Cancer and the chemokine network

Inflammation and cancer

Coussens, L. M., & Werb, Z. (2002) · Nature · doi:10.1038/nature01322 · Cited by 15,111 · see citing works

Stem cells, cancer, and cancer stem cells

Reya, T., Morrison, S. J., Clarke, M. F., & Weissman, I. L. (2001) · Nature · doi:10.1038/35102167 · Cited by 9,738 · see citing works

Inflammation and cancer: back to Virchow?

Balkwill, F., & Mantovani, A. (2001) · The Lancet · doi:10.1016/s0140-6736(00)04046-0 · Cited by 7,746 · see citing works

International Union of Pharmacology: Approaches to the Nomenclature of Voltage-Gated Ion Channels

Catterall, W. A., Chandy, K. G., Clapham, D. E., Gutman, G. A., Hofmann, F., Harmar, A. J., Abernethy, D. R., & Spedding, M. (2003) · Pharmacological Reviews · doi:10.1124/pr.55.4.5 · Cited by 7,126 · see citing works

Macrophage polarization: tumor-associated macrophages as a paradigm for polarized M2 mononuclear phagocytes

MANTOVANI, A., SOZZANI, S., LOCATI, M., ALLAVENA, P., & SICA, A. (2002) · Trends in Immunology · doi:10.1016/s1471-4906(02)02302-5 · Cited by 5,528 · see citing works

Involvement of chemokine receptors in breast cancer metastasis

Müller, A., Homey, B., Soto, H., Ge, N., Catron, D., Buchanan, M. E., McClanahan, T., Murphy, E., Yuan, W., Wagner, S. N., et al. (2001) · Nature · doi:10.1038/35065016 · Cited by 5,340 · see citing works

Chemokines

Zlotnik, A., & Yoshie, O. (2000) · Immunity · doi:10.1016/s1074-7613(00)80165-x · Cited by 3,859 · see citing works

Intratumoral T Cells, Recurrence, and Survival in Epithelial Ovarian Cancer

Zhang, L., Conejo-Garcia, J. R., Katsaros, D., Gimotty, P. A., Massobrio, M., Regnani, G., Makrigiannakis, A., Gray, H., Schlienger, K., Liebman, M. N., et al. (2003) · New England Journal of Medicine · doi:10.1056/nejmoa020177 · Cited by 3,397 · see citing works

Tumour-educated macrophages promote tumour progression and metastasis

Pollard, J. W. (2004) · Nature reviews. Cancer · doi:10.1038/nrc1256 · Cited by 3,365 · see citing works

A multigenic program mediating breast cancer metastasis to bone

Kang, Y., Siegel, P. M., Shu, W., Drobnjak, M., Käkönen, S.-M., Cordon‐Cardo, C., Guise, T. A., & Massagué, J. (2003) · Cancer Cell · doi:10.1016/s1535-6108(03)00132-6 · Cited by 2,562 · see citing works

Function of the chemokine receptor CXCR4 in haematopoiesis and in cerebellar development

Zou, Y.-R., Kottmann, A. H., Kuroda, M., Taniuchi, I., & Littman, D. R. (1998) · Nature · doi:10.1038/31269 · Cited by 2,494 · see citing works

The Biology of Chemokines and their Receptors

Rossi, D., & Zlotnik, A. (2000) · Annual Review of Immunology · doi:10.1146/annurev.immunol.18.1.217 · Cited by 2,410 · see citing works

The role of tumour‐associated macrophages in tumour progression: implications for new anticancer therapies

Bingle, L., Brown, N. J., & Lewis, C. E. (2002) · The Journal of Pathology · doi:10.1002/path.1027 · Cited by 2,022 · see citing works

International Union of Pharmacology. XXII. Nomenclature for Chemokine Receptors

Murphy, P. M., Baggiolini, M., Charo, I. F., Hébert, C. A., Horuk, R., Matsushima, K., Miller, L. H., Oppenheim, J. J., & Power, C. A. (2000) · Pharmacological Reviews · doi:10.1016/s0031-6997(24)01439-x · Cited by 1,817 · see citing works

Colony-Stimulating Factor 1 Promotes Progression of Mammary Tumors to Malignancy

Lin, E. Y., Nguyen, A. V., Russell, R. G., & Pollard, J. W. (2001) · The Journal of Experimental Medicine · doi:10.1084/jem.193.6.727 · Cited by 1,594 · see citing works

The chemokine receptor CXCR4 is essential for vascularization of the gastrointestinal tract

Tachibana, K., Hirota, S., Iizasa, H., Yoshida, H., Kawabata, K., Kataoka, Y., Kitamura, Y., Matsushima, K., Yoshida, N., Nishikawa, S.-I., et al. (1998) · Nature · doi:10.1038/31261 · Cited by 1,527 · see citing works

G-CSF induces stem cell mobilization by decreasing bone marrow SDF-1 and up-regulating CXCR4

Petit, I., Szyper‐Kravitz, M., Nagler, A., Lahav, M., Peled, A., Habler, L., Ponomaryov, T., Taichman, R. S., Arenzana‐Seisdedos, F., Fujii, N., et al. (2002) · Nature Immunology · doi:10.1038/ni813 · Cited by 1,331 · see citing works

The origin and function of tumor-associated macrophages

Mantovani, A., Bottazzi, B., Colotta, F., Sozzani, S., & Ruco, L. P. (1992) · Immunology Today · doi:10.1016/0167-5699(92)90008-u · Cited by 1,088 · see citing works

Chemokine receptor CXCR4 downregulated by von Hippel–Lindau tumour suppressor pVHL

Staller, P., Sulitkova, J., Lisztwan, J., Moch, H., Oakeley, E. J., & Krek, W. (2003) · Nature · doi:10.1038/nature01874 · Cited by 870 · see citing works

Regulation of the Chemokine Receptor CXCR4 by Hypoxia

Schioppa, T., Uranchimeg, B., Saccani, A., Biswas, S. K., Doni, A., Rapisarda, A., Bernasconi, S., Saccani, S., Nebuloni, M., Vago, L., et al. (2003) · The Journal of Experimental Medicine · doi:10.1084/jem.20030267 · Cited by 841 · see citing works

Mice deficient in tumor necrosis factor-α are resistant to skin carcinogenesis

Moore, R. J., Owens, D. M., Stamp, G., Arnott, C., Burke, F., East, N., Holdsworth, H., Turner, L., Rollins, B., Pasparakis, M., et al. (1999) · Nature Medicine · doi:10.1038/10552 · Cited by 839 · see citing works

Control of TH2 polarization by the chemokine monocyte chemoattractant protein-1

Gu, L., Tseng, S., Horner, R. M., Tam‐Amersdorfer, C., Loda, M. F., & Rollins, B. J. (2000) · Nature · doi:10.1038/35006097 · Cited by 832 · see citing works

CXC chemokines in angiogenesis

Belperio, J. A., Keane, M. P., Arenberg, D. A., Addison, C., Ehlert, J. E., Burdick, M. D., & Strieter, R. M. (2000) · Journal of Leukocyte Biology · doi:10.1189/jlb.68.1.1 · Cited by 801 · see citing works

Disruption of the CXCR4/CXCL12 chemotactic interaction during hematopoietic stem cell mobilization induced by GCSF or cyclophosphamide

Lévesque, J.-P., Hendy, J., Takamatsu, Y., Simmons, P. J., & Bendall, L. J. (2003) · Journal of Clinical Investigation · doi:10.1172/jci15994 · Cited by 760 · see citing works

The significance of cancer cell expression of the chemokine receptor CXCR4

Balkwill, F. R. (2004) · Seminars in Cancer Biology · doi:10.1016/j.semcancer.2003.10.003 · Cited by 759 · see citing works

Chemokine receptors: multifaceted therapeutic targets

Proudfoot, A. E. I. (2002) · Nature reviews. Immunology · doi:10.1038/nri722 · Cited by 755 · see citing works

