Mammalian iron transport
Open accessAbstract
Iron is essential for basic cellular processes but is toxic when present in excess. Consequently, iron transport into and out of cells is tightly regulated. Most iron is delivered to cells bound to plasma transferrin via a process that involves transferrin receptor 1, divalent metal-ion transporter 1 and several other proteins. Non-transferrin-bound iron can also be taken up efficiently by cells, although the mechanism is poorly understood. Cells can divest themselves of iron via the iron export protein ferroportin in conjunction with an iron oxidase. The linking of an oxidoreductase to a membrane permease is a common theme in membrane iron transport. At the systemic level, iron transport is regulated by the liver-derived peptide hepcidin which acts on ferroportin to control iron release to the plasma.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
During periods of high iron requirement, such as iron deficiency or pregnancy, hepcidin levels are reduced to increase duodenal iron absorption and release from macrophages.
“During periods of high iron requirement, such as in iron deficiency or pregnancy, its levels are reduced to increase duodenal iron absorption and release from macrophages (Anderson and Vulpe, 2009).”
From Iron at the Centre of Candida albicans Interactions (2018) · cites this paper as Anderson and Vulpe, 2009
Transferrin transfers iron to cells through transferrin receptor 1 (TfR1) found on the surface of most body cells, and via transferrin receptor 2 (TfR2) expressed mainly in hepatocytes.
“Transferrin transfers iron to cells through transferrin receptor 1 (TfR1) found on the surface of most body cells, and via transferrin receptor 2 (TfR2) expressed mainly in hepatocytes (Anderson and Vulpe, 2009; Caza and Kronstad, 2013).”
From Iron at the Centre of Candida albicans Interactions (2018) · cites this paper as Anderson and Vulpe, 2009
Transferrin-TfR1 interaction triggers cell-mediated endocytosis of the complex and iron bound on transferrin dissociates within endosomes at a low pH (~5.5) since apotransferrin binds iron with a higher affinity at physiological pH relative to a low pH.
“Transferrin-Transferrin receptor (TfR1) interaction triggers cell-mediated endocytosis of the complex and iron bound on transferrin dissociates within endosomes at a low pH (~5.5) since apotransferrin binds iron with a higher affinity at physiological pH relative to a low pH (Bali and Aisen, 1992; Anderson and Vulpe, 2009).”
From Iron at the Centre of Candida albicans Interactions (2018) · cites this paper as Anderson and Vulpe, 2009
Cites
Targeting Hypoxia-Inducible Factors for the Treatment of Anemia in Chronic Kidney Disease Patients
Locatelli, F., Fishbane, S. N., Block, G. A., & Macdougall, I. C. (2017) · American Journal of Nephrology · doi:10.1159/000455166 · Cited by 4,834 · see citing works
Hepcidin Regulates Cellular Iron Efflux by Binding to Ferroportin and Inducing Its Internalization
Nemeth, E., Tuttle, M. S., Powelson, J., Vaughn, M. B., Donovan, A., Ward, D. M., Ganz, T., & Kaplan, J. (2004) · Science · doi:10.1126/science.1104742 · Cited by 4,803 · see citing works
Cloning and characterization of a mammalian proton-coupled metal-ion transporter
Gunshin, H., Mackenzie, B., Berger, U. V., Gunshin, Y., Romero, M. F., Boron, W. F., Nussberger, S., Gollan, J. L., & Hediger, M. A. (1997) · Nature · doi:10.1038/41343 · Cited by 3,166 · see citing works
The ferritins: molecular properties, iron storage function and cellular regulation
Harrison, P. M., & Arosio, P. (1996) · Biochimica et Biophysica Acta (BBA) - Bioenergetics · doi:10.1016/0005-2728(96)00022-9 · Cited by 2,667 · see citing works
Identification of the haemoglobin scavenger receptor
Kristiansen, M., Graversen, J. H., Jacobsen, C., Sonne, O., Hoffman, H.-J., Law, S. K. A., & Moestrup, S. K. (2001) · Nature · doi:10.1038/35051594 · Cited by 1,712 · see citing works
Pigeon, C., Ilyin, G., Courselaud, B., Leroyer, P., Turlin, B., Brissot, P., & Loréal, O. (2001) · Journal of Biological Chemistry · doi:10.1074/jbc.m008923200 · Cited by 1,697 · see citing works
Positional cloning of zebrafish ferroportin1 identifies a conserved vertebrate iron exporter
Donovan, A., Brownlie, A., Zhou, Y., Shepard, J., Pratt, S. J., Moynihan, J., Paw, B. H., Drejer, A., Barut, B., Zapata, A., et al. (2000) · Nature · doi:10.1038/35001596 · Cited by 1,667 · see citing works
McKie, A. T., Marciani, P., Rolfs, A., Brennan, K., Wehr, K., Barrow, D., Miret, S., Bomford, A., Peters, T. J., Farzaneh, F., et al. (2000) · Molecular Cell · doi:10.1016/s1097-2765(00)80425-6 · Cited by 1,422 · see citing works
Dysmetabolic Hyperferritinemia: All Iron Overload Is Not Hemochromatosis
Makker, J. S., Hanif, A., Bajantri, B., & Chilimuri, S. S. (2015) · Case Reports in Gastroenterology · doi:10.1159/000373883 · Cited by 1,353 · see citing works
The iron exporter ferroportin/Slc40a1 is essential for iron homeostasis
Donovan, A., Lima, C. A., Pinkus, J. L., Pinkus, G. S., Zon, L. I., Robine, S., & Andrews, N. C. (2005) · Cell Metabolism · doi:10.1016/j.cmet.2005.01.003 · Cited by 1,275 · see citing works
A Novel Mammalian Iron-regulated Protein Involved in Intracellular Iron Metabolism
Abboud, S., & Haile, D. J. (2000) · Journal of Biological Chemistry · doi:10.1074/jbc.m000713200 · Cited by 1,267 · see citing works
Nicolas, G., Bennoun, M., Devaux, I., Beaumont, C., Grandchamp, B., Kahn, A., & Vaulont, S. (2001) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.151179498 · Cited by 1,233 · see citing works
Nicolas, G., Chauvet, C., Viatte, L., Danan, J. L., Bigard, X., Devaux, I., Beaumont, C., Kahn, A., & Vaulont, S. (2002) · Journal of Clinical Investigation · doi:10.1172/jci0215686 · Cited by 1,214 · see citing works
Microcytic anaemia mice have a mutation in Nramp2, a candidate iron transporter gene
Fleming, M. D., Trenor, C. C., Su, M. A., Foernzler, D., Beier, D. R., Dietrich, W. F., & Andrews, N. C. (1997) · Nature Genetics · doi:10.1038/ng0897-383 · Cited by 1,159 · see citing works
Natural resistance to infection with intracellular parasites: isolation of a candidate for Bcg
Vidal, S. M., Malo, D., Vogan, K., Skamene, E., & Gros, P. (1993) · Cell · doi:10.1016/0092-8674(93)90135-d · Cited by 1,104 · see citing works
An iron-regulated ferric reductase associated with the absorption of dietary iron
McKie, A. T., Barrow, D., Latunde-Dada, G. O., Rolfs, A., Sager, G., Mudaly, E., Mudaly, M., Richardson, C., Barlow, D., Bomford, A., et al. (2001) · Science · doi:10.1126/science.1057206 · Cited by 1,101 · see citing works
LRP: a multifunctional scavenger and signaling receptor
Herz, J., & Strickland, D. K. (2001) · Journal of Clinical Investigation · doi:10.1172/jci13992 · Cited by 1,094 · see citing works
Vulpe, C. D., Kuo, Y.-M., Murphy, T. L., Cowley, L., Askwith, C., Libina, N., Gitschier, J., & Anderson, G. J. (1999) · Nature Genetics · doi:10.1038/5979 · Cited by 1,084 · see citing works
Self-citationThe role of iron regulatory proteins in mammalian iron homeostasis and disease
Rouault, T. A. (2006) · Nature Chemical Biology · doi:10.1038/nchembio807 · Cited by 1,055 · see citing works
Bone morphogenetic protein signaling by hemojuvelin regulates hepcidin expression
Babitt, J. L., Huang, F. W., Wrighting, D. M., Xia, Y., Sidis, Y., Samad, T. A., Campagna, J. A., Chung, R. T., Schneyer, A. L., Woolf, C. J., et al. (2006) · Nature Genetics · doi:10.1038/ng1777 · Cited by 1,026 · see citing works
Mutations in HFE2 cause iron overload in chromosome 1q–linked juvenile hemochromatosis
Papanikolaou, G., Samuels, M. E., Ludwig, E. H., MacDonald, M. L. E., Franchini, P. L., Dubé, M.-P., Andres, L., MacFarlane, J., Sakellaropoulos, N., Politou, M., et al. (2004) · Nature Genetics · doi:10.1038/ng1274 · Cited by 974 · see citing works
Fleming, M. D., Romano, M. A., Su, M. A., Garrick, L. M., Garrick, M. D., & Andrews, N. C. (1998) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.95.3.1148 · Cited by 936 · see citing works
C ERULOPLASMIN M ETABOLISM AND F UNCTION
Hellman, N. E., & Gitlin, J. D. (2002) · Annual Review of Nutrition · doi:10.1146/annurev.nutr.22.012502.114457 · Cited by 930 · see citing works
LRP: a multifunctional scavenger and signaling receptor
Herz, J., & Strickland, D. K. (2001) · Journal of Clinical Investigation · doi:10.1172/jci200113992 · Cited by 906 · see citing works
Severe iron deficiency anemia in transgenic mice expressing liver hepcidin
Nicolas, G., Bennoun, M., Porteu, A., Mativet, S., Beaumont, C., Grandchamp, B., Sirito, M., Sawadogo, M., Kahn, A., & Vaulont, S. (2002) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.072632499 · Cited by 880 · see citing works
Mutant antimicrobial peptide hepcidin is associated with severe juvenile hemochromatosis
Roetto, A., Papanikolaou, G., Politou, M., Alberti, F., Girelli, D., Christakis, J., Loukopoulos, D., & Camaschella, C. (2003) · Nature Genetics · doi:10.1038/ng1053 · Cited by 860 · see citing works
Qiu, A., Jansen, M., Sakaris, A., Min, S. H., Chattopadhyay, S., Tsai, E., Sandoval, C., Zhao, R., Akabas, M. H., & Goldman, I. D. (2006) · Cell · doi:10.1016/j.cell.2006.09.041 · Cited by 847 · see citing works
The gene TFR2 is mutated in a new type of haemochromatosis mapping to 7q22
Camaschella, C., Roetto, A., Calì, A., De Gobbi, M., Garozzo, G., Carella, M., Majorano, N., Totaro, A., & Gasparini, P. (2000) · Nature Genetics · doi:10.1038/75534 · Cited by 803 · see citing works
Ohgami, R. S., Campagna, D. R., Greer, E. L., Antiochos, B., McDonald, A., Chen, J., Sharp, J. J., Fujiwara, Y., Barker, J. E., & Fleming, M. D. (2005) · Nature Genetics · doi:10.1038/ng1658 · Cited by 775 · see citing works
