Cited by 128Alzheimer's disease research and treatmentsGenetic Associations and EpidemiologyDementia and Cognitive Impairment Research

Examination of the current top candidate genes for AD in a genome-wide association study

Feulner, T M, Laws, S M, Friedrich, P, Wagenpfeil, S, Wurst, S H R, Riehle, C, Kuhn, K A, Krawczak, M +5 more·2010·Molecular Psychiatry

Abstract

With the advent of technologies that allow simultaneous genotyping of thousands of single-nucleotide polymorphisms (SNPs) across the genome, the genetic contributions to complex diseases can be explored at an unprecedented detail. This study is among the first to apply the genome-wide association study (GWAS) approach to Alzheimer disease (AD). We present our GWAS results from the German population for genes included in the 'Top Results' list on the AlzGene database website. In addition to the apolipoprotein E locus, we identified nominally significant association signals in six of the ten genes investigated, albeit predominantly for SNPs other than those already published as being disease associated. Further, all of the four AD genes previously identified through GWAS also showed nominally significant association signals in our data. The results of our comparative study reinforce the necessity for replication and validation, not only of GWAS but also of candidate gene case-control studies, in different populations. Furthermore, cross-platform comparison of genotyping results can also identify new association signals. Finally, our data confirm that GWAS, regardless of the platform, are valuable for the identification of genetic variants associated with AD.

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Crossref · 10.1038/mp.2008.141

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  • Seven of the earliest GWAS, each of which used less than 2,000 cases, identified only APOE as significantly associated with Alzheimer's disease.

    “seven of the earliest GWAS, each of which used less than 2,000 cases, identified only APOE as significantly associated with AD [84–90].”

    From Genetic architecture of Alzheimer's disease (2020) · cites this paper as [84]

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Authors
Feulner, T. M., Laws, S. M., Friedrich, P., Wagenpfeil, S., Wurst, S. H. R., Riehle, C., Kuhn, K. A., Krawczak, M., Schreiber, S., Nikolaus, S., Förstl, H., Kurz, A., & Riemenschneider, M.
Affiliations
  • Technical University of Munich (DE)
  • Edith Cowan University (AU)
  • Christian-Albrechts-Universität zu Kiel (DE)
Corresponding author
Riemenschneider, M
Venue
Molecular Psychiatry
Published
2009-01-06
Volume
15
Issue
7
Pages
756-766
ISSN
  • 1359-4184 (ISSN-L)
  • 1476-5578
OpenAlex
W2080162788
Cited by
128
References
54
Citations by year
2026: 1 · 2025: 2 · 2024: 3 · 2023: 3 · 2022: 2 · 2021: 4 · 2020: 5 · 2019: 1 · 2018: 6 · 2017: 9 · 2016: 6 · 2015: 8 · 2014: 3 · 2013: 14 · 2012: 14
FWCI
13.32
Type
journal article
Language
en
Open access
closed
Locations
  • Molecular Psychiatry (publishedVersion)
  • PubMed (publishedVersion)
  • Australasian Journal of Paramedicine (submittedVersion)
  • mediaTUM – the media and publications repository of the Technical University Munich (Technical University Munich) (submittedVersion)
Topics
  • Health Sciences › Medicine › Physiology › Alzheimer's disease research and treatments
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetic Associations and Epidemiology
  • Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
Keywords
Alzheimer's disease, genome-wide association study, candidate genes, single nucleotide polymorphisms, apolipoprotein E, replication, genetic susceptibility, German population
MeSH terms
Aged, Alzheimer Disease, Female, Genotype, Humans, Male, Genetic Predisposition to Disease, Polymorphism, Single Nucleotide, Databases, Genetic, Genome-Wide Association Study

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