Mobilization of hematopoietic progenitor cells in healthy volunteers by AMD3100, a CXCR4 antagonist

Liles, W. C., Broxmeyer, H. E., Rodger, E., Wood, B. L., Hübel, K., Cooper, S. H., Hangoc, G., Bridger, G. J., Henson, G. W., Calandra, G., et al. (2003) · Blood · doi:10.1182/blood-2003-02-0663 · Cited by 718 · see citing works

Stromal-derived factor-1 in human tumors recruits and alters the function of plasmacytoid precursor dendritic cells

Zou, W., Machelon, V., L’Herminé, A. C., Borvak, J., Mercier‐Nomé, F., Isaeva, T., Wei, S., Krzysiek, R., Durand–Gasselin, I., Gordon, A. N., et al. (2001) · Nature Medicine · doi:10.1038/nm1201-1339 · Cited by 653 · see citing works

NF-κ B Promotes Breast Cancer Cell Migration and Metastasis by Inducing the Expression of the Chemokine Receptor CXCR4

Helbig, G., Christopherson, K. W., Bhat-Nakshatri, P., Kumar, S., Kishimoto, H., Miller, K. D., Broxmeyer, H. E., & Nakshatri, H. (2003) · Journal of Biological Chemistry · doi:10.1074/jbc.m300609200 · Cited by 639 · see citing works

A small-molecule antagonist of CXCR4 inhibits intracranial growth of primary brain tumors

Rubin, J. B., Kung, A. L., Klein, R. S., Chan, J. A.-W., Sun, Y., Schmidt, K. F., Kieran, M. W., Luster, A. D., & Segal, R. A. (2003) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2235846100 · Cited by 615 · see citing works

HGF, SDF-1, and MMP-9 are involved in stress-induced human CD34+ stem cell recruitment to the liver

Kollet, Ó., Shivtiel, S., Chen, Y.-Q., Suriawinata, J., Thung, S. N., Dabeva, M. D., Kahn, J., Spiegel, A., Dar, A., Samira, S., et al. (2003) · Journal of Clinical Investigation · doi:10.1172/jci17902 · Cited by 593 · see citing works

The role of cytokines in classical Hodgkin lymphoma

Skinnider, B., & Mak, T. W. (2002) · Blood · doi:10.1182/blood-2002-01-0099 · Cited by 506 · see citing works

Multiple actions of the chemokine CXCL12 on epithelial tumor cells in human ovarian cancer.

Scotton, C. J., Wilson, J. L., Scott, K. A., Stamp, G., Wilbanks, G. D., Fricker, S. P., Bridger, G. J., & Balkwill, F. R. (2002) · PubMed · Cited by 476 · see citing works

The bicyclam AMD3100 story

Clercq, E. D. (2003) · Nature Reviews Drug Discovery · doi:10.1038/nrd1134 · Cited by 460 · see citing works

The Stromal Derived Factor–1/CXCL12–CXC Chemokine Receptor 4 Biological Axis in Non–Small Cell Lung Cancer Metastases

Phillips, R. J., Burdick, M. D., Lutz, M., Belperio, J. A., Keane, M. P., & Strieter, R. M. (2003) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/rccm.200301-071oc · Cited by 458 · see citing works

The essential roles of the chemokine SDF-1 and its receptor CXCR4 in human stem cell homing and repopulation of transplanted immune-deficient NOD/SCID and NOD/SCID/B2mnull mice

Lapidot, T., & Kollet, Ó. (2002) · Leukemia · doi:10.1038/sj.leu.2402684 · Cited by 457 · see citing works

Expression of CXCR4 and CXCL12 (SDF‐1) in human prostate cancers (PCa) in vivo

Sun, Y.-X., Wang, J., Shelburne, C. E., Lopatin, D. E., Chinnaiyan, A. M., Rubin, M. A., Pienta, K. J., & Taichman, R. S. (2003) · Journal of Cellular Biochemistry · doi:10.1002/jcb.10522 · Cited by 443 · see citing works

The chemokine receptor CXCR4 is required for outgrowth of colon carcinoma micrometastases.

Zeelenberg, I. S., Stalle, L. R.-V., & Roos, E. (2003) · PubMed · Cited by 434 · see citing works

Vascular endothelial growth factor promotes breast carcinoma invasion in an autocrine manner by regulating the chemokine receptor CXCR4.

Bachelder, R. E., Wendt, M. A., & Mercurio, A. M. (2002) · PubMed · Cited by 428 · see citing works

Expression of stromal cell-derived factor 1 and CXCR4 ligand receptor system in pancreatic cancer: a possible role for tumor progression.

Koshiba, T., Hosotani, R., Miyamoto, Y., Ida, J., Tsuji, S., Nakajima, S., Kawaguchi, M., Kobayashi, H., Doi, R., Hori, T., et al. (2000) · PubMed · Cited by 427 · see citing works

Autocrine Production of IL-10 Mediates Defective IL-12 Production and NF-κB Activation in Tumor-Associated Macrophages

Sica, A., Saccani, A., Bottazzi, B., Polentarutti, N., Vecchi, A., Damme, J. V., & Mantovani, A. (2000) · The Journal of Immunology · doi:10.4049/jimmunol.164.2.762 · Cited by 423 · see citing works

Transgenic Expression of the Chemokine Receptor Encoded by Human Herpesvirus 8 Induces an Angioproliferative Disease Resembling Kaposi's Sarcoma

Yang, T., Chen, S., Leach, M. W., Manfra, D. J., Homey, B., Wiekowski, M., Sullivan, L., Jenh, C., Narula, S. K., Chensue, S. W., et al. (2000) · The Journal of Experimental Medicine · doi:10.1084/jem.191.3.445 · Cited by 416 · see citing works

Chemokines and the Molecular Basis of Cancer Metastasis

Murphy, P. M. (2001) · New England Journal of Medicine · doi:10.1056/nejm200109133451113 · Cited by 415 · see citing works

Chemokine Receptors in Human Endothelial Cells

Gupta, S. K., Lysko, P. G., Pillarisetti, K., Ohlstein, E. H., & Stadel, J. M. (1998) · Journal of Biological Chemistry · doi:10.1074/jbc.273.7.4282 · Cited by 408 · see citing works

A Possible Role for CXCR4 and Its Ligand, the CXC Chemokine Stromal Cell-Derived Factor-1, in the Development of Bone Marrow Metastases in Neuroblastoma

Geminder, H., Sagi‐Assif, O., Goldberg, L., Meshel, T., Rechavi, G., Witz, I. P., & Ben‐Baruch, A. (2001) · The Journal of Immunology · doi:10.4049/jimmunol.167.8.4747 · Cited by 408 · see citing works

Chemokines: agents for the immunotherapy of cancer?

Homey, B., Müller, A., & Zlotnik, A. (2002) · Nature Reviews Immunology · doi:10.1038/nri748 · Cited by 398 · see citing works

Expression of CC Chemokine Receptor-7 and Regional Lymph Node Metastasis of B16 Murine Melanoma

Wiley, H. E., Gonzalez, E. B., Maki, W. C., Wu, M., & Hwang, S. T. (2001) · JNCI Journal of the National Cancer Institute · doi:10.1093/jnci/93.21.1638 · Cited by 379 · see citing works

CXCR4 Is a Major Chemokine Receptor on Glioma Cells and Mediates Their Survival

Zhou, Y., Larsen, P. H., Hao, C., & Yong, V. W. (2002) · Journal of Biological Chemistry · doi:10.1074/jbc.m206222200 · Cited by 363 · see citing works

Tumour necrosis factor α: a potential target for the therapy of solid tumours

Szlosarek, P. W., & Balkwill, F. R. (2003) · The Lancet Oncology · doi:10.1016/s1470-2045(03)01196-3 · Cited by 356 · see citing works

Untitled work

(2003) · PubMed · Cited by 355 · see citing works

Regulation of the Macrophage Content of Neoplasms by Chemoattractants

Bottazzi, B., Polentarutti, N., Acero, R., Balsari, A., Boraschi, D., Ghezzi, P., Salmona, M., & Mantovani, A. (1983) · Science · doi:10.1126/science.6828888 · Cited by 352 · see citing works

Expression of CXC chemokine receptor-4 enhances the pulmonary metastatic potential of murine B16 melanoma cells.

