Association Between Clonal Hematopoiesis of Indeterminate Potential and Brain β-Amyloid Deposition in Korean Patients With Cognitive Impairment
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and the C:G>T:A single-nucleotide variants were identified as the primary characteristics, which reflect aged hematopoiesis in the study population. Multivariate logistic regression revealed that the presence of CHIP was not associated with brain Aβ deposition. As both CHIP and brain Aβ deposition are associated with aging, further research is required to elucidate their possible interplay.
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Yun et al. reported no significant association between CHIP and brain β-amyloid deposition in a small underpowered cohort of 58 participants.
“Yun et al., examining a small cohort of Korean patients with cognitive impairment using amyloid positron emission tomography imaging, reported no significant association between CHIP and brain β-amyloid deposition; however, this analysis was critically underpowered with only 58 participants [12].”
From Clonal Hematopoiesis of Indeterminate Potential as an Emerging Interdisciplinary Risk Factor in Alzheimer’s Disease: Current Evidence and Future Directions (2026) · cites this paper as [12]
The Abstract reports 58 Korean patients with cognitive impairment who underwent amyloid PET, and the analysis found no significant association between CHIP and brain Aβ deposition. The limitations passage calls the study preliminary and says statistical power may have been insufficient, but it reports no power calculation; it does not establish that the analysis was critically underpowered. (LLM, conf=0.87)
Experimental — accuracy not yet measuredSmaller biomarker-focused cohorts and genotype-stratified sequencing projects report either neutral effects or an increased risk of AD pathology.
“smaller, biomarker-focused cohorts (n < 100) and specific genotype-stratified sequencing projects (n ≈ 30,000) indicate a different trajectory, reporting either neutral effects or an increased risk of AD pathology [12,13].”
From Clonal Hematopoiesis of Indeterminate Potential as an Emerging Interdisciplinary Risk Factor in Alzheimer’s Disease: Current Evidence and Future Directions (2026) · cites this paper as [12]
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Cites
Diagnostic and Statistical Manual of Mental Disorders
American Psychiatric Association (2022) · doi:10.1176/appi.books.9780890425787 · Cited by 23,476 · see citing works
Signatures of mutational processes in human cancer
Initiative, A. P. C. G., Alexandrov, L. B., ICGC Breast Cancer Consortium, ICGC MMML-Seq Consortium, PedBrain, I., Nik-Zainal, S., Wedge, D. C., Aparicio, S. A. J. R., Behjati, S., Biankin, A. V., et al. (2013) · Nature · doi:10.1038/nature12477 · Cited by 9,660 · see citing works
Age-related clonal hematopoiesis associated with adverse outcomes
Jaiswal, S., Fontanillas, P., Flannick, J., Manning, A., Grauman, P. V., Mar, B. G., Lindsley, R. C., Mermel, C. H., Burtt, N., Chavez, A., et al. (2014) · New England Journal of Medicine · doi:10.1056/nejmoa1408617 · Cited by 4,841 · see citing works
Jessen, F., Amariglio, R. E., van Boxtel, M., Breteler, M., Ceccaldi, M., Chételat, G., Dubois, B., Dufouil, C., Ellis, K. A., van der Flier, W. M., et al. (2014) · Alzheimer's & Dementia · doi:10.1016/j.jalz.2014.01.001 · Cited by 3,014 · see citing works
Clonal hematopoiesis of indeterminate potential and its distinction from myelodysplastic syndromes
Steensma, D. P., Bejar, R., Jaiswal, S., Lindsley, R. C., Sekeres, M. A., Hasserjian, R. P., & Ebert, B. L. (2015) · Blood · doi:10.1182/blood-2015-03-631747 · Cited by 1,971 · see citing works
Petersen, R. C. (2011) · New England Journal of Medicine · doi:10.1056/nejmcp0910237 · Cited by 1,289 · see citing works
Clonal hematopoiesis, with and without candidate driver mutations, is common in the elderly
Zink, F., Stacey, S. N., Norddahl, G. L., Frigge, M. L., Magnusson, O. T., Jonsdottir, I., Thorgeirsson, T. E., Sigurdsson, A., Gudjonsson, S. A., Gudmundsson, J., et al. (2017) · Blood · doi:10.1182/blood-2017-02-769869 · Cited by 777 · see citing works
Dorsheimer, L., Assmus, B., Rasper, T., Ortmann, C. A., Ecke, A., Abou-El-Ardat, K., Schmid, T., Brüne, B., Wagner, S., Serve, H., et al. (2019) · JAMA Cardiology · doi:10.1001/jamacardio.2018.3965 · Cited by 470 · see citing works
Clonal haematopoiesis: connecting ageing and inflammation in cardiovascular disease
Jaiswal, S., & Libby, P. (2020) · Nature Reviews Cardiology · doi:10.1038/s41569-019-0247-5 · Cited by 386 · see citing works
