Early Safety Monitoring of COVID-19 Vaccines in Healthcare Workers
Open accessAbstract
Hospital-based surveillance for adverse events was conducted on healthcare workers after they received the first dose of coronavirus disease 2019 (COVID-19) vaccine. Among the two new platform vaccines (messenger RNA- and adenoviral vector-based vaccines), the rates of systemic adverse events were significantly higher among adenovirus-vectored vaccine recipients. Fatigue (87.6% vs. 53.8%), myalgia (80.8% vs. 50.0%), headache (72.0% vs. 28.8%), and fever (≥ 38.0°C, 38.7% vs. 0%) were the most common adverse events among adenovirus-vectored vaccine recipients, but most symptoms resolved within 2 days. Both types of COVID-19 vaccines were generally safe, and serious adverse events rarely occurred.
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
High-quality real-world safety data on the messenger RNA-based Covid-19 vaccines remain relatively sparse in the literature.
“but high-quality real-world safety data on the messenger RNA (mRNA)–based Covid-19 vaccines remain relatively sparse in the literature.”
From Safety of the BNT162b2 mRNA Covid-19 Vaccine in a Nationwide Setting (2021) · cites this paper as [14]
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Cites
Safety and Efficacy of the BNT162b2 mRNA Covid-19 Vaccine
Polack, F. P., Thomas, S. J., Kitchin, N., Absalon, J., Gurtman, A., Lockhart, S., Perez, J. L., Pérez Marc, G., Moreira, E. D., Zerbini, C., et al. (2020) · New England Journal of Medicine · doi:10.1056/nejmoa2034577 · Cited by 14,592 · see citing works
Voysey, M., Clemens, S. A. C., Madhi, S. A., Weckx, L. Y., Folegatti, P. M., Aley, P. K., Angus, B., Baillie, V. L., Barnabas, S. L., Bhorat, Q. E., et al. (2021) · The Lancet · doi:10.1016/s0140-6736(20)32661-1 · Cited by 4,616 · see citing works
Ramasamy, M. N., Minassian, A. M., Ewer, K. J., Flaxman, A. L., Folegatti, P. M., Owens, D. R., Voysey, M., Aley, P. K., Angus, B., Babbage, G., et al. (2020) · The Lancet · doi:10.1016/s0140-6736(20)32466-1 · Cited by 1,324 · see citing works
Flagged first, then by citations
1 of the 4 references couldn’t be matched to a known paper.
Cited by
Sorted by citations
Safety of the BNT162b2 mRNA Covid-19 Vaccine in a Nationwide Setting
Barda, N., Dagan, N., Ben-Shlomo, Y., Kepten, E., Waxman, J., Ohana, R., Hernán, M. A., Lipsitch, M., Kohane, I., Netzer, D., et al. (2021) · New England Journal of Medicine · doi:10.1056/nejmoa2110475 · Cited by 1,027 · see citing works
Evaluation of the safety profile of COVID-19 vaccines: a rapid review
Wu, Q., Dudley, M. Z., Chen, X., Bai, X., Dong, K., Zhuang, T., Salmon, D. A., & Yu, H. (2021) · BMC Medicine · doi:10.1186/s12916-021-02059-5 · Cited by 241 · see citing works
Sex and Gender in COVID-19 Vaccine Research: Substantial Evidence Gaps Remain
Vassallo, A. J., Shajahan, S., Harris, K., Hallam, L., Hockham, C., Womersley, K., Woodward, M., & Sheel, M. (2021) · Frontiers in Global Women s Health · doi:10.3389/fgwh.2021.761511 · Cited by 78 · see citing works
Castaldo, M., Waliszewska‐Prosół, M., Koutsokera, M., Robotti, M., Straburzyński, M., Apostolakopoulou, L., Capizzi, M., Çibuku, O., Ambat, F. D. F., Frattale, I., et al. (2022) · The Journal of Headache and Pain · doi:10.1186/s10194-022-01400-4 · Cited by 70 · see citing works
Teerawattananon, Y., Anothaisintawee, T., Pheerapanyawaranun, C., Botwright, S., Akksilp, K., Sirichumroonwit, N., Budtarad, N., & Isaranuwatchai, W. (2022) · PLoS ONE · doi:10.1371/journal.pone.0261930 · Cited by 50 · see citing works
Safety Monitoring after the BNT162b2 COVID-19 Vaccine among Adults Aged 75 Years or Older