Murakami, T., Maki, W. C., Cardones, A. R., Fang, H., Tun-Kyi, A., Nestle, F. O., & Hwang, S. T. (2002) · PubMed · Cited by 347 · see citing works

Quantitative assessment of the leukocyte infiltrate in ovarian cancer and its relationship to the expression of C-C chemokines.

Negus, R. P. M., Stamp, G. W. H., Hadley, J., & Balkwill, F. R. (1997) · Europe PMC (PubMed Central) · Cited by 341 · see citing works

The CC chemokine RANTES in breast carcinoma progression: regulation of expression and potential mechanisms of promalignant activity.

Azenshtein, E., Luboshits, G., Shina, S., Neumark, E., Shahbazian, D., Weil, M., Wigler, N., Keydar, I., & Ben‐Baruch, A. (2002) · PubMed · Cited by 335 · see citing works

Epithelial cancer cell migration: a role for chemokine receptors?

Scotton, C. J., Wilson, J. L., Milliken, D., Stamp, G., & Balkwill, F. R. (2001) · PubMed · Cited by 335 · see citing works

Stromal cell-derived factor 1alpha stimulates human glioblastoma cell growth through the activation of both extracellular signal-regulated kinases 1/2 and Akt.

Barbero, S., Bonavia, R., Bajetto, A., Porcile, C., Pirani, P., Ravetti, J. L., Zona, G., Spaziante, R., Florio, T., & Schettini, G. (2003) · PubMed · Cited by 335 · see citing works

The detection and localization of monocyte chemoattractant protein-1 (MCP-1) in human ovarian cancer.

Negus, R. P., Stamp, G. W., Relf, M. G., Burke, F., Malik, S. T., Bernasconi, S., Allavena, P., Sozzani, S., Mantovani, A., & Balkwill, F. R. (1995) · Journal of Clinical Investigation · doi:10.1172/jci117933 · Cited by 315 · see citing works

Role of CXCL1 in tumorigenesis of melanoma

Dhawan, P., & Richmond, A. J. (2002) · Journal of Leukocyte Biology · doi:10.1189/jlb.72.1.9 · Cited by 303 · see citing works

CXCR4–SDF-1 signaling is active in rhabdomyosarcoma cells and regulates locomotion, chemotaxis, and adhesion

Libura, J., Drukała, J., Majka, M., Tomescu, O. A., Navenot, J. M., Kucia, M., Marquez‐Curtis, L. A., Peiper, S. C., Barr, F. G., Janowska‐Wieczorek, A., et al. (2002) · Blood · doi:10.1182/blood-2002-01-0031 · Cited by 303 · see citing works

Expression of chemokine receptor CCR7 is associated with lymph node metastasis of gastric carcinoma.

Mashino, K., Sadanaga, N., Yamaguchi, H., Tanaka, F., Ohta, M., Shibuta, K., Inoue, H., & Mori, M. (2002) · PubMed · Cited by 300 · see citing works

Elevated expression of the CC chemokine regulated on activation, normal T cell expressed and secreted (RANTES) in advanced breast carcinoma.

Luboshits, G., Shina, S., Kaplan, O., Engelberg, S., Nass, D., Lifshitz-Mercer, B., Chaitchik, S., Keydar, I., & Ben‐Baruch, A. (1999) · PubMed · Cited by 297 · see citing works

Stromal Cell-Derived Factor 1, a Novel Target of Estrogen Receptor Action, Mediates the Mitogenic Effects of Estradiol in Ovarian and Breast Cancer Cells

Hall, J. M., & Korach, K. S. (2003) · Molecular Endocrinology · doi:10.1210/me.2002-0438 · Cited by 295 · see citing works

Significant correlation of monocyte chemoattractant protein-1 expression with neovascularization and progression of breast carcinoma

Saji, H., Koike, M., Yamori, T., Saji, S., Seiki, M., Matsushima, K., & Toi, M. (2001) · Cancer · doi:10.1002/1097-0142(20010901)92:5 · Cited by 283 · see citing works

Regulation of cellular proliferation, cytoskeletal function, and signal transduction through CXCR4 and c-Kit in small cell lung cancer cells.

Kijima, T., Maulik, G., Ma, P. C., Tibaldi, E. V., Turner, R. E., Rollins, B. J., Sattler, M., Johnson, B. E., & Salgia, R. (2002) · PubMed · Cited by 275 · see citing works

Expression pattern of CXC chemokine receptor-4 is correlated with lymph node metastasis in human invasive ductal carcinoma

Kato, M., Kitayama, J., Kazama, S., & Nagawa, H. (2003) · Breast Cancer Research · doi:10.1186/bcr627 · Cited by 267 · see citing works

A chemokine receptor antagonist inhibits experimental breast tumor growth.

Robinson, S. C., Scott, K. A., Wilson, J. L., Thompson, R. G., Proudfoot, A. E. I., & Balkwill, F. R. (2003) · PubMed · Cited by 259 · see citing works

CXCR4/CXCL12 expression and signalling in kidney cancer

Schrader, A. J., Lechner, O., Templin, M. F., Dittmar, K. E. J., Machtens, S. A., Mengel, M., Probst‐Kepper, M., Franzke, A., Wollensak, T., Gatzlaff, P., et al. (2002) · British Journal of Cancer · doi:10.1038/sj.bjc.6600221 · Cited by 254 · see citing works

Chemokine biology in cancer

Balkwill, F. R. (2002) · Seminars in Immunology · doi:10.1016/s1044-5323(02)00127-6 · Cited by 236 · see citing works

Low-Level Monocyte Chemoattractant Protein-1 Stimulation of Monocytes Leads to Tumor Formation in Nontumorigenic Melanoma Cells

Nesbit, M., Schaider, H., Miller, T. H., & Herlyn, M. (2001) · The Journal of Immunology · doi:10.4049/jimmunol.166.11.6483 · Cited by 235 · see citing works

Tumors and inflammatory infiltrates: Friends or foes?

Brigati, C., Noonan, D. M., Albini, A., & Benelli, R. (2002) · Clinical & Experimental Metastasis · doi:10.1023/a:1015587423262 · Cited by 230 · see citing works

The chemokine receptor CCR7 and α4 integrin are important for migration of chronic lymphocytic leukemia cells into lymph nodes

Till, K. J., Lin, K., Zuzel, M., & Cawley, J. C. (2002) · Blood · doi:10.1182/blood.v99.8.2977 · Cited by 222 · see citing works

The Earliest Stages of B Cell Development Require a Chemokine Stromal Cell-Derived Factor/Pre-B Cell Growth-Stimulating Factor

Egawa, T., Kawabata, K., Kawamoto, H., Amada, K., Okamoto, R., Fujii, N., Kishimoto, T., Katsura, Y., & Nagasawa, T. (2001) · Immunity · doi:10.1016/s1074-7613(01)00185-6 · Cited by 220 · see citing works

The CC chemokine MCP-1/CCL2 in pancreatic cancer progression: regulation of expression and potential mechanisms of antimalignant activity.

Monti, P., Leone, B. E., Marchesi, F., Balzano, G., Zerbi, A., Scaltrini, F., Pasquali, C., Calori, G., Pessi, F., Sperti, C., et al. (2003) · PubMed · Cited by 208 · see citing works

CXCR4 neutralization, a novel therapeutic approach for non-Hodgkin's lymphoma.

Bertolini, F., Dell’Agnola, C., Mancuso, P., Rabascio, C., Burlini, A., Monestiroli, S., Gobbi, A., Pruneri, G., & Martinelli, G. (2002) · PubMed · Cited by 204 · see citing works

Association of CC chemokine receptor 7 with lymph node metastasis of esophageal squamous cell carcinoma.