BMP6 is a key endogenous regulator of hepcidin expression and iron metabolism
Andriopoulos Jr, B., Corradini, E., Xia, Y., Faasse, S. A., Chen, S., Grgurevic, L., Knutson, M. D., Pietrangelo, A., Vukicevic, S., Lin, H. Y., et al. (2009) · Nature Genetics · doi:10.1038/ng.335 · Cited by 769 · see citing works
Identification of an Intestinal Heme Transporter
Shayeghi, M., Latunde-Dada, G. O., Oakhill, J. S., Laftah, A. H., Takeuchi, K., Halliday, N., Khan, Y., Warley, A., McCann, F. E., Hider, R. C., et al. (2005) · Cell · doi:10.1016/j.cell.2005.06.025 · Cited by 755 · see citing works
Self-citationThe Steap proteins are metalloreductases
Ohgami, R. S., Campagna, D. R., McDonald, A., & Fleming, M. D. (2006) · Blood · doi:10.1182/blood-2006-02-003681 · Cited by 744 · see citing works
Puccio, H., Simon, D., Cossée, M., Criqui-Filipe, P., Tiziano, F., Melki, J., Hindelang, C., Matyas, R., Rustin, P., & Koenig, M. (2001) · Nature Genetics · doi:10.1038/84818 · Cited by 738 · see citing works
Molecular Cloning of Transferrin Receptor 2
Kawabata, H., Yang, R., Hirama, T., Vuong, P. T., Kawano, S., Gombart, A. F., & Koeffler, H. P. (1999) · Journal of Biological Chemistry · doi:10.1074/jbc.274.30.20826 · Cited by 646 · see citing works
Regulation of iron homeostasis by the hypoxia-inducible transcription factors (HIFs)
Peyssonnaux, C., Zinkernagel, A. S., Schuepbach, R. A., Rankin, E., Vaulont, S., Haase, V. H., Nizet, V., & Johnson, R. S. (2007) · Journal of Clinical Investigation · doi:10.1172/jci31370 · Cited by 639 · see citing works
Mitoferrin is essential for erythroid iron assimilation
Shaw, G. C., Cope, J. J., Li, L., Corson, K., Hersey, C., Ackermann, G. E., Gwynn, B., Lambert, A. J., Wingert, R. A., Traver, D., et al. (2006) · Nature · doi:10.1038/nature04512 · Cited by 624 · see citing works
Forging a field: the golden age of iron biology.
Andrews, N. C. (2008) · Blood · doi:10.1182/blood-2007-12-077388 · Cited by 623 · see citing works
Bridle, K. R., Frazer, D. M., Wilkins, S. J., Dixon, J. L., Purdie, D. M., Crawford, D. H., Subramaniam, V. N., Powell, L. W., Anderson, G. J., & Ramm, G. A. (2003) · The Lancet · doi:10.1016/s0140-6736(03)12602-5 · Cited by 620 · see citing works
Self-citationA role of SMAD4 in iron metabolism through the positive regulation of hepcidin expression
Wang, R.-H., Li, C., Xu, X., Zheng, Y., Xiao, C., Zerfas, P., Cooperman, S., Eckhaus, M., Rouault, T., Mishra, L., et al. (2005) · Cell Metabolism · doi:10.1016/j.cmet.2005.10.010 · Cited by 614 · see citing works
Binding of apotransferrin to K562 cells: explanation of the transferrin cycle.
Klausner, R. D., Ashwell, G., van Renswoude, J., Harford, J. B., & Bridges, K. R. (1983) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.80.8.2263 · Cited by 604 · see citing works
Stoichiometric and site characteristics of the binding of iron to human transferrin
Aisen, P., Leibman, A., & Zweier, J. (1978) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(19)62337-9 · Cited by 601 · see citing works
Lack of the bone morphogenetic protein BMP6 induces massive iron overload
Meynard, D., Kautz, L., Darnaud, V., Canonne-Hergaux, F., Coppin, H., & Roth, M.-P. (2009) · Nature Genetics · doi:10.1038/ng.320 · Cited by 587 · see citing works
Zip14 (Slc39a14) mediates non-transferrin-bound iron uptake into cells
Liuzzi, J. P., Aydemir, F., Nam, H., Knutson, M. D., & Cousins, R. J. (2006) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0606424103 · Cited by 577 · see citing works
Transferrin receptor is necessary for development of erythrocytes and the nervous system
Levy, J. E., Jin, O., Fujiwara, Y., Kuo, F., & Andrews, N. (1999) · Nature Genetics · doi:10.1038/7727 · Cited by 574 · see citing works
Structure of the human transferrin receptor-transferrin complex
Cheng, Y., Zak, O., Aisen, P., Harrison, S. C., & Walz, T. (2004) · Cell · doi:10.1016/s0092-8674(04)00130-8 · Cited by 571 · see citing works
Targeted gene disruption reveals an essential role for ceruloplasmin in cellular iron efflux
Harris, Z. L., Durley, A. P., Man, T. K., & Gitlin, J. D. (1999) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.96.19.10812 · Cited by 568 · see citing works
A cytosolic iron chaperone that delivers iron to ferritin
Shi, H., Bencze, K. Z., Stemmler, T. L., & Philpott, C. C. (2008) · Science · doi:10.1126/science.1157643 · Cited by 536 · see citing works
Labile iron pool: the main determinant of cellular response to oxidative stress
Kruszewski, M. K. (2003) · Mutation research. Fundamental and molecular mechanisms of mutagenesis · doi:10.1016/j.mrfmmm.2003.08.004 · Cited by 529 · see citing works
Function and regulation of transferrin and ferritin.
Ponka, P., Beaumont, C., & Richardson, D. R. (1998) · PubMed · Cited by 524 · see citing works
The NRAMP family of metal-ion transporters
Nevo, Y., & Nelson, N. (2006) · Biochimica et Biophysica Acta (BBA) - Molecular Cell Research · doi:10.1016/j.bbamcr.2006.05.007 · Cited by 513 · see citing works
LaVaute, T., Smith, S., Cooperman, S., Iwai, K., Land, W., Meyron-Holtz, E., Drake, S. K., Miller, G., Abu-Asab, M., Tsokos, M., et al. (2001) · Nature Genetics · doi:10.1038/84859 · Cited by 509 · see citing works
Iron Metabolism and the IRE/IRP Regulatory System: An Update
Pantopoulos, K. (2004) · Annals of the New York Academy of Sciences · doi:10.1196/annals.1306.001 · Cited by 505 · see citing works
Biosynthesis of heme in mammals
Ajioka, R. S., Phillips, J. D., & Kushner, J. P. (2006) · Biochimica et Biophysica Acta (BBA) - Molecular Cell Research · doi:10.1016/j.bbamcr.2006.05.005 · Cited by 493 · see citing works
Oudit, G. Y., Sun, H., Trivieri, M. G., Koch, S. E., Dawood, F., Ackerley, C., Yazdanpanah, M., Wilson, G. J., Schwartz, A., Liu, P. P., et al. (2003) · Nature Medicine · doi:10.1038/nm920 · Cited by 480 · see citing works
Identification of the receptor scavenging hemopexin-heme complexes
Hvidberg, V., Maniecki, M. B., Jacobsen, C., Højrup, P., Møller, H. J., & Moestrup, S. K. (2005) · Blood · doi:10.1182/blood-2005-03-1185 · Cited by 473 · see citing works
The macrophage scavenger receptor CD163
Fabriek, B. O., Dijkstra, C. D., & van den Berg, T. K. (2005) · Immunobiology · doi:10.1016/j.imbio.2005.05.010 · Cited by 456 · see citing works
Inorganic Biochemistry of Iron Metabolism: From Molecular Mechanisms to Clinical Consequences
Crichton, R. (2001) · doi:10.1002/0470845791 · Cited by 453 · see citing works
CD163: a regulated hemoglobin scavenger receptor with a role in the anti‐inflammatory response
Moestrup, S. K., & Møller, H. J. (2004) · Annals of Medicine · doi:10.1080/07853890410033171 · Cited by 444 · see citing works
The Molecular Mechanism of Hepcidin-mediated Ferroportin Down-Regulation
De Domenico, I., Ward, D. M., Langelier, C., Vaughn, M. B., Nemeth, E., Sundquist, W. I., Ganz, T., Musci, G., & Kaplan, J. (2007) · Molecular Biology of the Cell · doi:10.1091/mbc.e07-01-0060 · Cited by 434 · see citing works
Iron–sulphur cluster biogenesis and mitochondrial iron homeostasis
Rouault, T. A., & Tong, W.-H. (2005) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm1620 · Cited by 432 · see citing works
Gruenheid, S., Pinner, E., Desjardins, M., & Gros, P. (1997) · The Journal of Experimental Medicine · doi:10.1084/jem.185.4.717 · Cited by 428 · see citing works
Hemopexin: structure, function, and regulation
Tolosano, E., & Altruda, F. (2002) · DNA and Cell Biology · doi:10.1089/104454902753759717 · Cited by 426 · see citing works
Identification of a Human Heme Exporter that Is Essential for Erythropoiesis
Quigley, J. G., Yang, Z., Worthington, M., Phillips, J. D., Sabo, K. M., Sabath, D. E., Berg, C. L., Sassa, S., Wood, B. L., & Abkowitz, J. L. (2004) · Cell · doi:10.1016/j.cell.2004.08.014 · Cited by 423 · see citing works
Gunshin, H., Fujiwara, Y., Custodio, A. O., DiRenzo, C., Robine, S., & Andrews, N. C. (2005) · Journal of Clinical Investigation · doi:10.1172/jci24356 · Cited by 419 · see citing works
Flemming (1998) · Medical Entomology and Zoology · Cited by 412 · see citing works
Meyron‐Holtz, E. G., Ghosh, M. C., Iwai, K., LaVaute, T., Brazzolotto, X., Berger, U. V., Land, W., Ollivierre‐Wilson, H., Grinberg, A., Love, P., et al. (2004) · The EMBO Journal · doi:10.1038/sj.emboj.7600041 · Cited by 408 · see citing works
A Heme Export Protein Is Required for Red Blood Cell Differentiation and Iron Homeostasis
Keel, S. B., Doty, R. T., Yang, Z., Quigley, J. G., Chen, J., Knoblaugh, S., Kingsley, P. D., De Domenico, I., Vaughn, M. B., Kaplan, J., et al. (2008) · Science · doi:10.1126/science.1151133 · Cited by 404 · see citing works
Hepcidin is decreased in TFR2 hemochromatosis
Nemeth, E., Roetto, A., Garozzo, G., Ganz, T., & Camaschella, C. (2004) · Blood · doi:10.1182/blood-2004-08-3042 · Cited by 396 · see citing works
Hepcidin—a regulator of intestinal iron absorption and iron recycling by macrophages
GANZ, T. (2005) · Best Practice & Research Clinical Haematology · doi:10.1016/j.beha.2004.08.020 · Cited by 393 · see citing works
Identification of a hypoxia response element in the transferrin receptor gene
Lok, C. N., & Ponka, P. (1999) · Journal of Biological Chemistry · doi:10.1074/jbc.274.34.24147 · Cited by 380 · see citing works
Transferrin Receptor Induction by Hypoxia
Tacchini, L., Bianchi, L., Bernelli-Zazzera, A., & Cairo, G. (1999) · Journal of Biological Chemistry · doi:10.1074/jbc.274.34.24142 · Cited by 379 · see citing works
Jeong, S. Y., & David, S. (2003) · Journal of Biological Chemistry · doi:10.1074/jbc.m301988200 · Cited by 377 · see citing works
(2004) · ASM Press eBooks · doi:10.1128/9781555816544 · Cited by 368 · see citing works
The role of ceruloplasmin in iron metabolism.
