The DOI matches its Crossref record; 5 of the 5 references it cites were found in a registry or an index.
The Lethal Phenotype of Cancer: The Molecular Basis of Death Due to Malignancy
Open accessAbstract
The last decade has seen an explosion in knowledge of the molecular basis and treatment of cancer. The molecular events that define the lethal phenotype of various cancers--the genetic and cellular alterations that lead to a cancer with a poor or incurable prognosis--are being defined. While these studies describe the cellular events of the lethal phenotype of cancer in detail, how these events result in the common clinical syndromes that kill the majority of cancer patients is not well understood. It is clear that the central step that makes most cancers incurable is metastasis. Understanding the traits that a cancer acquires to successfully grow and metastasize to distant sites gives insight into how tumors produce multiple factors that result in multiple different clinical syndromes that are lethal for the patient.
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Cites
Targeting HIF-1 for cancer therapy
Semenza, G. L. (2003) · Nature Reviews Cancer · doi:10.1038/nrc1187 · Cited by 6,717
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The pathogenesis of cancer metastasis: the ‘seed and soil’ hypothesis revisited
Fidler, I. J. (2003) · Nature Reviews Cancer · doi:10.1038/nrc1098 · Cited by 4,686 · cited 1×
“These hallmarks include the following: (1) genetic instability; (2) limitless replicative potential (immortality); (3) anchorageindependent growth; (4) stimulation of angiogenesis; (5) evasion of programmed cell death (apoptosis); and (6) ability to grow independently of stimulation by growth factors.”
BackgroundGlinsky, G. V., Berezovska, O., & Glinskii, A. B. (2005) · Journal of Clinical Investigation · doi:10.1172/jci23412 · Cited by 916
HIF-1 as a target for drug development
Giaccia, A., Siim, B. G., & Johnson, R. S. (2003) · Nature Reviews Drug Discovery · doi:10.1038/nrd1199 · Cited by 631
Cited by
Cytokines and their relationship to the symptoms and outcome of cancer
Seruga, B., Zhang, H., Bernstein, L. J., & Tannock, I. F. (2008) · Nature Reviews Cancer · doi:10.1038/nrc2507 · Cited by 652
Levolger, S., van Vugt, J. L. A., de Bruin, R. W. F., & IJzermans, J. N. M. (2015) · British Journal of Surgery · doi:10.1002/bjs.9893 · Cited by 270
van Vugt, J. L. A., Levolger, S., Gharbharan, A., Koek, M., Niessen, W. J., Burger, J. W. A., Willemsen, S. P., de Bruin, R. W. F., & IJzermans, J. N. M. (2017) · Journal of Cachexia, Sarcopenia and Muscle · doi:10.1002/jcsm.12158 · Cited by 217
Nutritional interventions for cancer-induced cachexia
Gullett, N. P., Mazurak, V. C., Hebbar, G., & Ziegler, T. R. (2011) · Current Problems in Cancer · doi:10.1016/j.currproblcancer.2011.01.001 · Cited by 114
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Metadata
- Authors
- Loberg, R. D., Bradley, D. A., Tomlins, S. A., Chinnaiyan, A. M., & Pienta, K. J.
- Venue
- CA: A Cancer Journal for Clinicians
- Publisher
- Wiley
- Published
- 2007-07-01
- Volume
- 57
- Issue
- 4
- Pages
- 225-241
- ISSN
- 0007-9235 (ISSN-L)
- OpenAlex
- W2113103362
- Cited by
- 161
- References
- 5
- FWCI
- 4.07
- Type
- journal article
- Language
- en
- Open access
- gold
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- Loberg, R. D., Bradley, D. A., Tomlins, S. A., Chinnaiyan, A. M., & Pienta, K. J. (2007). The Lethal Phenotype of Cancer: The Molecular Basis of Death Due to Malignancy. CA: A Cancer Journal for Clinicians. https://doi.org/10.3322/canjclin.57.4.225
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