Ding, Y., Shimada, Y., Maeda, M., Kawabe, A., Kaganoi, J., Komoto, I., Hashimoto, Y., Miyake, M., Hashida, H., & Imamura, M. (2003) · PubMed · Cited by 201 · see citing works

Overexpression of CCR7 mRNA in nonsmall cell lung cancer: Correlation with lymph node metastasis

Takanami, I. (2003) · International Journal of Cancer · doi:10.1002/ijc.11063 · Cited by 199 · see citing works

A Role of CXC Chemokine Ligand 12/Stromal Cell-Derived Factor-1/Pre-B Cell Growth Stimulating Factor and Its Receptor CXCR4 in Fetal and Adult T Cell Development in Vivo

Ara, T., Itoi, M., Kawabata, K., Egawa, T., Tokoyoda, K., Sugiyama, T., Fujii, N., Amagai, T., & Nagasawa, T. (2003) · The Journal of Immunology · doi:10.4049/jimmunol.170.9.4649 · Cited by 183 · see citing works

Analysis of the Gene Expression Profile Activated by the CC Chemokine Ligand 5/RANTES and by Lipopolysaccharide in Human Monocytes

Locati, M., Deuschle, U., Massardi, M. L., Martínez, F. O., Sironi, M., Sozzani, S., Bartfai, T., & Mantovani, A. (2002) · The Journal of Immunology · doi:10.4049/jimmunol.168.7.3557 · Cited by 181 · see citing works

Immune Enhancement of Skin Carcinogenesis by CD4+ T Cells

Daniel, D., Meyer-Morse, N., Bergsland, E. K., Dehne, K., Coussens, L. M., & Hanahan, D. (2003) · The Journal of Experimental Medicine · doi:10.1084/jem.20021047 · Cited by 180 · see citing works

Expression of functional CXCR4 chemokine receptors on human colonic epithelial cells

Jordan, N., Kolios, G. C., Abbot, S. E., Sinai, M. A., Thompson, D. A., Petraki, K., & Westwick, J. K. (1999) · Journal of Clinical Investigation · doi:10.1172/jci6685 · Cited by 173 · see citing works

The chemokine receptor switch paradigm and dendritic cell migration: its significance in tumor tissues

Allavena, P., Sica, A., Vecchi, A., Locati, M., Sozzani, S., & Mantovani, A. (2000) · Immunological Reviews · doi:10.1034/j.1600-065x.2000.17714.x · Cited by 172 · see citing works

Immune Evasion by Murine Melanoma Mediated through CC Chemokine Receptor-10

Murakami, T., Cardones, A. R., Finkelstein, S. E., Restifo, N. P., Klaunberg, B. A., Nestle, F. O., Castillo, S. S., Dennis, P. A., & Hwang, S. T. (2003) · The Journal of Experimental Medicine · doi:10.1084/jem.20030593 · Cited by 168 · see citing works

The Viral Chemokine Macrophage Inflammatory Protein-II Is a Selective Th2 Chemoattractant

Sozzani, S., Luini, W., Bianchi, G., Allavena, P., Wells, T. N. C., Napolitano, M., Bernardini, G., Vecchi, A., D’Ambrosio, D., Mazzeo, D., et al. (1998) · Blood · doi:10.1182/blood.v92.11.4036 · Cited by 167 · see citing works

Amino-terminally Modified RANTES Analogues Demonstrate Differential Effects on RANTES Receptors

Proudfoot, A. E. I., Buser, R., Borlat, F., Alouani, S., Soler, D. F., Offord, R. E., Schröder, J.-M., Power, C., & Wells, T. N. C. (1999) · Journal of Biological Chemistry · doi:10.1074/jbc.274.45.32478 · Cited by 153 · see citing works

Monocyte chemoattractant protein‐1 expression correlates with macrophage infiltration and tumor vascularity in human esophageal squamous cell carcinomas

Ohta, M., Kitadai, Y., Tanaka, S., Yoshihara, M., Yasui, W., Mukaida, N., Haruma, K., & Chayama, K. (2002) · International Journal of Cancer · doi:10.1002/ijc.10705 · Cited by 152 · see citing works

Defective Expression of the Monocyte Chemotactic Protein-1 Receptor CCR2 in Macrophages Associated with Human Ovarian Carcinoma

Sica, A., Saccani, A., Bottazzi, B., Bernasconi, S., Allavena, P., Gaetano, B., Fei, F., LaRosa, G., Scotton, C. J., Balkwill, F. R., et al. (2000) · The Journal of Immunology · doi:10.4049/jimmunol.164.2.733 · Cited by 146 · see citing works

CCR5 Expression Influences the Progression of Human Breast Cancer in a p53-dependent Manner

Mañes, S., Mira, E., Colomer, R., Montero, S., Real, L. M., Gómez‐Moutón, C., Jiménez-Baranda, S., Garzón, A., Lacalle, R. A., Harshman, K., et al. (2003) · The Journal of Experimental Medicine · doi:10.1084/jem.20030580 · Cited by 140 · see citing works

Analysis of chemokines and chemokine receptor expression in ovarian cancer ascites.

Milliken, D., Scotton, C. J., Raju, S., Balkwill, F. R., & Wilson, J. L. (2002) · PubMed · Cited by 136 · see citing works

CXCR4 enhances adhesion of B16 tumor cells to endothelial cells in vitro and in vivo via beta(1) integrin.

Cardones, A. R., Murakami, T., & Hwang, S. T. (2003) · PubMed · Cited by 134 · see citing works

CXC Chemokine Receptor 4 Expression and Function in Human Anaplastic Thyroid Cancer Cells

Hwang, J. H., Hwang, J. H., Chung, H. K., Kim, D. W., Hwang, E. S., Suh, J. M., Kim, H., You, K., Kwon, O., Ro, H. K., et al. (2003) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2002-021381 · Cited by 125 · see citing works

CTLA-4 regulates cell cycle progression during a primary immune response

Greenwald, R. J., Oosterwegel, M. A., van der Woude, D., Kubal, A., Mandelbrot, D. A., Boussiotis, V. A., & Sharpe, A. H. (2002) · European Journal of Immunology · doi:10.1002/1521-4141(200202)32:2 · Cited by 120 · see citing works

RANTES expression is a predictor of survival in stage I lung adenocarcinoma.

Moran, C. J., Arenberg, D. A., Huang, C. C., Giordano, T. J., Thomas, D. G., Misek, D. E., Chen, G., Iannettoni, M. D., Orringer, M. B., Hanash, S., et al. (2002) · PubMed · Cited by 112 · see citing works

Stromal Cell-Derived Factor-1 as a Chemoattractant for Follicular Center Lymphoma B Cells

Corcione, A., Ottonello, L. C., Tortolina, G., Facchetti, P., Airoldi, I., Guglielmino, R., Dadati, P., Truini, M., Sozzani, S., Dallegri, F., et al. (2000) · JNCI Journal of the National Cancer Institute · doi:10.1093/jnci/92.8.628 · Cited by 99 · see citing works

Analysis of CC chemokine and chemokine receptor expression in solid ovarian tumours

Scotton, C. J., Milliken, D., Wilson, J. L., Raju, S., & Balkwill, F. R. (2001) · British Journal of Cancer · doi:10.1054/bjoc.2001.2020 · Cited by 89 · see citing works

Functional expression of the eotaxin receptor CCR3 in CD30+ cutaneous T-cell lymphoma

Kleinhans, M., Tun-Kyi, A., Gilliet, M. F., Kadin, M. E., Dummer, R., Burg, G., & Nestle, F. O. (2003) · Blood · doi:10.1182/blood-2002-02-0475 · Cited by 88 · see citing works

PARC/CCL18 Is a Plasma CC Chemokine with Increased Levels in Childhood Acute Lymphoblastic Leukemia