Roeser, H. P., Lee, G. R., Nacht, S., & Cartwright, G. E. (1970) · Journal of Clinical Investigation · doi:10.1172/jci106460 · Cited by 365 · see citing works
Iron-Sulfur Protein Biogenesis in Eukaryotes: Components and Mechanisms
Lill, R., & Mühlenhoff, U. (2006) · Annual Review of Cell and Developmental Biology · doi:10.1146/annurev.cellbio.22.010305.104538 · Cited by 365 · see citing works
Paradkar, P. N., Zumbrennen, K. B., Paw, B. H., Ward, D. M., & Kaplan, J. (2008) · Molecular and Cellular Biology · doi:10.1128/mcb.01685-08 · Cited by 362 · see citing works
ROLE OF ABCG2/BCRP IN BIOLOGY AND MEDICINE
Krishnamurthy, P., & Schuetz, J. D. (2005) · The Annual Review of Pharmacology and Toxicology · doi:10.1146/annurev.pharmtox.46.120604.141238 · Cited by 357 · see citing works
Scara5 Is a Ferritin Receptor Mediating Non-Transferrin Iron Delivery
Li, J. Y., Paragas, N., Ned, R. M., Qiu, A., Viltard, M., Leete, T., Drexler, I. R., Chen, X., Sanna‐Cherchi, S., Mohammed, F., et al. (2009) · Developmental Cell · doi:10.1016/j.devcel.2008.12.002 · Cited by 355 · see citing works
De Domenico, I., Ward, D. M., di Patti, M. C. B., Jeong, S. Y., David, S., Musci, G., & Kaplan, J. (2007) · The EMBO Journal · doi:10.1038/sj.emboj.7601735 · Cited by 350 · see citing works
Iron Metabolism in the Reticuloendothelial System
Knutson, M. D., & Wessling‐Resnick, M. (2003) · Critical Reviews in Biochemistry and Molecular Biology · doi:10.1080/713609210 · Cited by 349 · see citing works
Aisen, P. (2004) · The International Journal of Biochemistry & Cell Biology · doi:10.1016/j.biocel.2004.02.007 · Cited by 329 · see citing works
Crystal Structure of the Ectodomain of Human Transferrin Receptor
Lawrence, C. M., Ray, S., Babyonyshev, M., Galluser, R., Borhani, D. W., & Harrison, S. C. (1999) · Science · doi:10.1126/science.286.5440.779 · Cited by 315 · see citing works
Hepcidin: from discovery to differential diagnosis
Kemna, E., Tjalsma, H., Willems, H. L., & Swinkels, D. W. (2007) · Haematologica · doi:10.3324/haematol.11705 · Cited by 313 · see citing works
Intracellular Copper Transport in Mammals
Prohaska, J. R., & Gybina, A. A. (2004) · Journal of Nutrition · doi:10.1093/jn/134.5.1003 · Cited by 307 · see citing works
Iron-dependent regulation of the divalent metal ion transporter
Gunshin, H., Allerson, C. R., Polycarpou-Schwarz, M., Rofts, A., Rogers, J. T., Kishi, F., Hentze, M. W., Rouault, T. A., Andrews, N. C., & Hediger, M. A. (2001) · FEBS Letters · doi:10.1016/s0014-5793(01)03189-1 · Cited by 305 · see citing works
Genetic Evidence that Ferric Reductase Is Required for Iron Uptake in Saccharomyces cerevisiae
Dancis, A., Klausner, R. D., Hinnebusch, A. G., & Barriocanal, J. G. (1990) · Molecular and Cellular Biology · doi:10.1128/mcb.10.5.2294-2301.1990 · Cited by 304 · see citing works
Sec15 Is an Effector for the Rab11 GTPase in Mammalian Cells
Zhang, X., Ellis, S. L., Sriratana, A., Mitchell, C. A., & Rowe, T. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.m402264200 · Cited by 288 · see citing works
Iron trafficking in the mitochondrion: novel pathways revealed by disease
Napier, I. A., Ponka, P., & Richardson, D. R. (2004) · Blood · doi:10.1182/blood-2004-10-3856 · Cited by 287 · see citing works
Bekri, S., Kispál, G., Lange, H., Fitzsimons, E. J., Tolmie, J., Lill, R., & Bishop, D. F. (2000) · Blood · doi:10.1182/blood.v96.9.3256 · Cited by 281 · see citing works
Decreased Liver Hepcidin Expression in the Hfe Knockout Mouse
Ahmad, K. A., Ahmann, J. R., Migas, M. C., Waheed, A., Britton, R. S., Bacon, B. R., Sly, W. S., & Fleming, R. E. (2002) · Blood Cells Molecules and Diseases · doi:10.1006/bcmd.2002.0575 · Cited by 276 · see citing works
Fleming, R. E., Migas, M. C., Holden, C. C., Waheed, A., Britton, R. S., Tomatsu, S., Bacon, B. R., & Sly, W. S. (2000) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.040548097 · Cited by 273 · see citing works
Direct interorganellar transfer of iron from endosome to mitochondrion
Sheftel, A. D., Zhang, A., Brown, C. M., Shirihai, O. S., & Ponka, P. (2007) · Blood · doi:10.1182/blood-2007-01-068148 · Cited by 266 · see citing works
The role of transporters in cellular heme and porphyrin homeostasis
Krishnamurthy, P. C., Xie, T., & Schuetz, J. D. (2007) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2007.02.001 · Cited by 260 · see citing works
Craven, C. M., Alexander, J., Eldridge, M., Kushner, J. P., Bernstein, S., & Kaplan, J. (1987) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.84.10.3457 · Cited by 259 · see citing works
Mechanisms of heme iron absorption: Current questions and controversies
West, A. R., & Oates, P. S. (2008) · World Journal of Gastroenterology · doi:10.3748/wjg.14.4101 · Cited by 257 · see citing works
Mammalian Tissue Oxygen Levels Modulate Iron-Regulatory Protein Activities in Vivo
Meyron‐Holtz, E. G., Ghosh, M. C., & Rouault, T. A. (2004) · Science · doi:10.1126/science.1103786 · Cited by 246 · see citing works
Response to Iron Deprivation in <i>Saccharomyces cerevisiae</i>
Philpott, C. C., & Protchenko, O. (2008) · Eukaryotic Cell · doi:10.1128/ec.00354-07 · Cited by 246 · see citing works
Inorganic Biochemistry of Iron Metabolism: From Molecular Mechanisms to Clinical Consequences
Crichton, R. R. (2001) · Cited by 244 · see citing works
Targeted mutagenesis of the murine transferrin receptor-2 gene produces hemochromatosis
Fleming, R. E., Ahmann, J. R., Migas, M. C., Waheed, A., Koeffler, H. P., Kawabata, H., Britton, R. S., Bacon, B. R., & Sly, W. S. (2002) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.162360699 · Cited by 244 · see citing works
MDB: the Metalloprotein Database and Browser at The Scripps Research Institute
Castagnetto, J. M. (2002) · Nucleic Acids Research · doi:10.1093/nar/30.1.379 · Cited by 236 · see citing works
Trinder, D., Oates, P. S., Thomas, C., Sadleir, J., & Morgan, E. H. (2000) · Gut · doi:10.1136/gut.46.2.270 · Cited by 230 · see citing works
Bernstein, S. E. (1987) · PubMed · Cited by 222 · see citing works
Galy, B., Ferring–Appel, D., Miñana, B., Bell, O., Janser, H., Muckenthaler, M. U., Schümann, K., & Hentze, M. W. (2005) · Blood · doi:10.1182/blood-2005-04-1365 · Cited by 222 · see citing works
TIM-2 is expressed on B cells and in liver and kidney and is a receptor for H-ferritin endocytosis
Chen, T. T., Li, L., Chung, D.-H., Allen, C. D. C., Torti, S. V., Torti, F. M., Cyster, J. G., Chen, C.-Y., Brodsky, F. M., Niemi, E. C., et al. (2005) · The Journal of Experimental Medicine · doi:10.1084/jem.20042433 · Cited by 219 · see citing works
Natural-resistance-associated macrophage protein 1 is an H+/bivalent cation antiporter
GOSWAMI, T., BHATTACHARJEE, A., BABAL, P., SEARLE, S., MOORE, E., LI, M., & BLACKWELL, J. M. (2001) · Biochemical Journal · doi:10.1042/bj3540511 · Cited by 218 · see citing works
Role of the hypoxia inducible factors HIF in iron metabolism
Peyssonnaux, C., Nizet, V., & Johnson, R. S. (2008) · Cell Cycle · doi:10.4161/cc.7.1.5145 · Cited by 217 · see citing works
Increased Susceptibility in Hp Knockout Mice During Acute Hemolysis
Lim, S. K., Kim, H., Lim, S. K., bin Ali, A., Lim, Y. K., Wang, Y., Chong, S. M., Costantini, F. D., & Baumman, H. (1998) · Blood · doi:10.1182/blood.v92.6.1870 · Cited by 215 · see citing works
Iron Imports. II. Iron uptake at the apical membrane in the intestine
Mackenzie, B., & Garrick, M. D. (2005) · American Journal of Physiology-Gastrointestinal and Liver Physiology · doi:10.1152/ajpgi.00363.2005 · Cited by 211 · see citing works
The orchestration of body iron intake: how and where do enterocytes receive their cues?
