Altered brain activation in ventral frontal-striatal regions following a 16-week pharmacotherapy in unmedicated obsessive-compulsive disorder
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Recent studies have reported that cognitive inflexibility associated with impairments in a frontal-striatal circuit and parietal region is a core cognitive deficit of obsessive-compulsive disorder (OCD). However, few studies have examined progressive changes in these regions following clinical improvement in obsessive-compulsive symptoms. To determine if treatment changes the aberrant activation pattern associated with task switching in OCD, we examined the activation patterns in brain areas after treatment. The study was conducted on 10 unmedicated OCD patients and 20 matched controls using event-related functional magnetic resonance imaging. Treatment improved the clinical symptoms measured by the Yale-Brown Obsessive Compulsive Scale and behavioral flexibility indicated by the switching cost. At baseline, OCD showed significantly less activation in the dorsal and ventral frontal-striatal circuit and parietal regions under the task-switch minus task-repeat condition compared with controls. After treatment, the neural responses in the ventral frontal-striatal circuit in OCD were partially normalized, whereas the activation deficit in dorsal frontoparietal regions that mediate shifting attention or behavioral flexibility persisted. It is suggested that altered brain activation in ventral frontal-striatal regions in OCD patients is associated with their cognitive flexibility and changes in these regions may underlie the pathophysiology of OCD.
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The dACC cluster was reported in 4 of the 25 cognitive inhibition experiments (16%) and came from four different articles.
“This location was reported in 4 of the 25 experiments (corresponding to 16 % of the experiments) and came from four different articles (Gu et al., 2008, Han et al., 2011, Nakao et al., 2005, Yücel et al., 2007).”
From Inhibitory control in obsessive compulsive disorder: a systematic review and activation likelihood estimation meta-analysis of functional magnetic resonance imaging studies (2022) · cites this paper as Han et al., 2011
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- Authors
- Han, J. Y., Kang, D.-H., Gu, B.-M., Jung, W. H., Choi, J.-S., Choi, C.-H., Jang, J. H., & Kwon, J. S.
- Affiliations
- Seoul National University (KR)
- National Medical Center (KR)
- Corresponding author
- Kwon, Jun Soo
- ORCID
- Venue
- Journal of Korean Medical Science
- Publisher
- XMLink
- Published
- 2011
- Volume
- 26
- Issue
- 5
- Pages
- 665
- ISSN
- 1011-8934 (ISSN-L)
- 1598-6357
- PMC
- PMC3082120
- OpenAlex
- W2070671537
- Cited by
- 32
- References
- 32
- Citations by year
- 2025: 2 · 2024: 1 · 2023: 1 · 2022: 2 · 2021: 1 · 2020: 3 · 2019: 1 · 2018: 2 · 2017: 1 · 2016: 5 · 2015: 3 · 2014: 2 · 2013: 6 · 2012: 1
- FWCI
- 3.45
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- Locations
- Journal of Korean Medical Science (publishedVersion, cc-by-nc)
- PubMed Central (publishedVersion, cc-by-nc)
- PubMed (publishedVersion)
- Topics
- Social Sciences › Psychology › Clinical Psychology › Obsessive-Compulsive Spectrum Disorders
- Life Sciences › Neuroscience › Cognitive Neuroscience › Neural and Behavioral Psychology Studies
- Social Sciences › Psychology › Experimental and Cognitive Psychology › Anxiety, Depression, Psychometrics, Treatment, Cognitive Processes
- Keywords
- obsessive-compulsive disorder, unmedicated patients, pharmacotherapy, task switching, cognitive flexibility, behavioral flexibility, switching costs, parietal activation, frontoparietal network, treatment response
- MeSH terms
- Adult, Basal Ganglia, Behavioral Symptoms, Female, Frontal Lobe, Humans, Magnetic Resonance Imaging, Male, Obsessive-Compulsive Disorder, Parietal Lobe
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