alzheimer’s disease Nat Genet 41 1094 1099 19734903
- [46]Seshadri S Fitzpatrick AL Ikram MA DeStefano AL Gudnason V Boada M Bis JC Smith AV Carassquillo MM Lambert JC Harold D Schrijvers EM Ramirez-Lorca R Debette S Longstreth WT Jr Janssens AC Pankratz VS Dartigues JF Hollingworth P Aspelund T Hernandez I Beiser A Kuller LH Koudstaal PJ Dickson DW Tzourio C Abraham R Antunez C Du Y Rotter JI Aulchenko YS Harris TB Petersen RC Berr C Owen MJ Lopez-Arrieta J Varadarajan BN Becker JT Rivadeneira F Nalls MA Graff-Radford NR Campion D Auerbach S Rice K Hofman A Jonsson PV Schmidt H Lathrop M Mosley TH Au R Psaty BM Uitterlinden AG Farrer LA Lumley T Ruiz A Williams J Amouyel P Younkin SG Wolf PA Launer LJ Lopez OL van Duijn CM Breteler MM 2010 Genome-wide analysis of genetic loci associated with Alzheimer disease JAMA 303 1832 1840 20460622 PMC2989531
Cited by
Sorted by citations
Memory loss in Alzheimer's disease
Jahn, H. (2013) · Dialogues in Clinical Neuroscience · doi:10.31887/dcns.2013.15.4/hjahn · Cited by 653
Deciphering the mechanism underlying late-onset Alzheimer disease
Krstic, D., & Knuesel, I. (2013) · Nature Reviews Neurology · doi:10.1038/nrneurol.2012.236 · Cited by 457
Cruchaga, C., Chakraverty, S., Mayo, K., Vallania, F. L. M., Mitra, R. D., Faber, K., Williamson, J., Bird, T., Diaz-Arrastia, R., Foroud, T. M., et al. (2012) · PLoS ONE · doi:10.1371/journal.pone.0031039 · Cited by 320
Self-citationTranscriptome-wide Discovery of microRNA Binding Sites in Human Brain
Boudreau, R. L., Jiang, P., Gilmore, B. L., Spengler, R. M., Tirabassi, R., Nelson, J. A., Ross, C. A., Xing, Y., & Davidson, B. L. (2014) · Neuron · doi:10.1016/j.neuron.2013.10.062 · Cited by 217
Metadata
- Authors
- Gerrish, A., Russo, G., Richards, A., Moskvina, V., Ivanov, D., Harold, D., Sims, R., Abraham, R., Hollingworth, P., Chapman, J., Hamshere, M., Pahwa, J. S., Dowzell, K., Williams, A., Jones, N., Thomas, C., Stretton, A., Morgan, A. R., Lovestone, S., Powell, J., Proitsi, P., Lupton, M. K., Brayne, C., Rubinsztein, D. C., Gill, M., Lawlor, B., Lynch, A., Morgan, K., Brown, K. S., Passmore, P. A., Craig, D., McGuinness, B., Todd, S., Johnston, J. A., Holmes, C., Mann, D., Smith, A. D., Love, S., Kehoe, P. G., Hardy, J., Mead, S., Fox, N., Rossor, M., Collinge, J., Maier, W., Jessen, F., Kölsch, H., Heun, R., Schürmann, B., Bussche, H. V. D., Heuser, I., Kornhuber, J., Wiltfang, J., Dichgans, M., Frölich, L., Hampel, H., Hüll, M., Rujescu, D., Goate, A. M., Kauwe, J. S. K., Cruchaga, C., Nowotny, P., Morris, J. C., Mayo, K., Livingston, G., Bass, N. J., Gurling, H., McQuillin, A., Gwilliam, R., Deloukas, P., Davies, G., Harris, S. E., Starr, J. M., Deary, I. J., Al-Chalabi, A., Shaw, C. E., Tsolaki, M., Singleton, A. B., Guerreiro, R., Mühleisen, T. W., Nöthen, M. M., Moebus, S., Jöckel, K.-H., Klopp, N., Wichmann, H.-E., Carrasquillo, M. M., Pankratz, V. S., Younkin, S. G., Jones, L., Holmans, P. A., O'Donovan, M. C., Owen, M. J., & Williams, J.