Struyf, S., Schutyser, E., Gouwy, M., Gijsbers, K., Proost, P., Benoît, Y., Opdenakker, G., Damme, J. V., & Laureys, G. (2003) · American Journal Of Pathology · doi:10.1016/s0002-9440(10)63564-x · Cited by 78 · see citing works

Retention of CXCR4 in the endoplasmic reticulum blocks dissemination of a T cell hybridoma

Zeelenberg, I. S., Stalle, L. R.-V., & Roos, E. (2001) · Journal of Clinical Investigation · doi:10.1172/jci11330 · Cited by 62 · see citing works

Normal pathogen-specific immune responses mounted by CTLA-4-deficient T cells: a paradigm reconsidered

Bachmann, M. F., Gallimore, A., Jones, E., Ecabert, B., Acha‐Orbea, H., & Köpf, M. (2001) · European Journal of Immunology · doi:10.1002/1521-4141(200102)31:2 · Cited by 60 · see citing works

Expression of cyclin D2 and D3 in lymphoid lesions

Teramoto, N., Tamm, K. P., Székely, L., Polack, A., Yoshino, T., Akagi, T., & Klein, G. (1999) · International Journal of Cancer · doi:10.1002/(sici)1097-0215(19990517)81:4 · Cited by 42 · see citing works

Radiolabelled lymphokines and growth factors for in vivo imaging of inflammation, infection and cancer

Signore, A., Capriotti, G., Scopinaro, F., Bonanno, E., & Modesti, A. (2003) · Trends in Immunology · doi:10.1016/s1471-4906(03)00174-1 · Cited by 16 · see citing works

Stem cells take a shortcut to the bone marrow

Dick, J. E., & Lapidot, T. (2003) · Blood · doi:10.1182/blood-2003-02-0392 · Cited by 6 · see citing works

Cancer-related inflammation

Mantovani, A., Allavena, P., Sica, A., & Balkwill, F. (2008) · Nature · doi:10.1038/nature07205 · Cited by 11,399 · see citing works

The senescence-associated secretory phenotype: the dark side of tumor suppression

Coppé, J.-P., Desprez, P.-Y., Krtolica, A., & Campisi, J. (2010) · Annual Review of Pathology: Mechanisms of Disease · doi:10.1146/annurev-pathol-121808-102144 · Cited by 5,206 · see citing works

Stromal Fibroblasts Present in Invasive Human Breast Carcinomas Promote Tumor Growth and Angiogenesis through Elevated SDF-1/CXCL12 Secretion

Orimo, A., Gupta, P. B., Sgroi, D. C., Arenzana-Seisdedos, F., Delaunay, T., Naeem, R., Carey, V. J., Richardson, A. L., & Weinberg, R. A. (2005) · Cell · doi:10.1016/j.cell.2005.02.034 · Cited by 3,759 · see citing works

Mesenchymal stem cells within tumour stroma promote breast cancer metastasis

Karnoub, A. E., Dash, A. B., Vo, A. P., Sullivan, A., Brooks, M. W., Bell, G. W., Richardson, A. L., Polyak, K., Tubo, R., & Weinberg, R. A. (2007) · Nature · doi:10.1038/nature06188 · Cited by 3,206 · see citing works

Genes that mediate breast cancer metastasis to lung

Minn, A. J., Gupta, G. P., Siegel, P. M., Bos, P. D., Shu, W., Giri, D. D., Viale, A., Olshen, A. B., Gerald, W. L., & Massagué, J. (2005) · Nature · doi:10.1038/nature03799 · Cited by 2,922 · see citing works

Cancer-related inflammation, the seventh hallmark of cancer: links to genetic instability

Colotta, F., Allavena, P., Sica, A., Garlanda, C., & Mantovani, A. (2009) · Carcinogenesis · doi:10.1093/carcin/bgp127 · Cited by 2,882 · see citing works

NF-κB, inflammation, immunity and cancer: coming of age

Taniguchi, K., & Karin, M. (2018) · Nature Reviews Immunology · doi:10.1038/nri.2017.142 · Cited by 2,679 · see citing works

Capturing complex 3D tissue physiology in vitro

Griffith, L. G., & Swartz, M. A. (2006) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm1858 · Cited by 2,274 · see citing works

Chemokines in the cancer microenvironment and their relevance in cancer immunotherapy

Nagarsheth, N., Wicha, M. S., & Zou, W. (2017) · Nature reviews. Immunology · doi:10.1038/nri.2017.49 · Cited by 2,196 · see citing works

Molecular requirements for epithelial–mesenchymal transition during tumor progression

Huber, M. A., Kraut, N., & Beug, H. (2005) · Current Opinion in Cell Biology · doi:10.1016/j.ceb.2005.08.001 · Cited by 1,813 · see citing works

Role of autophagy in cancer

Mathew, R., Karantza-Wadsworth, V., & White, E. (2007) · Nature Reviews Cancer · doi:10.1038/nrc2254 · Cited by 1,798 · see citing works

Smoldering and polarized inflammation in the initiation and promotion of malignant disease

Balkwill, F., Charles, K. A., & Mantovani, A. (2005) · Cancer Cell · doi:10.1016/j.ccr.2005.02.013 · Cited by 1,769 · see citing works

Inhibitory B7-family molecules in the tumour microenvironment

Zou, W., & Chen, L. (2008) · Nature Reviews Immunology · doi:10.1038/nri2326 · Cited by 1,608 · see citing works

Tumor-Associated Macrophages as Major Players in the Tumor Microenvironment

Chanmee, T., Ontong, P., Konno, K., & Itano, N. (2014) · Cancers · doi:10.3390/cancers6031670 · Cited by 1,537 · see citing works

Gut microbiome–mediated bile acid metabolism regulates liver cancer via NKT cells

Ma, C., Han, M., Heinrich, B., Fu, Q., Zhang, Q., Sandhu, M., Agdashian, D., Terabe, M., Berzofsky, J. A., Fako, V., et al. (2018) · Science · doi:10.1126/science.aan5931 · Cited by 1,508 · see citing works

CXCL12 (SDF-1)/CXCR4 Pathway in Cancer

Teicher, B. A., & Fricker, S. P. (2010) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-09-2329 · Cited by 1,453 · see citing works

Tumour-associated macrophages are a distinct M2 polarised population promoting tumour progression: Potential targets of anti-cancer therapy

Sica, A., Schioppa, T., Mantovani, A., & Allavena, P. (2006) · European Journal of Cancer · doi:10.1016/j.ejca.2006.01.003 · Cited by 1,451 · see citing works

Galectins as modulators of tumour progression

Liu, F., & Rabinovich, G. A. (2005) · Nature reviews. Cancer · doi:10.1038/nrc1527 · Cited by 1,435 · see citing works

Tumor-associated macrophages (TAM) as major players of the cancer-related inflammation

Solinas, G., Germano, G., Mantovani, A., & Allavena, P. (2009) · Journal of Leukocyte Biology · doi:10.1189/jlb.0609385 · Cited by 1,418 · see citing works

G-protein-coupled receptors and cancer

Dorsam, R. T., & Gutkind, J. S. (2007) · Nature reviews. Cancer · doi:10.1038/nrc2069 · Cited by 1,399 · see citing works

Validating matrix metalloproteinases as drug targets and anti-targets for cancer therapy

Overall, C. M., & Kleifeld, O. (2006) · Nature reviews. Cancer · doi:10.1038/nrc1821 · Cited by 1,212 · see citing works

Tumor-associated macrophages: an accomplice in solid tumor progression

Chen, Y., Song, Y., Du, W., Gong, L., Chang, H., & Zou, Z. (2019) · Journal of Biomedical Science · doi:10.1186/s12929-019-0568-z · Cited by 1,096 · see citing works

A CXCL1 Paracrine Network Links Cancer Chemoresistance and Metastasis

Acharyya, S., Oskarsson, T., Vanharanta, S., Malladi, S., Kim, J., Morris, P. G., Manova-Todorova, K., Leversha, M., Hogg, N., Seshan, V. E., et al. (2012) · Cell · doi:10.1016/j.cell.2012.04.042 · Cited by 1,085 · see citing works

Immune infiltration in human tumors: a prognostic factor that should not be ignored

Pagès, F., Galon, J., Dieu‐Nosjean, M., Tartour, É., Sautès‐Fridman, C., & Fridman, W. H. (2009) · Oncogene · doi:10.1038/onc.2009.416 · Cited by 1,082 · see citing works

Radiotherapy and immunotherapy: a beneficial liaison?