Buscarlet, M., Provost, S., Zada, Y. F., Barhdadi, A., Bourgoin, V., Lépine, G., Mollica, L., Szuber, N., Dubé, M.-P., & Busque, L. (2017) · Blood · doi:10.1182/blood-2017-04-777029 · Cited by 383 · see citing works
Mas‐Peiró, S., Hoffmann, J., Fichtlscherer, S., Dorsheimer, L., Rieger, M. A., Dimmeler, S., Vasa‐Nicotera, M., & Zeiher, A. M. (2019) · European Heart Journal · doi:10.1093/eurheartj/ehz591 · Cited by 239 · see citing works
Clonal hematopoiesis is associated with protection from Alzheimer’s disease
Bouzid, H., Belk, J. A., Jan, M., Qi, Y., Sarnowski, C., Wirth, S., Ma, L., Chrostek, M. R., Ahmad, H., Nachun, D., et al. (2023) · Nature Medicine · doi:10.1038/s41591-023-02397-2 · Cited by 169 · see citing works
Beta-amyloid imaging with florbetaben
Sabri, O., Seibyl, J., Rowe, C., & Barthel, H. (2015) · Clinical and translational imaging · doi:10.1007/s40336-015-0102-6 · Cited by 167 · see citing works
Clonal hematopoiesis is associated with risk of severe Covid-19
Bolton, K. L., Koh, Y., Foote, M. B., Im, H., Jee, J., Sun, C.-H., Safonov, A. M., Ptashkin, R. N., Moon, J. H., Lee, J. Y., et al. (2021) · Nature Communications · doi:10.1038/s41467-021-26138-6 · Cited by 141 · see citing works
Self-citationClonal hematopoiesis in patients with rheumatoid arthritis
Savola, P., Lundgren, S., Keränen, M. A. I., Almusa, H., Ellonen, P., Leirisalo‐Repo, M., Kelkka, T., & Mustjoki, S. M. (2018) · Blood Cancer Journal · doi:10.1038/s41408-018-0107-2 · Cited by 111 · see citing works
Association Between Aortic Valve Sclerosis and Clonal Hematopoiesis of Indeterminate Potential
Kim, M., Kim, J. J., Lee, S., Shim, Y., Lee, H., Bae, S., Son, N., Shin, S., & Jung, I. H. (2024) · Annals of Laboratory Medicine · doi:10.3343/alm.2023.0268 · Cited by 12 · see citing works
Moon, I., Kong, M. G., Ji, Y. S., Kim, S. H., Park, S. K., Suh, J., & Jang, M. (2022) · Annals of Laboratory Medicine · doi:10.3343/alm.2023.43.2.145 · Cited by 9 · see citing works
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Zhang, J.-L., Tong, S.-L., Zhuang, Q., Jin, S., Li, J., & Sun, J. (2025) · Military Medical Research · doi:10.1186/s40779-025-00654-8 · Cited by 5 · see citing works
Kopp, K., Silva, P., Damm, F., & Cosma, N. C. (2026) · Biomedicines · doi:10.3390/biomedicines14051012
Song, K., Park, M., & Kim, S. Y. (2025) · Research Square · doi:10.21203/rs.3.rs-6621562/v1
Dolgopolov, I. S., Гривцова, Л. Ю., Kovalenko, N. I., Shatalov, P. A., Bryukhovetsky, A. S., & Rykov, M. Y. (2025) · Russian Journal for Personalized Medicine · doi:10.18705/2782-3806-2025-5-4-314-329
Dolgopolov, I. S., Grivtsova, L., Kovalenko, N., Shatalov, P. A., Bryukhovetsky, A. S., & Rykov, M. Y. (2025) · Srpski arhiv za celokupno lekarstvo · doi:10.2298/sarh250627086d
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Suwanlikit, Y., Crofts, S., Moodie, J. E., Marioni, R. E., Robertson, N., Tan, S. H., Vivithanaporn, P., Bastin, M. E., Wardlaw, J. M., Kirschner, K., et al. (2026) · medRxiv · doi:10.64898/2026.09.10.26362681
- Authors
- Yun, J., Youn, Y. C., & Kim, H. R.
- Affiliations
- Korea University (KR)
- Chung-Ang University Healthcare System (KR)
- Chung-Ang University Hospital (KR)
- Corresponding author
- Kim, Hye Ryoun
- Venue
- Annals of Laboratory Medicine
- Publisher
- Annals of Laboratory Medicine
- Published
- 2024-05-28
- Volume
- 44
- Issue
- 6
- Pages
- 576-580
- ISSN
- 2234-3806 (ISSN-L)
- 2234-3814
- PMC
- PMC11375198
- OpenAlex
- W4399100120
- Cited by
- 6
- References
- 17
- Citations by year
- 2026: 2 · 2025: 4
- FWCI
- 1.76
- Type
- journal article
- Language
- en
- Open access
- diamond
- doi.org
- Licence
- Locations
- Annals of Laboratory Medicine (publishedVersion, cc-by-nc)
- PubMed Central (publishedVersion, cc-by-nc)
- PubMed (publishedVersion)
- Funders
- National Research Foundation of Korea (NRF-2017R1A2B4011631, 2021R1A2C2013359)
- Ministry of Science and ICT, South Korea
- Topics
- Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
- Health Sciences › Medicine › Hematology › Acute Myeloid Leukemia Research
- Health Sciences › Medicine › Physiology › Alzheimer's disease research and treatments
- Keywords
- clonal hematopoiesis of indeterminate potential, cognitive impairment, single nucleotide variants, aging, hematopoiesis, Alzheimer's disease, Korean patients
- MeSH terms
- Clonal Hematopoiesis, DNA Methyltransferase 3A, East Asian People, Aged, Aged, 80 and over, Alzheimer Disease, Brain, DNA (Cytosine-5-)-Methyltransferases, Female, Humans, Male, Middle Aged, Mutation, Logistic Models, Amyloid beta-Peptides, Polymorphism, Single Nucleotide, Asian People, Positron-Emission Tomography, Republic of Korea, High-Throughput Nucleotide Sequencing, Cognitive Dysfunction
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