Frazer, D. M., & Anderson, G. J. (2003) · Blood Cells Molecules and Diseases · doi:10.1016/s1079-9796(03)00039-1 · Cited by 211 · see citing works
Self-citationPondarré, C., Antiochos, B., Campagna, D. R., Clarke, S. L., Greer, E. L., Deck, K. M., McDonald, A. A., Han, A., Medlock, A. E., Kutok, J. L., et al. (2006) · Human Molecular Genetics · doi:10.1093/hmg/ddl012 · Cited by 208 · see citing works
Haptoglobin: function and polymorphism.
Wassell, J. (2000) · PubMed · Cited by 204 · see citing works
Melefors, Ö., Goossen, B., Johansson, H. E., Stripecke, R., Gray, N. K., & Hentze, M. W. (1993) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)53414-1 · Cited by 200 · see citing works
Characterization of non-transferrin-bound iron clearance by rat liver.
Wright, T. L., Brissot, P., L, W., & Weisiger, R. A. (1986) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)67473-3 · Cited by 196 · see citing works
Hepcidin excess induces the sequestration of iron and exacerbates tumor-associated anemia
Rivera, S., Liu, L., Nemeth, E., Gabayan, V., Sorensen, O. E., & Ganz, T. (2005) · Blood · doi:10.1182/blood-2004-08-3375 · Cited by 196 · see citing works
Galy, B., Ferring-Appel, D., Kaden, S., Gröne, H.-J., & Hentze, M. W. (2008) · Cell Metabolism · doi:10.1016/j.cmet.2007.10.006 · Cited by 195 · see citing works
The role of transferrin in the mechanism of cellular iron uptake
Thorstensen, K., & Romslo, I. (1990) · Biochemical Journal · doi:10.1042/bj2710001 · Cited by 194 · see citing works
Picard, V., Govoni, G. R., Jabado, N., & Gros, P. (2000) · Journal of Biological Chemistry · doi:10.1074/jbc.m005387200 · Cited by 191 · see citing works
Cybrd1 (duodenal cytochrome b) is not necessary for dietary iron absorption in mice
Gunshin, H., Starr, C. N., DiRenzo, C., Fleming, M. D., Jin, J., Greer, E. L., Sellers, V. M., Galica, S. M., & Andrews, N. C. (2005) · Blood · doi:10.1182/blood-2005-02-0716 · Cited by 188 · see citing works
Cellular regulation and molecular interactions of the ferritins
Hintze, K. J., & Theil, E. C. (2006) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-005-5285-y · Cited by 187 · see citing works
A new role for the transferrin receptor in the release of iron from transferrin
Bali, P. K., Zak, O., & Aisen, P. (1991) · Biochemistry · doi:10.1021/bi00216a003 · Cited by 186 · see citing works
Breuer, W., Shvartsman, M., & Cabantchik, Z. I. (2008) · The International Journal of Biochemistry & Cell Biology · doi:10.1016/j.biocel.2007.03.010 · Cited by 175 · see citing works
The Regulation of Cellular Iron Metabolism
Chua, A. C. G., Graham, R. M., Trinder, D., & Olynyk, J. K. (2007) · Critical Reviews in Clinical Laboratory Sciences · doi:10.1080/10408360701428257 · Cited by 168 · see citing works
Steap Proteins: Implications for Iron and Copper Metabolism
Knutson, M. D. (2008) · Nutrition Reviews · doi:10.1111/j.1753-4887.2007.tb00311.x · Cited by 165 · see citing works
Transferrin receptors and iron uptake during erythroid cell development
Iacopetta, B. J., Morgan, E. H., & Yeoh, G. C. (1982) · Biochimica et Biophysica Acta (BBA) - Biomembranes · doi:10.1016/0005-2736(82)90547-8 · Cited by 164 · see citing works
Koorts, A. M., & Viljoen, M. (2007) · Archives of Physiology and Biochemistry · doi:10.1080/13813450701318583 · Cited by 164 · see citing works
Modification of iron regulation by the inflammatory response
WEISS, G. (2005) · Best Practice & Research Clinical Haematology · doi:10.1016/j.beha.2004.09.001 · Cited by 161 · see citing works
Aceruloplasminemia: An Inherited Neurodegenerative Disease with Impairment of Iron Homeostasis
XU, X., PIN, S., GATHINJI, M., FUCHS, R., & HARRIS, Z. L. (2004) · Annals of the New York Academy of Sciences · doi:10.1196/annals.1306.024 · Cited by 160 · see citing works
Unexpected role of ceruloplasmin in intestinal iron absorption
Cherukuri, S., Potla, R., Sarkar, J., Nurko, S., Harris, Z. L., & Fox, P. L. (2005) · Cell Metabolism · doi:10.1016/j.cmet.2005.10.003 · Cited by 158 · see citing works
Molecular and Cellular Iron Transport
(2002) · CRC Press eBooks · doi:10.1201/9780824744175.fmatt1 · Cited by 150 · see citing works
Defective Recovery and Severe Renal Damage After Acute Hemolysis in Hemopexin-Deficient Mice
Tolosano, E., Hirsch, E., Patrucco, E., Camaschella, C., Navone, R., Silengo, L., & Altruda, F. (1999) · Blood · doi:10.1182/blood.v94.11.3906 · Cited by 149 · see citing works
The Heme Oxygenase System: Update 2005
Maines, M. D. (2005) · Antioxidants and Redox Signaling · doi:10.1089/ars.2005.7.1761 · Cited by 146 · see citing works
Foot, N. J., Dalton, H. E., Shearwin-Whyatt, L. M., Dorstyn, L., Tan, S.-S., Yang, B., & Kumar, S. (2008) · Blood · doi:10.1182/blood-2008-04-150953 · Cited by 143 · see citing works
Domenico, I. D., Lo, E., Ward, D. M., & Kaplan, J. (2009) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0900453106 · Cited by 143 · see citing works
Crusade for iron: iron uptake in unicellular eukaryotes and its significance for virulence
Šuťák, R., Lesuisse, E., Tachezy, J., & Richardson, D. R. (2008) · Trends in Microbiology · doi:10.1016/j.tim.2008.03.005 · Cited by 142 · see citing works
Sibille, J., Kondo, H. G., & Aisen, P. (1988) · Hepatology · doi:10.1002/hep.1840080218 · Cited by 139 · see citing works
Nature of nontransferrin‐bound iron
Hider, R. C. (2002) · European Journal of Clinical Investigation · doi:10.1046/j.1365-2362.2002.0320s1050.x · Cited by 139 · see citing works
Anderson, G. J., & Frazer, D. M. (2005) · Seminars in Liver Disease · doi:10.1055/s-2005-923314 · Cited by 138 · see citing works
Self-citationFrazer, D. M., Vulpe, C. D., McKie, A. T., Wilkins, S. J., Trinder, D., Cleghorn, G. J., & Anderson, G. J. (2001) · American Journal of Physiology-Gastrointestinal and Liver Physiology · doi:10.1152/ajpgi.2001.281.4.g931 · Cited by 137 · see citing works
Self-citationThe Macrophage Cell Surface Glyceraldehyde-3-phosphate Dehydrogenase Is a Novel Transferrin Receptor
Raje, C. I., Kumar, S., Harle, A. S., Nanda, J. S., & Raje, M. (2006) · Journal of Biological Chemistry · doi:10.1074/jbc.m608328200 · Cited by 135 · see citing works
Courville, P., Chaloupka, R., & Cellier, M. F. (2006) · Biochemistry and Cell Biology · doi:10.1139/o06-193 · Cited by 132 · see citing works
Sendamarai, A. K., Ohgami, R. S., Fleming, M. D., & Lawrence, C. M. (2008) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0801318105 · Cited by 130 · see citing works
Randell, E. W., Parkes, J. G., Olivieri, N. F., & Templeton, D. M. (1994) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(17)33971-6 · Cited by 127 · see citing works
Pietrangelo, A. (2004) · Hepatology · doi:10.1002/hep.20007 · Cited by 127 · see citing works
Investigation of a role for reduction in ferric iron uptake by mouse duodenum
Raja, K. B., Simpson, R. J., & Peters, T. J. (1992) · Biochimica et Biophysica Acta (BBA) - Molecular Cell Research · doi:10.1016/0167-4889(92)90129-y · Cited by 124 · see citing works
Iron-regulatory proteins: molecular biology and pathophysiological implications
Cairo, G., & Recalcati, S. (2007) · Expert Reviews in Molecular Medicine · doi:10.1017/s1462399407000531 · Cited by 124 · see citing works
Mims, M. P., & Prchal, J. T. (2005) · Hematology · doi:10.1080/10245330500093419 · Cited by 123 · see citing works
Ceruloplasmin/hephaestin knockout mice model morphologic and molecular features of AMD
Hadziahmetovic, M., Dentchev, T., Song, Y., Haddad, N., He, X., Hahn, P., Pratico, D., Wen, R., Harris, Z. L., Lambris, J. D., et al. (2008) · Investigative Opthalmology & Visual Science · doi:10.1167/iovs.07-1472 · Cited by 121 · see citing works
The Testicular Iron Shuttle: A “Nurse” Function of the Sertoli Cells
Sylvester, S. R., & Griswold, M. D. (1994) · Journal of Andrology · doi:10.1002/j.1939-4640.1994.tb00468.x · Cited by 120 · see citing works
Copper and Iron Transport Across the Placenta: Regulation and Interactions
McArdle, H. J., Andersen, H. S., Jones, H. N., & Gambling, L. (2008) · Journal of Neuroendocrinology · doi:10.1111/j.1365-2826.2008.01658.x · Cited by 120 · see citing works
Thorstensen, K., & Romslo, I. (1988) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)68384-x · Cited by 119 · see citing works
Studies on familial hypotransferrinemia: unique clinical course and molecular pathology.
