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In vivo high resolution 3D-QCT of the human forearm
Abstract
In vivo examinations of bone microarchitecture have become available recently through high resolution computed tomography (3D-QCT) and magnetic resonance imaging. The spatial resolution of the resulting images, however, is not sufficient to depict individual trabeculae in their true shape. Nevertheless, structural indices such as relative bone volume, trabecular number, mean thickness and mean separation can be extracted with the help of a ridge detection algorithm. Precision of the procedure is of the order of 1%, accuracy is ascertained using a micro-CT based calibration. In this work we report first results of time serial examinations. Eighteen healthy postmenopausal women (no HRT) were measured at months 0, 6, and 12, and the temporal changes were analyzed. Examination site was the distal radius. The above mentioned structural indices, the average densities and the thickness of the cortical shell were determined. Of the 18 women 6 showed no significant bone loss of any kind, 5 lost primarily cancellous bone, 4 lost primarily cortical bone, and 3 had a substantial loss of cortical as well as cancellous bone. We conclude that even in a homogenous group such as postmenopausal women, there are considerable differences in the reason why bone is weakened and that high resolution 3D-QCT allows to differentiate between various types of bone loss.
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Cited by
Nilsson, A. G., Sundh, D., Bäckhed, F., & Lorentzon, M. (2018) · Journal of Internal Medicine · doi:10.1111/joim.12805 · Cited by 323
Nilsson, A. G., Sundh, D., Johansson, L., Nilsson, M., Mellström, D., Rudäng, R., Zoulakis, M., Wallander, M., Darelid, A., & Lorentzon, M. (2017) · Journal of Bone and Mineral Research · doi:10.1002/jbmr.3057 · Cited by 217
Shanbhogue, V. V., Hansen, S., Frost, M., Jørgensen, N. R., Hermann, A. P., Henriksen, J. E., & Brixen, K. (2015) · Journal of Bone and Mineral Research · doi:10.1002/jbmr.2573 · Cited by 183
Nishiyama, K. K., Macdonald, H. M., Moore, S. A., Fung, T., Boyd, S. K., & McKay, H. A. (2012) · Journal of Bone and Mineral Research · doi:10.1002/jbmr.552 · Cited by 122
Madeira, M., Neto, L. V., de Paula Paranhos Neto, F., Barbosa Lima, I. C., Carvalho de Mendonça, L. M., Gadelha, M. R., & Fleiuss de Farias, M. L. (2013) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2012-4073 · Cited by 114
Farr, J. N., Charkoudian, N., Barnes, J. N., Monroe, D. G., McCready, L. K., Atkinson, E. J., Amin, S., Melton, L. J., Joyner, M. J., & Khosla, S. (2012) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2012-2381 · Cited by 79
Sundh, D., Rudäng, R., Zoulakis, M., Nilsson, A. G., Darelid, A., & Lorentzon, M. (2016) · Journal of Bone and Mineral Research · doi:10.1002/jbmr.2747 · Cited by 76
Rudäng, R., Darelid, A., Nilsson, M., Nilsson, S., Mellström, D., Ohlsson, C., & Lorentzon, M. (2012) · Journal of Bone and Mineral Research · doi:10.1002/jbmr.1674 · Cited by 54
Tsuji, K., Kitamura, M., Chiba, K., Muta, K., Yokota, K., Okazaki, N., Osaki, M., Mukae, H., & Nishino, T. (2022) · Renal Failure · doi:10.1080/0886022x.2022.2043375 · Cited by 16
Pauchard, Y., Mattmann, C., Kuhn, A., Gasser, J. A., & Boyd, S. K. (2008) · Journal of Biomechanics · doi:10.1016/j.jbiomech.2008.07.036 · Cited by 12
Metadata
- Authors
- Laib, A., Häuselmann, H. J., & Rüegsegger, P.
- Venue
- Technology and Health Care
- Publisher
- SAGE Publications
- Published
- 1998-12-01
- Volume
- 6
- Issue
- 5-6
- Pages
- 329-337
- ISSN
- 0928-7329 (ISSN-L)
- 1878-7401
- OpenAlex
- W1702563725
- Cited by
- 454
- References
- 0
- FWCI
- 5.45
- Type
- journal article
- Language
- en
- Open access
- closed
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