Altered activation in fronto-striatal circuits during sequential processing of conflict in unmedicated adults with obsessive-compulsive disorder
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Background The aim of this study was to examine the functioning of fronto-striatal brain circuits that support self-regulatory capacities including conflict resolution and sequential processing in unmedicated adults with obsessive-compulsive disorder (OCD).Methods We compared functional magnetic resonance imaging blood oxygen level-dependent response in 22 adults with OCD with 22 healthy, age-matched control subjects during performance of a Simon Spatial Incompatibility task. We used general linear modeling to compare groups in their patterns of brain activation during correct responses to conflict-laden stimuli and explore the effects of trial sequence on group differences.Results Behavioral performance on the Simon task did not differ between groups. In response to conflict-laden stimuli, OCD participants activated fronto-striatal regions significantly more than control subjects, specifically a right hemisphere cluster encompassing the putamen, insula, and inferior frontal gyrus. Their activation of this cluster was driven not by conflict on a current trial but by their response to the alternation of stimulus congruence (incongruent or congruent) across trial sequences (i.e., current and preceding trials) and was most accentuated in participants with more severe symptoms in the doubt/checking dimension. Functional connectivity from the putamen to other fronto-striatal regions was also greater in the OCD compared with control participants.Conclusions When engaging the self-regulatory control necessary to resolve conflict and process alternating stimuli, OCD participants displayed excessive activation in a fronto-striatal circuit that differs from the orbitofrontal cortex-anterior cingulate cortex-caudate circuit typically implicated in OCD. Dysfunction in this circuit was associated with processing changes in the stimulus context. We speculate that this dysfunction might be related to the cognitive inflexibility typical of persons with OCD.
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Increased activation in frontal-striatal regions, including the IFG and putamen, was seen in OCD patients during performance of a Simon task.
“Increased activation in frontal–striatal regions, including the IFG and putamen, was seen in OCD patients during performance of a Simon task (Marsh et al., 2013).”
From Response Inhibition and Interference Control in Obsessive–Compulsive Spectrum Disorders (2014) · cites this paper as Marsh et al., 2013
Increased functional connectivity between the putamen and the inferior parietal cortex, caudate, thalamus, and frontal areas was observed in OCD patients during performance of a Simon task.
“Increased functional connectivity between the putamen and the inferior parietal cortex, caudate, thalamus, and frontal areas was observed in patients during performance of a Simon task (Marsh et al., 2013).”
From Response Inhibition and Interference Control in Obsessive–Compulsive Spectrum Disorders (2014) · cites this paper as Marsh et al., 2013
The authors previously found altered conflict-related activity in frontal-striatal and insular cortices in adults with OCD during the Simon task.
“we previously identified altered conflictrelated activity (incongruent > congruent) in frontal-striatal and insular cortices in adults with OCD performing this task (21)”
From Task-based fMRI predicts response and remission to exposure therapy in obsessive-compulsive disorder (2019) · cites this paper as [21]
The authors previously found increased conflict-related activity in right insula, putamen, and inferior frontal gyrus in a similar OCD sample using the Simon task.
“Using the Simon task, we previously detected increased conflict-related activity in the right insula, putamen, and inferior frontal gyrus in a demographically and clinically similar sample of participants with OCD (21).”