- Affiliations
- MRC Centre for Neuropsychiatric Genetics and Genomics, Department of Psychological Medicine and Neurology, School of Medicine, Neuroscience and Mental Health Research Institute, Cardiff University, Cardiff, UK
- King's College London, Institute of Psychiatry, Kings College, London, UK
- Department of Neuroscience, Institute of Psychiatry, Kings College, London, UK
- Institute of Public Health, University of Cambridge, Cambridge, UK
- Cambridge Institute for Medical Research, University of Cambridge, Cambridge, UK
- Mercer's Institute for Research on Aging, St. James Hospital and Trinity College, Dublin, Ireland
- Human Genetics Group, School of Molecular Medical Sciences, Queen's Medical Centre, University of Nottingham, UK
- Ageing Group, Centre for Public Health, School of Medicine, Dentistry and Biomedical Sciences, Queen's University Belfast, UK
- Division of Clinical Neurosciences, School of Medicine, University of Southampton, Southampton, UK
- Neurodegeneration and Mental Health Research Group, School of Community Based Medicine, University of Manchester, Salford, UK
- Oxford Project to Investigate Memory and Ageing, University of Oxford, John Radcliffe Hospital, Oxford, UK
- Dementia Research Group, University of Bristol Institute of Clinical Neurosciences, Frenchay Hospital, Bristol, UK
- Department of Molecular Neuroscience and Reta Lilla Weston Laboratories, Institute of Neurology, London, UK
- MRC Prion Unit and Department of Neurodegenerative Disease, Institute of Neurology, University College London
- Dementia Research Centre, Department of Neurodegenerative Diseases, UCL Institute of Neurology, London, UK
- Department of Psychiatry, University of Bonn, Bonn, Germany
- Institute of Primary Medical Care, University Medical Center Hamburg-Eppendorf, Germany
- Department of Psychiatry, Charit'e Berlin, Berlin, Germany
- Department of Psychiatry and Psychotherapy, University of Erlangen-Nuremberg, Germany
- LVR-Hospital Essen, Department of Psychiatry and Psychotherapy, University Duisburg-Essen, Germany
- Institute for Stroke and Dementia Research, Klinikum der Universität München, Munich, Germany
- Department of Geriatric Psychiatry, Central Institute of Mental Health, Medical Faculty Mannheim, University of Heidelberg, Mannheim, Germany
- Department of Psychiatry, Psychosomatic Medicine and Psychotherapy, Goethe University, Frankfurt, Germany
- Ludwig-Maximilians-University, Department of Psychiatry, Munich, Germany
- Departments of Psychiatry, Neurology and Genetics, Washington University School of Medicine, St. Louis, Missouri, USA
- Department of Biology, Brigham Young University, Provo, Utah, USA
- Mental Health Unit, UCL, London, UK
- The Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, Cambridge, UK
- Centre for Cognitive Ageing and Cognitive Epidemiology, University of Edinburgh, Edinburgh, UK
- MRC Centre for Neurodegeneration Research, King's College London, Institute of Psychiatry, Department of Clinical Neuroscience, London, UK
- Third Department of Neurology, Aristotle University of Thessaloniki, Thessaloniki, Greece
- Laboratory of Neurogenetics, National Institute on Aging, National Institutes of Health, Bethesda, Maryland, USA
- Department of Genomics, Life and Brain Center, University of Bonn, Bonn, Germany
- Institute for Medical Informatics, Biometry and Epidemiology, University Hospital of Essen, University Duisburg-Essen, Essen, Germany
- Institute of Epidemiology, Helmholtz Zentrum M¨nchen, German Research Center for Environmental Health, Neuherberg, Germany
- Department of Neuroscience, Mayo Clinic College of Medicine, Jacksonville, Florida, USA
- Division of Biomedical Statistics and Informatics, Mayo Clinic and Mayo Foundation, Rochester, Minnesota, USA
- Venue
- Journal of Alzheimer's Disease
- Publisher
- SAGE Publications
- Published
- 2012-01-25
- Volume
- 28
- Issue
- 2
- Pages
- 377-387
- ISSN
- 1875-8908
- 1387-2877
- PMC
- PMC4118466
- Cited by
- 49
- References
- 8
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review