Hayashi, A., Wada, Y., Suzuki, T., & Shimizu, A. (1993) · Europe PMC (PubMed Central) · Cited by 117 · see citing works
Iron accumulation in the liver of male patients with Wilson's disease
Shiono, Y., Wakusawa, S., Hayashi, H., Takikawa, T., Yano, M., Okada, T., Mabuchi, H., Kono, S., & Miyajima, H. (2001) · The American Journal of Gastroenterology · doi:10.1111/j.1572-0241.2001.05269.x · Cited by 116 · see citing works
Dietary iron induces rapid changes in rat intestinal divalent metal transporter expression
Yeh, K., YEH, M. K. Y., Watkins, J. A., Rodriguez‐Paris, J., & Glass, J. (2000) · American Journal of Physiology-Gastrointestinal and Liver Physiology · doi:10.1152/ajpgi.2000.279.5.g1070 · Cited by 113 · see citing works
Recent advances in mammalian haem transport
Latunde-Dada, G. O., Simpson, R. J., & McKie, A. T. (2006) · Trends in Biochemical Sciences · doi:10.1016/j.tibs.2006.01.005 · Cited by 113 · see citing works
The Ceruloplasmin Homolog Hephaestin and the Control of Intestinal Iron Absorption
Anderson, G. J., Frazer, D. M., McKie, A. T., & Vulpe, C. D. (2002) · Blood Cells Molecules and Diseases · doi:10.1006/bcmd.2002.0576 · Cited by 111 · see citing works
Self-citationTchernitchko, D., Bourgeois, M., Martin, M., & Beaumont, C. (2002) · Biochemical Journal · doi:10.1042/0264-6021:3630449 · Cited by 110 · see citing works
IRON AND PROTEIN KINETICS STUDIED BY MEANS OF DOUBLY LABELED HUMAN CRYSTALLINE TRANSFERRIN*
Katz, J. H. (1961) · Journal of Clinical Investigation · doi:10.1172/jci104440 · Cited by 108 · see citing works
Pietrangelo, A. (2005) · Seminars in Liver Disease · doi:10.1055/s-2005-923316 · Cited by 102 · see citing works
Wyllie, S., Seu, P., & Goss, J. A. (2002) · Microbes and Infection · doi:10.1016/s1286-4579(02)01548-4 · Cited by 101 · see citing works
Wallace, D. F. (2007) · World Journal of Gastroenterology · doi:10.3748/wjg.v13.i35.4690 · Cited by 101 · see citing works
Johnson, M. B., Chen, J., Murchison, N., Green, F. A., & Enns, C. A. (2006) · Molecular Biology of the Cell · doi:10.1091/mbc.e06-09-0798 · Cited by 101 · see citing works
Wilson, M. T., & Reeder, B. J. (2007) · Experimental Physiology · doi:10.1113/expphysiol.2007.039735 · Cited by 99 · see citing works
Rice, A. E., Mendez, M. J., Hokanson, C. A., Rees, D. C., & Björkman, P. J. (2009) · Journal of Molecular Biology · doi:10.1016/j.jmb.2008.12.063 · Cited by 97 · see citing works
A mutation in Sec15l1 causes anemia in hemoglobin deficit (hbd) mice
Lim, J. E., Jin, O., Bennett, C. M., Morgan, K. J., Wang, F., Trenor, C. C., Fleming, M. D., & Andrews, N. C. (2005) · Nature Genetics · doi:10.1038/ng1659 · Cited by 97 · see citing works
Transferrin binding and iron uptake in mouse hepatocytes
Cole, E. S., & Glass, J. (1983) · Biochimica et Biophysica Acta (BBA) - Molecular Cell Research · doi:10.1016/0167-4889(83)90122-2 · Cited by 93 · see citing works
Millard, K. N., Frazer, D. M., Wilkins, S. J., & Anderson, G. J. (2004) · Gut · doi:10.1136/gut.2003.031153 · Cited by 93 · see citing works
Self-citationCasey, J. L., Jeso, B. D., Rao, K., Klausner, R. D., & Harford, J. B. (1988) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.85.6.1787 · Cited by 92 · see citing works
Trinder, D. (1996) · Hepatology · doi:10.1053/jhep.1996.v23.pm0008675172 · Cited by 91 · see citing works
Jordan, I., & Kaplan, J. (1994) · Biochemical Journal · doi:10.1042/bj3020875 · Cited by 88 · see citing works
Functional Expression Cloning and Characterization of SFT, a Stimulator of Fe Transport
Gutierrez, J. A., Yu, J., Rivera, S. B., & Wessling‐Resnick, M. (1997) · The Journal of Cell Biology · doi:10.1083/jcb.139.4.895 · Cited by 87 · see citing works
Deaglio, S., Capobianco, A., Calı̀, A., Bellora, F., Alberti, F., Righi, L., Sapino, A., Camaschella, C., & Malavasi, F. (2002) · Blood · doi:10.1182/blood-2002-01-0076 · Cited by 86 · see citing works
Trinder, D., Zak, O., & Aisen, P. (1996) · Hepatology · doi:10.1002/hep.510230631 · Cited by 84 · see citing works
Pandolfo, M. (2003) · Seminars in Pediatric Neurology · doi:10.1016/s1071-9091(03)00025-1 · Cited by 81 · see citing works
Anemia of the Belgrade rat: evidence for defective membrane transport of iron
Bowen, B., & Morgan, E. (1987) · Blood · doi:10.1182/blood.v70.1.38.38 · Cited by 79 · see citing works
Friedreich's Ataxia: From Disease Mechanisms to Therapeutic Interventions
Lodi, R., Tonon, C., Calabrese, V., & Schapira, A. H. V. (2006) · Antioxidants and Redox Signaling · doi:10.1089/ars.2006.8.438 · Cited by 79 · see citing works
Molecular and Cellular Iron Transport
Templeton, D. M. (2002) · CRC Press eBooks · doi:10.1201/9780824744175 · Cited by 78 · see citing works
nm1054: a spontaneous, recessive, hypochromic, microcytic anemia mutation in the mouse
Ohgami, R. S., Campagna, D. R., Antiochos, B., Wood, E., Sharp, J. J., Barker, J. E., & Fleming, M. D. (2005) · Blood · doi:10.1182/blood-2005-01-0379 · Cited by 74 · see citing works
Mok, H., Jelinek, J., Pai, S., Cattanach, B. M., Prchal, J. T., Youssoufian, H., & Schumacher, A. (2004) · Development · doi:10.1242/dev.01081 · Cited by 73 · see citing works
Genetic variation in Mon1a affects protein trafficking and modifies macrophage iron loading in mice
Wang, F., Paradkar, P. N., Custodio, Á. O., Ward, D. M., Fleming, M. D., Campagna, D. R., Roberts, K. A., Boyartchuk, V., Dietrich, W. F., Kaplan, J., et al. (2007) · Nature Genetics · doi:10.1038/ng2059 · Cited by 72 · see citing works
Evidence for the multimeric structure of ferroportin.