From Task-based fMRI predicts response and remission to exposure therapy in obsessive-compulsive disorder (2019) · cites this paper as [21]
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Multivariate pattern analysis of obsessive–compulsive disorder using structural neuroanatomy
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Atomoxetine Decreases Vulnerability to Develop Compulsivity in High Impulsive Rats
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Cyr, M., Pagliaccio, D., Yanes-Lukin, P. K., Fontaine, M., Rynn, M. A., & Marsh, R. (2020) · Neuropsychopharmacology · doi:10.1038/s41386-020-0613-3 · Cited by 41 · see citing works
Self-citationNeural Circuitry of Interoception: New Insights into Anxiety and Obsessive-Compulsive Disorders
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Functional brain networks underlying detection and integration of disconfirmatory evidence
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Reward-Based Spatial Learning in Teens With Bulimia Nervosa
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Self-citationCognitive Neuroscience of Obsessive-Compulsive Disorder
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Aberrant spontaneous and task-dependent functional connections in the anxious brain
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Always on guard: test of high vs. low control conditions in obsessive-compulsive disorder patients
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Task-based fMRI predicts response and remission to exposure therapy in obsessive-compulsive disorder
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Brain Structural Correlates of Subclinical Obsessive-Compulsive Symptoms in Healthy Children
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Self-citationFunch Uhre, V., Melissa Larsen, K., Marc Herz, D., Baaré, W., Katrine Pagsberg, A., & Roman Siebner, H. (2022) · NeuroImage: Clinical · doi:10.1016/j.nicl.2022.103268 · Cited by 18 · see citing works
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Neural Dysfunction in Cognitive Control Circuits in Persons at Clinical High-Risk for Psychosis
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Self-citationInferior frontal gyrus white matter abnormalities in obsessive–compulsive disorder
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Margolis, A. E., Davis, K. S., Pao, L. S., Lewis, A., Yang, X., Tau, G. Z., Zhao, G., Wang, Z., & Marsh, R. (2017) · Developmental Science · doi:10.1111/desc.12550 · Cited by 16 · see citing works
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Self-citationDevelopmental Neuroimaging in Pediatric Obsessive-Compulsive Disorder
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From Circuit Activity to Network Connectivity and Back: The Case of Obsessive-Compulsive Disorder
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Age-related differences in information, but not task control in the color-word Stroop task
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Neuroimaging Connectivity Analyses and Their Application in Psychiatric Research
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Self-citationError-related brain activity associated with obsessive-compulsive symptoms in youth
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Evidence for trial-by-trial dynamic adjustment of task control in unmedicated adults with OCD
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Self-citationSubcortical shape in pediatric and adult obsessive‐compulsive disorder
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- Authors
- Marsh, R., Horga, G., Parashar, N., Wang, Z., Peterson, B. S., & Simpson, H. B.
- Affiliations
- New York State Psychiatric Institute (US)
- Corresponding author
- Marsh, Rachel
- Venue
- Biological Psychiatry
- Publisher
- Elsevier BV
- Published
- 2014-04
- Volume
- 75
- Issue
- 8
- Pages
- 615-622
- ISSN
- 0006-3223 (ISSN-L)
- PMC
- PMC3722261
- OpenAlex
- W2092581471
- Cited by
- 79
- References
- 71
- Citations by year
- 2025: 1 · 2024: 3 · 2023: 5 · 2022: 3 · 2021: 4 · 2020: 10 · 2019: 3 · 2018: 5 · 2017: 13 · 2016: 11 · 2015: 8 · 2014: 10 · 2013: 3
- FWCI
- 11.87
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Biological Psychiatry (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Institutes of Health (5k02mh074677-05)
- National Institute of Mental Health (K02 MH-74677, K24MH091555, K01MH077652, R21MH093889, K02-MH-074677)
- Topics
- Social Sciences › Psychology › Clinical Psychology › Obsessive-Compulsive Spectrum Disorders
- Life Sciences › Neuroscience › Cognitive Neuroscience › Neural and Behavioral Psychology Studies
- Social Sciences › Psychology › Experimental and Cognitive Psychology › Anxiety, Depression, Psychometrics, Treatment, Cognitive Processes
- Keywords
- obsessive-compulsive disorder, frontostriatal circuits, conflict processing, putamen, insula, inferior frontal gyrus, functional connectivity, self-regulation, cognitive inflexibility
- MeSH terms
- Adult, Attention, Brain, Brain Mapping, Corpus Striatum, Female, Frontal Lobe, Humans, Magnetic Resonance Imaging, Male, Neural Pathways, Neuropsychological Tests, Obsessive-Compulsive Disorder, Signal Processing, Computer-Assisted, Linear Models, Executive Function
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