Choi, Y. Y., Kim, M.-K., Kwon, H. C., & Kim, G. H. (2021) · Journal of Korean Medical Science · doi:10.3346/jkms.2021.36.e318 · Cited by 20 · see citing works
Self-citationSafety of Global SARS-CoV-2 Vaccines, a Meta-Analysis
Chen, L., Cai, X., Zhao, T., Han, B., Xie, M., Cui, J., Zhang, J., Wang, C., Liu, B., Lu, Q., et al. (2022) · Vaccines · doi:10.3390/vaccines10040596 · Cited by 20 · see citing works
Wang, S., Liu, W.-Q., Li, Y., Li, J., & Zhu, F. (2023) · Expert Review of Vaccines · doi:10.1080/14760584.2023.2242528 · Cited by 18 · see citing works
Park, J. Y., Choi, S., Chung, J.-W., Hwang, M.-H., & Kim, M. (2021) · Journal of Clinical Medicine · doi:10.3390/jcm10132844 · Cited by 18 · see citing works
Self-citationSubedi, P., Yadav, G. K., Paudel, B., Regmi, A., & Pyakurel, P. (2021) · PLoS ONE · doi:10.1371/journal.pone.0260638 · Cited by 18 · see citing works
Polyarthralgia and Myalgia Syndrome after ChAdOx1 nCOV-19 Vaccination
Hyun, H., Song, J. Y., Seong, H., Yoon, J. G., Noh, J. Y., Cheong, H. J., & Kim, W. J. (2021) · Journal of Korean Medical Science · doi:10.3346/jkms.2021.36.e245 · Cited by 17 · see citing works
Self-citationRifai, A., Wu, W., Tang, Y.-W., Lu, M.-Y., Chiu, P.-J., Strong, C., Lin, C., Chen, P., Ko, W., & Ko, N. (2023) · Vaccines · doi:10.3390/vaccines11010129 · Cited by 17 · see citing works
Kim, T., Park, S. Y., Yu, S., Park, J. W., Lee, E. J., Jeon, M. H., Kim, T. H., & Choo, E. J. (2021) · Vaccines · doi:10.3390/vaccines9060648 · Cited by 15 · see citing works
Anaphylaxis and Related Events Following COVID‐19 Vaccination: A Systematic Review
Paul, P., Janjua, E., Al-Subaie, M., Ramadorai, V., Mushannen, B., Vattoth, A. L., Khan, W., Bshesh, K., Nauman, A., Mohammed, I., et al. (2022) · The Journal of Clinical Pharmacology · doi:10.1002/jcph.2120 · Cited by 15 · see citing works
Kang, Y. M., Lim, J., Choe, K. W., Lee, K.-D., Jo, D. H., Kim, M. J., Kim, J. M., & Kim, K. N. (2021) · Clinical and Experimental Vaccine Research · doi:10.7774/cevr.2021.10.3.282 · Cited by 13 · see citing works
Self-citationBatı, S., Burucu, R., Cantekin, I., & DÖNMEZ, H. (2021) · Konuralp Tıp Dergisi · doi:10.18521/ktd.981790 · Cited by 12 · see citing works
Prevalence of COVID‐19 vaccine reactogenicity among Bangladeshi physicians
Majumder, M. A. A., Lutfor, A. B., Rabbi, A. M. F., Alam, A. B. M. M., Rahman, M., Saha, N. C., Campbell, M., Haque, M., Nessa, K., Khondoker, M. U., et al. (2022) · FASEB BioAdvances · doi:10.1096/fba.2021-00158 · Cited by 10 · see citing works
Lee, S. W., Lee, H. J., Lee, S.-K., Moon, J., Moon, S., Chung, S. J., Yeo, Y., Park, T. S., Park, D. W., Kim, T., et al. (2021) · Frontiers in Medicine · doi:10.3389/fmed.2021.738049 · Cited by 8 · see citing works
Self-citationCoronavirus disease 2019 vaccines and relevant adverse reactions
Chung, E. H. (2021) · Allergy Asthma & Respiratory Disease · doi:10.4168/aard.2021.9.3.124 · Cited by 6 · see citing works
Lee, J.-H., Kim, Y. Y., Heo, H. J., Park, J. H., Cho, H. G., & Kim, G. (2023) · Anesthesia and Pain Medicine · doi:10.17085/apm.22207 · Cited by 6 · see citing works
Central nervous system manifestations following vaccination against COVID-19
Khatami, S. S., Revheim, M.-E. R., Høilund‐Carlsen, P. F., Alavi, A. A., Shirkouhi, S. G., & Andalib, S. (2024) · Brain Behavior & Immunity - Health · doi:10.1016/j.bbih.2024.100788 · Cited by 5 · see citing works
Tan, L. J., Koh, C. P., Lai, S. K., Poh, W. C., Othman, M. S., & Hussin, H. (2022) · Forensic Science International · doi:10.1016/j.forsciint.2022.111469 · Cited by 5 · see citing works
Manilgama, S. R., Hettiarachchi, N. M., Jayasinghe, I. K., Silva, S., Jayalath, T. A., Wanigaratne, T., Bandusiri, R. P., Suganthan, N., Sudarshan, P., Pathirage, M. K. P., et al. (2022) · Asian Journal of Internal Medicine · doi:10.4038/ajim.v1i1.28 · Cited by 4 · see citing works
