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Hepcidin: A novel peptide hormone regulating iron metabolism

Singh, Bhawna, Arora, Sarika, Agrawal, Poonam, Gupta, S.K.·2011·Clinica Chimica Acta
DOI 10.1016/j.cca.2011.02.014
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Abstract

Background Hepcidin is a low-molecular weight hepatic peptide regulating iron homeostasis. Hepcidin inhibits the cellular efflux of iron by binding to, and inducing the internalization and degradation of, ferroportin, the exclusive iron exporter in iron-transporting cells. It has been recently recognized as a main hormone behind anemia of chronic disease. Method A comprehensive literature search was conducted from the websites of Pubmed Central, the US National Library of Medicine's digital archive of life sciences literature (http://www.pubmedcentral.nih.gov/) and the National Library of Medicine (http://www.ncbl.nlm.nih.gov). The data was also assessed from journals and books that published relevant articles in this field. Result Hepcidin regulates iron uptake constantly on a daily basis, to maintain sufficient iron stores for erythropoiesis. Hepcidin, by its iron regulatory action on iron metabolism may be expected to have an important role in immune regulation, inflammatory diseases and malignancies. Hepcidin is the underlying cause of anemia in these clinical settings. Conclusion Hepcidin analysis may prove to be a novel tool for differential diagnosis and monitoring of disorders of iron metabolism, and establishment of therapeutic measures in various disease conditions like hereditary hemochromatosis, anemia associated with chronic kidney disease, rheumatoid arthritis and cancers.

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Metadata

Authors
Singh, B., Arora, S., Agrawal, P., & Gupta, S. K.
Venue
Clinica Chimica Acta
Publisher
Elsevier BV
Published
2011-05
Volume
412
Issue
11-12
Pages
823-830
ISSN
0009-8981
DOI
10.1016/j.cca.2011.02.014
Cited by
61
References
29
Language
en
Licence
www.elsevier.com/tdm/userlicense/1.0/ (tdm)

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CoChat. (2026). Citation check: Hepcidin: A novel peptide hormone regulating iron metabolism. https://app.cochat.ai/papers/10.1016/j.cca.2011.02.014
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Singh, B., Arora, S., Agrawal, P., & Gupta, S. K. (2011). Hepcidin: A novel peptide hormone regulating iron metabolism. Clinica Chimica Acta. https://doi.org/10.1016/j.cca.2011.02.014