De Domenico, I., Ward, D. M., Musci, G., & Kaplan, J. (2007) · Blood · doi:10.1182/blood-2006-06-032516 · Cited by 72 · see citing works
Lam-Yuk-Tseung, S., & Gros, P. (2006) · Biochemistry · doi:10.1021/bi052307m · Cited by 72 · see citing works
Regulation of Transferrin Function and Expression: Review and Update
Lok, C., & Loh, T. T. (1998) · Neurosignals · doi:10.1159/000014542 · Cited by 71 · see citing works
Inman, R. S., Coughlan, M. M., & Wessling-Resnick, M. (1994) · Biochemistry · doi:10.1021/bi00205a022 · Cited by 70 · see citing works
Regulation of transferrin gene expression
Zakin, M. M. (1992) · The FASEB Journal · doi:10.1096/fasebj.6.14.1426763 · Cited by 67 · see citing works
Tchernitchko, D., Bourgeois, M., Martin, M., et al. (2002) · Biochemical Journal · doi:10.1042/bj3630449 · Cited by 65 · see citing works
Chapter 6 Iron Homeostasis and Erythropoiesis
Wrighting, D. M., & Andrews, N. C. (2008) · Current topics in developmental biology/Current Topics in Developmental Biology · doi:10.1016/s0070-2153(07)00006-3 · Cited by 58 · see citing works
The mechanisms of iron uptake by fetal rat hepatocytes in culture
Trinder, D., Morgan, E. H., & Baker, E. (1986) · Hepatology · doi:10.1002/hep.1840060508 · Cited by 58 · see citing works
Ultrastructural sequences during liver iron overload in genetic hemochromatosis
Iancu, T. C., Deugnier, Y., Halliday, J. W., Powell, L. W., & Brissot, P. (1997) · Journal of Hepatology · doi:10.1016/s0168-8278(97)80079-7 · Cited by 57 · see citing works
Wilkins, S. J., Frazer, D. M., Millard, K. N., McLaren, G. D., & Anderson, G. J. (2005) · Blood · doi:10.1182/blood-2005-07-2614 · Cited by 56 · see citing works
Self-citationNramp1 equips macrophages for efficient iron recycling
Soe-Lin, S., Sheftel, A. D., Wasyluk, B., & Ponka, P. (2008) · Experimental Hematology · doi:10.1016/j.exphem.2008.02.013 · Cited by 56 · see citing works
Uptake and subcellular processing of 59Fe-125I-labelled transferrin by rat liver
Morgan, E. H., Smith, G. D., & Peters, T. J. (1986) · Biochemical Journal · doi:10.1042/bj2370163 · Cited by 50 · see citing works
Pathogenesis of hereditary hemochromatosis
Fleming, R. E., Britton, R. S., Waheed, A., Sly, W. S., & Bacon, B. R. (2004) · Clinics in Liver Disease · doi:10.1016/j.cld.2004.06.004 · Cited by 48 · see citing works
The endocytosis of transferrin by rat intestinal epithelial cells
Anderson, G. J., Powell, L. W., & Halliday, J. W. (1994) · Gastroenterology · doi:10.1016/0016-5085(94)90600-9 · Cited by 45 · see citing works
Self-citationRobb, A., Ericsson, M., & Wessling‐Resnick, M. (2004) · American Journal of Physiology-Cell Physiology · doi:10.1152/ajpcell.00337.2004 · Cited by 45 · see citing works
Trinder, D., Morgan, E. H., & Baker, E. (1988) · Biochimica et Biophysica Acta (BBA) - Biomembranes · doi:10.1016/0005-2736(88)90375-6 · Cited by 45 · see citing works
The anemia of “haemoglobin-deficit” (hbd/hbd) mice is caused by a defect in transferrin cycling
Zhang, A., Sheftel, A. D., & Ponka, P. (2006) · Experimental Hematology · doi:10.1016/j.exphem.2006.02.004 · Cited by 44 · see citing works
Oshiro, S., Nakajima, H., Markello, T. C., Krasnewich, D. M., Bernardini, I. M., & Gahl, W. A. (1993) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(20)80581-x · Cited by 41 · see citing works
White, R. A., Boydston, L. A., Brookshier, T. R., McNulty, S. G., Nsumu, N. N., Brewer, B. P., & Blackmore, K. (2005) · Genomics · doi:10.1016/j.ygeno.2005.09.015 · Cited by 41 · see citing works
Watkins, J. A., Altazan, J. D., Elder, P., Li, C. Y., Núñez, M. T., Cui, X. X., & Glass, J. (1992) · Biochemistry · doi:10.1021/bi00140a018 · Cited by 40 · see citing works
Effects of Cell Proliferation on the Uptake of Transferrin–Bound Iron by Human Hepatoma Cells
Lee, A. W. M., Oates, P. S., & Trinder, D. (2003) · Hepatology · doi:10.1053/jhep.2003.50422 · Cited by 38 · see citing works
Flagged first, then by citations
Cited by
Sorted by citations
The Metabolic Underpinnings of Ferroptosis
Zheng, J., & Conrad, M. (2020) · Cell Metabolism · doi:10.1016/j.cmet.2020.10.011 · Cited by 1,340 · see citing works
Current understanding of iron homeostasis
Anderson, G. J., & Frazer, D. M. (2017) · The American Journal of Clinical Nutrition · doi:10.3945/ajcn.117.155804 · Cited by 688 · see citing works
Self-citationNon-transferrin bound iron: a key role in iron overload and iron toxicity
Brissot, P., Ropert, M., Le Lan, C., & Loréal, O. (2012) · Biochimica et Biophysica Acta (BBA) - General Subjects · doi:10.1016/j.bbagen.2011.07.014 · Cited by 654 · see citing works
Iron deficiency: an ominous sign in patients with systolic chronic heart failure
Jankowska, E. A., Rozentryt, P., Witkowska, A., Nowak, J., Hartmann, O., Ponikowska, B., Borodulin-Nadzieja, L., Banasiak, W., Polonski, L., Filippatos, G., et al. (2010) · European Heart Journal · doi:10.1093/eurheartj/ehq158 · Cited by 652 · see citing works
Dental Enamel Formation and Implications for Oral Health and Disease
Lacruz, R. S., Habelitz, S., Wright, J. T., & Paine, M. L. (2017) · Physiological Reviews · doi:10.1152/physrev.00030.2016 · Cited by 610 · see citing works
Regulation of iron transport and the role of transferrin
Gkouvatsos, K., Papanikolaou, G., & Pantopoulos, K. (2012) · Biochimica et Biophysica Acta (BBA) - General Subjects · doi:10.1016/j.bbagen.2011.10.013 · Cited by 518 · see citing works
Ferroptosis, radiotherapy, and combination therapeutic strategies
Lei, G., Mao, C., Yan, Y., Zhuang, L., & Gan, B. (2021) · Protein & Cell · doi:10.1007/s13238-021-00841-y · Cited by 519 · see citing works
The role of mitochondria in cellular iron–sulfur protein biogenesis and iron metabolism
Lill, R., Hoffmann, B., Molik, S., Pierik, A. J., Rietzschel, N., Stehling, O., Uzarska, M. A., Webert, H., Wilbrecht, C., & Mühlenhoff, U. (2012) · Biochimica et Biophysica Acta (BBA) - Molecular Cell Research · doi:10.1016/j.bbamcr.2012.05.009 · Cited by 501 · see citing works
Protein Design: Toward Functional Metalloenzymes
Yu, F., Cangelosi, V. M., Zastrow, M. L., Tegoni, M., Plegaria, J. S., Tebo, A. G., Mocny, C. S., Ruckthong, L., Qayyum, H., & Pecoraro, V. L. (2014) · Chemical Reviews · doi:10.1021/cr400458x · Cited by 442 · see citing works
Iron deficiency and heart failure: diagnostic dilemmas and therapeutic perspectives
Jankowska, E. A., von Haehling, S., Anker, S. D., Macdougall, I. C., & Ponikowski, P. (2013) · European Heart Journal · doi:10.1093/eurheartj/ehs224 · Cited by 399 · see citing works
Targeting the transferrin receptor for brain drug delivery
Johnsen, K. B., Burkhart, A., Thomsen, L. B., Andresen, T. L., & Moos, T. (2019) · Progress in Neurobiology · doi:10.1016/j.pneurobio.2019.101665 · Cited by 372 · see citing works
Urrutia, P., Aguirre, P., Esparza, A., Tapia, V., Mena, N. P., Arredondo, M., González‐Billault, C., & Núñez, M. T. (2013) · Journal of Neurochemistry · doi:10.1111/jnc.12244 · Cited by 364 · see citing works
Iron Homeostasis in Health and Disease
Gozzelino, R., & Arosio, P. (2016) · International Journal of Molecular Sciences · doi:10.3390/ijms17010130 · Cited by 370 · see citing works
Mitochondria as a Therapeutic Target in Heart Failure
Bayeva, M., Gheorghiade, M., & Ardehali, H. (2012) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2012.08.1021 · Cited by 336 · see citing works
Emerging mechanisms and targeted therapy of ferroptosis in cancer
Wang, H., Cheng, Y., Mao, C., Liu, S., Xiao, D., Huang, J. X., & Tao, Y. (2021) · Molecular Therapy · doi:10.1016/j.ymthe.2021.03.022 · Cited by 321 · see citing works
Essential functions of iron-requiring proteins in DNA replication, repair and cell cycle control
Zhang, C. (2014) · Protein & Cell · doi:10.1007/s13238-014-0083-7 · Cited by 299 · see citing works
A highly selective turn-on fluorescent probe for iron(ii) to visualize labile iron in living cells
Hirayama, T., Okuda, K., & Nagasawa, H. (2012) · Chemical Science · doi:10.1039/c2sc21649c · Cited by 297 · see citing works
Iron Deficiency Predicts Impaired Exercise Capacity in Patients With Systolic Chronic Heart Failure
Jankowska, E. A., Rozentryt, P., Witkowska, A., Nowak, J., Hartmann, O., Ponikowska, B., Borodulin-Nadzieja, L., von Haehling, S., Doehner, W., Banasiak, W., et al. (2011) · Journal of Cardiac Failure · doi:10.1016/j.cardfail.2011.08.003 · Cited by 281 · see citing works
