The DOI matches its Crossref record; 37 of the 37 references it cites were found in a registry or an index.
Hepcidin: from discovery to differential diagnosis
Open accessAbstract
Although iron is essential for living organisms to survive, its reactive properties require strict regulation in order to prevent toxic effects. Hepcidin, a liver produced peptide hormone, is thought to be the central regulator of body iron metabolism. Its production is mainly controlled by the erythropoietic activity of the bone-marrow, the amount of circulating and stored body iron, and inflammation. Recent reports, however, provide new hypotheses on how hepcidin might exert its regulatory function. Although hepcidin was first discovered in human urine and serum, most of our understanding of hepcidin regulation and action comes from in vitro and mice studies that often use hepcidin mRNA expression as a read out. The difficulties in carrying out studies in humans have mostly been due to the lack of suitable hepcidin assay. The recent development of assays to measure hepcidin in serum and urine has offered new opportunities to study hepcidin regulation in humans. However, for the moment, only a small number of laboratories are able to perform these assays. The aim of this review is to discuss insights into hepcidin regulation obtained from recent clinical studies in the light of findings from in vitro and mice studies. Ongoing studies in humans should provide us with more information on the etiology of iron metabolism disorders in order to create new therapeutic strategies and improve differential diagnosis protocols for these diseases.
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Cites
Hepcidin Regulates Cellular Iron Efflux by Binding to Ferroportin and Inducing Its Internalization
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Cited by
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Iron deficiency: an ominous sign in patients with systolic chronic heart failure
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“Hence, hepcidin blocks intestinal absorption of iron, and diverts iron from the circulation into the reticuloendothelial system.(66,67) Decreased intestinal iron absorption together with its accumulation in the reticuloendothelial stores reduces the availability of iron to target tissues.”
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Serum hepcidin: reference ranges and biochemical correlates in the general population
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Self-citationHepcidin in Human Iron Disorders: Diagnostic Implications
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Self-citationAnemia in Hodgkin's Lymphoma: The Role of Interleukin-6 and Hepcidin
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Hepcidin: A novel peptide hormone regulating iron metabolism
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A dual-monoclonal sandwich ELISA specific for hepcidin-25
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The transferrin/log(ferritin) ratio: A new tool for the diagnosis of iron deficiency anemia
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Metadata
- Authors
- Kemna, E. H. J. M., Tjalsma, H., Willems, H. L., & Swinkels, D. W.
- Venue
- Haematologica
- Published
- 2008-01-01
- Volume
- 93
- Issue
- 1
- Pages
- 90-97
- ISSN
- 0390-6078 (ISSN-L)
- 1592-8721
- OpenAlex
- W2132437552
- Cited by
- 313
- References
- 37
- FWCI
- 16.08
- Type
- journal article
- Language
- en
- Open access
- gold
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