The DOI matches its Crossref record; 14 of the 14 references it cites were found in a registry or an index.
Clinical Significance of a High SARS-CoV-2 Viral Load in the Saliva
Open accessAbstract
Background: Patients with coronavirus disease 2019 (COVID-19) can unknowingly spread the virus to several people during the early subclinical period.Methods: We evaluated the viral dynamics in various body fluid specimens, such as nasopharyngeal swab, oropharyngeal swab, saliva, sputum, and urine specimens, of two patients with COVID-19 from hospital day 1 to 9. Additional samples of the saliva were taken at 1 hour, 2 hours, and 4 hours after using a chlorhexidine mouthwash.The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) viral load was determined by real-time reverse transcriptase polymerase chain reaction (rRT-PCR).Results: SARS-CoV-2 was detected from all the five specimens of both patients by rRT-PCR.The viral load was the highest in the nasopharynx (patient 1 = 8.41 log 10 copies/mL; patient 2 = 7.49 log 10 copies/mL), but it was also remarkably high in the saliva (patient 1 = 6.63 log 10 copies/mL; patient 2 = 7.10 log 10 copies/mL).SARS-CoV-2 was detected up to hospital day 6 (illness day 9 for patient 2) from the saliva of both patients.The viral load in the saliva decreased transiently for 2 hours after using the chlorhexidine mouthwash.Conclusion: SARS-CoV-2 viral load was consistently high in the saliva; it was relatively higher than that in the oropharynx during the early stage of COVID-19.Chlorhexidine mouthwash was effective in reducing the SARS-CoV-2 viral load in the saliva for a short-term period.
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All-printed soft human-machine interface for robotic physicochemical sensing
Yu, Y., Li, J., Solomon, S. A., Min, J., Tu, J., Guo, W., Xu, C., Song, Y., & Gao, W. (2022) · Science Robotics · doi:10.1126/scirobotics.abn0495 · Cited by 365
On the whereabouts of SARS-CoV-2 in the human body: A systematic review
Trypsteen, W., Van Cleemput, J., Snippenberg, W. V., Gerlo, S., & Vandekerckhove, L. (2020) · PLOS Pathogens · doi:10.1371/journal.ppat.1009037 · Cited by 199
Metadata
- Authors
- Yoon, J. G., Yoon, J., Song, J. Y., Yoon, S.-Y., Lim, C. S., Seong, H., Noh, J. Y., Cheong, H. J., & Kim, W. J.
- Venue
- Journal of Korean Medical Science
- Publisher
- XMLink
- Published
- 2020
- Volume
- 35
- Issue
- 20
- Pages
- e195-e195
- ISSN
- 1011-8934 (ISSN-L)
- 1598-6357
- OpenAlex
- W3026373277
- Cited by
- 313
- References
- 14
- FWCI
- 8.48
- Type
- journal article
- Language
- en
- Open access
- gold
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- Yoon, J. G., Yoon, J., Song, J. Y., Yoon, S.-Y., Lim, C. S., Seong, H., Noh, J. Y., Cheong, H. J., & Kim, W. J. (2020). Clinical Significance of a High SARS-CoV-2 Viral Load in the Saliva. Journal of Korean Medical Science. https://doi.org/10.3346/jkms.2020.35.e195
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