Dietary coconut sprout beneficially modulates cardiac damage induced by isoproterenol in rats
Open accessAbstract
This work evaluates the cardioprotective potential of dietary coconut sprout (Cocos nucifera Linn.) on isoproterenol induced myocardial infarction in rats. Male Sprague Dawley rats were pretreated with coconut sprout (50, 100 and 200 mg/100 g body weight) orally for 45 days and then cardiotoxicity was induced with isoproterenol (20 mg/100 g body weight) twice at an interval of 24 hours. Activity of cardiac marker enzymes were significantly increased in the serum and decreased in the heart of isoproterenol treated rats indicating cardiac damage. These effects were significantly reduced in coconut sprout pretreated rats. Moreover, pretreatment with coconut sprout increased anti-oxidant status and decreased oxidative stress in the heart. Histopathological examination revealed almost normal tissue morphology in the heart of these rats. These observed beneficial effects indicate that coconut sprout possesses significant cardioprotective and antioxidant properties.
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Rats fed with 100 mg/100 g body weight showed better results than other treatment groups.
“Rats fed with 100 mg/100 g body weight showed better results than other treatment groups.”
From Cocos nucifera (L.) (Arecaceae): A phytochemical and pharmacological review (2015) · cites this paper as [68]
Pretreatment with coconut sprout decreased oxidative stress in the heart and increased antioxidant status.
“In addition, pretreatment with coconut sprout decreased oxidative stress in the heart and increased antioxidant status.”
From Cocos nucifera (L.) (Arecaceae): A phytochemical and pharmacological review (2015) · cites this paper as [68]
Sprouts contain bioactive components, such as vitamins, alkaloids, and polyphenols.
“Biochemical analyses showed that sprouts contains bioactive components, such as vitamins, alkaloids, and polyphenols.”
From Cocos nucifera (L.) (Arecaceae): A phytochemical and pharmacological review (2015) · cites this paper as [68]
Dietary coconut sprout (West Coast Tall variety) decreased levels of cardiac markers (CK-MB and troponin-T) in serum of the group pretreated with coconut sprout (50, 100, or 200 mg/100 g body weight) orally for 45 days.
“There was a decrease in the levels of cardiac markers (CK-MB and troponin-T) in serum of the group pretreated with coconut sprout (50, 100, or 200 mg/100 g body weight) orally for 45 days.”
From Cocos nucifera (L.) (Arecaceae): A phytochemical and pharmacological review (2015) · cites this paper as [68]
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- Authors
- Chikku, A. M., & Rajamohan, T.
- Affiliations
- University of Kerala (IN)
- Venue
- Bangladesh Journal of Pharmacology
- Publisher
- Bangladesh Journals Online (JOL)
- Published
- 2012-10-29
- Volume
- 7
- Issue
- 4
- ISSN
- 1991-007X (ISSN-L)
- 1991-0088
- OpenAlex
- W2073301451
- Cited by
- 20
- References
- 34
- Citations by year
- 2025: 2 · 2024: 1 · 2023: 1 · 2022: 3 · 2021: 2 · 2020: 2 · 2019: 1 · 2018: 3 · 2017: 3 · 2016: 1 · 2015: 1
- FWCI
- 0.17
- Type
- journal article
- Language
- en
- Open access
- diamond
- doi.org
- Licence
- cc-by
- Locations
- Bangladesh Journal of Pharmacology (publishedVersion, cc-by)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion)
- Funders
- Council of Scientific and Industrial Research, India
- Topics
- Physical Sciences › Chemistry › Inorganic Chemistry › Coconut Research and Applications
- Health Sciences › Medicine › Pathology and Forensic Medicine › Cardiac Ischemia and Reperfusion
- Physical Sciences › Materials Science › Biomaterials › Phytochemistry and Bioactive Compounds
- Keywords
- Cocos nucifera, isoproterenol, myocardial infarction, cardioprotection, oxidative stress, antioxidant status, cardiac biomarkers, cardiac histopathology
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