NRF2, a Superstar of Ferroptosis
Yan, R., Lin, B., Jin, W., Tang, L., Hu, S., & Cai, R. (2023) · Antioxidants · doi:10.3390/antiox12091739 · Cited by 261 · see citing works
Bajracharya, R., Song, J. G., Patil, B. R., Lee, S. H., Noh, H.-M., Kim, D.-H., Kim, G.-L., Seo, S.-H., Park, J., Jeong, S. H., et al. (2022) · Drug Delivery · doi:10.1080/10717544.2022.2089296 · Cited by 249 · see citing works
Fuqua, B. K., Vulpe, C. D., & Anderson, G. J. (2012) · Journal of Trace Elements in Medicine and Biology · doi:10.1016/j.jtemb.2012.03.015 · Cited by 241 · see citing works
Self-citationCarter, A. M. (2012) · Physiological Reviews · doi:10.1152/physrev.00040.2011 · Cited by 237 · see citing works
Ferritin is secreted via 2 distinct nonclassical vesicular pathways
Truman-Rosentsvit, M., Berenbaum, D., Spektor, L., Cohen, L. A., Belizowsky-Moshe, S., Lifshitz, L., Ma, J., Li, W., Kesselman, E., Abutbul-Ionita, I., et al. (2018) · Blood · doi:10.1182/blood-2017-02-768580 · Cited by 223 · see citing works
The regulation of iron transport
Frazer, D. M., & Anderson, G. J. (2013) · BioFactors · doi:10.1002/biof.1148 · Cited by 215 · see citing works
Self-citationAnemia and iron deficiency in heart failure: mechanisms and therapeutic approaches
van Veldhuisen, D. J., Anker, S. D., Ponikowski, P. P., & Macdougall, I. C. (2011) · Nature Reviews Cardiology · doi:10.1038/nrcardio.2011.77 · Cited by 207 · see citing works
The role of lysosomes in iron metabolism and recycling
Kurz, T., Eaton, J. W., & Brunk, U. T. (2011) · The International Journal of Biochemistry & Cell Biology · doi:10.1016/j.biocel.2011.08.016 · Cited by 207 · see citing works
mTOR regulates cellular iron homeostasis through tristetraprolin
Bayeva, M., Khechaduri, A., Puig, S., Chang, H.-C., Patial, S., Blackshear, P. J., & Ardehali, H. (2012) · Cell Metabolism · doi:10.1016/j.cmet.2012.10.001 · Cited by 197 · see citing works
Letelier, M. E., Sánchez-Jofré, S., Peredo-Silva, L., Cortés-Troncoso, J., & Aracena-Parks, P. (2010) · Chemico-Biological Interactions · doi:10.1016/j.cbi.2010.06.013 · Cited by 169 · see citing works
Skjørringe, T., Burkhart, A., Johnsen, K. B., & Moos, T. (2015) · Frontiers in Molecular Neuroscience · doi:10.3389/fnmol.2015.00019 · Cited by 167 · see citing works
Intersection of Iron and Copper Metabolism in the Mammalian Intestine and Liver
Doğuer, Ç., Ha, J., & Collins, J. F. (2018) · Comprehensive physiology · doi:10.1002/cphy.c170045 · Cited by 214 · see citing works
Insulin resistance impairs nigrostriatal dopamine function
Morris, J. K., Bomhoff, G. L., Gorres, B. K., Davis, V. A., Kim, J., Lee, P., Brooks, W. M., Gerhardt, G. A., Geiger, P. C., & Stanford, J. A. (2011) · Experimental Neurology · doi:10.1016/j.expneurol.2011.06.005 · Cited by 150 · see citing works
Iron homeostasis and tumorigenesis: molecular mechanisms and therapeutic opportunities
Zhang, C., & Zhang, F. (2014) · Protein & Cell · doi:10.1007/s13238-014-0119-z · Cited by 146 · see citing works
Iron and non-alcoholic fatty liver disease
Britton, L., Subramaniam, V., & Crawford, D. (2016) · World Journal of Gastroenterology · doi:10.3748/wjg.v22.i36.8112 · Cited by 136 · see citing works
Mammalian iron transporters: Families SLC11 and SLC40
Montalbetti, N., Simonin, A., Kovács, G., & Hediger, M. A. (2013) · Molecular Aspects of Medicine · doi:10.1016/j.mam.2013.01.002 · Cited by 147 · see citing works
Iron Deposition and Ferritin Heavy Chain (Fth) Localization in Rodent Teeth
Wen, X., & Paine, M. L. (2013) · BMC Research Notes · doi:10.1186/1756-0500-6-1 · Cited by 139 · see citing works
Thiosemicarbazones as Potent Anticancer Agents and their Modes of Action
Shakya, B., & Yadav, P. N. (2019) · Mini-Reviews in Medicinal Chemistry · doi:10.2174/1389557519666191029130310 · Cited by 136 · see citing works
McKie, A. T., & Simpson, R. J. (2011) · Humana Press eBooks · doi:10.1007/978-1-60327-485-2_6 · Cited by 132 · see citing works
Appropriate nutrient supplementation in celiac disease
Caruso, R., Pallone, F., Stasi, E., Romeo, S., & Monteleone, G. (2013) · Annals of Medicine · doi:10.3109/07853890.2013.849383 · Cited by 130 · see citing works
Iron at the Centre of Candida albicans Interactions
Fourie, R., Kuloyo, O. O., Mochochoko, B. M., Albertyn, J., & Pohl, C. H. (2018) · Frontiers in Cellular and Infection Microbiology · doi:10.3389/fcimb.2018.00185 · Cited by 118 · see citing works
Brain iron homeostasis, the choroid plexus, and localization of iron transport proteins
Rouault, T. A., Zhang, D., & Jeong, S. Y. (2009) · Metabolic Brain Disease · doi:10.1007/s11011-009-9169-y · Cited by 123 · see citing works
Chen, H., Attieh, Z. K., Syed, B. A., Kuo, Y.-M., Stevens, V., Fuqua, B. K., Andersen, H. S., Naylor, C. E., Evans, R. W., Gambling, L., et al. (2010) · The Journal of Nutrition · doi:10.3945/jn.109.117531 · Cited by 122 · see citing works
Self-citationThe Iron Metallome in Eukaryotic Organisms
Dlouhy, A. C., & Outten, C. E. (2012) · Metal ions in life sciences · doi:10.1007/978-94-007-5561-1_8 · Cited by 121 · see citing works
Multivalent Display and Receptor‐Mediated Endocytosis of Transferrin on Virus‐Like Particles
Banerjee, D., Liu, A. P., Voss, N. R., Schmid, S. L., & Finn, M. G. (2010) · ChemBioChem · doi:10.1002/cbic.201000125 · Cited by 118 · see citing works
Ferroptosis in mitochondrial cardiomyopathy
Ahola, S., & Langer, T. (2023) · Trends in Cell Biology · doi:10.1016/j.tcb.2023.06.002 · Cited by 115 · see citing works
Insect transferrins: Multifunctional proteins
Geiser, D. L., & Winzerling, J. J. (2011) · Biochimica et Biophysica Acta (BBA) - General Subjects · doi:10.1016/j.bbagen.2011.07.011 · Cited by 116 · see citing works
Mammalian Siderophores, Siderophore-binding Lipocalins, and the Labile Iron Pool
Correnti, C., & Strong, R. K. (2012) · Journal of Biological Chemistry · doi:10.1074/jbc.r111.311829 · Cited by 115 · see citing works
Research on ferroptosis as a therapeutic target for the treatment of neurodegenerative diseases
Wang, Y., Lv, M.-N., & Zhao, W. (2023) · Ageing Research Reviews · doi:10.1016/j.arr.2023.102035 · Cited by 117 · see citing works
Ferroptosis in colorectal cancer: a future target?
Yan, H. Y., Talty, R., Aladelokun, O. B., Bosenberg, M., & Johnson, C. H. (2023) · British Journal of Cancer · doi:10.1038/s41416-023-02149-6 · Cited by 113 · see citing works
Ji, C., & Kosman, D. J. (2015) · Journal of Neurochemistry · doi:10.1111/jnc.13040 · Cited by 109 · see citing works
Niwa, M., Hirayama, T., Okuda, K., & Nagasawa, H. (2014) · Organic & Biomolecular Chemistry · doi:10.1039/c4ob00935e · Cited by 108 · see citing works
Brain iron accumulation in aging and neurodegenerative disorders
Hagemeier, J., Geurts, J. J. G., & Zivadinov, R. (2012) · Expert Review of Neurotherapeutics · doi:10.1586/ern.12.128 · Cited by 110 · see citing works
Cellular and mitochondrial iron homeostasis in vertebrates
Chen, C., & Paw, B. H. (2012) · Biochimica et Biophysica Acta (BBA) - Molecular Cell Research · doi:10.1016/j.bbamcr.2012.01.003 · Cited by 106 · see citing works
An overview of ferroptosis in non-alcoholic fatty liver disease
Wang, S., Liu, Z., Geng, J., Li, L., & Feng, X. (2022) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2022.113374 · Cited by 106 · see citing works
Metal-mediated DNA damage and cell death: mechanisms, detection methods, and cellular consequences
Angelé-Martínez, C., Goodman, C., & Brumaghim, J. L. (2014) · Metallomics · doi:10.1039/c4mt00057a · Cited by 105 · see citing works
Nutritional and Metabolic Control of Ferroptosis
Mishima, E., & Conrad, M. (2022) · Annual Review of Nutrition · doi:10.1146/annurev-nutr-062320-114541 · Cited by 103 · see citing works
Regulation of iron pathways in response to hypoxia
Chepelev, N. L., & Willmore, W. G. (2010) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2010.12.023 · Cited by 102 · see citing works
Lane, D. J. R., Robinson, S. R., Czerwinska, H., Bishop, G. M., & Lawen, A. (2010) · Biochemical Journal · doi:10.1042/bj20101317 · Cited by 101 · see citing works
McCarthy, R. C., & Kosman, D. J. (2015) · Frontiers in Molecular Neuroscience · doi:10.3389/fnmol.2015.00031 · Cited by 97 · see citing works
The iron-regulatory hormone hepcidin: A possible therapeutic target?
