The DOI matches its Crossref record; 6 of the 6 references it cites were found in a registry or an index.
Chronic Inflammation: A Common and Important Factor in the Pathogenesis of Neoplasia
Open accessAbstract
A causal link between chronic inflammation and carcinogenesis is explored by reviewing illustrative examples of specific cancers and causal agents and mechanisms. The causal agents or pathologic conditions include microbial agents, gastroesophageal reflux, chronic cholecystitis and cholelithiasis, inflammatory bowel disease, and specific agents that cause chronic obstructive or diffuse interstitial lung disease. The proportion of total cancer deaths attributable to infectious agents is estimated to be about 20% to 25% in developing countries and 7% to 10% in more industrialized countries. Recurrent or persistent inflammation may induce, promote, or influence susceptibility to carcinogenesis by causing DNA damage, inciting tissue reparative proliferation, and/or creating a stromal "soil" that is enriched with cytokines and growth factors. Future research on the complex cascade of cellular and humoral factors participating in the chronic inflammatory process will further understanding of the pathogenesis of various cancers and potentially provide a rationale for targeted chemopreventive interventions.
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Cited by
Inflammation: Gearing the journey to cancer
KUNDU, J., & SURH, Y. (2008) · Mutation Research/Reviews in Mutation Research · doi:10.1016/j.mrrev.2008.03.002 · Cited by 803
Cholangiocarcinoma: Epidemiology and risk factors
Khan, S. A., Tavolari, S., & Brandi, G. (2019) · Liver International · doi:10.1111/liv.14095 · Cited by 783
Advances in targeted therapy for esophageal cancer
Yang, Y.-M., Hong, P., Xu, W. W., He, Q.-Y., & Li, B. (2020) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-020-00323-3 · Cited by 508
Morris, P. G., Hudis, C. A., Giri, D., Morrow, M., Falcone, D. J., Zhou, X. K., Du, B., Brogi, E., Crawford, C. B., Kopelovich, L., et al. (2011) · Cancer Prevention Research · doi:10.1158/1940-6207.capr-11-0110 · Cited by 465
NF-κB Signaling Pathway, Inflammation and Colorectal Cancer
Wang, S., Liu, Z., Wang, L., & Zhang, X. (2009) · Cellular & Molecular Immunology · doi:10.1038/cmi.2009.43 · Cited by 405
Metadata
- Authors
- Schottenfeld, D., & Beebe-Dimmer, J.
- Venue
- CA: A Cancer Journal for Clinicians
- Publisher
- Wiley
- Published
- 2006-03-01
- Volume
- 56
- Issue
- 2
- Pages
- 69-83
- ISSN
- 0007-9235 (ISSN-L)
- OpenAlex
- W2148702138
- Cited by
- 475
- References
- 6
- FWCI
- 15.85
- Type
- journal article
- Language
- en
- Open access
- gold
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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