Prevalence of Adverse Events Post-COVID-19 Vaccination amongst the Adult Zambian Population
Chileshe, M., Mupeta, G., Kasanga, M., Mfune, R. L., Mudenda, S., Biemba, M., Shimaponda-Mataa, N. M., Sinkala, M., & Daka, V. (2021) · Journal of Biomedical Research & Environmental Sciences · doi:10.37871/jbres1389 · Cited by 3 · see citing works
Syed, A. S., Sultana, S., Begum, A., Nadeem, K., Ara, J., Askarey, S. H., Siddiqui, A. A., Anwar, A., & Hashmi, A. A. (2023) · Cureus · doi:10.7759/cureus.46682 · Cited by 1 · see citing works
New-onset anesthesia/paresthesia following the administration of COVID-19 vaccines in Quebec, Canada
Rouleau, I., Kana, K. D. N. I., Zafack, J. G., Viger, Y. B., & Serres, G. D. (2025) · Vaccine · doi:10.1016/j.vaccine.2025.127217 · Cited by 1 · see citing works
Determination of early side effects after covid-19 vaccinations
Şimşek, N. Y., Açıksöz, S., & Atar, N. Y. (2023) · Acibadem Universitesi Saglik Bilimleri Dergisi · doi:10.31067/acusaglik.1109356 · Cited by 1 · see citing works
Inequalities in COVID-19 healthcare and research affecting women
(2023) · Frontiers research topics · doi:10.3389/978-2-8325-2493-0
Adverse Events Related to SARS-Cov-2 Vaccination: A Systematic Review and Meta-Analysis
Bello, S., Ajayi, D. T., Adepoju, A., Omotosho, T., Afolabi, R. F., Gbadebo, B. M., Salawu, M. M., Bamgboye, E. A., Oduwole, O. A., Fagbamigbe, A. F., et al. (2023) · Journal of Epidemiology and Public Health · doi:10.26911/jepublichealth.2023.08.03.01
Aslan, T. K., Cantekin, I., Burucu, R., & Akdoğan, Y. (2024) · Ageing International · doi:10.1007/s12126-023-09536-7
Castaldo, M., Waliszewska‐Prosół, M., Koutsokera, M., Robotti, M., Straburzyński, M., Apostolakopoulou, L., Capizzi, M., Çibuku, O., Ambat, F. D. F., Frattale, I., et al. (2022) · Figshare · doi:10.6084/m9.figshare.19498266
Additional file 1 of Evaluation of the safety profile of COVID-19 vaccines: a rapid review
Wu, Q., Dudley, M. Z., Chen, X., Bai, X., Dong, K., Zhuang, T., Salmon, D., & Yu, H. (2021) · Figshare · doi:10.6084/m9.figshare.15064656
- Authors
- Song, J. Y., Cheong, H. J., Kim, S. R., Lee, S. E., Kim, S. H., Noh, J. Y., Yoon, Y. K., Choi, W. S., Park, D. W., Sohn, J. W., Kim, W. J., & Kim, M. J.
- Affiliations
- Korea University Guro Hospital (KR)
- Korea University Anam Hospital (KR)
- Korea University Ansan Hospital (KR)
- Corresponding author
- Cheong, Hee Jin
- ORCID
- Venue
- Journal of Korean Medical Science
- Publisher
- XMLink
- Published
- 2021
- Volume
- 36
- Issue
- 15
- Pages
- e110-e110
- ISSN
- 1011-8934 (ISSN-L)
- 1598-6357
- PMC
- PMC8055510
- OpenAlex
- W3154242194
- Cited by
- 31
- References
- 4
- Citations by year
- 2025: 1 · 2024: 2 · 2023: 6 · 2022: 7 · 2021: 15
- FWCI
- 2.37
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- Locations
- Journal of Korean Medical Science (publishedVersion, cc-by-nc)
- PubMed Central (publishedVersion, cc-by-nc)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Infectious Diseases › SARS-CoV-2 and COVID-19 Research
- Life Sciences › Pharmacology, Toxicology and Pharmaceutics › Toxicology › Pharmacovigilance and Adverse Drug Reactions
- Health Sciences › Medicine › Infectious Diseases › COVID-19 Clinical Research Studies
- Keywords
- COVID-19 vaccines, vaccine safety, healthcare workers, hospital surveillance, adverse events, adenovirus vector vaccine, mRNA vaccines, fatigue, myalgia, headache, fever, serious adverse events
- MeSH terms
- COVID-19, SARS-CoV-2, COVID-19 Vaccines, Adult, Aged, Female, Health Personnel, Humans, Male, Middle Aged, Vaccination
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