Rochette, L., Gudjoncik, A., Guénancia, C., Zeller, M., Cottin, Y., & Vergely, C. (2014) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2014.09.004 · Cited by 99 · see citing works
Bone Morphogenetic Proteins as Regulators of Iron Metabolism
Parrow, N. L., & Fleming, R. E. (2014) · Annual Review of Nutrition · doi:10.1146/annurev-nutr-071813-105646 · Cited by 99 · see citing works
Wang, C., & Knutson, M. D. (2013) · Hepatology · doi:10.1002/hep.26401 · Cited by 98 · see citing works
Iron deficiency and iron deficiency anemia in women
Coad, J. E., & Pedley, K. C. (2014) · Scandinavian Journal of Clinical and Laboratory Investigation · doi:10.3109/00365513.2014.936694 · Cited by 97 · see citing works
Compartmentalization of iron between mitochondria and the cytosol and its regulation
Mühlenhoff, U., Hoffmann, B., Richter, N., Rietzschel, N., Spantgar, F., Stehling, O., Uzarska, M. A., & Lill, R. (2015) · European Journal of Cell Biology · doi:10.1016/j.ejcb.2015.05.003 · Cited by 95 · see citing works
Hirayama, T., Inden, M., Tsuboi, H., Niwa, M., Uchida, Y., Naka, Y., Hozumi, I., & Nagasawa, H. (2018) · Chemical Science · doi:10.1039/c8sc04386h · Cited by 95 · see citing works
Burkhart, A., Skjørringe, T., Johnsen, K. B., Siupka, P., Thomsen, L. B., Nielsen, M. S., Thomsen, L. L., & Moos, T. (2015) · Molecular Neurobiology · doi:10.1007/s12035-015-9582-7 · Cited by 96 · see citing works
Manganese Homeostasis and Transport
Roth, J. A., Ponzoni, S., & Aschner, M. (2012) · Metal ions in life sciences · doi:10.1007/978-94-007-5561-1_6 · Cited by 94 · see citing works
Down the Iron Path: Mitochondrial Iron Homeostasis and Beyond
Dietz, J. V., Fox, J. L., & Khalimonchuk, O. (2021) · Cells · doi:10.3390/cells10092198 · Cited by 89 · see citing works
McCarthy, R. C., & Kosman, D. J. (2013) · Journal of Biological Chemistry · doi:10.1074/jbc.m113.455428 · Cited by 89 · see citing works
Blumenstein, I., Shanbhag, S., Langguth, P., Kalra, P. A., Zoller, H., & Lim, W. (2021) · Expert Opinion on Drug Safety · doi:10.1080/14740338.2021.1912010 · Cited by 85 · see citing works
Iron, oxidative stress, and redox signaling in the cardiovascular system
Gudjoncik, A., Guénancia, C., Zeller, M., Cottin, Y., Vergely, C., & Rochette, L. (2014) · Molecular Nutrition & Food Research · doi:10.1002/mnfr.201400036 · Cited by 84 · see citing works
Ferroptosis: mechanisms and therapeutic targets
Zhou, Q., Meng, Y., Le, J., Sun, Y., Dian, Y., Yao, L., Xiong, Y., Zeng, F., Chen, X., & Deng, G. (2024) · MedComm · doi:10.1002/mco2.70010 · Cited by 86 · see citing works
Li, J., Zheng, S., Fan, Y., & Tan, K. (2023) · Cell Death and Disease · doi:10.1038/s41419-023-06144-w · Cited by 82 · see citing works
Du, F., Qian, C., Qian, Z., Wu, X., Xie, H., Yung, W., & Ke, Y. (2011) · Glia · doi:10.1002/glia.21166 · Cited by 81 · see citing works
The biology of mammalian multi-copper ferroxidases
Helman, S. L., Zhou, J., Fuqua, B. K., Lu, Y., Collins, J. F., Chen, H., Vulpe, C. D., Anderson, G. J., & Frazer, D. M. (2022) · BioMetals · doi:10.1007/s10534-022-00370-z · Cited by 77 · see citing works
Self-citationIron metabolism in aerobes: Managing ferric iron hydrolysis and ferrous iron autoxidation
Kosman, D. J. (2012) · Coordination Chemistry Reviews · doi:10.1016/j.ccr.2012.06.030 · Cited by 77 · see citing works
Leichtmann‐Bardoogo, Y., Cohen, L. A., Weiss, A., Marohn, B., Schubert, S., Meinhardt, A., & Meyron‐Holtz, E. G. (2012) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00007.2012 · Cited by 77 · see citing works
A naphthalene derived Schiff base as a selective fluorescent probe for Fe2+
Santhoshkumar, S., Velmurugan, K., Prabhu, J., Radhakrishnan, G., & Nandhakumar, R. (2015) · Inorganica Chimica Acta · doi:10.1016/j.ica.2015.09.030 · Cited by 75 · see citing works
Iron Deficiency in Heart Failure: A Scientific Statement from the Heart Failure Society of America
Beavers, C. J., Ambrosy, A. P., Butler, J., Davidson, B. T., Gale, S. E., Piña, I. L., Mastoris, I., Reza, N., Mentz, R. J., & Lewis, G. D. (2023) · Journal of Cardiac Failure · doi:10.1016/j.cardfail.2023.03.025 · Cited by 74 · see citing works
Key players in the regulation of iron homeostasis at the host-pathogen interface
Ullah, I., & Lang, M. (2023) · Frontiers in Immunology · doi:10.3389/fimmu.2023.1279826 · Cited by 76 · see citing works
The influence of microbiota on ferroptosis in intestinal diseases
Yao, T. S., & Li, L. (2023) · Gut Microbes · doi:10.1080/19490976.2023.2263210 · Cited by 72 · see citing works
Kolarš, B., Mijatović Jovin, V., Živanović, N., Minaković, I., Gvozdenović, N., Dickov Kokeza, I., & Lesjak, M. (2025) · Pharmaceuticals · doi:10.3390/ph18081104 · Cited by 71 · see citing works
Xuan, W., Pan, R., Wei, Y., Cao, Y., Li, H., Liang, F., Liu, K., & Wang, W. (2015) · Bioconjugate Chemistry · doi:10.1021/acs.bioconjchem.5b00259 · Cited by 71 · see citing works
Xiao, G., Liu, Z., Zhao, M., Wang, H.-L., & Zhou, B. (2019) · Cell Reports · doi:10.1016/j.celrep.2018.12.053 · Cited by 72 · see citing works
Quercetin attenuates chronic ethanol hepatotoxicity: Implication of “free” iron uptake and release
Tang, Y., Li, Y., Yu, H., Gao, C., Liu, L., Xing, M., Liu, L., & Yao, P. (2014) · Food and Chemical Toxicology · doi:10.1016/j.fct.2014.02.022 · Cited by 70 · see citing works
Genome-wide RNAi ionomics screen reveals new genes and regulation of human trace element metabolism
Malinouski, M., Hasan, N. M., Zhang, Y., Seravalli, J., Lin, J., Avanesov, A. S., Lutsenko, S., & Gladyshev, V. N. (2014) · Nature Communications · doi:10.1038/ncomms4301 · Cited by 69 · see citing works
Moliner, P., Jankowska, E. A., van Veldhuisen, D. J., Farre, N., Rozentryt, P., Enjuanes, C., Polonski, L., Meroño, O., Voors, A. A., Ponikowski, P., et al. (2017) · International Journal of Cardiology · doi:10.1016/j.ijcard.2017.04.110 · Cited by 67 · see citing works
Ferroptosis and Its Potential Role in Metabolic Diseases: A Curse or Revitalization?
Duan, J.-Y., Lin, X., Xu, F., Shan, S., Guo, B., Li, F., Wang, Y., Zheng, M.-H., Xu, Q.-S., Lei, L.-M., et al. (2021) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2021.701788 · Cited by 68 · see citing works
Transferrin receptor-mediated liposomal drug delivery: recent trends in targeted therapy of cancer
Mojarad-Jabali, S., Mahdinloo, S., Farshbaf, M., Sarfraz, M., Fatahi, Y., Atyabi, F., & Valizadeh, H. (2022) · Expert Opinion on Drug Delivery · doi:10.1080/17425247.2022.2083106 · Cited by 67 · see citing works
Adverse Outcome Prediction of Iron Deficiency in Patients with Acute Coronary Syndrome
Zeller, T., Waldeyer, C., Ojeda, F., Schnabel, R. B., Schäfer, S., Altay, A., Lackner, K. J., Anker, S. D., Westermann, D., Blankenberg, S., et al. (2018) · Biomolecules · doi:10.3390/biom8030060 · Cited by 65 · see citing works
Revisiting hemochromatosis: genetic vs. phenotypic manifestations
Anderson, G. J., & Bardou‐Jacquet, E. (2021) · Annals of Translational Medicine · doi:10.21037/atm-20-5512 · Cited by 63 · see citing works
Self-citationBiophysical Investigation of the Ironome of Human Jurkat Cells and Mitochondria
Jhurry, N. D., Chakrabarti, M., McCormick, S. P., Holmes‐Hampton, G. P., & Lindahl, P. A. (2012) · Biochemistry · doi:10.1021/bi300382d · Cited by 62 · see citing works
Niwa, M., Hirayama, T., Oomoto, I., Wang, D. O., & Nagasawa, H. (2018) · ACS Chemical Biology · doi:10.1021/acschembio.7b00939 · Cited by 61 · see citing works
Dong, X., Gao, W., Shao, T.-M., Hong-lin, X., Jiang-tao, B., Jing-yi, Z., & Xi-qing, C. (2014) · Journal of Trace Elements in Medicine and Biology · doi:10.1016/j.jtemb.2014.11.009 · Cited by 59 · see citing works
Moliner, P., Enjuanes, C., Tajes, M., Cainzos‐Achirica, M., Lupón, J., Garay, A., Jiménez‐Marrero, S., Yun, S., Farré, N., Cladellas, M., et al. (2019) · Journal of the American Heart Association · doi:10.1161/jaha.118.010887 · Cited by 61 · see citing works
Ferroptosis in cancer: revealing the multifaceted functions of mitochondria
Ding, X., Cui, L., Mi, Y., Hu, J., Cai, Z., Tang, Q., Yang, L., Yang, Z., Wang, Q., Li, H., et al. (2025) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-025-05812-8 · Cited by 57 · see citing works
Reaction-based turn-on fluorescent probes with magnetic responses for Fe 2+ detection in live cells
Maiti, S. K., Aydın, Z., Zhang, Y., & Guo, M. (2015) · Dalton Transactions · doi:10.1039/c4dt03792h · Cited by 57 · see citing works
Gorman, M. J. (2022) · Annual Review of Entomology · doi:10.1146/annurev-ento-040622-092836 · Cited by 53 · see citing works
Yang, L., Wang, D., Wang, X., Lu, Y., & Zhu, L. (2018) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2018.10.185 · Cited by 54 · see citing works
Rietzschel, N., Pierik, A. J., Bill, E., Lill, R., & Mühlenhoff, U. (2014) · Molecular and Cellular Biology · doi:10.1128/mcb.01033-14 · Cited by 55 · see citing works
Ziegler, L., Terzulli, A., Gaur, R., McCarthy, R., & Kosman, D. J. (2011) · Molecular Microbiology · doi:10.1111/j.1365-2958.2011.07704.x · Cited by 53 · see citing works
- Authors
- Anderson, G. J., & Vulpe, C. D.
- Affiliations
- QIMR Berghofer Medical Research Institute (AU)
- Corresponding author
- Anderson, Gregory Jon
- Venue
- Cellular and Molecular Life Sciences
- Published
- 2009-05-31
- Volume
- 66
- Issue
- 20
- Pages
- 3241-3261
- ISSN
- 1420-682X (ISSN-L)
- 1420-9071
- PMC
- PMC11115736
- OpenAlex
- W1981407334
- Cited by
- 317
- References
- 217
- Citations by year
- 2026: 6 · 2025: 25 · 2024: 21 · 2023: 21 · 2022: 24 · 2021: 17 · 2020: 14 · 2019: 18 · 2018: 16 · 2017: 14 · 2016: 9 · 2015: 16 · 2014: 20 · 2013: 23 · 2012: 33
- FWCI
- 3.34
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Cellular and Molecular Life Sciences (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Hematology › Iron Metabolism and Disorders
- Health Sciences › Medicine › Pulmonary and Respiratory Medicine › Ferroptosis and cancer prognosis
- Health Sciences › Nursing › Nutrition and Dietetics › Trace Elements in Health
- Keywords
- iron transport, transferrin, transferrin receptor 1, DMT1, ferroportin, hepcidin, non-transferrin-bound iron, iron export, iron homeostasis, membrane transporters
- MeSH terms
- Animals, Biological Transport, Carrier Proteins, Gene Expression Regulation, Homeostasis, Iron, Macrophages, Mammals, Mitochondria, Models, Biological, Oxidoreductases, Hepatocytes, Antimicrobial Cationic Peptides, Erythroid Cells, Hepcidins
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review