The DOI matches its Crossref record; 17 of the 17 references it cites were found in a registry or an index.
Advanced glycation end-products and advanced oxidation protein products in patients with diabetes mellitus
Open accessAbstract
Accelerated glycoxidation takes part in the development of diabetic complications. We determined advanced glycation end-products (AGEs) and advanced oxidation protein products (AOPP) in the sera of 52 patients with diabetes mellitus (DM) - 18 with DM Type 1 and 34 with DM Type 2 and examined their relationship to the compensation of the disease. AGEs were estimated spectrofluorimetrically (350 nm/440 nm) whereas AOPP were determined spectro-photometrically (340 nm). AGEs were elevated only in DM Type 2 (DM2 5.11±1.15x103 AU/g vs controls 4.08±0.71x103 AU/g, p<0.001, vs DM1 4.14±0.86x103 AU/g, p<0.005, DM1 vs controls were not significant). AOPP were elevated significantly in both types of DM with higher levels in DM Type 2 (DM2 157.50±75.15 mmol/l vs healthy subjects 79.80±23.72 mmol/l, p<0.001, vs DM1 97.50±30.91 mmol/l, p<0.005, DM1 vs controls p<0.05). There was a tight correlation between AGEs and AOPP in both types of DM (DM1 r=0.75, DM2 r=0.47 (p<0.05)) and both AGEs and AOPP correlated with triglycerides. In DM Type 1 only, AGEs correlated with HbA1c r=0.47 (p<0.05) and with blood glucose. Slight but not significant differences in AGEs and AOPP levels were observed in patients with or without diabetic complications. Oxidative stress is increased in both types of DM, more in Type 2 where it contributes to the formation of glycoxidation products.
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Cites
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Advanced oxidation protein products as a novel marker of oxidative stress in uremia
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Cited by
Measurement and Clinical Significance of Biomarkers of Oxidative Stress in Humans
Marrocco, I., Altieri, F., & Peluso, I. (2017) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2017/6501046 · Cited by 855
Markers of Oxidative Stress during Diabetes Mellitus
Tiwari, B. K., Pandey, K. B., Abidi, A. B., & Rizvi, S. I. (2013) · Journal of Biomarkers · doi:10.1155/2013/378790 · Cited by 517
Dietary Advanced Glycation End Products and Aging
Luevano-Contreras, C., & Chapman-Novakofski, K. (2010) · Nutrients · doi:10.3390/nu2121247 · Cited by 396
Maciejczyk, M., Zalewska, A., & Ładny, J. R. (2019) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2019/4393460 · Cited by 117
Świderska, M., Maciejczyk, M., Zalewska, A., Pogorzelska, J., Flisiak, R., & Chabowski, A. (2019) · Free Radical Research · doi:10.1080/10715762.2019.1635691 · Cited by 107
Metadata
- Authors
- Kalousová, M., Škrha, J., & Zima, T.
- Venue
- Physiological Research
- Published
- 2002
- Volume
- 51
- Issue
- 6
- Pages
- 597-604
- ISSN
- 0862-8408 (ISSN-L)
- 1802-9973
- OpenAlex
- W2100322364
- Cited by
- 455
- References
- 17
- FWCI
- 3.67
- Type
- journal article
- Language
- en
- Open access
- gold
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