Weichselbaum, R. R., Liang, H. L., Deng, L., & Fu, Y. (2017) · Nature Reviews Clinical Oncology · doi:10.1038/nrclinonc.2016.211 · Cited by 1,073 · see citing works

The inflammatory micro-environment in tumor progression: the role of tumor-associated macrophages.

Allavena, P., Sica, A., Solinas, G., Porta, C., & Mantovani, A. (2008) · Critical Reviews in Oncology/Hematology · doi:10.1016/j.critrevonc.2007.07.004 · Cited by 1,044 · see citing works

Macrophages in Tumor Microenvironments and the Progression of Tumors

Hao, N.-B., Lü, M.-H., Fan, Y.-H., Cao, Y.-L., Zhang, Z.-R., & Yang, S.-M. (2012) · Clinical and Developmental Immunology · doi:10.1155/2012/948098 · Cited by 1,003 · see citing works

TUMOR STROMA AND REGULATION OF CANCER DEVELOPMENT

Tlsty, T. D., & Coussens, L. M. (2006) · Annual Review of Pathology Mechanisms of Disease · doi:10.1146/annurev.pathol.1.110304.100224 · Cited by 981 · see citing works

Macrophages sequentially change their functional phenotype in response to changes in microenvironmental influences

Stout, R. D., Jiang, C., Matta, B., Tietzel, I., Watkins, S. K., & Suttles, J. (2005) · The Journal of Immunology · doi:10.4049/jimmunol.175.1.342 · Cited by 968 · see citing works

Local Radiation Therapy of B16 Melanoma Tumors Increases the Generation of Tumor Antigen-Specific Effector Cells That Traffic to the Tumor

Lugade, A. A., Moran, J. P., Gerber, S. A., Rose, R. C., Frelinger, J. G., & Lord, E. M. (2005) · The Journal of Immunology · doi:10.4049/jimmunol.174.12.7516 · Cited by 966 · see citing works

Extracellular matrix and its therapeutic potential for cancer treatment

Huang, J., Zhang, L., Wan, D., Zhou, L., Zheng, S., Lin, S., & Qiao, Y. (2021) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-021-00544-0 · Cited by 962 · see citing works

PROSTAGLANDINS AND CANCER

Wang, D. (2005) · Gut · doi:10.1136/gut.2004.047100 · Cited by 906 · see citing works

Chemotaxis in cancer

Torres, E. T. R., Condeelis, J. S., & Patsialou, A. (2011) · Nature reviews. Cancer · doi:10.1038/nrc3078 · Cited by 900 · see citing works

Bone metastases: an overview

Macedo, F., Ladeira, K., Pinho, F. S., Saraiva, N., Bonito, N., Pinto, L., & Gonçalves, F. (2017) · Oncology Reviews · doi:10.4081/oncol.2017.321 · Cited by 881 · see citing works

Autocrine TGF-β and stromal cell-derived factor-1 (SDF-1) signaling drives the evolution of tumor-promoting mammary stromal myofibroblasts

Kojima, Y., Acar, A., Eaton, E. N., Mellody, K. T., Scheel, C., Ben‐Porath, I., Önder, T. T., Wang, Z. C., Richardson, A. L., Weinberg, R. A., et al. (2010) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1013805107 · Cited by 851 · see citing works

Chemokines and the immune response to cancer

Ozga, A. J., Chow, M. T., & Luster, A. D. (2021) · Immunity · doi:10.1016/j.immuni.2021.01.012 · Cited by 846 · see citing works

Chemokine:Receptor Structure, Interactions, and Antagonism

Allen, S. J., Crown, S. E., & Handel, T. M. (2007) · Annual Review of Immunology · doi:10.1146/annurev.immunol.24.021605.090529 · Cited by 842 · see citing works

The tumour microenvironment as a target for chemoprevention

Albini, A., & Sporn, M. B. (2007) · Nature reviews. Cancer · doi:10.1038/nrc2067 · Cited by 823 · see citing works

Stromal Fibroblasts in Cancer: A Novel Tumor-Promoting Cell Type

Orimo, A., & Weinberg, R. A. (2006) · Cell Cycle · doi:10.4161/cc.5.15.3112 · Cited by 798 · see citing works

The role of interleukin-8 and its receptors in gliomagenesis and tumoral angiogenesis

Brat, D. J., Bellail, A. C., & Meir, E. G. V. (2005) · Neuro-Oncology · doi:10.1215/s1152851704001061 · Cited by 760 · see citing works

CXCL12 / CXCR4 / CXCR7 chemokine axis and cancer progression

Sun, X., Cheng, G., Hao, M., Zheng, J., Zhou, X., Zhang, J., Taichman, R. S., Pienta, K. J., & Wang, J. (2010) · Cancer and Metastasis Reviews · doi:10.1007/s10555-010-9256-x · Cited by 729 · see citing works

G protein-coupled receptors: novel targets for drug discovery in cancer

Lappano, R., & Maggiolini, M. (2010) · Nature Reviews Drug Discovery · doi:10.1038/nrd3320 · Cited by 717 · see citing works

Radiation-Induced CXCL16 Release by Breast Cancer Cells Attracts Effector T Cells

Matsumura, S., Wang, B., Kawashima, N., Braunstein, S. E., Badura, M. L., Cameron, T. O., Babb, J. S., Schneider, R. J., Formenti, S. C., Dustin, M. L., et al. (2008) · The Journal of Immunology · doi:10.4049/jimmunol.181.5.3099 · Cited by 711 · see citing works

The Intricate Role of CXCR4 in Cancer

Chatterjee, S., Azad, B. B., & Nimmagadda, S. (2014) · Advances in cancer research · doi:10.1016/b978-0-12-411638-2.00002-1 · Cited by 674 · see citing works

Cytokines and their relationship to the symptoms and outcome of cancer

Seruga, B., Zhang, H., Bernstein, L. J., & Tannock, I. F. (2008) · Nature Reviews Cancer · doi:10.1038/nrc2507 · Cited by 652 · see citing works

The secreted factors responsible for pre-metastatic niche formation: Old sayings and new thoughts

Peinado, H., Lavotshkin, S., & Lyden, D. C. (2011) · Seminars in Cancer Biology · doi:10.1016/j.semcancer.2011.01.002 · Cited by 657 · see citing works

Senescent cells as a source of inflammatory factors for tumor progression

Davalos, A. R., Coppe, J.-P., Campisi, J., & Desprez, P.-Y. (2010) · Cancer and Metastasis Reviews · doi:10.1007/s10555-010-9220-9 · Cited by 636 · see citing works

The role of CXC chemokines and their receptors in cancer

Vandercappellen, J., Damme, J. V., & Struyf, S. (2008) · Cancer Letters · doi:10.1016/j.canlet.2008.04.050 · Cited by 643 · see citing works

An inflammatory link

Balkwill, F. R., & Coussens, L. M. (2004) · Nature · doi:10.1038/431405a · Cited by 627 · see citing works

Clodronate-liposome-mediated depletion of tumour-associated macrophages: a new and highly effective antiangiogenic therapy approach

Zeisberger, S. M., Odermatt, B., Marty, C., Zehnder-Fjällman, A. H. M., Ballmer‐Hofer, K., & Schwendener, R. A. (2006) · British Journal of Cancer · doi:10.1038/sj.bjc.6603240 · Cited by 622 · see citing works

Regulation of CXCR4 signaling

Busillo, J. M., & Benovic, J. (2006) · Biochimica et Biophysica Acta (BBA) - Biomembranes · doi:10.1016/j.bbamem.2006.11.002 · Cited by 617 · see citing works

TAMeless traitors: macrophages in cancer progression and metastasis

Aras, S., & Zaidi, M. (2017) · British Journal of Cancer · doi:10.1038/bjc.2017.356 · Cited by 550 · see citing works

Cancer related inflammation: the macrophage connection

Sica, A., Allavena, P., & Mantovani, A. (2008) · Cancer Letters · doi:10.1016/j.canlet.2008.03.028 · Cited by 601 · see citing works

Biomolecular gradients in cell culture systems

Keenan, T. M., & Folch, A. (2008) · Lab Chip · doi:10.1039/b711887b · Cited by 596 · see citing works

NF‐κB signaling in inflammation and cancer

Zhang, T., Ma, C., Zhang, Z., Zhang, H., & Hu, H. (2021) · MedComm · doi:10.1002/mco2.104 · Cited by 615 · see citing works

Tumor associated macrophages and neutrophils in cancer

Galdiero, M. R., Bonavita, E., Barajon, I., Garlanda, C., Mantovani, A., & Jaillon, S. (2013) · Immunobiology · doi:10.1016/j.imbio.2013.06.003 · Cited by 597 · see citing works

Chemokines and Chemokine Receptors: New Targets for Cancer Immunotherapy

Poeta, V. M., Massara, M., Capucetti, A., & Bonecchi, R. (2019) · Frontiers in Immunology · doi:10.3389/fimmu.2019.00379 · Cited by 585 · see citing works

Role of chemokines in tumor growth

Raman, D., Baugher, P. J., Thu, Y. M., & Richmond, A. (2007) · Cancer Letters · doi:10.1016/j.canlet.2007.05.013 · Cited by 578 · see citing works

Therapeutic targeting of the tumor microenvironment

Joyce, J. A. (2005) · Cancer Cell · doi:10.1016/j.ccr.2005.05.024 · Cited by 580 · see citing works

Stat3 mediates myeloid cell–dependent tumor angiogenesis in mice

Kujawski, M., Kortylewski, M., Lee, H., Herrmann, A., Kay, H. D., & Yu, H. (2008) · Journal of Clinical Investigation · doi:10.1172/jci35213 · Cited by 581 · see citing works

Inflammation and tumor microenvironments: defining the migratory itinerary of mesenchymal stem cells

Spaeth, E., Klopp, A., Dembinski, J., Andreeff, M., & Marini, F. (2008) · Gene Therapy · doi:10.1038/gt.2008.39 · Cited by 579 · see citing works

Meeting the challenge of ascites in ovarian cancer: new avenues for therapy and research

Kipps, E., Tan, D. S., & Kaye, S. (2013) · Nature Reviews. Cancer · doi:10.1038/nrc3432 · Cited by 552 · see citing works

Tumor-induced myeloid deviation: when myeloid-derived suppressor cells meet tumor-associated macrophages

Ugel, S., Sanctis, F. D., Mandruzzato, S., & Bronte, V. (2015) · Journal of Clinical Investigation · doi:10.1172/jci80006 · Cited by 563 · see citing works

CXCR7 (RDC1) promotes breast and lung tumor growth in vivo and is expressed on tumor-associated vasculature

Miao, Z., Luker, K. E., Summers, B. C., Berahovich, R., Bhojani, M. S., Rehemtulla, A., Kleer, C. G., Essner, J. J., Nasevicius, A., Luker, G. D., et al. (2007) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0610444104 · Cited by 528 · see citing works

The tumor microenvironment and its contribution to tumor evolution toward metastasis

Lorusso, G., & Rüegg, C. (2008) · Histochemistry and Cell Biology · doi:10.1007/s00418-008-0530-8 · Cited by 527 · see citing works

Mechanisms of transcoelomic metastasis in ovarian cancer

Tan, D. S. P., Agarwal, R., & Kaye, S. B. (2006) · The Lancet Oncology · doi:10.1016/s1470-2045(06)70939-1 · Cited by 521 · see citing works

Enhanced Tumor Trafficking of GD2 Chimeric Antigen Receptor T Cells by Expression of the Chemokine Receptor CCR2b

Craddock, J. A., Lu, A., Bear, A. S., Pulè, M. A., Brenner, M. K., Rooney, C. M., & Foster, A. E. (2010) · Journal of Immunotherapy · doi:10.1097/cji.0b013e3181ee6675 · Cited by 514 · see citing works

Perineural invasion and associated pain in pancreatic cancer

Bapat, A., Hostetter, G. H., Hoff, D. D. V., & Han, H. (2011) · Nature reviews. Cancer · doi:10.1038/nrc3131 · Cited by 502 · see citing works

Targeting the CCL2-CCR2 signaling axis in cancer metastasis

Lim, S. Y., Yuzhalin, A. E., Gordon-Weeks, A. N., & Muschel, R. J. (2016) · Oncotarget · doi:10.18632/oncotarget.7376 · Cited by 504 · see citing works

Targeting Macrophages in Cancer: From Bench to Bedside

Poh, A. R., & Ernst, M. (2018) · Frontiers in Oncology · doi:10.3389/fonc.2018.00049 · Cited by 497 · see citing works

Chemokines in Cancer

Chow, M. T., & Luster, A. D. (2014) · Cancer Immunology Research · doi:10.1158/2326-6066.cir-14-0160 · Cited by 491 · see citing works

Immune suppression in cancer: Effects on immune cells, mechanisms and future therapeutic intervention

WHITESIDE, T. (2005) · Seminars in Cancer Biology · doi:10.1016/j.semcancer.2005.07.008 · Cited by 486 · see citing works

Radiation-Induced IFN-γ Production within the Tumor Microenvironment Influences Antitumor Immunity

Lugade, A. A., Sorensen, E. W., Gerber, S. A., Moran, J. P., Frelinger, J. G., & Lord, E. M. (2008) · The Journal of Immunology · doi:10.4049/jimmunol.180.5.3132 · Cited by 485 · see citing works

Immune Checkpoint Inhibitors: Basics and Challenges

Li, B., Chan, H. L., & Chen, P. (2017) · Current Medicinal Chemistry · doi:10.2174/0929867324666170804143706 · Cited by 473 · see citing works

Chronic Inflammation: A Common and Important Factor in the Pathogenesis of Neoplasia

Schottenfeld, D., & Beebe‐Dimmer, J. (2006) · CA A Cancer Journal for Clinicians · doi:10.3322/canjclin.56.2.69 · Cited by 477 · see citing works

CXCL12/CXCR4: a symbiotic bridge linking cancer cells and their stromal neighbors in oncogenic communication networks

Guo, F., Wang, Y., Liu, J., Mok, S. C., Xue, F., & Zhang, W. (2015) · Oncogene · doi:10.1038/onc.2015.139 · Cited by 468 · see citing works

PGE2-Induced CXCL12 Production and CXCR4 Expression Controls the Accumulation of Human MDSCs in Ovarian Cancer Environment

Obermajer, N., Muthuswamy, R., Odunsi, K. O., Edwards, R. P., & Kaliński, P. (2011) · Cancer Research · doi:10.1158/0008-5472.can-11-2449 · Cited by 465 · see citing works

Tumour-associated mesenchymal stem/stromal cells: emerging therapeutic targets

Shi, Y.-F., Du, L., Lin, L.-Y., & Wang, Y. (2016) · Nature reviews. Drug discovery · doi:10.1038/nrd.2016.193 · Cited by 409 · see citing works

Cancer Cell Adhesion and Metastasis: Selectins, Integrins, and the Inhibitory Potential of Heparins

Bendas, G., & Borsig, L. (2012) · International Journal of Cell Biology · doi:10.1155/2012/676731 · Cited by 459 · see citing works

Chemokine-Induced Macrophage Polarization in Inflammatory Conditions

Ruytinx, P., Proost, P., Damme, J. V., & Struyf, S. (2018) · Frontiers in Immunology · doi:10.3389/fimmu.2018.01930 · Cited by 452 · see citing works

Epithelial-mesenchymal transition can suppress major attributes of human epithelial tumor-initiating cells

Celià-Terrassa, T., Meca‐Cortés, Ó., Mateo, F., de Paz, A. M., Rubio, N., Estape, A. A., Ell, B. J., Bermudo, R., Díaz, A., Guerra‐Rebollo, M., et al. (2012) · Journal of Clinical Investigation · doi:10.1172/jci59218 · Cited by 448 · see citing works

Absorption, metabolism, anti-cancer effect and molecular targets of epigallocatechin gallate (EGCG): An updated review

Gan, R., Li, H., Sui, Z., & Corke, H. (2016) · Critical Reviews in Food Science and Nutrition · doi:10.1080/10408398.2016.1231168 · Cited by 441 · see citing works

Tumor associated macrophages and neutrophils in tumor progression

Galdiero, M. R., Garlanda, C., Jaillon, S., Marone, G., & Mantovani, A. (2012) · Journal of Cellular Physiology · doi:10.1002/jcp.24260 · Cited by 440 · see citing works

Tumor-Infiltrating Monocytic Myeloid-Derived Suppressor Cells Mediate CCR5-Dependent Recruitment of Regulatory T Cells Favoring Tumor Growth

Schlecker, E., Stojanovic, A., Eisen, C., Quack, C., Falk, C. S., Umansky, V., & Cerwenka, A. (2012) · The Journal of Immunology · doi:10.4049/jimmunol.1201018 · Cited by 439 · see citing works

Pathways connecting inflammation and cancer

Allavena, P., Garlanda, C., Borrello, M. G., Sica, A., & Mantovani, A. (2008) · Current Opinion in Genetics & Development · doi:10.1016/j.gde.2008.01.003 · Cited by 436 · see citing works

Breast cancer as an example of tumour heterogeneity and tumour cell plasticity during malignant progression

Lüönd, F., Tiede, S., & Christofori, G. (2021) · British Journal of Cancer · doi:10.1038/s41416-021-01328-7 · Cited by 442 · see citing works

Unique Ectopic Lymph Node-Like Structures Present in Human Primary Colorectal Carcinoma Are Identified by Immune Gene Array Profiling

Coppola, D., Nebozhyn, M., Khalil, F., Dai, H., Yeatman, T., Loboda, A., & Mulé, J. J. (2011) · The American Journal of Pathology · doi:10.1016/j.ajpath.2011.03.007 · Cited by 434 · see citing works

12-Chemokine Gene Signature Identifies Lymph Node-like Structures in Melanoma: Potential for Patient Selection for Immunotherapy?

Messina, J. L., Fenstermacher, D. A., Eschrich, S., Qu, X., Berglund, A. E., Lloyd, M. C., Schell, M. J., Sondak, V. K., Weber, J. S., & Mulé, J. J. (2012) · Scientific Reports · doi:10.1038/srep00765 · Cited by 426 · see citing works

Rb Regulates Interactions between Hematopoietic Stem Cells and Their Bone Marrow Microenvironment

Walkley, C. R., Shea, J. M., Sims, N. A., Purton, L. E., & Orkin, S. H. (2007) · Cell · doi:10.1016/j.cell.2007.03.055 · Cited by 424 · see citing works

Upregulation of miRNA-155 promotes tumour angiogenesis by targeting VHL and is associated with poor prognosis and triple-negative breast cancer

Kong, W. W., He, L., Richards, E. J., Challa, S., Cx, X., Permuth‐Wey, J., Lancaster, J., Coppola, D., Sellers, T. A., Djeu, J. Y., et al. (2013) · Oncogene · doi:10.1038/onc.2012.636 · Cited by 422 · see citing works

Molecular Link Mechanisms between Inflammation and Cancer

Costa, D. B. V., & de Carvalho, J. E. (2012) · Current Pharmaceutical Design · doi:10.2174/138161212802083707 · Cited by 416 · see citing works

The chemokine system and cancer

Balkwill, F. R. (2011) · The Journal of Pathology · doi:10.1002/path.3029 · Cited by 414 · see citing works

Immune regulation by atypical chemokine receptors

Nibbs, R. J. B., & Graham, G. J. (2013) · Nature reviews. Immunology · doi:10.1038/nri3544 · Cited by 409 · see citing works

Ovarian Cancer Cells Polarize Macrophages Toward A Tumor-Associated Phenotype

Hagemann, T., Wilson, J. L., Burke, F., Kulbe, H., Li, N. F., Plüddemann, A., Charles, K. A., Gordon, S., & Balkwill, F. R. (2006) · The Journal of Immunology · doi:10.4049/jimmunol.176.8.5023 · Cited by 409 · see citing works

Interleukin‐8 is associated with proliferation, migration, angiogenesis and chemosensitivity in vitro and in vivo in colon cancer cell line models

Ning, Y., Manegold, P. C., Hong, Y. K., Zhang, W., Pohl, A., Lurje, G., Winder, T., Yang, D., LaBonte, M. J., Wilson, P. M., et al. (2010) · International Journal of Cancer · doi:10.1002/ijc.25562 · Cited by 405 · see citing works

CXCL12 (SDF1α)-CXCR4/CXCR7 Pathway Inhibition: An Emerging Sensitizer for Anticancer Therapies?

Duda, D. G., Kozin, S. V., Kirkpatrick, N. D., Xu, L., Fukumura, D., & Jain, R. K. (2011) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-10-2636 · Cited by 397 · see citing works

Macrophage polarization and plasticity in health and disease

Biswas, S. K., Chittezhath, M., Shalova, I. N., & Lim, J.-Y. (2012) · Immunologic Research · doi:10.1007/s12026-012-8291-9 · Cited by 396 · see citing works

The IL-8/IL-8R Axis: A Double Agent in Tumor Immune Resistance

David, J. M., Dominguez, C. L., Hamilton, D. H., & Palena, C. (2016) · Vaccines · doi:10.3390/vaccines4030022 · Cited by 397 · see citing works

Role of the CCL2‐CCR2 signalling axis in cancer: Mechanisms and therapeutic targeting

Xu, M., Wang, Y., Xia, R., Wei, Y., & Wei, X. (2021) · Cell Proliferation · doi:10.1111/cpr.13115 · Cited by 382 · see citing works

Inhibition of CXCR2 profoundly suppresses inflammation-driven and spontaneous tumorigenesis

Jamieson, T., Clarke, M., Steele, C. W., Samuel, M. S., Neumann, J., Jung, A., Huels, D., Olson, M. F., Das, S., Nibbs, R. J. B., et al. (2012) · Journal of Clinical Investigation · doi:10.1172/jci61067 · Cited by 391 · see citing works

Chemokine biology in cancer

Balkwill, F. R. (2002) · Seminars in Immunology · doi:10.1016/s1044-5323(02)00127-6 · Cited by 236 · see citing works

Manipulating the chemokine‐chemokine receptor network to treat cancer

Ruffini, P. A., Morandi, P., Cabıoğlu, N., Altundağ, K., & Cristofanilli, M. (2007) · Cancer · doi:10.1002/cncr.22706 · Cited by 114 · see citing works

Chemokines and cancer: migration, intracellular signalling and intercellular communication in the microenvironment

O’Hayre, M., Salanga, C. L., Handel, T. M., & Allen, S. J. (2008) · Biochemical Journal · doi:10.1042/bj20071493 · Cited by 297 · see citing works

Chemokines and Metastasis

Nannuru, K. C., Singh, S., & Singh, R. K. (2010) · Springer eBooks · doi:10.1007/978-1-4419-6615-5_27 · Cited by 7 · see citing works

Chemokines and Chemokine Receptors: Orchestrating Tumor Metastasization

Marcuzzi, E., Angioni, R., Molon, B., & Calì, B. (2018) · International Journal of Molecular Sciences · doi:10.3390/ijms20010096 · Cited by 158 · see citing works